BRPI0513196A - formulações tópicas antivirais - Google Patents

formulações tópicas antivirais

Info

Publication number
BRPI0513196A
BRPI0513196A BRPI0513196-0A BRPI0513196A BRPI0513196A BR PI0513196 A BRPI0513196 A BR PI0513196A BR PI0513196 A BRPI0513196 A BR PI0513196A BR PI0513196 A BRPI0513196 A BR PI0513196A
Authority
BR
Brazil
Prior art keywords
topical formulations
formulations
antiviral topical
antiviral
antivial
Prior art date
Application number
BRPI0513196-0A
Other languages
English (en)
Portuguese (pt)
Inventor
Terrence C Dahl
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35839705&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0513196(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of BRPI0513196A publication Critical patent/BRPI0513196A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F6/00—Contraceptive devices; Pessaries; Applicators therefor
    • A61F6/02—Contraceptive devices; Pessaries; Applicators therefor for use by males
    • A61F6/04—Condoms, sheaths or the like, e.g. combined with devices protecting against contagion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Reproductive Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dispersion Chemistry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Urology & Nephrology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Endocrinology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
BRPI0513196-0A 2004-07-09 2005-07-01 formulações tópicas antivirais BRPI0513196A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58683904P 2004-07-09 2004-07-09
PCT/US2005/023492 WO2006017044A2 (en) 2004-07-09 2005-07-01 Topical antiviral formulations

Publications (1)

Publication Number Publication Date
BRPI0513196A true BRPI0513196A (pt) 2008-04-29

Family

ID=35839705

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0513196-0A BRPI0513196A (pt) 2004-07-09 2005-07-01 formulações tópicas antivirais

Country Status (30)

