UA84927C2 - Piperazine derivatives of alkyl oxindoles - Google Patents

Piperazine derivatives of alkyl oxindoles

Info

Publication number
UA84927C2
UA84927C2 UAA200613076A UAA200613076A UA84927C2 UA 84927 C2 UA84927 C2 UA 84927C2 UA A200613076 A UAA200613076 A UA A200613076A UA A200613076 A UAA200613076 A UA A200613076A UA 84927 C2 UA84927 C2 UA 84927C2
Authority
UA
Ukraine
Prior art keywords
piperazine derivatives
oxindoles
alkyl
alkyl oxindoles
derivatives
Prior art date
Application number
UAA200613076A
Other languages
English (en)
Ukrainian (uk)
Inventor
Балаж Волк
Дьюла Симиг
Тибор Месей
Дежефи Рита Капиллерне
Каталин Паллаги
Габор Гиглер
Кристина Мориц
Нора Сирай
Габор Сенаши
Андраш Эдьед
Ласло Габор Харсинг
Original Assignee
Эгиш Дьёдьсердьяр Нирт.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эгиш Дьёдьсердьяр Нирт. filed Critical Эгиш Дьёдьсердьяр Нирт.
Publication of UA84927C2 publication Critical patent/UA84927C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

Изобретение связано с производными индол-2-она Формулы (І), которые имеют необходимые терапевтические свойства для профилактики и лечения нарушений центральной нервной и сердечно-сосудистой систем.
UAA200613076A 2004-05-11 2005-05-11 Piperazine derivatives of alkyl oxindoles UA84927C2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU0400953A HUP0400953A3 (en) 2004-05-11 2004-05-11 Piperazine derivatives of alkyl-oxindoles, pharmaceutical compositions containing them, process for producing them and their use

Publications (1)

Publication Number Publication Date
UA84927C2 true UA84927C2 (en) 2008-12-10

Family

ID=89982207

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200613076A UA84927C2 (en) 2004-05-11 2005-05-11 Piperazine derivatives of alkyl oxindoles

Country Status (27)

Country Link
US (1) US7910591B2 (ru)
EP (1) EP1751105B1 (ru)
JP (1) JP2007537227A (ru)
CN (1) CN101010296B (ru)
AT (1) ATE412633T1 (ru)
AU (1) AU2005240843B2 (ru)
BG (1) BG109769A (ru)
CA (1) CA2566096A1 (ru)
CZ (1) CZ2006779A3 (ru)
DE (1) DE602005010693D1 (ru)
DK (1) DK1751105T3 (ru)
EA (1) EA010789B1 (ru)
ES (1) ES2319795T3 (ru)
HR (1) HRP20060420A2 (ru)
HU (1) HUP0400953A3 (ru)
IL (1) IL179028A (ru)
MX (1) MXPA06013068A (ru)
NO (1) NO20065609L (ru)
NZ (1) NZ551545A (ru)
PL (2) PL381615A1 (ru)
PT (1) PT1751105E (ru)
RS (1) RS20060621A (ru)
SI (1) SI1751105T1 (ru)
SK (1) SK51102006A3 (ru)
UA (1) UA84927C2 (ru)
WO (1) WO2005108364A1 (ru)
ZA (1) ZA200610345B (ru)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0400953A3 (en) * 2004-05-11 2008-02-28 Egis Gyogyszergyar Nyilvanosan Piperazine derivatives of alkyl-oxindoles, pharmaceutical compositions containing them, process for producing them and their use
CN104163813B (zh) * 2013-05-16 2017-02-01 广东东阳光药业有限公司 取代的吲哚化合物及其使用方法和用途
CN106243088B (zh) 2015-06-03 2019-01-04 广东东阳光药业有限公司 取代的哌嗪化合物及其使用方法和用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4452808A (en) * 1982-12-07 1984-06-05 Smithkline Beckman Corporation 4-Aminoalkyl-2(3H)-indolones
MX173362B (es) * 1987-03-02 1994-02-23 Pfizer Compuestos de piperazinil heterociclicos y procedimiento para su preparacion
FR2635104B1 (fr) * 1988-08-03 1992-04-30 Synthelabo Derives d'indolone, leur preparation et leur application en therapeutique
GB8830312D0 (en) * 1988-12-28 1989-02-22 Lundbeck & Co As H Heterocyclic compounds
WO1998008816A1 (fr) * 1996-08-26 1998-03-05 Meiji Seika Kaisha, Ltd. Derives d'indoxyle et psychotropes
HUP0400953A3 (en) * 2004-05-11 2008-02-28 Egis Gyogyszergyar Nyilvanosan Piperazine derivatives of alkyl-oxindoles, pharmaceutical compositions containing them, process for producing them and their use

Also Published As

Publication number Publication date
DK1751105T3 (da) 2009-03-09
HU0400953D0 (en) 2004-07-28
SK51102006A3 (sk) 2007-05-03
JP2007537227A (ja) 2007-12-20
CN101010296B (zh) 2011-08-17
ZA200610345B (en) 2008-05-28
EP1751105B1 (en) 2008-10-29
PL381615A1 (pl) 2007-06-11
SI1751105T1 (sl) 2009-06-30
CA2566096A1 (en) 2005-11-17
HUP0400953A2 (en) 2007-09-28
US20080161323A1 (en) 2008-07-03
WO2005108364A1 (en) 2005-11-17
IL179028A0 (en) 2007-03-08
DE602005010693D1 (de) 2008-12-11
IL179028A (en) 2011-08-31
CZ2006779A3 (cs) 2007-03-07
EA010789B1 (ru) 2008-10-30
CN101010296A (zh) 2007-08-01
AU2005240843A1 (en) 2005-11-17
RS20060621A (en) 2008-09-29
BG109769A (bg) 2008-03-31
ATE412633T1 (de) 2008-11-15
HRP20060420A2 (en) 2007-04-30
AU2005240843B2 (en) 2012-02-02
ES2319795T3 (es) 2009-05-12
US7910591B2 (en) 2011-03-22
NO20065609L (no) 2007-02-05
MXPA06013068A (es) 2007-05-04
EP1751105A1 (en) 2007-02-14
PT1751105E (pt) 2009-02-10
NZ551545A (en) 2010-07-30
EA200602084A1 (ru) 2007-04-27
HUP0400953A3 (en) 2008-02-28
PL1751105T3 (pl) 2009-07-31

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