RU2448970C2 - Способ получения производных рапамицина - Google Patents
Способ получения производных рапамицина Download PDFInfo
- Publication number
- RU2448970C2 RU2448970C2 RU2008134424/04A RU2008134424A RU2448970C2 RU 2448970 C2 RU2448970 C2 RU 2448970C2 RU 2008134424/04 A RU2008134424/04 A RU 2008134424/04A RU 2008134424 A RU2008134424 A RU 2008134424A RU 2448970 C2 RU2448970 C2 RU 2448970C2
- Authority
- RU
- Russia
- Prior art keywords
- formula
- compound
- compounds
- mixture
- deoxorapamycin
- Prior art date
Links
- 0 CC(CCCCCC(C)=CC=CC=CCCC(C)C(C(C(C(C)=C[C@@](C)C(*)C[C@@](C*)OC(C(CCCC1)N1C(C1=O)=O)=O)O)OC)=*)C1([O-])O Chemical compound CC(CCCCCC(C)=CC=CC=CCCC(C)C(C(C(C(C)=C[C@@](C)C(*)C[C@@](C*)OC(C(CCCC1)N1C(C1=O)=O)=O)O)OC)=*)C1([O-])O 0.000 description 1
- CARWLUDBSNWZKZ-UHFFFAOYSA-N CC(Oc1ccccc1)=S Chemical compound CC(Oc1ccccc1)=S CARWLUDBSNWZKZ-UHFFFAOYSA-N 0.000 description 1
- VSIIHWOJPSSIDI-UHFFFAOYSA-N CCOc(cc1)ccc1I Chemical compound CCOc(cc1)ccc1I VSIIHWOJPSSIDI-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Transplantation (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0601406.2 | 2006-01-24 | ||
| GBGB0601406.2A GB0601406D0 (en) | 2006-01-24 | 2006-01-24 | Organic Compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2008134424A RU2008134424A (ru) | 2010-02-27 |
| RU2448970C2 true RU2448970C2 (ru) | 2012-04-27 |
Family
ID=36060760
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2008134424/04A RU2448970C2 (ru) | 2006-01-24 | 2007-01-22 | Способ получения производных рапамицина |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8138344B2 (enExample) |
| EP (1) | EP1979359A1 (enExample) |
| JP (2) | JP5416412B2 (enExample) |
| KR (1) | KR101423343B1 (enExample) |
| CN (2) | CN101374847A (enExample) |
| AU (1) | AU2007209569B2 (enExample) |
| BR (1) | BRPI0707330A2 (enExample) |
| CA (1) | CA2637075A1 (enExample) |
| GB (1) | GB0601406D0 (enExample) |
| RU (1) | RU2448970C2 (enExample) |
| WO (1) | WO2007085400A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2718058C2 (ru) * | 2015-06-23 | 2020-03-30 | Синбиас Фарма АГ | Способ синтеза производных рапамицина |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0601406D0 (en) * | 2006-01-24 | 2006-03-08 | Novartis Ag | Organic Compounds |
| US9876615B2 (en) * | 2012-11-13 | 2018-01-23 | Lg Electronics Inc. | Method and apparatus for transmitting and receiving data multiple times in consecutive subframes |
| WO2014145780A1 (en) | 2013-03-15 | 2014-09-18 | Biosensors International Group, Ltd. | Purification of rapamycin derivatives |
| UY37900A (es) | 2017-09-26 | 2019-04-30 | Novartis Ag | Nuevos derivados de rapamicina |
| LT3898637T (lt) | 2018-12-18 | 2025-03-10 | Novartis Ag | Rapamicino dariniai |
| KR102643707B1 (ko) | 2019-01-22 | 2024-03-04 | 에오비안 파마슈티컬스, 인크. | Mtorc 조절제 및 이의 용도 |
| MX2022011964A (es) * | 2020-03-27 | 2022-12-02 | Aeovian Pharmaceuticals Inc | Moduladores de mtorc1 y usos de los mismos. |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5256790A (en) * | 1992-08-13 | 1993-10-26 | American Home Products Corporation | 27-hydroxyrapamycin and derivatives thereof |
| RU2143434C1 (ru) * | 1992-10-09 | 1999-12-27 | Новартис Аг | Производные рапамицина и фармацевтическая композиция |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100400620B1 (ko) * | 1995-06-09 | 2004-02-18 | 노파르티스 아게 | 라파마이신유도체 |
| AU2930501A (en) * | 2000-01-07 | 2001-07-24 | Transform Pharmaceuticals, Inc. | High-throughput formation, identification, and analysis of diverse solid-forms |
| GB0601406D0 (en) * | 2006-01-24 | 2006-03-08 | Novartis Ag | Organic Compounds |
-
2006
- 2006-01-24 GB GBGB0601406.2A patent/GB0601406D0/en not_active Ceased
-
2007
- 2007-01-22 CA CA002637075A patent/CA2637075A1/en not_active Abandoned
- 2007-01-22 CN CNA2007800034190A patent/CN101374847A/zh active Pending
- 2007-01-22 KR KR1020087018088A patent/KR101423343B1/ko not_active Expired - Fee Related
- 2007-01-22 US US12/160,110 patent/US8138344B2/en not_active Expired - Fee Related
- 2007-01-22 RU RU2008134424/04A patent/RU2448970C2/ru not_active IP Right Cessation
- 2007-01-22 AU AU2007209569A patent/AU2007209569B2/en not_active Ceased
- 2007-01-22 BR BRPI0707330-5A patent/BRPI0707330A2/pt not_active IP Right Cessation
- 2007-01-22 WO PCT/EP2007/000514 patent/WO2007085400A1/en not_active Ceased
- 2007-01-22 CN CN201410391783.0A patent/CN104211716A/zh active Pending
- 2007-01-22 EP EP07702931A patent/EP1979359A1/en not_active Withdrawn
- 2007-01-22 JP JP2008551707A patent/JP5416412B2/ja not_active Expired - Fee Related
-
2013
- 2013-03-18 JP JP2013055494A patent/JP2013136631A/ja active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5256790A (en) * | 1992-08-13 | 1993-10-26 | American Home Products Corporation | 27-hydroxyrapamycin and derivatives thereof |
| RU2143434C1 (ru) * | 1992-10-09 | 1999-12-27 | Новартис Аг | Производные рапамицина и фармацевтическая композиция |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2718058C2 (ru) * | 2015-06-23 | 2020-03-30 | Синбиас Фарма АГ | Способ синтеза производных рапамицина |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2013136631A (ja) | 2013-07-11 |
| AU2007209569B2 (en) | 2011-09-15 |
| WO2007085400A1 (en) | 2007-08-02 |
| US20090012298A1 (en) | 2009-01-08 |
| CN104211716A (zh) | 2014-12-17 |
| CA2637075A1 (en) | 2007-08-02 |
| US8138344B2 (en) | 2012-03-20 |
| GB0601406D0 (en) | 2006-03-08 |
| JP5416412B2 (ja) | 2014-02-12 |
| CN101374847A (zh) | 2009-02-25 |
| KR101423343B1 (ko) | 2014-07-24 |
| RU2008134424A (ru) | 2010-02-27 |
| AU2007209569A1 (en) | 2007-08-02 |
| KR20080090453A (ko) | 2008-10-08 |
| BRPI0707330A2 (pt) | 2011-05-03 |
| JP2009523836A (ja) | 2009-06-25 |
| EP1979359A1 (en) | 2008-10-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20160123 |