Country Link
US (5) US20080035155A1 (cg-RX-API-DMAC7.html)
EP (4) EP2138162A3 (cg-RX-API-DMAC7.html)
JP (2) JP5121451B2 (cg-RX-API-DMAC7.html)
KR (1) KR101225707B1 (cg-RX-API-DMAC7.html)
CN (1) CN1984640B (cg-RX-API-DMAC7.html)
AP (1) AP2666A (cg-RX-API-DMAC7.html)
AR (1) AR050424A1 (cg-RX-API-DMAC7.html)
AT (1) ATE447396T1 (cg-RX-API-DMAC7.html)
AU (1) AU2005272032B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0513196A (cg-RX-API-DMAC7.html)
CA (1) CA2570877C (cg-RX-API-DMAC7.html)
CY (1) CY1109757T1 (cg-RX-API-DMAC7.html)
DE (1) DE602005017497D1 (cg-RX-API-DMAC7.html)
DK (1) DK1773296T3 (cg-RX-API-DMAC7.html)
EA (2) EA017763B1 (cg-RX-API-DMAC7.html)
ES (1) ES2336017T3 (cg-RX-API-DMAC7.html)
HR (2) HRP20070040A2 (cg-RX-API-DMAC7.html)
IL (2) IL180172A (cg-RX-API-DMAC7.html)
IS (1) IS8584A (cg-RX-API-DMAC7.html)
MX (1) MX2007000122A (cg-RX-API-DMAC7.html)
NO (1) NO20070762L (cg-RX-API-DMAC7.html)
NZ (1) NZ552172A (cg-RX-API-DMAC7.html)
PL (2) PL1773296T3 (cg-RX-API-DMAC7.html)
PT (1) PT1773296E (cg-RX-API-DMAC7.html)
RS (1) RS51213B (cg-RX-API-DMAC7.html)
SI (1) SI1773296T1 (cg-RX-API-DMAC7.html)
TW (1) TW200612955A (cg-RX-API-DMAC7.html)
UA (1) UA93354C2 (cg-RX-API-DMAC7.html)
WO (1) WO2006017044A2 (cg-RX-API-DMAC7.html)
ZA (1) ZA200700932B (cg-RX-API-DMAC7.html)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8512718B2 (en) 2000-07-03 2013-08-20 Foamix Ltd. Pharmaceutical composition for topical application
IL152486A0 (en) 2002-10-25 2003-05-29 Meir Eini Alcohol-free cosmetic and pharmaceutical foam carrier
US7700076B2 (en) * 2002-10-25 2010-04-20 Foamix, Ltd. Penetrating pharmaceutical foam
JP2006505583A (ja) 2002-10-25 2006-02-16 フォーミックス エルティーディー． 化粧剤および医薬用フォーム
US8119150B2 (en) 2002-10-25 2012-02-21 Foamix Ltd. Non-flammable insecticide composition and uses thereof
US20080138296A1 (en) 2002-10-25 2008-06-12 Foamix Ltd. Foam prepared from nanoemulsions and uses
US10117812B2 (en) 2002-10-25 2018-11-06 Foamix Pharmaceuticals Ltd. Foamable composition combining a polar solvent and a hydrophobic carrier
US8119109B2 (en) * 2002-10-25 2012-02-21 Foamix Ltd. Foamable compositions, kits and methods for hyperhidrosis
US7820145B2 (en) 2003-08-04 2010-10-26 Foamix Ltd. Oleaginous pharmaceutical and cosmetic foam
US9265725B2 (en) 2002-10-25 2016-02-23 Foamix Pharmaceuticals Ltd. Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof
US9668972B2 (en) 2002-10-25 2017-06-06 Foamix Pharmaceuticals Ltd. Nonsteroidal immunomodulating kit and composition and uses thereof
US20080317679A1 (en) * 2002-10-25 2008-12-25 Foamix Ltd. Foamable compositions and kits comprising one or more of a channel agent, a cholinergic agent, a nitric oxide donor, and related agents and their uses
US8486376B2 (en) 2002-10-25 2013-07-16 Foamix Ltd. Moisturizing foam containing lanolin
US20060018937A1 (en) * 2002-10-25 2006-01-26 Foamix Ltd. Steroid kit and foamable composition and uses thereof
US20060233721A1 (en) * 2002-10-25 2006-10-19 Foamix Ltd. Foam containing unique oil globules
US7704518B2 (en) 2003-08-04 2010-04-27 Foamix, Ltd. Foamable vehicle and pharmaceutical compositions thereof
US8900554B2 (en) 2002-10-25 2014-12-02 Foamix Pharmaceuticals Ltd. Foamable composition and uses thereof
US9211259B2 (en) 2002-11-29 2015-12-15 Foamix Pharmaceuticals Ltd. Antibiotic kit and composition and uses thereof
US7575739B2 (en) 2003-04-28 2009-08-18 Foamix Ltd. Foamable iodine composition
US8795693B2 (en) 2003-08-04 2014-08-05 Foamix Ltd. Compositions with modulating agents
US8486374B2 (en) 2003-08-04 2013-07-16 Foamix Ltd. Hydrophilic, non-aqueous pharmaceutical carriers and compositions and uses
UA93354C2 (ru) * 2004-07-09 2011-02-10 Гилиад Сайенсиз, Инк. Местный противовирусный препарат
AU2006313443A1 (en) * 2005-05-09 2007-05-18 Foamix Ltd. Foamable vehicle and pharmaceutical compositions thereof
US20080152596A1 (en) * 2005-07-19 2008-06-26 Foamix Ltd. Polypropylene glycol foamable vehicle and pharmaceutical compositions thereof
US20080260655A1 (en) * 2006-11-14 2008-10-23 Dov Tamarkin Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses
EP2073794A2 (en) * 2006-11-14 2009-07-01 Foamix Ltd. Stable non-alcoholic foamable pharmaceutical emulsion compositions with an unctuous emollient and their uses
US20080292560A1 (en) * 2007-01-12 2008-11-27 Dov Tamarkin Silicone in glycol pharmaceutical and cosmetic compositions with accommodating agent
US8636982B2 (en) 2007-08-07 2014-01-28 Foamix Ltd. Wax foamable vehicle and pharmaceutical compositions thereof
WO2009069006A2 (en) 2007-11-30 2009-06-04 Foamix Ltd. Foam containing benzoyl peroxide
US8518376B2 (en) 2007-12-07 2013-08-27 Foamix Ltd. Oil-based foamable carriers and formulations
WO2009090495A2 (en) 2007-12-07 2009-07-23 Foamix Ltd. Oil and liquid silicone foamable carriers and formulations
CA2712120A1 (en) 2008-01-14 2009-07-23 Foamix Ltd. Poloxamer foamable pharmaceutical compositions with active agents and/or therapeutic cells and uses
ES2572631T3 (es) 2008-01-25 2016-06-01 Chimerix, Inc. Métodos de tratamiento de infecciones virales
CA2716838C (en) * 2008-02-29 2014-01-07 Schering Corporation Ccr5 antagonists as prophylactics for preventing hiv infection and methods of inhibiting transmission of same
US20120087872A1 (en) 2009-04-28 2012-04-12 Foamix Ltd. Foamable Vehicles and Pharmaceutical Compositions Comprising Aprotic Polar Solvents and Uses Thereof
CA2769625C (en) 2009-07-29 2017-04-11 Foamix Ltd. Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses
WO2011013008A2 (en) 2009-07-29 2011-02-03 Foamix Ltd. Non surface active agent non polymeric agent hydro-alcoholic foamable compositions, breakable foams and their uses
US9849142B2 (en) 2009-10-02 2017-12-26 Foamix Pharmaceuticals Ltd. Methods for accelerated return of skin integrity and for the treatment of impetigo
WO2011039638A2 (en) 2009-10-02 2011-04-07 Foamix Ltd. Topical tetracycline compositions
PL2534150T3 (pl) 2010-02-12 2017-09-29 Chimerix, Inc. Sposoby leczenia infekcji wirusowej
AU2011248620B2 (en) 2010-04-26 2015-11-26 Chimerix, Inc. Methods of treating retroviral infections and related dosage regimes
EP2389929A1 (en) * 2010-05-30 2011-11-30 Abdi Ibrahim Ilac Sanayi ve Ticaret Anonim Sirketi Pharmaceutical formulations of tenofovir
PT2579871E (pt) * 2010-06-11 2015-11-17 Gilead Sciences Inc Formulações antivirais tópicas para a prevenção da transmissão do hsv-2
AU2012250862B2 (en) 2011-05-02 2015-07-09 Adare Pharmaceuticals, Inc. Rapid dissolve tablet compositions for vaginal administration
WO2013095684A1 (en) 2011-12-22 2013-06-27 Geron Corporation Guanine analogs as telomerase substrates and telomere length affectors
AP2014008149A0 (en) * 2012-06-13 2014-12-31 Evofem Inc Compositions and methods for enhancing the efficacy of contraceptive microbicides
CN102786549B (zh) * 2012-08-13 2013-07-03 洛阳聚慧投资股份有限公司 一组具有抑制hiv-1病毒复制活性的替诺福韦双酯化合物、制备方法及其药物用途
CN103665043B (zh) * 2012-08-30 2017-11-10 江苏豪森药业集团有限公司 一种替诺福韦前药及其在医药上的应用
CA2885037A1 (en) * 2012-09-14 2014-03-20 Cipla Limited Topical pharmaceutical composition
MX2015012409A (es) * 2013-03-15 2016-06-02 Conrad Formulaciones bajas en glicerina para prevencion y tratamiento de vih.
WO2015095793A1 (en) 2013-12-19 2015-06-25 Evofem, Inc. Compositions and methods for inhibiting inflammation and diseases using an alginic acid-based antimicrobial compound
CN107427529A (zh) 2014-12-26 2017-12-01 埃莫里大学 N4‑羟基胞苷和衍生物及与其相关的抗病毒用途
MX2020012139A (es) 2016-09-08 2021-01-29 Vyne Pharmaceuticals Inc Composiciones y metodos para tratar rosacea y acne.
AU2017338748A1 (en) 2016-10-04 2019-05-02 Evofem Inc. Method of treatment and prevention of bacterial vaginosis
ES2995458T3 (en) 2017-12-07 2025-02-10 Univ Emory N4-hydroxycytidine derivative and anti-viral uses related thereto
CN108096206A (zh) * 2018-02-01 2018-06-01 海南天煌制药有限公司 一种富马酸替诺福韦二吡呋酯片剂及其制备方法
EP3870167A4 (en) * 2018-10-23 2022-07-27 Eastern Virginia Medical School PHARMACEUTICAL COMPOSITIONS AND PROCESSES FOR MANUFACTURE OF SOLID DOSAGE FORMS ON REQUEST
CN114761014A (zh) * 2019-09-20 2022-07-15 雅培快速诊断国际无限公司 针对替诺福韦及其衍生物的抗体
CN112891323B (zh) * 2020-01-22 2023-08-18 首都医科大学附属北京地坛医院 一种抗hiv外用消毒剂及其制备方法
CN117338733B (zh) * 2023-10-12 2024-05-28 杭州和泽坤元药业有限公司 一种富马酸替诺福韦二吡呋酯片及其制备工艺

