BRPI0707330A2 - processo para preparação de derivados de rapamicina - Google Patents

processo para preparação de derivados de rapamicina Download PDF

Info

Publication number
BRPI0707330A2
BRPI0707330A2 BRPI0707330-5A BRPI0707330A BRPI0707330A2 BR PI0707330 A2 BRPI0707330 A2 BR PI0707330A2 BR PI0707330 A BRPI0707330 A BR PI0707330A BR PI0707330 A2 BRPI0707330 A2 BR PI0707330A2
Authority
BR
Brazil
Prior art keywords
formula
compound
alkyl
aryl
hydroxy
Prior art date
Application number
BRPI0707330-5A
Other languages
English (en)
Portuguese (pt)
Inventor
Murat Acemoglu
Sabine Pfeffer
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BRPI0707330A2 publication Critical patent/BRPI0707330A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Transplantation (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
BRPI0707330-5A 2006-01-24 2007-01-22 processo para preparação de derivados de rapamicina BRPI0707330A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0601406.2 2006-01-24
GBGB0601406.2A GB0601406D0 (en) 2006-01-24 2006-01-24 Organic Compounds
PCT/EP2007/000514 WO2007085400A1 (en) 2006-01-24 2007-01-22 Process for the preparation of rapamycin derivatives

Publications (1)

Publication Number Publication Date
BRPI0707330A2 true BRPI0707330A2 (pt) 2011-05-03

Family

ID=36060760

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0707330-5A BRPI0707330A2 (pt) 2006-01-24 2007-01-22 processo para preparação de derivados de rapamicina

Country Status (11)

Country Link
US (1) US8138344B2 (enExample)
EP (1) EP1979359A1 (enExample)
JP (2) JP5416412B2 (enExample)
KR (1) KR101423343B1 (enExample)
CN (2) CN104211716A (enExample)
AU (1) AU2007209569B2 (enExample)
BR (1) BRPI0707330A2 (enExample)
CA (1) CA2637075A1 (enExample)
GB (1) GB0601406D0 (enExample)
RU (1) RU2448970C2 (enExample)
WO (1) WO2007085400A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0601406D0 (en) * 2006-01-24 2006-03-08 Novartis Ag Organic Compounds
JP6378192B2 (ja) * 2012-11-13 2018-08-22 エルジー エレクトロニクス インコーポレイティド データ送信方法及び装置、並びにデータ送信方法及び装置
CN108864149B (zh) 2013-03-15 2022-04-05 生物传感器国际集团有限公司 雷帕霉素衍生物的纯化
EP3109250A1 (en) * 2015-06-23 2016-12-28 Synbias Pharma AG Method for the synthesis of rapamycin derivatives
UY37900A (es) 2017-09-26 2019-04-30 Novartis Ag Nuevos derivados de rapamicina
LT3898637T (lt) 2018-12-18 2025-03-10 Novartis Ag Rapamicino dariniai
CA3127448C (en) 2019-01-22 2024-06-04 Aeovian Pharmaceuticals, Inc. Mtorc modulators and uses thereof
KR20260115158A (ko) 2019-03-26 2026-07-23 노파르티스 아게 이소티아졸리딘 1,1-디옥시드 및 1,4-부탄 술톤 함유 라파마이신 유도체 및 이의 용도
CN115776907B (zh) 2020-03-27 2025-02-25 艾奥维安制药公司 Mtorc1调节剂及其用途
WO2026080482A1 (en) * 2024-10-07 2026-04-16 Tornado Therapeutics, Inc. Rapamycin derivatives and uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5256790A (en) * 1992-08-13 1993-10-26 American Home Products Corporation 27-hydroxyrapamycin and derivatives thereof
GB9221220D0 (en) * 1992-10-09 1992-11-25 Sandoz Ag Organic componds
DE69624921T2 (de) * 1995-06-09 2003-09-11 Novartis Ag, Basel Rapamycinderivate
IL150524A0 (en) * 2000-01-07 2003-02-12 Transform Pharmaceuticals Inc High-throughput formation, identification, and analysis of diverse solid-forms
GB0601406D0 (en) * 2006-01-24 2006-03-08 Novartis Ag Organic Compounds

Also Published As

Publication number Publication date
US8138344B2 (en) 2012-03-20
RU2008134424A (ru) 2010-02-27
WO2007085400A1 (en) 2007-08-02
JP2009523836A (ja) 2009-06-25
JP5416412B2 (ja) 2014-02-12
RU2448970C2 (ru) 2012-04-27
GB0601406D0 (en) 2006-03-08
US20090012298A1 (en) 2009-01-08
CN104211716A (zh) 2014-12-17
KR101423343B1 (ko) 2014-07-24
CN101374847A (zh) 2009-02-25
EP1979359A1 (en) 2008-10-15
JP2013136631A (ja) 2013-07-11
KR20080090453A (ko) 2008-10-08
AU2007209569A1 (en) 2007-08-02
AU2007209569B2 (en) 2011-09-15
CA2637075A1 (en) 2007-08-02

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 10A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2394 DE 22-11-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.