BRPI0509079B8 - molécula de ácido nucléico, vetor, célula hospedeira, partículas tipo vírus, método para produzir vlps, vacina, composições farmacêuticas, e, métodos para evitar infecção por hpv e para induzir uma resposta imune em um animal - Google Patents

molécula de ácido nucléico, vetor, célula hospedeira, partículas tipo vírus, método para produzir vlps, vacina, composições farmacêuticas, e, métodos para evitar infecção por hpv e para induzir uma resposta imune em um animal

Info

Publication number
BRPI0509079B8
BRPI0509079B8 BRPI0509079A BRPI0509079A BRPI0509079B8 BR PI0509079 B8 BRPI0509079 B8 BR PI0509079B8 BR PI0509079 A BRPI0509079 A BR PI0509079A BR PI0509079 A BRPI0509079 A BR PI0509079A BR PI0509079 B8 BRPI0509079 B8 BR PI0509079B8
Authority
BR
Brazil
Prior art keywords
hpv
virus
particles
pharmaceutical compositions
vlps
Prior art date
Application number
BRPI0509079A
Other languages
English (en)
Portuguese (pt)
Inventor
T Bryan Janine
U Jansen Kathrin
D Schultz Loren
K Brownlow Michelle
Original Assignee
Merck & Co Inc
Merck Sharp & Dohme
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc, Merck Sharp & Dohme, Schering Corp filed Critical Merck & Co Inc
Publication of BRPI0509079A publication Critical patent/BRPI0509079A/pt
Publication of BRPI0509079B1 publication Critical patent/BRPI0509079B1/pt
Publication of BRPI0509079B8 publication Critical patent/BRPI0509079B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/01—DNA viruses
    • C07K14/025—Papovaviridae, e.g. papillomavirus, polyomavirus, SV40, BK virus, JC virus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/04—Inactivation or attenuation; Producing viral sub-units
    • C12N7/045—Pseudoviral particles; Non infectious pseudovirions, e.g. genetically engineered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5258—Virus-like particles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20023—Virus like particles [VLP]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
BRPI0509079A 2004-03-24 2005-03-18 molécula de ácido nucléico, vetor, célula hospedeira, partículas tipo vírus, método para produzir vlps, vacina, composições farmacêuticas, e, métodos para evitar infecção por hpv e para induzir uma resposta imune em um animal BRPI0509079B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55592604P 2004-03-24 2004-03-24
PCT/US2005/009199 WO2005097821A1 (en) 2004-03-24 2005-03-18 Optimized expression of hpv 52 l1 in yeast

Publications (3)

Publication Number Publication Date
BRPI0509079A BRPI0509079A (pt) 2007-08-21
BRPI0509079B1 BRPI0509079B1 (pt) 2020-05-19
BRPI0509079B8 true BRPI0509079B8 (pt) 2021-07-06

Family

ID=34964085

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0509079A BRPI0509079B8 (pt) 2004-03-24 2005-03-18 molécula de ácido nucléico, vetor, célula hospedeira, partículas tipo vírus, método para produzir vlps, vacina, composições farmacêuticas, e, métodos para evitar infecção por hpv e para induzir uma resposta imune em um animal

Country Status (31)

Country Link
US (2) US7700103B2 (forum.php)
EP (1) EP1730175B1 (forum.php)
JP (1) JP4833962B2 (forum.php)
KR (1) KR101203403B1 (forum.php)
CN (1) CN1934131B (forum.php)
AR (1) AR048191A1 (forum.php)
AT (1) ATE466022T1 (forum.php)
AU (1) AU2005230907C1 (forum.php)
BE (1) BE2015C066I2 (forum.php)
BR (1) BRPI0509079B8 (forum.php)
CA (1) CA2560487C (forum.php)
CY (2) CY1110349T1 (forum.php)
DE (1) DE602005020913D1 (forum.php)
DK (1) DK1730175T3 (forum.php)
ES (1) ES2343255T3 (forum.php)
FR (1) FR15C0085I2 (forum.php)
HU (1) HUS1500062I1 (forum.php)
IL (1) IL178140A (forum.php)
LT (2) LTPA2015050I1 (forum.php)
LU (1) LU92903I2 (forum.php)
MY (1) MY148656A (forum.php)
NL (1) NL300777I2 (forum.php)
NO (3) NO338055B1 (forum.php)
NZ (1) NZ549898A (forum.php)
PL (1) PL1730175T3 (forum.php)
PT (1) PT1730175E (forum.php)
RU (1) RU2373219C2 (forum.php)
SI (1) SI1730175T1 (forum.php)
TW (1) TWI349036B (forum.php)
WO (1) WO2005097821A1 (forum.php)
ZA (1) ZA200607575B (forum.php)

