BRPI0517753A - composto ou um sal do mesmo, pró-droga, medicamento, inibidor de hidrolase de amida de ácido graxo, uso do composto ou a pró-droga, métodos de inibição de hidrolase de amida de ácido graxo em um mamìfero, de proteção de células cerebrais e/ou células neurais em um mamìfero, de prevenção ou tratamento de distúrbios cerebrovasculares, lesão na cabeça ou dano na medula espinhal em um mamìfero, de prevenção ou tratamento de doença, de proteção de células cerebrais e/ou células neurais em um mamìfero, de medição de uma atividade de hidrolase de amida de ácido graxo e de prevenção ou tratamento de distúrbios do sono em um mamìfero, agentes cérebro-neuroprotetor e terapêutico ou profilático, kit, e, processo para produzir um composto - Google Patents

composto ou um sal do mesmo, pró-droga, medicamento, inibidor de hidrolase de amida de ácido graxo, uso do composto ou a pró-droga, métodos de inibição de hidrolase de amida de ácido graxo em um mamìfero, de proteção de células cerebrais e/ou células neurais em um mamìfero, de prevenção ou tratamento de distúrbios cerebrovasculares, lesão na cabeça ou dano na medula espinhal em um mamìfero, de prevenção ou tratamento de doença, de proteção de células cerebrais e/ou células neurais em um mamìfero, de medição de uma atividade de hidrolase de amida de ácido graxo e de prevenção ou tratamento de distúrbios do sono em um mamìfero, agentes cérebro-neuroprotetor e terapêutico ou profilático, kit, e, processo para produzir um composto

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Publication number
BRPI0517753A
BRPI0517753A BRPI0517753-7A BRPI0517753A BRPI0517753A BR PI0517753 A BRPI0517753 A BR PI0517753A BR PI0517753 A BRPI0517753 A BR PI0517753A BR PI0517753 A BRPI0517753 A BR PI0517753A
Authority
BR
Brazil
Prior art keywords
mammal
compound
fatty acid
acid amide
amide hydrolase
Prior art date
Application number
BRPI0517753-7A
Other languages
English (en)
Inventor
Takahiro Matsumoto
Masakuni Kori
Junichi Miyazaki
Yoshihiro Kiyota
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of BRPI0517753A publication Critical patent/BRPI0517753A/pt

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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
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Abstract

COMPOSTO OU UM SAL DO MESMO, PRó-DROGA, MEDICAMENTO, INIBIDOR DE HIDROLASE DE AMIDA DE áCIDO GRAXO, USO DO COMPOSTO OU A PRó-DROGA, MéTODOS DE INIBIçãO DE HIDROLASE DE AMIDA DE áCIDO GRAXO EM UM MAMìFERO, DE PROTEçãO DE CéLULAS CEREBRAIS E/OU CéLULAS NEURAIS EM UM MAMìFERO, DE PREVENçãO OU TRATAMENTO DE DISTúRBIOS CEREBROVASCULARES, LESãO NA CABEçA OU DANO NA MEDULA ESPINHAL EM UM MAMìFERO, DE PREVENçãO OU TRATAMENTO DE DOENçA, DE PROTEçãO DE CéLULAS CEREBRAIS E/OU CéLULAS NEURAIS EM UM MAMìFERO, DE MEDIçãO DE UMA ATIVIDADE DE HIDROLASE DE AMIDA DE áCIDO GRAXO OU UMA ATIVIDADE INIBIDORA DE HIDROLASE DE AMIDA DE áCIDO GRAXO E DE PREVENçãO OU TRATAMENTO DE DISTúRBIOS DO SONO EM UM MAMìFERO, AGENTES CéREBRO-NEUROPROTETOR E TERAPêUTICO OU PROFILáTICO, KIT, E, PROCESSO PARA PRODUZIR UM COMPOSTO. Um inibidor de FAAH, e um agente preventivo/terapêutico para distúrbios cerebrovasculares e um agente preventivo/terapêutico para distúrbios do sono, sendo que cada um contém o inibidor. O inibidor de FAAH é um composto representado pela fórmula (I~ 0~'): (sendo que Z representa oxigênio ou enxofre; R¬ 1¬ representa arila opcionalmente substituído ou um grupo heterocíclico opcionalmente substituído; R¬ 1a¬ representa h, ou um grupo hidrocarboneto opcionalmente substituído, hidróxi, etc; R representa piperidino- 1 ,4-diila opcionalmente substituído ou piperazina- 1 ,4-diila opcionalmente substituído; R¬ 3¬ representa um grupo opcionalmente substituído formado por meio de remoção de dois átomos de hidrogênio de um heterociclo aromático com 5 membros apresentando de 1 a 3 heteroátomos selecionados dentre nitrogênio, oxigênio, e enxofre, ou representa -CO-, etc; e R¬ 4¬ representa um grupo hidrocarboneto opcionalmente substituído ou grupo heterociclico opcionalmente substituído) ou um sal do composto.
BRPI0517753-7A 2004-11-18 2005-11-17 composto ou um sal do mesmo, pró-droga, medicamento, inibidor de hidrolase de amida de ácido graxo, uso do composto ou a pró-droga, métodos de inibição de hidrolase de amida de ácido graxo em um mamìfero, de proteção de células cerebrais e/ou células neurais em um mamìfero, de prevenção ou tratamento de distúrbios cerebrovasculares, lesão na cabeça ou dano na medula espinhal em um mamìfero, de prevenção ou tratamento de doença, de proteção de células cerebrais e/ou células neurais em um mamìfero, de medição de uma atividade de hidrolase de amida de ácido graxo e de prevenção ou tratamento de distúrbios do sono em um mamìfero, agentes cérebro-neuroprotetor e terapêutico ou profilático, kit, e, processo para produzir um composto BRPI0517753A (pt)

