BRPI0517753A - composto ou um sal do mesmo, pró-droga, medicamento, inibidor de hidrolase de amida de ácido graxo, uso do composto ou a pró-droga, métodos de inibição de hidrolase de amida de ácido graxo em um mamìfero, de proteção de células cerebrais e/ou células neurais em um mamìfero, de prevenção ou tratamento de distúrbios cerebrovasculares, lesão na cabeça ou dano na medula espinhal em um mamìfero, de prevenção ou tratamento de doença, de proteção de células cerebrais e/ou células neurais em um mamìfero, de medição de uma atividade de hidrolase de amida de ácido graxo e de prevenção ou tratamento de distúrbios do sono em um mamìfero, agentes cérebro-neuroprotetor e terapêutico ou profilático, kit, e, processo para produzir um composto - Google Patents
composto ou um sal do mesmo, pró-droga, medicamento, inibidor de hidrolase de amida de ácido graxo, uso do composto ou a pró-droga, métodos de inibição de hidrolase de amida de ácido graxo em um mamìfero, de proteção de células cerebrais e/ou células neurais em um mamìfero, de prevenção ou tratamento de distúrbios cerebrovasculares, lesão na cabeça ou dano na medula espinhal em um mamìfero, de prevenção ou tratamento de doença, de proteção de células cerebrais e/ou células neurais em um mamìfero, de medição de uma atividade de hidrolase de amida de ácido graxo e de prevenção ou tratamento de distúrbios do sono em um mamìfero, agentes cérebro-neuroprotetor e terapêutico ou profilático, kit, e, processo para produzir um compostoInfo
- Publication number
- BRPI0517753A BRPI0517753A BRPI0517753-7A BRPI0517753A BRPI0517753A BR PI0517753 A BRPI0517753 A BR PI0517753A BR PI0517753 A BRPI0517753 A BR PI0517753A BR PI0517753 A BRPI0517753 A BR PI0517753A
- Authority
- BR
- Brazil
- Prior art keywords
- mammal
- compound
- fatty acid
- acid amide
- amide hydrolase
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
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Abstract
COMPOSTO OU UM SAL DO MESMO, PRó-DROGA, MEDICAMENTO, INIBIDOR DE HIDROLASE DE AMIDA DE áCIDO GRAXO, USO DO COMPOSTO OU A PRó-DROGA, MéTODOS DE INIBIçãO DE HIDROLASE DE AMIDA DE áCIDO GRAXO EM UM MAMìFERO, DE PROTEçãO DE CéLULAS CEREBRAIS E/OU CéLULAS NEURAIS EM UM MAMìFERO, DE PREVENçãO OU TRATAMENTO DE DISTúRBIOS CEREBROVASCULARES, LESãO NA CABEçA OU DANO NA MEDULA ESPINHAL EM UM MAMìFERO, DE PREVENçãO OU TRATAMENTO DE DOENçA, DE PROTEçãO DE CéLULAS CEREBRAIS E/OU CéLULAS NEURAIS EM UM MAMìFERO, DE MEDIçãO DE UMA ATIVIDADE DE HIDROLASE DE AMIDA DE áCIDO GRAXO OU UMA ATIVIDADE INIBIDORA DE HIDROLASE DE AMIDA DE áCIDO GRAXO E DE PREVENçãO OU TRATAMENTO DE DISTúRBIOS DO SONO EM UM MAMìFERO, AGENTES CéREBRO-NEUROPROTETOR E TERAPêUTICO OU PROFILáTICO, KIT, E, PROCESSO PARA PRODUZIR UM COMPOSTO. Um inibidor de FAAH, e um agente preventivo/terapêutico para distúrbios cerebrovasculares e um agente preventivo/terapêutico para distúrbios do sono, sendo que cada um contém o inibidor. O inibidor de FAAH é um composto representado pela fórmula (I~ 0~'): (sendo que Z representa oxigênio ou enxofre; R¬ 1¬ representa arila opcionalmente substituído ou um grupo heterocíclico opcionalmente substituído; R¬ 1a¬ representa h, ou um grupo hidrocarboneto opcionalmente substituído, hidróxi, etc; R representa piperidino- 1 ,4-diila opcionalmente substituído ou piperazina- 1 ,4-diila opcionalmente substituído; R¬ 3¬ representa um grupo opcionalmente substituído formado por meio de remoção de dois átomos de hidrogênio de um heterociclo aromático com 5 membros apresentando de 1 a 3 heteroátomos selecionados dentre nitrogênio, oxigênio, e enxofre, ou representa -CO-, etc; e R¬ 4¬ representa um grupo hidrocarboneto opcionalmente substituído ou grupo heterociclico opcionalmente substituído) ou um sal do composto.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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JP2004334748 | 2004-11-18 | ||
