BRPI0508080A - emprego de derivados de amida de metileno em distúrbios cardiovasculares - Google Patents

emprego de derivados de amida de metileno em distúrbios cardiovasculares

Info

Publication number
BRPI0508080A
BRPI0508080A BRPI0508080-0A BRPI0508080A BRPI0508080A BR PI0508080 A BRPI0508080 A BR PI0508080A BR PI0508080 A BRPI0508080 A BR PI0508080A BR PI0508080 A BRPI0508080 A BR PI0508080A
Authority
BR
Brazil
Prior art keywords
amide derivatives
cardiovascular disorders
methylene amide
prevention
formula
Prior art date
Application number
BRPI0508080-0A
Other languages
English (en)
Inventor
Rob Hooft Van Huijsduijnen
Vincent Richard
Original Assignee
Applied Research Systems
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems filed Critical Applied Research Systems
Publication of BRPI0508080A publication Critical patent/BRPI0508080A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"EMPREGO DE DERIVADOS DE AMIDA DE METILENO EM DISTúRBIOS CARDIOVASCULARES". A presente invenção refere-se ao uso de derivados de amida de metileno substituído de Fórmula (I) para o tratamento e/ou prevenção de distúrbios cardiovasculares tais como obstrução de coronária e insuficiência cardíaca. Em particular, a presente invenção refere-se ao uso de derivados de amida de metileno substituído de Fórmula (I) em particular para o tratamento e/ou prevenção de disfunção endotelial em insuficiência cardíaca.
BRPI0508080-0A 2004-02-27 2005-02-25 emprego de derivados de amida de metileno em distúrbios cardiovasculares BRPI0508080A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04100778 2004-02-27
PCT/EP2005/050823 WO2005082347A1 (en) 2004-02-27 2005-02-25 Use of methylene amide derivatives in cardiovascular disorders

Publications (1)

Publication Number Publication Date
BRPI0508080A true BRPI0508080A (pt) 2007-07-17

Family

ID=34896106

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0508080-0A BRPI0508080A (pt) 2004-02-27 2005-02-25 emprego de derivados de amida de metileno em distúrbios cardiovasculares

Country Status (24)