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BRPI0517753-7A BRPI0517753A (pt) 2004-11-18 2005-11-17 composto ou um sal do mesmo, pró-droga, medicamento, inibidor de hidrolase de amida de ácido graxo, uso do composto ou a pró-droga, métodos de inibição de hidrolase de amida de ácido graxo em um mamìfero, de proteção de células cerebrais e/ou células neurais em um mamìfero, de prevenção ou tratamento de distúrbios cerebrovasculares, lesão na cabeça ou dano na medula espinhal em um mamìfero, de prevenção ou tratamento de doença, de proteção de células cerebrais e/ou células neurais em um mamìfero, de medição de uma atividade de hidrolase de amida de ácido graxo e de prevenção ou tratamento de distúrbios do sono em um mamìfero, agentes cérebro-neuroprotetor e terapêutico ou profilático, kit, e, processo para produzir um composto

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Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4734119B2 (ja) * 2004-02-12 2011-07-27 田辺三菱製薬株式会社 インダゾール化合物及びその医薬用途
DE102005018389A1 (de) 2005-04-20 2006-10-26 Sanofi-Aventis Deutschland Gmbh Azolderivate als Inhibitoren von Lipasen und Phospholipasen
JP5388574B2 (ja) * 2005-05-31 2014-01-15 バーテックス ファーマシューティカルズ インコーポレイテッド イオンチャネルのモジュレーターとして有用なヘテロ環式類
WO2007005510A1 (en) * 2005-06-30 2007-01-11 Janssen Pharmaceutica N.V. N-heteroarylpiperazinyl ureas as modulators of fatty acid amide hydrolase
EP1832585A1 (en) * 2006-03-10 2007-09-12 ORIDIS BIOMED Forschungs- und Entwicklungs GmbH Thiazole-piperidine derivatives for treatment of hyperproliferative diseases
FR2903405B1 (fr) * 2006-07-04 2011-09-09 Pasteur Institut Composes a effet potentialisateur de l'activite de l'ethionamide et leurs applications
WO2008013622A2 (en) * 2006-07-27 2008-01-31 E. I. Du Pont De Nemours And Company Fungicidal azocyclic amides
US9090604B2 (en) 2006-07-27 2015-07-28 E I Du Pont De Nemours And Company Fungicidal azocyclic amides
EP2058309A4 (en) * 2006-08-04 2010-12-22 Takeda Pharmaceutical CONDENSED HETEROCYCLIC COMPOUND
WO2008023720A1 (fr) 2006-08-23 2008-02-28 Astellas Pharma Inc. COMPOSÉ D'URÉE OU SEL DUDIT COMPOSé
US20080119820A1 (en) * 2006-09-20 2008-05-22 Phan Phillip C Methods for Delivering Volatile Anesthetics for Regional Anesthesia and/or Pain Relief
KR101181194B1 (ko) 2006-10-18 2012-09-18 화이자 프로덕츠 인코포레이티드 바이아릴 에터 우레아 화합물
JP5150091B2 (ja) * 2006-11-01 2013-02-20 日本澱粉工業株式会社 低酸素状態下での細胞及び心臓保存剤
US7638541B2 (en) 2006-12-28 2009-12-29 Metabolex Inc. 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine
CA2682733A1 (en) * 2007-04-13 2008-10-23 Supergen, Inc. Axl kinase inhibitors