JP2005226950 | 2005-08-04 | ||
PCT/JP2005/021136 WO2006054652A1 (ja) | 2004-11-18 | 2005-11-17 | アミド化合物 |
Publications (1)
Publication Number | Publication Date |
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BRPI0517753A true BRPI0517753A (pt) | 2008-10-21 |
Family
ID=36407190
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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BRPI0517753-7A BRPI0517753A (pt) | 2004-11-18 | 2005-11-17 | composto ou um sal do mesmo, pró-droga, medicamento, inibidor de hidrolase de amida de ácido graxo, uso do composto ou a pró-droga, métodos de inibição de hidrolase de amida de ácido graxo em um mamìfero, de proteção de células cerebrais e/ou células neurais em um mamìfero, de prevenção ou tratamento de distúrbios cerebrovasculares, lesão na cabeça ou dano na medula espinhal em um mamìfero, de prevenção ou tratamento de doença, de proteção de células cerebrais e/ou células neurais em um mamìfero, de medição de uma atividade de hidrolase de amida de ácido graxo e de prevenção ou tratamento de distúrbios do sono em um mamìfero, agentes cérebro-neuroprotetor e terapêutico ou profilático, kit, e, processo para produzir um composto |
Country Status (15)
Country | Link |
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US (1) | US7851473B2 (pt) |
EP (1) | EP1813606A4 (pt) |
JP (1) | JPWO2006054652A1 (pt) |
KR (1) | KR20070085376A (pt) |
AR (1) | AR052141A1 (pt) |
AU (1) | AU2005307383A1 (pt) |
BR (1) | BRPI0517753A (pt) |
CA (1) | CA2584619A1 (pt) |
IL (1) | IL182727A0 (pt) |
MX (1) | MX2007005821A (pt) |
NO (1) | NO20073114L (pt) |
PE (1) | PE20061123A1 (pt) |
SG (1) | SG140618A1 (pt) |
TW (1) | TW200633990A (pt) |
WO (1) | WO2006054652A1 (pt) |
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-
2005
- 2005-11-16 TW TW094140215A patent/TW200633990A/zh unknown
- 2005-11-17 EP EP05807084A patent/EP1813606A4/en not_active Withdrawn
- 2005-11-17 US US11/667,821 patent/US7851473B2/en not_active Expired - Fee Related
- 2005-11-17 AR ARP050104834A patent/AR052141A1/es not_active Application Discontinuation
- 2005-11-17 MX MX2007005821A patent/MX2007005821A/es not_active Application Discontinuation
- 2005-11-17 KR KR1020077011106A patent/KR20070085376A/ko not_active Application Discontinuation
- 2005-11-17 SG SG200801846-7A patent/SG140618A1/en unknown
- 2005-11-17 BR BRPI0517753-7A patent/BRPI0517753A/pt not_active Application Discontinuation
- 2005-11-17 PE PE2005001351A patent/PE20061123A1/es not_active Application Discontinuation
- 2005-11-17 JP JP2006545136A patent/JPWO2006054652A1/ja active Pending
- 2005-11-17 CA CA002584619A patent/CA2584619A1/en not_active Abandoned
- 2005-11-17 AU AU2005307383A patent/AU2005307383A1/en not_active Abandoned
- 2005-11-17 WO PCT/JP2005/021136 patent/WO2006054652A1/ja active Application Filing
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2007
- 2007-04-22 IL IL182727A patent/IL182727A0/en unknown
- 2007-06-18 NO NO20073114A patent/NO20073114L/no not_active Application Discontinuation
Also Published As
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CA2584619A1 (en) | 2006-05-26 |
US20080312226A1 (en) | 2008-12-18 |
EP1813606A1 (en) | 2007-08-01 |
JPWO2006054652A1 (ja) | 2008-05-29 |
WO2006054652A1 (ja) | 2006-05-26 |
EP1813606A4 (en) | 2009-09-09 |
IL182727A0 (en) | 2007-07-24 |
AU2005307383A1 (en) | 2006-05-26 |
NO20073114L (no) | 2007-06-18 |
KR20070085376A (ko) | 2007-08-27 |
MX2007005821A (es) | 2007-07-20 |
SG140618A1 (en) | 2008-03-28 |
US7851473B2 (en) | 2010-12-14 |
AR052141A1 (es) | 2007-03-07 |
PE20061123A1 (es) | 2006-12-01 |
TW200633990A (en) | 2006-10-01 |
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