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EP2129394B1 (en) 2007-03-09 2012-06-20 Merck Sharp & Dohme Corp. Papillomavirus vaccine compositions
EP2479187A1 (en) 2007-11-23 2012-07-25 Shanghai Zerun Biotechnology Co., Ltd. Genes encoding major capsid protein L1 of human papilloma viruses
CN101440371B (zh) * 2007-11-23 2012-09-05 上海泽润生物科技有限公司 一种16型人乳头状瘤病毒主要衣壳蛋白l1基因
SI2569008T1 (sl) * 2010-05-14 2020-02-28 Baxalta Incorporated Himere OSPA in njihova uporaba v cepivih
JP6153866B2 (ja) 2010-05-25 2017-06-28 キアゲン ガイサーズバーグ アイエヌシー． 迅速なハイブリッド捕捉アッセイ、及び関連する戦略的に切断されたプローブ
DK2589604T3 (en) 2010-07-02 2017-01-16 Univ Xiamen TRUNCATED L1 PROTEIN OF HUMAN PAPILLOMAVIRUS TYPE 52
US8361720B2 (en) 2010-11-15 2013-01-29 Exact Sciences Corporation Real time cleavage assay
BR112013013377A2 (pt) 2010-12-03 2016-11-22 Ms Technologies Llc molécula de ácido nucléico codificante de uma sintase de ácido 5-enolpiruvil-3-fosfo-chiquímico (epsps), constructo, vetor, célula de planta, planta, método para produzir uma planta tendo
CN102154325B (zh) * 2011-01-01 2013-08-21 上海生物制品研究所有限责任公司 针对人乳头瘤状病毒的疫苗及其制法和用途
RU2445357C1 (ru) * 2011-02-15 2012-03-20 Закрытое акционерное общество научно-производственная компания "Комбиотех" Рекомбинантный штамм дрожжей pichia angusta - продуцент капсидного белка l1 вируса папилломы человека типа 16
RU2445358C1 (ru) * 2011-02-15 2012-03-20 Закрытое акционерное общество научно-производственная компания "Комбиотех" Рекомбинантный штамм дрожжей pichia angusta - продуцент капсидного белка l1 вируса папилломы человека типа 18
CN110484554B (zh) * 2013-04-26 2024-04-16 北京安百胜生物科技有限公司 用汉逊酵母表达系统产生hpv52 l1蛋白的方法
CN104164374B (zh) * 2013-05-17 2019-10-22 北京安百胜生物科技有限公司 用汉逊酵母表达系统产生hpv31 l1蛋白的方法
US9782470B2 (en) 2013-10-16 2017-10-10 Merck Sharp & Dohme Corp. Method of obtaining thermostable dried vaccine formulations
CN104878022A (zh) * 2015-04-27 2015-09-02 段青姣 编码hpv58l1、hpv52l1蛋白的核苷酸序列及其应用
CN106701796B (zh) * 2015-08-12 2021-11-16 北京康乐卫士生物技术股份有限公司 52型重组人乳头瘤病毒病毒样颗粒及其制备方法
CN109750049B (zh) * 2017-11-07 2023-08-18 上海泽润生物科技有限公司 重组人乳头瘤病毒52亚型蛋白表达
CN115103687A (zh) 2020-02-14 2022-09-23 默沙东有限公司 Hpv疫苗
CN114539365B (zh) * 2020-11-26 2023-12-01 中国医学科学院基础医学研究所 一种改造的人乳头瘤病毒52型l1蛋白及其用途
CN113073105B (zh) * 2021-03-23 2023-06-13 重庆博唯佰泰生物制药有限公司 一种表达hpv 56l1的多核苷酸序列及其表达载体、宿主细胞和应用
CN113549634B (zh) * 2021-06-07 2023-03-31 郑州大学 编码可溶性hpv58 l1蛋白的基因及其重组质粒的构建与应用
WO2023014853A1 (en) 2021-08-06 2023-02-09 Merck Sharp & Dohme Llc Hpv vaccine
TW202315602A (zh) 2021-08-19 2023-04-16 美商默沙東有限責任公司 新穎熱穩定脂質奈米粒子及其使用方法
AR132886A1 (es) 2023-06-09 2025-08-06 Merck Sharp & Dohme Llc Composiciones adyuvantes en nanoemulsión para vacunas contra el papilomavirus humano