Family Cites Families (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2149240A (en) 1938-05-19 1939-02-28 Calco Chemical Co Inc Vaginal preparation
US2330846A (en) 1939-05-01 1943-10-05 Ortho Products Inc Spermicide
US2467884A (en) 1944-02-02 1949-04-19 Nathaniel M Elias Spermicides
US2436184A (en) * 1945-11-08 1948-02-17 Eaton Lab Inc Pharmaceutical jelly
BE471273A (cg-RX-API-DMAC7.html) * 1946-06-21
US2541103A (en) 1948-04-27 1951-02-13 Ortho Pharma Corp Spermicidal composition
US2623839A (en) 1950-11-21 1952-12-30 Schmid Inc Julius Spermicidal compositions
US2623841A (en) 1950-11-21 1952-12-30 Schmid Inc Julius Spermicidal compositions
US3062715A (en) 1953-11-18 1962-11-06 George S Pfaus Vaginal tablet
US3067743A (en) * 1958-11-12 1962-12-11 Alginate Ind Ltd Alginic compounds
US3108043A (en) 1960-05-09 1963-10-22 Ortho Pharma Corp Spermicidal sheet-like material
US3174900A (en) * 1962-10-10 1965-03-23 Holland Rantos Company Inc Thioether spermicidal method and composition
US3244589A (en) * 1962-10-26 1966-04-05 Sunnen Alkyl phenoxy polyethoxy ether spermicidal aerosol
US3916898A (en) 1964-05-20 1975-11-04 Searle & Co Administration of medicaments and the like
US3887699A (en) * 1969-03-24 1975-06-03 Seymour Yolles Biodegradable polymeric article for dispensing drugs
US3640741A (en) * 1970-02-24 1972-02-08 Hollister Inc Composition containing gel
FR2097520A5 (cg-RX-API-DMAC7.html) 1970-07-09 1972-03-03 Morel Paul
US3888975A (en) 1972-12-27 1975-06-10 Alza Corp Erodible intrauterine device
US4017730A (en) * 1974-05-01 1977-04-12 Raytheon Company Radiographic imaging system for high energy radiation
US4017641A (en) 1975-01-31 1977-04-12 The Procter & Gamble Company Skin moisturizing compositions containing 2-pyrrolidinone
US3989816A (en) 1975-06-19 1976-11-02 Nelson Research & Development Company Vehicle composition containing 1-substituted azacycloheptan-2-ones
US4011312A (en) * 1975-06-25 1977-03-08 American Home Products Corporation Prolonged release drug form for the treatment of bovine mastitis
IT1039699B (it) 1975-07-03 1979-12-10 Prephar Composizione spermicida a base di derivati benzisotiazolici
US4130667A (en) 1976-01-12 1978-12-19 The Procter & Gamble Company Dermatological compositions
US4108309A (en) 1976-10-15 1978-08-22 All One God Faith, Inc. Contraceptive containing device
FR2433949A1 (fr) 1978-08-25 1980-03-21 Commissariat Energie Atomique Substrat hydrophobe apte a liberer une substance chimique
US4321277A (en) 1978-12-04 1982-03-23 Research Lab Products, Inc. Germicidal use of compositions containing certain quaternary ammonium compounds
US4187286A (en) 1979-01-02 1980-02-05 G&W Laboratories, Inc. Contraceptive suppository
US4954487A (en) 1979-01-08 1990-09-04 The Procter & Gamble Company Penetrating topical pharmaceutical compositions
US4306013A (en) 1980-03-10 1981-12-15 Rca Corporation Asymmetrical radiation exposure of spin coated photoresist to obtain uniform thickness coating used to replicate spiral grooves in plastic substrate
US4360013A (en) 1980-04-21 1982-11-23 Minnesota Mining And Manufacturing Company Polymeric acid contraceptive devices
IT1131833B (it) 1980-06-20 1986-06-25 Crinos Industria Farmaco Eccipienti per sostanze spermicide
US4389330A (en) 1980-10-06 1983-06-21 Stolle Research And Development Corporation Microencapsulation process
US4368186A (en) 1981-05-07 1983-01-11 Syntex (U.S.A.) Inc. Methods and compositions for intravaginal contraception
US4415585A (en) 1982-03-11 1983-11-15 University Of Illinois Foundation Contraceptive method
US5248700A (en) 1982-05-14 1993-09-28 Akzo Nv Active agent containing solid structures for prolonged release of active agents
US4961931A (en) 1982-07-29 1990-10-09 Alza Corporation Method for the management of hyperplasia
US4499154A (en) 1982-09-03 1985-02-12 Howard L. Podell Dipped rubber article
US4551148A (en) 1982-09-07 1985-11-05 Kv Pharmaceutical Company Vaginal delivery systems and their methods of preparation and use
US4816570A (en) 1982-11-30 1989-03-28 The Board Of Regents Of The University Of Texas System Biologically reversible phosphate and phosphonate protective groups
US4537776A (en) 1983-06-21 1985-08-27 The Procter & Gamble Company Penetrating topical pharmaceutical compositions containing N-(2-hydroxyethyl) pyrrolidone
US4557934A (en) 1983-06-21 1985-12-10 The Procter & Gamble Company Penetrating topical pharmaceutical compositions containing 1-dodecyl-azacycloheptan-2-one
US4552872A (en) 1983-06-21 1985-11-12 The Procter & Gamble Company Penetrating topical pharmaceutical compositions containing corticosteroids
US4589880A (en) 1983-07-14 1986-05-20 Southern Research Institute Disposable spermicide-releasing diaphragm
US5231112A (en) 1984-04-12 1993-07-27 The Liposome Company, Inc. Compositions containing tris salt of cholesterol hemisuccinate and antifungal
CS263951B1 (en) 1985-04-25 1989-05-12 Antonin Holy 9-(phosponylmethoxyalkyl)adenines and method of their preparation
US4895724A (en) 1985-06-07 1990-01-23 Pfizer Inc. Chitosan compositions for controlled and prolonged release of macromolecules
US4968788A (en) 1986-04-04 1990-11-06 Board Of Regents, The University Of Texas System Biologically reversible phosphate and phosphonate protective gruops
US4795642A (en) 1986-05-01 1989-01-03 Pharmacaps, Inc. Gelatin-encapsulated controlled-release composition
US4808176A (en) 1986-12-31 1989-02-28 Kimberly-Clark Corporation Elasticized waist integration member for disposable absorbent garments
IE66830B1 (en) * 1987-08-12 1996-02-07 Hem Res Inc Topically active compositions of double-stranded RNAs
US5015474A (en) 1988-11-22 1991-05-14 Parnell Pharmaceuticals, Inc. Composition for imparting moisture to a substrate
US5208031A (en) 1989-06-06 1993-05-04 Kelly Patrick D Sexual lubricants containing zinc as an anti-viral agent
DE69115694T2 (de) 1990-06-13 1996-10-17 Arnold Newton Mass. Glazier Phosphorylierte prodrugs
US5143731A (en) 1990-08-07 1992-09-01 Mediventures Incorporated Body cavity drug delivery with thermo-irreversible polyoxyalkylene and ionic polysaccharide gels
DE10399025I2 (de) 1990-09-14 2007-11-08 Acad Of Science Czech Republic Wirkstoffvorläufer von Phosphonaten
GB9021061D0 (en) 1990-09-27 1990-11-07 Unilever Plc Encapsulating method and products containing encapsulated material
GB9104740D0 (en) * 1991-03-06 1991-04-17 Wellcome Found Antiviral nucleoside combination
GB9110624D0 (en) * 1991-05-16 1991-07-03 Glaxo Group Ltd Combinations
US6057305A (en) 1992-08-05 2000-05-02 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Antiretroviral enantiomeric nucleotide analogs
US6200557B1 (en) * 1993-07-06 2001-03-13 Perry A. Ratcliff Method of treating HIV by a topical composition
GR940100370A (el) * 1993-07-28 1994-07-26 Johnson & Johnson Consumer Products Inc. Μια σπερμοκτονος λιπαντικη αντι-ιου συνθεση και μεθοδος χρησης της.
US5798340A (en) * 1993-09-17 1998-08-25 Gilead Sciences, Inc. Nucleotide analogs
US6028115A (en) 1995-10-13 2000-02-22 Rush-Presbyterian-St. Luke's Medical Center Method for preventing sexually transmitted diseases
US5733788A (en) 1996-07-26 1998-03-31 Gilead Sciences, Inc. PMPA preparation
EP1243590B1 (en) * 1997-07-25 2005-02-09 Gilead Sciences, Inc. Nucleotide analog composition and synthesis method
ATE305009T1 (de) * 1997-07-25 2005-10-15 Gilead Sciences Inc Nukleotid-analog zusamensetzung und synthese verfahren
US6312662B1 (en) 1998-03-06 2001-11-06 Metabasis Therapeutics, Inc. Prodrugs phosphorus-containing compounds
GB9820420D0 (en) * 1998-09-18 1998-11-11 Glaxo Group Ltd Antiviral combinations
US20020136757A1 (en) 2000-01-28 2002-09-26 Samuel Baron Methods and devices for preventing transmission of sexually transmitted diseases
US6899890B2 (en) * 2002-03-20 2005-05-31 Kv Pharmaceutical Company Bioadhesive drug delivery system
KR20040094855A (ko) * 2002-03-26 2004-11-10 이스턴 버지니아 메디컬 스쿨 국소용 살균제 및 피임제로서의 수라민 또는 그 유도체
AR039540A1 (es) * 2002-05-13 2005-02-23 Tibotec Pharm Ltd Compuestos microbicidas con contenido de pirimidina o triazina
UA93354C2 (ru) * 2004-07-09 2011-02-10 Гилиад Сайенсиз, Инк. Местный противовирусный препарат

Also Published As

Publication number Publication date
AP2666A (en) 2013-05-17
AU2005272032B2 (en) 2011-07-07
EP2138163A2 (en) 2009-12-30
US20150366795A1 (en) 2015-12-24
EP2283812A3 (en) 2011-08-31
HK1103026A1 (en) 2007-12-14
HRP20070040A2 (hr) 2007-04-30
US20110132376A1 (en) 2011-06-09
EP1773296B1 (en) 2009-11-04
DE602005017497D1 (de) 2009-12-17
UA93354C2 (ru) 2011-02-10
JP2012255021A (ja) 2012-12-27
NO20070762L (no) 2007-02-08
EA017763B1 (ru) 2013-03-29
IL180172A (en) 2011-08-31
CA2570877A1 (en) 2006-02-16
AR050424A1 (es) 2006-10-25
EP1773296A2 (en) 2007-04-18
ZA200700932B (en) 2008-07-30
EA201370001A1 (ru) 2015-02-27
HRP20100038T1 (hr) 2010-02-28
TW200612955A (en) 2006-05-01
ES2336017T3 (es) 2010-04-07
CN1984640A (zh) 2007-06-20
PT1773296E (pt) 2010-02-04
WO2006017044A3 (en) 2006-07-27
CY1109757T1 (el) 2014-09-10
CA2570877C (en) 2014-09-09
US9060933B2 (en) 2015-06-23
EP2283812A2 (en) 2011-02-16
JP2008505902A (ja) 2008-02-28
EP2138163A3 (en) 2011-08-31
RS51213B (sr) 2010-12-31
DK1773296T3 (da) 2010-03-08
EA200700311A1 (ru) 2007-06-29
JP5121451B2 (ja) 2013-01-16
ATE447396T1 (de) 2009-11-15
PL1773296T3 (pl) 2010-04-30
AU2005272032A1 (en) 2006-02-16
IL206031A0 (en) 2010-11-30
CN1984640B (zh) 2010-09-29
US20060058265A1 (en) 2006-03-16
PL382306A1 (pl) 2007-08-20
MX2007000122A (es) 2007-05-10
EP2138162A2 (en) 2009-12-30
WO2006017044A2 (en) 2006-02-16
IL180172A0 (en) 2007-06-03
EP2138162A3 (en) 2011-08-31
NZ552172A (en) 2010-11-26
US9283182B2 (en) 2016-03-15
US20110120475A1 (en) 2011-05-26
US20080035155A1 (en) 2008-02-14
AP2007003873A0 (en) 2007-02-28
IS8584A (is) 2006-12-21
KR20070041537A (ko) 2007-04-18
SI1773296T1 (sl) 2010-04-30
KR101225707B1 (ko) 2013-01-24

Similar Documents

Publication Publication Date Title
BRPI0513196A (pt) formulações tópicas antivirais
ECSP099250A (es) USO DE 2-6-(3-amino-piperidin-1-Il)-3-metil-2,4-dioxo-3,4-dihIdro-2H-pIrimidin-1-IlmetIL-4-fluoro-benzonitrilo
UY26758A1 (es) Agentes antivirales de imidazopiridina e imidazopirimidina
NO20091258L (no) Entantiomerisk rene fosfoindoler as HIV inhibitorer
BRPI0407306A (pt) 1,2,4- triazinas de inibição de hiv
NO20045152L (no) Ikke-nukleosid-reverstranskriptaseinhibitorer
BRPI0516751A (pt) pirimidinas bicìclicas que inibem hcv
EA200800726A1 (ru) Введение ингибиторов дипептидилпептидазы
BRPI0709266B8 (pt) 5-(hidroximetileno e aminometileno) pirimidinas substituídas e composição farmacêutica que as compreende
TR200102313T2 (tr) Antiviral maddeler olarak (1R, SíS)-4-(6-amino-9H-purin-9-il)-2-siklopenten-1-metanoln mono-, di ve tri-fosfat esterleri ve fosforamidatlarì
EA200601654A1 (ru) Ингибиторы интегразы вич
CL2007001392A1 (es) Compuestos derivados de quinolina o benzopirano inhibidores de la replicacion del hiv; composicion farmaceutica que comprende a dichos compuestos; y su uso en el tratamiento de una infeccion por vih
CL2007001847A1 (es) Composicion farmaceutica intramuscular o subcutanea que comprende tmc278 (rilpivirina); proceso para preparar la composicion; y uso para el tratamiento o prevencion de infeccion por vih.
BRPI0513085A (pt) 8-pirrolidinoxantinas bicìclicas substituìdas, e uso das mesmas como inibidoras de dipeptidil peptidase
IN2012DN06436A (cg-RX-API-DMAC7.html)
BRPI0414948A (pt) derivados de pirazolo-e-imidazo pirimidina
BR0314195A (pt) Derivados de piridina substituìda como agentes antitumorais
BR0317282A (pt) Derivados de 3h-quinazolin-4-ona
UY30788A1 (es) Compuestos quimicos
NO20090332L (no) 4-amino-3-arylamino-6-arylpyrazol[3,4-D]pyrimidinderivater, fremgangsmater for deres fremstilling og dere anvendelse som antivirale midler
NO20065898L (no) 1-heterocyklyl-1,5-dihydro-pyrido[3,2-b]indol-2-oner
TW200710091A (en) (1,10B-dihydro-2-(aminoalkyl-phenyl)-5H-pyrazolo [1,5-c][1,3]benzoxazin-5-yl)phenyl methanone derivatives as HIV viral replication inhibitors
GT200500268A (es) Inhibidores de la adenilato ciclasa soluble
TR200103398T2 (tr) íkameli fenilsikloheksankarboksamitler ve bunlarìn adenozin alìnìmìnìn inhibit”rleri olarak kullanìmì
NO20065582L (no) (1,lOB-dihydro-2-(amtnokarbonyl-fenyl)-SH-pyrazolo[1,5-C][1,3]benzoksazin-5-yl)fenylmetanonderivater som HIV-virusreplikasjonsinhibitorer

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 9A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2261 DE 06/05/2014.