Country Link
US (1) US20070185118A1 (pt)
EP (1) EP1732534B1 (pt)
JP (1) JP5001138B2 (pt)
KR (1) KR101188940B1 (pt)
CN (1) CN1933827B (pt)
AT (1) ATE401877T1 (pt)
AU (1) AU2005216649B2 (pt)
BR (1) BRPI0508080A (pt)
CA (1) CA2554919C (pt)
CY (1) CY1108252T1 (pt)
DE (1) DE602005008412D1 (pt)
DK (1) DK1732534T3 (pt)
EA (1) EA011811B1 (pt)
ES (1) ES2308458T3 (pt)
HK (1) HK1098073A1 (pt)
HR (1) HRP20080367T3 (pt)
IL (1) IL177494A (pt)
NO (1) NO20064295L (pt)
PL (1) PL1732534T3 (pt)
PT (1) PT1732534E (pt)
RS (1) RS50596B (pt)
SI (1) SI1732534T1 (pt)
UA (1) UA84453C2 (pt)
WO (1) WO2005082347A1 (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0307394A (pt) * 2002-01-29 2004-11-09 Applied Research Systems Derivados de metileno amida substituìda como moduladores de proteìnas tirosinas fosfatases (ptps), uso de um derivado de metileno amida substituìda, composição farmacêutica contendo pelo menos um derivado de metileno amida substituìda e método de preparação de um derivado de metileno amida substituìda
EP1654247B1 (en) 2003-07-21 2010-01-20 Merck Serono SA Alkynyl aryl carboxamides
EP2072498A4 (en) * 2006-10-12 2012-07-18 Inst Med Molecular Design Inc N-PHENYLOXAMIDE ACID DERIVATIVE
US8633245B2 (en) * 2008-04-11 2014-01-21 Institute Of Medicinal Molecular Design, Inc. PAI-1 inhibitor
US9051514B2 (en) 2011-08-29 2015-06-09 Ticona Llc High flow liquid crystalline polymer composition
US8669341B2 (en) 2011-08-29 2014-03-11 Ticona Llc Solid-state polymerization of a liquid crystalline polymer
US9074133B2 (en) 2011-08-29 2015-07-07 Ticona Llc Thermotropic liquid crystalline polymer with improved low shear viscosity
WO2013032967A1 (en) 2011-08-29 2013-03-07 Ticona Llc Cast molded parts formed form a liquid crystalline polymer
CN103764741B (zh) 2011-08-29 2015-09-23 提克纳有限责任公司 低熔体粘度液晶聚合物的熔融聚合
WO2013032971A1 (en) 2011-08-29 2013-03-07 Ticona Llc Melt-extruded substrate for use in thermoformed articles
WO2013032976A1 (en) 2011-08-29 2013-03-07 Ticona Llc High flow liquid crystalline polymer composition
JP2014529627A (ja) 2011-08-29 2014-11-13 ティコナ・エルエルシー 芳香族アミド化合物
WO2013032977A1 (en) 2011-08-29 2013-03-07 Ticona Llc Heat-resistant liquid crystalline polymer composition having a low melting temperature
WO2014095815A1 (en) 2012-12-17 2014-06-26 Shell Internationale Research Maatschappij B.V. Integrated gas-to-liquid condensate process
WO2014130275A2 (en) 2013-02-22 2014-08-28 Ticona Llc High performance polymer composition with improved flow properties
CN113912988A (zh) 2013-06-07 2022-01-11 提克纳有限责任公司 高强度热致液晶聚合物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60028791T2 (de) * 1999-09-10 2007-05-24 Novo Nordisk A/S Modulatoren der protein tyrosin phosphatase (ptpases)
US6627767B2 (en) * 2000-08-29 2003-09-30 Abbott Laboratories Amino(oxo) acetic acid protein tyrosine phosphatase inhibitors
DE10117823A1 (de) * 2001-04-10 2002-10-17 Merck Patent Gmbh Oxalsäurederivate
US20030055058A1 (en) * 2001-06-07 2003-03-20 Wyeth Combination of a PTPase inhibitor and an ACE inhibitor
WO2002098408A1 (en) * 2001-06-07 2002-12-12 Wyeth Ptpase inhibitors for improving cardiovascular risk profile
BR0307394A (pt) * 2002-01-29 2004-11-09 Applied Research Systems Derivados de metileno amida substituìda como moduladores de proteìnas tirosinas fosfatases (ptps), uso de um derivado de metileno amida substituìda, composição farmacêutica contendo pelo menos um derivado de metileno amida substituìda e método de preparação de um derivado de metileno amida substituìda

Also Published As

Publication number Publication date
CA2554919A1 (en) 2005-09-09
EA200601511A1 (ru) 2007-02-27
KR101188940B1 (ko) 2012-10-08
US20070185118A1 (en) 2007-08-09
CY1108252T1 (el) 2014-02-12
RS50596B (sr) 2010-05-07
CN1933827B (zh) 2011-07-27
JP2007524701A (ja) 2007-08-30
PL1732534T3 (pl) 2008-12-31
JP5001138B2 (ja) 2012-08-15
EA011811B1 (ru) 2009-06-30
DE602005008412D1 (de) 2008-09-04
PT1732534E (pt) 2008-08-08
NO20064295L (no) 2006-09-22
DK1732534T3 (da) 2008-11-17
WO2005082347A1 (en) 2005-09-09
CA2554919C (en) 2013-04-16
IL177494A (en) 2011-06-30
KR20060129066A (ko) 2006-12-14
SI1732534T1 (sl) 2008-10-31
ATE401877T1 (de) 2008-08-15
CN1933827A (zh) 2007-03-21
HK1098073A1 (en) 2007-07-13
HRP20080367T3 (en) 2008-09-30
ES2308458T3 (es) 2008-12-01
EP1732534B1 (en) 2008-07-23
IL177494A0 (en) 2006-12-31
AU2005216649A1 (en) 2005-09-09
AU2005216649B2 (en) 2010-09-09
EP1732534A1 (en) 2006-12-20
UA84453C2 (ru) 2008-10-27

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Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: LABORATOIRES SERONO S.A. (CH)

Free format text: TRANSFERIDO DE: APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.

B25D Requested change of name of applicant approved

Owner name: MERCK SERONO S.A. (CH)

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 11A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2364 DE 26-04-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.