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SE514982C2 (sv) * 1999-09-30 2001-05-28 Active Biotech Ab Bärare innehållande ett huvudkapsidprotein L1 från humant papillomavirus samt dess användning
DE60016765T2 (de) * 1999-08-25 2005-11-24 Merck & Co., Inc. Synthetische papillomavirus gene, welche für expression in menschlichen zellen optimiert sind
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MY139500A (en) * 2003-11-12 2009-10-30 Merck Sharp & Dohme Optimized expression of hpv 58 l1 in yeast

Also Published As

Publication number Publication date
BRPI0509079B1 (pt) 2020-05-19
KR20060134120A (ko) 2006-12-27
BE2015C066I2 (forum.php) 2024-08-08
CN1934131B (zh) 2010-12-29
EP1730175B1 (en) 2010-04-28
CY2015052I1 (el) 2016-06-22
ATE466022T1 (de) 2010-05-15
CY1110349T1 (el) 2015-04-29
NO338055B1 (no) 2016-07-25
PL1730175T3 (pl) 2010-09-30
EP1730175A1 (en) 2006-12-13
KR101203403B1 (ko) 2012-11-21
AR048191A1 (es) 2006-04-05
RU2373219C2 (ru) 2009-11-20
SI1730175T1 (sl) 2010-08-31
JP4833962B2 (ja) 2011-12-07
IL178140A (en) 2010-11-30
TWI349036B (en) 2011-09-21
CY2015052I2 (el) 2016-06-22
LU92903I2 (fr) 2016-03-08
NL300777I1 (forum.php) 2015-12-29
US20080226660A1 (en) 2008-09-18
AU2005230907C1 (en) 2016-07-28
HUS1500062I1 (hu) 2017-07-28
DE602005020913D1 (de) 2010-06-10
WO2005097821A1 (en) 2005-10-20
PT1730175E (pt) 2010-06-25
US20100035818A1 (en) 2010-02-11
US7700103B2 (en) 2010-04-20
TW200602490A (en) 2006-01-16
NL300777I2 (forum.php) 2015-12-29
FR15C0085I2 (fr) 2016-11-25
LTC1730175I2 (lt) 2017-05-10
NZ549898A (en) 2009-06-26
ES2343255T3 (es) 2010-07-27
NO2022050I1 (no) 2022-11-30
AU2005230907B2 (en) 2011-05-19
CN1934131A (zh) 2007-03-21
AU2005230907A1 (en) 2005-10-20
ZA200607575B (en) 2008-08-27
BRPI0509079A (pt) 2007-08-21
US7744892B2 (en) 2010-06-29
NO2017005I1 (no) 2017-01-20
CA2560487A1 (en) 2005-10-20
IL178140A0 (en) 2006-12-31
RU2006137363A (ru) 2008-04-27
JP2007530040A (ja) 2007-11-01
LTPA2015050I1 (lt) 2016-01-11
DK1730175T3 (da) 2010-08-23
MY148656A (en) 2013-05-15
FR15C0085I1 (forum.php) 2016-08-01
CA2560487C (en) 2013-01-29
NO20064815L (no) 2006-10-23

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