KR101423343B1 - 라파마이신 유도체의 제조 방법 - Google Patents

라파마이신 유도체의 제조 방법 Download PDF

Info

Publication number
KR101423343B1
KR101423343B1 KR1020087018088A KR20087018088A KR101423343B1 KR 101423343 B1 KR101423343 B1 KR 101423343B1 KR 1020087018088 A KR1020087018088 A KR 1020087018088A KR 20087018088 A KR20087018088 A KR 20087018088A KR 101423343 B1 KR101423343 B1 KR 101423343B1
Authority
KR
South Korea
Prior art keywords
formula
compound
compounds
rapamycin
mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1020087018088A
Other languages
English (en)
Korean (ko)
Other versions
KR20080090453A (ko
Inventor
무라트 아세모글루
자비네 페퍼
Original Assignee
노파르티스 아게
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 노파르티스 아게 filed Critical 노파르티스 아게
Publication of KR20080090453A publication Critical patent/KR20080090453A/ko
Application granted granted Critical
Publication of KR101423343B1 publication Critical patent/KR101423343B1/ko
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Transplantation (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
KR1020087018088A 2006-01-24 2007-01-22 라파마이신 유도체의 제조 방법 Expired - Fee Related KR101423343B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0601406.2 2006-01-24
GBGB0601406.2A GB0601406D0 (en) 2006-01-24 2006-01-24 Organic Compounds
PCT/EP2007/000514 WO2007085400A1 (en) 2006-01-24 2007-01-22 Process for the preparation of rapamycin derivatives

Publications (2)

Publication Number Publication Date
KR20080090453A KR20080090453A (ko) 2008-10-08
KR101423343B1 true KR101423343B1 (ko) 2014-07-24

Family

ID=36060760

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020087018088A Expired - Fee Related KR101423343B1 (ko) 2006-01-24 2007-01-22 라파마이신 유도체의 제조 방법

Country Status (11)

Country Link
US (1) US8138344B2 (enExample)
EP (1) EP1979359A1 (enExample)
JP (2) JP5416412B2 (enExample)
KR (1) KR101423343B1 (enExample)
CN (2) CN104211716A (enExample)
AU (1) AU2007209569B2 (enExample)
BR (1) BRPI0707330A2 (enExample)
CA (1) CA2637075A1 (enExample)
GB (1) GB0601406D0 (enExample)
RU (1) RU2448970C2 (enExample)
WO (1) WO2007085400A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0601406D0 (en) * 2006-01-24 2006-03-08 Novartis Ag Organic Compounds
JP6378192B2 (ja) * 2012-11-13 2018-08-22 エルジー エレクトロニクス インコーポレイティド データ送信方法及び装置、並びにデータ送信方法及び装置
CN108864149B (zh) 2013-03-15 2022-04-05 生物传感器国际集团有限公司 雷帕霉素衍生物的纯化
EP3109250A1 (en) * 2015-06-23 2016-12-28 Synbias Pharma AG Method for the synthesis of rapamycin derivatives
UY37900A (es) 2017-09-26 2019-04-30 Novartis Ag Nuevos derivados de rapamicina
LT3898637T (lt) 2018-12-18 2025-03-10 Novartis Ag Rapamicino dariniai
CA3127448C (en) 2019-01-22 2024-06-04 Aeovian Pharmaceuticals, Inc. Mtorc modulators and uses thereof
KR20260115158A (ko) 2019-03-26 2026-07-23 노파르티스 아게 이소티아졸리딘 1,1-디옥시드 및 1,4-부탄 술톤 함유 라파마이신 유도체 및 이의 용도
CN115776907B (zh) 2020-03-27 2025-02-25 艾奥维安制药公司 Mtorc1调节剂及其用途
WO2026080482A1 (en) * 2024-10-07 2026-04-16 Tornado Therapeutics, Inc. Rapamycin derivatives and uses thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR19990022780A (ko) * 1995-06-09 1999-03-25 한스 루돌프 하우스, 헨리테 브룬너, 베아트리체 귄터 라파마이신 유도체

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5256790A (en) * 1992-08-13 1993-10-26 American Home Products Corporation 27-hydroxyrapamycin and derivatives thereof
GB9221220D0 (en) * 1992-10-09 1992-11-25 Sandoz Ag Organic componds
IL150524A0 (en) * 2000-01-07 2003-02-12 Transform Pharmaceuticals Inc High-throughput formation, identification, and analysis of diverse solid-forms
GB0601406D0 (en) * 2006-01-24 2006-03-08 Novartis Ag Organic Compounds

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR19990022780A (ko) * 1995-06-09 1999-03-25 한스 루돌프 하우스, 헨리테 브룬너, 베아트리체 귄터 라파마이신 유도체

Also Published As

Publication number Publication date
US8138344B2 (en) 2012-03-20
RU2008134424A (ru) 2010-02-27
WO2007085400A1 (en) 2007-08-02
JP2009523836A (ja) 2009-06-25
BRPI0707330A2 (pt) 2011-05-03
JP5416412B2 (ja) 2014-02-12
RU2448970C2 (ru) 2012-04-27
GB0601406D0 (en) 2006-03-08
US20090012298A1 (en) 2009-01-08
CN104211716A (zh) 2014-12-17
CN101374847A (zh) 2009-02-25
EP1979359A1 (en) 2008-10-15
JP2013136631A (ja) 2013-07-11
KR20080090453A (ko) 2008-10-08
AU2007209569A1 (en) 2007-08-02
AU2007209569B2 (en) 2011-09-15
CA2637075A1 (en) 2007-08-02

Similar Documents

Publication Publication Date Title
JP5416412B2 (ja) ラパマイシン誘導体の製造方法
US8884016B2 (en) Apixaban preparation process
CA2112129C (en) Oxazolidine derivative and pharmaceutically acceptable salt thereof
US8901322B2 (en) Crystalline forms of cabazitaxel and process for preparation thereof
AU2013304102B2 (en) Chemical process
EP3630738B1 (en) Process for the production of ozanimod
EP2721017A1 (en) Method of producing beraprost
JP2022533405A (ja) カンナビジオール系化合物の製造方法
WO2020167829A1 (en) Method of preparing a don prodrug from l-pyroglutamic acid
AU656994B2 (en) Prostaglandins
JP2024530795A (ja) ニロガセスタットの合成
JP2019089848A (ja) ラパマイシン誘導体の精製
ES2881899T3 (es) Procedimiento de preparación de un inhibidor de fosfodiesterasa 4
MX2008009469A (en) Process for the preparation of rapamycin derivatives
AU2011254079A1 (en) Process for the preparation of rapamycin derivatives
WO2016090461A1 (en) Salts of prostaglandin analog intermediates
RU2142456C1 (ru) Производные антрапиразолонов, способы их получения и способы получения из них антрапиразолонов, обладающих противоопухолевой активностью
AU739292B2 (en) Processes and intermediates useful to make antifolates
WO2011077174A1 (en) Process for preparing pharmaceutical compounds and intermediate compounds
MXPA00007824A (enExample)

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

A201 Request for examination
E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E90F Notification of reason for final refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U12-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

LAPS Lapse due to unpaid annual fee
PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 20170719

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 20170719

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000