AU2008279447A1 (en) 2007-07-19 2009-01-29 Metabolex, Inc. N-azacyclic substituted pyrrole, pyrazole, imidazole, triazole and tetrazole derivatives as agonists of the RUP3 or GPR119 receptor for the treatment of diabetes and metabolic disorders
WO2009018844A1 (en) * 2007-08-09 2009-02-12 Oridis Biomed Forschungs- Und Entwicklungs Gmbh Thiazole-piperidine derivatives for treatment of hyperproliferative diseases
US8431608B2 (en) 2007-08-17 2013-04-30 Icagen Inc. Heterocycles as potassium channel modulators
US8058274B2 (en) * 2007-08-17 2011-11-15 Icagen, Inc. Heterocycles as potassium channel modulators
EA201070451A1 (ru) * 2007-10-10 2010-10-29 Такеда Фармасьютикал Компани Лимитед Амидные соединения
TWI428091B (zh) * 2007-10-23 2014-03-01 Du Pont 殺真菌劑混合物
EP2444403A1 (en) * 2008-04-18 2012-04-25 Shionogi Co., Ltd. Heterocyclic compound having inhibitory activity on PI3K
TWI434842B (zh) * 2008-07-14 2014-04-21 Astellas Pharma Inc Azole compounds
US20100113465A1 (en) * 2008-10-30 2010-05-06 Pfizer Inc. 7-azaspiro[3.5]nonane-7-carboxamide compounds
WO2010064597A1 (ja) * 2008-12-01 2010-06-10 武田薬品工業株式会社 ピペリジン誘導体
AU2009330821B2 (en) * 2008-12-24 2015-06-11 Bial - Portela & Ca, S.A. Pharmaceutical compounds
WO2010117014A1 (ja) * 2009-04-08 2010-10-14 武田薬品工業株式会社 トリアジン誘導体
US8765735B2 (en) 2009-05-18 2014-07-01 Infinity Pharmaceuticals, Inc. Isoxazolines as inhibitors of fatty acid amide hydrolase
US9149465B2 (en) 2009-05-18 2015-10-06 Infinity Pharmaceuticals, Inc. Isoxazolines as inhibitors of fatty acid amide hydrolase
US8927551B2 (en) 2009-05-18 2015-01-06 Infinity Pharmaceuticals, Inc. Isoxazolines as inhibitors of fatty acid amide hydrolase
AR076687A1 (es) * 2009-05-18 2011-06-29 Infinity Pharmaceuticals Inc Isoxazolinas como inhibidores de la amidahidrolasa de acidos grasos y com-posiciones farmaceuticas que los contienen
GB0916608D0 (en) * 2009-09-22 2009-11-04 Angeletti P Ist Richerche Bio Therapeutic compounds
US8410127B2 (en) 2009-10-01 2013-04-02 Metabolex, Inc. Substituted tetrazol-1-yl-phenoxymethyl-thiazol-2-yl-piperidinyl-pyrimidine salts
EP2518064A1 (en) 2009-12-25 2012-10-31 Mochida Pharmaceutical Co., Ltd. Novel aryl urea derivative
WO2011085216A2 (en) 2010-01-08 2011-07-14 Ironwood Pharmaceuticals, Inc. Use of faah inhibitors for treating parkinson's disease and restless legs syndrome
WO2011111070A2 (en) * 2010-03-09 2011-09-15 Bdr Pharmaceuticals International Pvt. Ltd. Novel injectable combination
WO2011123719A2 (en) 2010-03-31 2011-10-06 Ironwood Pharmaceuticals, Inc. Use of faah inhibitors for treating abdominal, visceral and pelvic pain
