BRPI0508193A - derivados de heteroaril-alquilcarbamatos, a preparação e a aplicação como inibidores da enzima faah - Google Patents

derivados de heteroaril-alquilcarbamatos, a preparação e a aplicação como inibidores da enzima faah

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Publication number
BRPI0508193A
BRPI0508193A BRPI0508193-9A BRPI0508193A BRPI0508193A BR PI0508193 A BRPI0508193 A BR PI0508193A BR PI0508193 A BRPI0508193 A BR PI0508193A BR PI0508193 A BRPI0508193 A BR PI0508193A
Authority
BR
Brazil
Prior art keywords
heteroaryl
preparation
group
application
faah enzyme
Prior art date
Application number
BRPI0508193-9A
Other languages
English (en)
Inventor
Ahmed Abouabdellah
Regine Bartsch-Li
Christian Hoornaert
Antoine Ravet
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of BRPI0508193A publication Critical patent/BRPI0508193A/pt

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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

DERIVADOS DE HETEROARIL-ALQUILCARBAMATOS, A PREPARAçãO E A APLICAçãO COMO INIBIDORES DA ENZIMA FAAH. A presente invenção refere-se a um composto correspondente à fórmula geral (1), na qual A é escolhido dentre um ou vários grupos X, Y e/ou Z; X representa um grupo metileno eventualmente substituído; Y representa um C~ 2~-alcenileno eventualmente substituído ou um C~ 2~-alcinileno; Z representa um grupo C~ 3-7~-cicloalquila; n representa um número inteiro que vai de 1 a 7; R~ 1~ representa um grupo de tipo naftalenila ou heterarila eventualmente substituído R~ 7~ representa um átomo de hidrogênio ou um grupo C~ 1-6~-alquila; R~ 8~ representa um átomo de hidrogênio ou um grupo C~1-6~-alquila, C~ 3-7~-cicloalquila, C~ 3-7~-cicloalquila-C~ 1-3~-alquileno; no estado de base, de sal de adição a um ácido, de hidrato ou de solvato. Esses compostos têm uma atividade inibidora sobre a enzima FAAH.
BRPI0508193-9A 2004-02-26 2005-02-25 derivados de heteroaril-alquilcarbamatos, a preparação e a aplicação como inibidores da enzima faah BRPI0508193A (pt)

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FR0401949A FR2866886B1 (fr) 2004-02-26 2004-02-26 Derives d'aryl-et d'heteroaryl-akylcarbamates, leur preparation et leur application en therapeutique
PCT/FR2005/000451 WO2005090292A1 (fr) 2004-02-26 2005-02-25 Derives d’heteroaryl-alkylcarbamates, leur preparation et leur application comme inhibiteurs de l’enzyme faah

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AU2005223423B2 (en) 2011-04-14
HRP20100017T1 (hr) 2010-02-28
IL177329A (en) 2012-01-31
SI1720829T1 (sl) 2010-02-26
HK1101759A1 (en) 2007-10-26
ATE445592T1 (de) 2009-10-15
AU2005223423A1 (en) 2005-09-29
DE602005017122D1 (de) 2009-11-26
MA28367A1 (fr) 2006-12-01
FR2866886B1 (fr) 2007-08-31
RS51246B (sr) 2010-12-31
RU2006134026A (ru) 2008-04-10
CA2554609A1 (fr) 2005-09-29
TW200533637A (en) 2005-10-16
WO2005090292A1 (fr) 2005-09-29
CY1109716T1 (el) 2014-08-13
AR047973A1 (es) 2006-03-15
NO20064329L (no) 2006-09-25
PL1720829T3 (pl) 2010-03-31
EP2251324A1 (fr) 2010-11-17
CN1926097A (zh) 2007-03-07
FR2866886A1 (fr) 2005-09-02
ES2334449T3 (es) 2010-03-10
RU2364586C2 (ru) 2009-08-20
US20100069405A1 (en) 2010-03-18
US20070021426A1 (en) 2007-01-25
PT1720829E (pt) 2010-01-13
NZ550008A (en) 2010-06-25
US7645757B2 (en) 2010-01-12
JP2007524705A (ja) 2007-08-30
ZA200606724B (en) 2007-12-27
US20110237595A1 (en) 2011-09-29
IL177329A0 (en) 2006-12-10
EP1720829A1 (fr) 2006-11-15
DK1720829T3 (da) 2010-03-01
JP4824668B2 (ja) 2011-11-30
EP1720829B1 (fr) 2009-10-14
CN1926097B (zh) 2011-06-08
KR20070011297A (ko) 2007-01-24

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