RU2448970C2 - Способ получения производных рапамицина - Google Patents

Способ получения производных рапамицина Download PDF

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Publication number
RU2448970C2
RU2448970C2 RU2008134424/04A RU2008134424A RU2448970C2 RU 2448970 C2 RU2448970 C2 RU 2448970C2 RU 2008134424/04 A RU2008134424/04 A RU 2008134424/04A RU 2008134424 A RU2008134424 A RU 2008134424A RU 2448970 C2 RU2448970 C2 RU 2448970C2
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RU
Russia
Prior art keywords
formula
compound
compounds
mixture
deoxorapamycin
Prior art date
Application number
RU2008134424/04A
Other languages
English (en)
Russian (ru)
Other versions
RU2008134424A (ru
Inventor
Мурат АЦЕМОГЛЫ (CH)
Мурат Ацемоглы
Забине ПФЕФФЕР (DE)
Забине ПФЕФФЕР
Original Assignee
Новартис Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Новартис Аг filed Critical Новартис Аг
Publication of RU2008134424A publication Critical patent/RU2008134424A/ru
Application granted granted Critical
Publication of RU2448970C2 publication Critical patent/RU2448970C2/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Transplantation (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
RU2008134424/04A 2006-01-24 2007-01-22 Способ получения производных рапамицина RU2448970C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0601406.2 2006-01-24
GBGB0601406.2A GB0601406D0 (en) 2006-01-24 2006-01-24 Organic Compounds

Publications (2)

Publication Number Publication Date
RU2008134424A RU2008134424A (ru) 2010-02-27
RU2448970C2 true RU2448970C2 (ru) 2012-04-27

Family

ID=36060760

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2008134424/04A RU2448970C2 (ru) 2006-01-24 2007-01-22 Способ получения производных рапамицина

Country Status (11)

Country Link
US (1) US8138344B2 (enExample)
EP (1) EP1979359A1 (enExample)
JP (2) JP5416412B2 (enExample)
KR (1) KR101423343B1 (enExample)
CN (2) CN104211716A (enExample)
AU (1) AU2007209569B2 (enExample)
BR (1) BRPI0707330A2 (enExample)
CA (1) CA2637075A1 (enExample)
GB (1) GB0601406D0 (enExample)
RU (1) RU2448970C2 (enExample)
WO (1) WO2007085400A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2718058C2 (ru) * 2015-06-23 2020-03-30 Синбиас Фарма АГ Способ синтеза производных рапамицина

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0601406D0 (en) * 2006-01-24 2006-03-08 Novartis Ag Organic Compounds
JP6378192B2 (ja) * 2012-11-13 2018-08-22 エルジー エレクトロニクス インコーポレイティド データ送信方法及び装置、並びにデータ送信方法及び装置
CN108864149B (zh) 2013-03-15 2022-04-05 生物传感器国际集团有限公司 雷帕霉素衍生物的纯化
UY37900A (es) 2017-09-26 2019-04-30 Novartis Ag Nuevos derivados de rapamicina
LT3898637T (lt) 2018-12-18 2025-03-10 Novartis Ag Rapamicino dariniai
CA3127448C (en) 2019-01-22 2024-06-04 Aeovian Pharmaceuticals, Inc. Mtorc modulators and uses thereof
KR20260115158A (ko) 2019-03-26 2026-07-23 노파르티스 아게 이소티아졸리딘 1,1-디옥시드 및 1,4-부탄 술톤 함유 라파마이신 유도체 및 이의 용도
CN115776907B (zh) 2020-03-27 2025-02-25 艾奥维安制药公司 Mtorc1调节剂及其用途
WO2026080482A1 (en) * 2024-10-07 2026-04-16 Tornado Therapeutics, Inc. Rapamycin derivatives and uses thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5256790A (en) * 1992-08-13 1993-10-26 American Home Products Corporation 27-hydroxyrapamycin and derivatives thereof
RU2143434C1 (ru) * 1992-10-09 1999-12-27 Новартис Аг Производные рапамицина и фармацевтическая композиция

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69624921T2 (de) * 1995-06-09 2003-09-11 Novartis Ag, Basel Rapamycinderivate
IL150524A0 (en) * 2000-01-07 2003-02-12 Transform Pharmaceuticals Inc High-throughput formation, identification, and analysis of diverse solid-forms
GB0601406D0 (en) * 2006-01-24 2006-03-08 Novartis Ag Organic Compounds

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5256790A (en) * 1992-08-13 1993-10-26 American Home Products Corporation 27-hydroxyrapamycin and derivatives thereof
RU2143434C1 (ru) * 1992-10-09 1999-12-27 Новартис Аг Производные рапамицина и фармацевтическая композиция

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2718058C2 (ru) * 2015-06-23 2020-03-30 Синбиас Фарма АГ Способ синтеза производных рапамицина

Also Published As

Publication number Publication date
US8138344B2 (en) 2012-03-20
RU2008134424A (ru) 2010-02-27
WO2007085400A1 (en) 2007-08-02
JP2009523836A (ja) 2009-06-25
BRPI0707330A2 (pt) 2011-05-03
JP5416412B2 (ja) 2014-02-12
GB0601406D0 (en) 2006-03-08
US20090012298A1 (en) 2009-01-08
CN104211716A (zh) 2014-12-17
KR101423343B1 (ko) 2014-07-24
CN101374847A (zh) 2009-02-25
EP1979359A1 (en) 2008-10-15
JP2013136631A (ja) 2013-07-11
KR20080090453A (ko) 2008-10-08
AU2007209569A1 (en) 2007-08-02
AU2007209569B2 (en) 2011-09-15
CA2637075A1 (en) 2007-08-02

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MM4A The patent is invalid due to non-payment of fees

Effective date: 20160123