US20130096160A1 (en) * 2010-04-14 2013-04-18 Secretary, Department Of Health And Human Services Arylthiazolyl piperidines and related compounds as modulators of survival motor neuron (smn) protein production
JP2013147430A (ja) * 2010-04-28 2013-08-01 Astellas Pharma Inc 夜間頻尿の予防又は治療剤
TW201206440A (en) * 2010-04-28 2012-02-16 Astellas Pharma Inc Prophylactic or therapeutic agent for diseases associated with pains in urinary organs
BR112012032248A2 (pt) 2010-06-23 2016-09-13 Metabolex Inc composições de 5-etil-2-{4-[-4(-4-tetrazol-1-il-fenoximetil)-tiazol-2-il]-piperidin-1-il}-pirimidina
CA2806634A1 (en) * 2010-08-20 2012-02-23 Gruenenthal Gmbh Substituted cyclic carboxamide and urea derivatives as ligands of the vanilloid receptor
WO2012104273A1 (de) * 2011-02-01 2012-08-09 Bayer Cropscience Ag Heteroarylpiperidin und -piperazinderivate als fungizide
CA2830516C (en) 2011-03-23 2017-01-24 Amgen Inc. Fused tricyclic dual inhibitors of cdk 4/6 and flt3
WO2013013188A1 (en) 2011-07-21 2013-01-24 Tolero Pharmaceuticals, Inc. Heterocyclic protein kinase inhibitors
AU2012311061B2 (en) 2011-09-23 2016-08-18 Advinus Therapeutics Limited Amide compounds, compositions and applications thereof
WO2014086704A1 (en) 2012-12-03 2014-06-12 F. Hoffmann-La Roche Ag Substituted isoxazole amide compounds as inhibitors of stearoyl-coa desaturase 1 (scd1)
WO2015005305A1 (ja) 2013-07-09 2015-01-15 小野薬品工業株式会社 Ａｌｘｒ作動化合物
CA2922703A1 (en) * 2013-08-29 2015-03-05 Baylor College Of Medicine Compositions and methods for the treatment of metabolic and body weight related disorders
ES2925471T3 (es) 2014-08-13 2022-10-18 Auckland Uniservices Ltd Inhibidores de las triptófano dioxigenasas (IDO1 y TDO) y sus usos en la terapia
AU2016312848A1 (en) * 2015-08-27 2018-03-29 Auckland Uniservices Limited Inhibitors of tryptophan dioxygenases (IDO1 and TDO) and their use in therapy
WO2018026890A1 (en) 2016-08-03 2018-02-08 Cymabay Therapeutics Oxymethylene aryl compounds for treating inflammatory gastrointestinal diseases or gastrointestinal conditions
KR20200119807A (ko) 2018-01-11 2020-10-20 켄타우루스 테라퓨틱스 질병 치료를 위한 디하이드로세라마이드 불포화화효소의 저해제
CN112533602A (zh) 2018-04-05 2021-03-19 大日本住友制药肿瘤公司 Axl激酶抑制剂及其用途
MX2021009371A (es) 2019-02-12 2021-09-10 Sumitomo Pharma Oncology Inc Formulaciones que comprenden inhibidores de proteina cinasa heterociclicos.
KR20210067005A (ko) * 2019-11-28 2021-06-08 제이투에이치바이오텍 (주) 에다라본 전구체 약물 화합물 및 이들의 신경퇴행성 또는 운동신경 질환의 치료 또는 개선을 위한 의약 용도
WO2022018638A1 (en) 2020-07-21 2022-01-27 Crispr Therapeutics Ag Genome-editing compositions and methods to modulate faah for treatment of neurological disorders
WO2024079733A1 (en) * 2022-10-12 2024-04-18 Adama Makhteshim Ltd. Process for the preparation of aminopyridazine derivatives

