EA200602084A1 - Пиперазиновые производные алкилоксиндолов - Google Patents

Пиперазиновые производные алкилоксиндолов

Info

Publication number
EA200602084A1
EA200602084A1 EA200602084A EA200602084A EA200602084A1 EA 200602084 A1 EA200602084 A1 EA 200602084A1 EA 200602084 A EA200602084 A EA 200602084A EA 200602084 A EA200602084 A EA 200602084A EA 200602084 A1 EA200602084 A1 EA 200602084A1
Authority
EA
Eurasian Patent Office
Prior art keywords
alkylsiloids
derivatives
piperizine
piperizine derivatives
indol
Prior art date
Application number
EA200602084A
Other languages
English (en)
Other versions
EA010789B1 (ru
Inventor
Балаж Вольк
Йожеф Баркоци
Дьюла Шимиг
Тибор Мезеи
Рита Капиллерне Дежёфи
Иштван Гачальи
Каталин Паллаги
Габор Гиглер
Дьёрдь Леваи
Кристина Мориц
Чилла Левелеки
Нора Сираи
Габор Сенаши
Андраш Эдьед
Ласло Габор Харсинг
Original Assignee
Эгиш Дьёдьсердьяр Нирт.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эгиш Дьёдьсердьяр Нирт. filed Critical Эгиш Дьёдьсердьяр Нирт.
Publication of EA200602084A1 publication Critical patent/EA200602084A1/ru
Publication of EA010789B1 publication Critical patent/EA010789B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

Настоящее изобретение связано с новыми производными индол-2-она формулы (I), которые обладают необходимыми терапевтическими свойствами для профилактики и лечения нарушений центральной нервной и сердечно-сосудистой систем.
EA200602084A 2004-05-11 2005-05-11 Пиперазиновые производные алкилоксиндолов EA010789B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU0400953A HUP0400953A3 (en) 2004-05-11 2004-05-11 Piperazine derivatives of alkyl-oxindoles, pharmaceutical compositions containing them, process for producing them and their use
PCT/HU2005/000050 WO2005108364A1 (en) 2004-05-11 2005-05-11 Piperazine derivatives of alkyl oxindoles

Publications (2)

Publication Number Publication Date
EA200602084A1 true EA200602084A1 (ru) 2007-04-27
EA010789B1 EA010789B1 (ru) 2008-10-30

Family

ID=89982207

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200602084A EA010789B1 (ru) 2004-05-11 2005-05-11 Пиперазиновые производные алкилоксиндолов

Country Status (27)

Country Link
US (1) US7910591B2 (ru)
EP (1) EP1751105B1 (ru)
JP (1) JP2007537227A (ru)
CN (1) CN101010296B (ru)
AT (1) ATE412633T1 (ru)
AU (1) AU2005240843B2 (ru)
BG (1) BG109769A (ru)
CA (1) CA2566096A1 (ru)
CZ (1) CZ2006779A3 (ru)
DE (1) DE602005010693D1 (ru)
DK (1) DK1751105T3 (ru)
EA (1) EA010789B1 (ru)
ES (1) ES2319795T3 (ru)
HR (1) HRP20060420A2 (ru)
HU (1) HUP0400953A3 (ru)
IL (1) IL179028A (ru)
MX (1) MXPA06013068A (ru)
NO (1) NO20065609L (ru)
NZ (1) NZ551545A (ru)
PL (2) PL381615A1 (ru)
PT (1) PT1751105E (ru)
RS (1) RS20060621A (ru)
SI (1) SI1751105T1 (ru)
SK (1) SK51102006A3 (ru)
UA (1) UA84927C2 (ru)
WO (1) WO2005108364A1 (ru)
ZA (1) ZA200610345B (ru)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0400953A3 (en) * 2004-05-11 2008-02-28 Egis Gyogyszergyar Nyilvanosan Piperazine derivatives of alkyl-oxindoles, pharmaceutical compositions containing them, process for producing them and their use
CN104163813B (zh) * 2013-05-16 2017-02-01 广东东阳光药业有限公司 取代的吲哚化合物及其使用方法和用途
CN106243088B (zh) 2015-06-03 2019-01-04 广东东阳光药业有限公司 取代的哌嗪化合物及其使用方法和用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4452808A (en) * 1982-12-07 1984-06-05 Smithkline Beckman Corporation 4-Aminoalkyl-2(3H)-indolones
MX173362B (es) * 1987-03-02 1994-02-23 Pfizer Compuestos de piperazinil heterociclicos y procedimiento para su preparacion
FR2635104B1 (fr) * 1988-08-03 1992-04-30 Synthelabo Derives d'indolone, leur preparation et leur application en therapeutique
GB8830312D0 (en) * 1988-12-28 1989-02-22 Lundbeck & Co As H Heterocyclic compounds
WO1998008816A1 (fr) * 1996-08-26 1998-03-05 Meiji Seika Kaisha, Ltd. Derives d'indoxyle et psychotropes
HUP0400953A3 (en) * 2004-05-11 2008-02-28 Egis Gyogyszergyar Nyilvanosan Piperazine derivatives of alkyl-oxindoles, pharmaceutical compositions containing them, process for producing them and their use

Also Published As

Publication number Publication date
DK1751105T3 (da) 2009-03-09
HU0400953D0 (en) 2004-07-28
SK51102006A3 (sk) 2007-05-03
JP2007537227A (ja) 2007-12-20
CN101010296B (zh) 2011-08-17
ZA200610345B (en) 2008-05-28
EP1751105B1 (en) 2008-10-29
PL381615A1 (pl) 2007-06-11
SI1751105T1 (sl) 2009-06-30
CA2566096A1 (en) 2005-11-17
HUP0400953A2 (en) 2007-09-28
US20080161323A1 (en) 2008-07-03
WO2005108364A1 (en) 2005-11-17
IL179028A0 (en) 2007-03-08
DE602005010693D1 (de) 2008-12-11
IL179028A (en) 2011-08-31
UA84927C2 (en) 2008-12-10
CZ2006779A3 (cs) 2007-03-07
EA010789B1 (ru) 2008-10-30
CN101010296A (zh) 2007-08-01
AU2005240843A1 (en) 2005-11-17
RS20060621A (en) 2008-09-29
BG109769A (bg) 2008-03-31
ATE412633T1 (de) 2008-11-15
HRP20060420A2 (en) 2007-04-30
AU2005240843B2 (en) 2012-02-02
ES2319795T3 (es) 2009-05-12
US7910591B2 (en) 2011-03-22
NO20065609L (no) 2007-02-05
MXPA06013068A (es) 2007-05-04
EP1751105A1 (en) 2007-02-14
PT1751105E (pt) 2009-02-10
NZ551545A (en) 2010-07-30
HUP0400953A3 (en) 2008-02-28
PL1751105T3 (pl) 2009-07-31

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU