BRPI0511808A - composto ou um sal, pró-droga ou solvato do mesmo, uso de um composto método para tratar doenças mediadas com glk, e, processo para a preparação de um composto - Google Patents

composto ou um sal, pró-droga ou solvato do mesmo, uso de um composto método para tratar doenças mediadas com glk, e, processo para a preparação de um composto

Info

Publication number
BRPI0511808A
BRPI0511808A BRPI0511808-5A BRPI0511808A BRPI0511808A BR PI0511808 A BRPI0511808 A BR PI0511808A BR PI0511808 A BRPI0511808 A BR PI0511808A BR PI0511808 A BRPI0511808 A BR PI0511808A
Authority
BR
Brazil
Prior art keywords
compound
het
solvate
salt
optionally substituted
Prior art date
Application number
BRPI0511808-5A
Other languages
English (en)
Inventor
Craig Johnstone
Darren Mckerrecher
Kurt Gordon Pike
Michael James Waring
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0412602.5A external-priority patent/GB0412602D0/en
Priority claimed from GB0423041A external-priority patent/GB0423041D0/en
Priority claimed from GB0502961A external-priority patent/GB0502961D0/en
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of BRPI0511808A publication Critical patent/BRPI0511808A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • C07D231/40—Acylated on said nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/08—1,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

Abstract

COMPOSTO OU UM SAL, PRó-DROGA OU SOLVATO DO MESMO, USO DE UM COMPOSTO MéTODO PARA TRATAR DOENçAS MEDIADAS COM GLK, E, PROCESSO PARA A PREPARAçãO DE UM COMPOSTO. Descreve-se compostos de Fórmula (I) sendo que: R é hidroximetila; R¬ 2¬ é selecionado dentre -C(O)NR¬ 4¬ R¬ 5¬, SO~ 2~NR¬ 4¬R¬ 5¬, 5(O), R¬ 4¬ e HET-2; HET-l é um anel heteroarila ligado a C, com 5 ou 6 membros, opcionalmente substituído; HET -2 é um anel heterociclila ligado a C ou N, com 4, 5 ou 6 membros, opcionalmente substituído; R¬ 3¬ é selecionado dentre halo, fluorometila, difluorometila, trifluorometila, metila, metóxi e ciano; R¬ 4¬ é selecionado dentre, por exemplo, hidrogênio, (1- 4C)alquila opcionalmente substituído e HET-2; R¬ 5¬ é hidrogênio ou (1- 4C)alquila; ou R¬ 4¬ e R¬ 5¬, em conjunto com o átomo de nitrogênio a que estão ligados, podem formar um sistema de anel heterociclila como definido por HET-3; HET-3 é, por exemplo, um anel heterociclila saturado ou particularmente insaturado, com 4, 5 ou 6 membros, ligado a N, opcionalmente substituído; p é (independentemente, em cada ocorrência) 0, 1 ou 2; m é 0 ou 1; n é 0, 1 ou 2; desde que, quando m é 0, então n é 1 ou 2; ou um sal, pró-droga ou solvato dos mesmos. Descreve-se também seu uso como ativadores de GLK, composições farmacêuticas contendo os mesmos, e processos para a preparação dos mesmos.
BRPI0511808-5A 2004-06-05 2005-06-01 composto ou um sal, pró-droga ou solvato do mesmo, uso de um composto método para tratar doenças mediadas com glk, e, processo para a preparação de um composto BRPI0511808A (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB0412602.5A GB0412602D0 (en) 2004-06-05 2004-06-05 Compounds
GB0423041A GB0423041D0 (en) 2004-10-16 2004-10-16 Chemical compounds
GB0502961A GB0502961D0 (en) 2005-02-12 2005-02-12 Chemical compounds
PCT/GB2005/002166 WO2005121110A1 (en) 2004-06-05 2005-06-01 Hetroaryl benzamide derivatives for use as glk activators in the treatment of diabetes

Publications (1)

Publication Number Publication Date
BRPI0511808A true BRPI0511808A (pt) 2008-01-15

Family

ID=34969165

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0511808-5A BRPI0511808A (pt) 2004-06-05 2005-06-01 composto ou um sal, pró-droga ou solvato do mesmo, uso de um composto método para tratar doenças mediadas com glk, e, processo para a preparação de um composto

Country Status (20)

Country Link
US (2) US7745475B2 (pt)
EP (2) EP1756076B1 (pt)
JP (1) JP4860606B2 (pt)
KR (1) KR20070024650A (pt)
AR (1) AR049139A1 (pt)
AT (1) ATE477249T1 (pt)
AU (1) AU2005251990B2 (pt)
BR (1) BRPI0511808A (pt)
CA (1) CA2566951A1 (pt)
DE (1) DE602005022859D1 (pt)
ES (1) ES2347451T3 (pt)
HK (1) HK1102091A1 (pt)
IL (1) IL179389A0 (pt)
MX (1) MXPA06014128A (pt)
MY (1) MY144048A (pt)
NO (1) NO20070032L (pt)
NZ (1) NZ551623A (pt)
TW (1) TW200600086A (pt)
UY (1) UY28936A1 (pt)
WO (1) WO2005121110A1 (pt)

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EP1756076B1 (en) 2010-08-11
DE602005022859D1 (de) 2010-09-23
CA2566951A1 (en) 2005-12-22
KR20070024650A (ko) 2007-03-02
US20080015203A1 (en) 2008-01-17
WO2005121110A1 (en) 2005-12-22
ES2347451T3 (es) 2010-10-29
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HK1102091A1 (en) 2007-11-02
AR049139A1 (es) 2006-06-28
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NO20070032L (no) 2007-02-27
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AU2005251990B2 (en) 2008-11-20
ATE477249T1 (de) 2010-08-15
US20090253676A1 (en) 2009-10-08
AU2005251990A1 (en) 2005-12-22
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IL179389A0 (en) 2007-03-08
MY144048A (en) 2011-07-29

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