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6514977B1 (en) 1997-05-22 2003-02-04 G.D. Searle & Company Substituted pyrazoles as p38 kinase inhibitors
HUP9903870A3 (en) * 1997-06-04 2002-01-28 Samjin Pharm Co Ltd Piperazine derivatives and process for the preparation thereof
DE19743435A1 (de) 1997-10-01 1999-04-08 Merck Patent Gmbh Benzamidinderivate
AU751139B2 (en) * 1997-10-13 2002-08-08 Astellas Pharma Inc. Amide derivative
AR017219A1 (es) 1997-12-19 2001-08-22 Smithkline Beecham Corp Derivados de imidazol 1,4,5 sustituidos, composiciones que los comprenden, procedimiento para la preparacion de dichos derivados, uso de los derivados parala manufactura de un medicamento
ES2243337T3 (es) 1999-12-16 2005-12-01 Schering Corporation Imidazoles sustituidos antagonistas del receptor y5 del neuropeptido y.
US6462054B1 (en) 2000-03-27 2002-10-08 The Scripps Research Institute Inhibitors of fatty acid amide hydrolase
EP1385520A4 (en) 2001-02-08 2007-03-21 Nps Pharma Inc METHODS AND COMPOUNDS FOR THE TREATMENT OF NEUROLOGICAL AND NEUROPSYCHIATRICAL DISEASES AND FOR THE IDENTIFICATION OF COMPOUNDS FOR THE TREATMENT THEREOF
EP1389107A4 (en) 2001-04-27 2005-10-12 Bristol Myers Squibb Co BISARYLIMIDAZOLYL-FATTY ACID AMIDE-HYDROLASE INHIBITORS
ATE345799T1 (de) 2001-10-15 2006-12-15 Janssen Pharmaceutica Nv Substituierte 4-phenyl-4-(1h-imidazol-2-yl)- piperidinderivate zur verringerung von ischämischer schädigung
US6806279B2 (en) 2001-12-17 2004-10-19 Sunesis Pharmaceuticals, Inc. Small-molecule inhibitors of interleukin-2
PL373970A1 (en) 2002-02-08 2005-09-19 Bristol-Myers Squibb Company (oxime)carbamoyl fatty acid amide hydrolase inhibitors
US6974818B2 (en) 2002-03-01 2005-12-13 Euro-Celtique S.A. 1,2,5-thiadiazol-3-YL-piperazine therapeutic agents useful for treating pain
AU2003223631B2 (en) 2002-04-18 2006-07-20 Schering Corporation 1-(4-Piperidinyl) benzimidazolones as histamine H3 antagonists
WO2004018439A1 (en) * 2002-08-22 2004-03-04 Orchid Chemicals & Pharmaceuticals Ltd Novel antibacterial agents
FR2854633B1 (fr) 2003-05-07 2005-06-24 Sanofi Synthelabo Derives de piperidinyl-et piperazinyl-alkylcarbamates, leur preparation et leur application en therapeutique
FR2864080B1 (fr) 2003-12-23 2006-02-03 Sanofi Synthelabo Derives de 1-piperazine-et-1-homopiperazine-carboxylates, leur preparation et leur application en therapeutique
FR2866884B1 (fr) 2004-02-26 2007-08-31 Sanofi Synthelabo Derives d'aryl-et d'heteroaryl-piperidinecarboxylates, leur preparation et leur application en therapeutique
UA89514C2 (uk) 2004-12-30 2010-02-10 Janssen Pharmaceutica Nv Похідні феніламідів 4-(бензил)-піперазин-1-карбонових кислот та споріднені сполуки як модулятори гідролази амідів жирних кислот для лікування тривоги, болю та інших станів
ES2528674T3 (es) 2005-02-17 2015-02-11 Astellas Pharma Inc. Piperidina y carboxilatos de piperacina como inhibidores de FAAH
WO2007005510A1 (en) 2005-06-30 2007-01-11 Janssen Pharmaceutica N.V. N-heteroarylpiperazinyl ureas as modulators of fatty acid amide hydrolase

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SG140618A1 (en) 2008-03-28
WO2006054652A1 (ja) 2006-05-26
EP1813606A4 (en) 2009-09-09
JPWO2006054652A1 (ja) 2008-05-29
KR20070085376A (ko) 2007-08-27
TW200633990A (en) 2006-10-01
IL182727A0 (en) 2007-07-24
PE20061123A1 (es) 2006-12-01
AU2005307383A1 (en) 2006-05-26
CA2584619A1 (en) 2006-05-26
EP1813606A1 (en) 2007-08-01
US7851473B2 (en) 2010-12-14
MX2007005821A (es) 2007-07-20
NO20073114L (no) 2007-06-18
AR052141A1 (es) 2007-03-07

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