AU2007209569B2 - Process for the preparation of rapamycin derivatives - Google Patents

Process for the preparation of rapamycin derivatives Download PDF

Info

Publication number
AU2007209569B2
AU2007209569B2 AU2007209569A AU2007209569A AU2007209569B2 AU 2007209569 B2 AU2007209569 B2 AU 2007209569B2 AU 2007209569 A AU2007209569 A AU 2007209569A AU 2007209569 A AU2007209569 A AU 2007209569A AU 2007209569 B2 AU2007209569 B2 AU 2007209569B2
Authority
AU
Australia
Prior art keywords
formula
compound
mixture
solvent
protected form
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2007209569A
Other languages
English (en)
Other versions
AU2007209569A1 (en
Inventor
Murat Acemoglu
Sabine Pfeffer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Publication of AU2007209569A1 publication Critical patent/AU2007209569A1/en
Application granted granted Critical
Publication of AU2007209569B2 publication Critical patent/AU2007209569B2/en
Priority to AU2011254079A priority Critical patent/AU2011254079A1/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Transplantation (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AU2007209569A 2006-01-24 2007-01-22 Process for the preparation of rapamycin derivatives Ceased AU2007209569B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2011254079A AU2011254079A1 (en) 2006-01-24 2011-12-15 Process for the preparation of rapamycin derivatives

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0601406.2 2006-01-24
GBGB0601406.2A GB0601406D0 (en) 2006-01-24 2006-01-24 Organic Compounds
PCT/EP2007/000514 WO2007085400A1 (en) 2006-01-24 2007-01-22 Process for the preparation of rapamycin derivatives

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2011254079A Division AU2011254079A1 (en) 2006-01-24 2011-12-15 Process for the preparation of rapamycin derivatives

Publications (2)

Publication Number Publication Date
AU2007209569A1 AU2007209569A1 (en) 2007-08-02
AU2007209569B2 true AU2007209569B2 (en) 2011-09-15

Family

ID=36060760

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2007209569A Ceased AU2007209569B2 (en) 2006-01-24 2007-01-22 Process for the preparation of rapamycin derivatives

Country Status (11)

Country Link
US (1) US8138344B2 (enExample)
EP (1) EP1979359A1 (enExample)
JP (2) JP5416412B2 (enExample)
KR (1) KR101423343B1 (enExample)
CN (2) CN104211716A (enExample)
AU (1) AU2007209569B2 (enExample)
BR (1) BRPI0707330A2 (enExample)
CA (1) CA2637075A1 (enExample)
GB (1) GB0601406D0 (enExample)
RU (1) RU2448970C2 (enExample)
WO (1) WO2007085400A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0601406D0 (en) * 2006-01-24 2006-03-08 Novartis Ag Organic Compounds
JP6378192B2 (ja) * 2012-11-13 2018-08-22 エルジー エレクトロニクス インコーポレイティド データ送信方法及び装置、並びにデータ送信方法及び装置
CN108864149B (zh) 2013-03-15 2022-04-05 生物传感器国际集团有限公司 雷帕霉素衍生物的纯化
EP3109250A1 (en) * 2015-06-23 2016-12-28 Synbias Pharma AG Method for the synthesis of rapamycin derivatives
UY37900A (es) 2017-09-26 2019-04-30 Novartis Ag Nuevos derivados de rapamicina
LT3898637T (lt) 2018-12-18 2025-03-10 Novartis Ag Rapamicino dariniai
CA3127448C (en) 2019-01-22 2024-06-04 Aeovian Pharmaceuticals, Inc. Mtorc modulators and uses thereof
KR20260115158A (ko) 2019-03-26 2026-07-23 노파르티스 아게 이소티아졸리딘 1,1-디옥시드 및 1,4-부탄 술톤 함유 라파마이신 유도체 및 이의 용도
CN115776907B (zh) 2020-03-27 2025-02-25 艾奥维安制药公司 Mtorc1调节剂及其用途
WO2026080482A1 (en) * 2024-10-07 2026-04-16 Tornado Therapeutics, Inc. Rapamycin derivatives and uses thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996041807A1 (en) * 1995-06-09 1996-12-27 Novartis Ag Rapamycin derivatives

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5256790A (en) * 1992-08-13 1993-10-26 American Home Products Corporation 27-hydroxyrapamycin and derivatives thereof
GB9221220D0 (en) * 1992-10-09 1992-11-25 Sandoz Ag Organic componds
IL150524A0 (en) * 2000-01-07 2003-02-12 Transform Pharmaceuticals Inc High-throughput formation, identification, and analysis of diverse solid-forms
GB0601406D0 (en) * 2006-01-24 2006-03-08 Novartis Ag Organic Compounds

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996041807A1 (en) * 1995-06-09 1996-12-27 Novartis Ag Rapamycin derivatives

Also Published As

Publication number Publication date
US8138344B2 (en) 2012-03-20
RU2008134424A (ru) 2010-02-27
WO2007085400A1 (en) 2007-08-02
JP2009523836A (ja) 2009-06-25
BRPI0707330A2 (pt) 2011-05-03
JP5416412B2 (ja) 2014-02-12
RU2448970C2 (ru) 2012-04-27
GB0601406D0 (en) 2006-03-08
US20090012298A1 (en) 2009-01-08
CN104211716A (zh) 2014-12-17
KR101423343B1 (ko) 2014-07-24
CN101374847A (zh) 2009-02-25
EP1979359A1 (en) 2008-10-15
JP2013136631A (ja) 2013-07-11
KR20080090453A (ko) 2008-10-08
AU2007209569A1 (en) 2007-08-02
CA2637075A1 (en) 2007-08-02

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Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired