EA200602083A1 - Новые пиперазиновые производные диалкилоксиндолов - Google Patents

Новые пиперазиновые производные диалкилоксиндолов

Info

Publication number
EA200602083A1
EA200602083A1 EA200602083A EA200602083A EA200602083A1 EA 200602083 A1 EA200602083 A1 EA 200602083A1 EA 200602083 A EA200602083 A EA 200602083A EA 200602083 A EA200602083 A EA 200602083A EA 200602083 A1 EA200602083 A1 EA 200602083A1
Authority
EA
Eurasian Patent Office
Prior art keywords
derivatives
dialkyloxindol
new piperazine
new
piperazine
Prior art date
Application number
EA200602083A
Other languages
English (en)
Other versions
EA014236B1 (ru
Inventor
Балаж Вольк
Йожеф Баркоци
Дьюла Шимиг
Тибор Мезеи
Рита Капиллерне Дежёфи
Эндрене Флориан
Иштван Гачальи
Каталин Паллаги
Габор Гиглер
Дьёрдь Леваи
Кристина Мориц
Чилла Левелеки
Нора Сираи
Габор Сенаши
Андраш Эдьед
Ласло Габор Харсинг
Original Assignee
Эгиш Дьёдьсердьяр Нирт.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU0400957A external-priority patent/HU0400957D0/hu
Priority claimed from HU0500464A external-priority patent/HUP0500464A3/hu
Application filed by Эгиш Дьёдьсердьяр Нирт. filed Critical Эгиш Дьёдьсердьяр Нирт.
Publication of EA200602083A1 publication Critical patent/EA200602083A1/ru
Publication of EA014236B1 publication Critical patent/EA014236B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Polyurethanes Or Polyureas (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Настоящее изобретение относится к новым 3,3-двузамещенным производным индол-2-она общей формулы (I), пригодным для лечения или профилактики заболеваний центральной нервной системы, желудочно-кишечного тракта и сердечно-сосудистой системы.
EA200602083A 2004-05-11 2005-05-11 Новые пиперазиновые производные диалкилоксиндолов EA014236B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
HU0400957A HU0400957D0 (en) 2004-05-11 2004-05-11 Piperazinbe derivatives of dialkyl oxindoles
HU0500464A HUP0500464A3 (en) 2005-05-05 2005-05-05 Piperazine derivatives of dialkyl-oxindoles
PCT/HU2005/000052 WO2005109987A2 (en) 2004-05-11 2005-05-11 3-(((4-phenyl)-piperazine-1-yl)-alkyl)-3-alkyl-1, 3-dihydro-2h-indol-2-one derivatives and related compounds for the treatment of central nervous system disorders

Publications (2)

Publication Number Publication Date
EA200602083A1 true EA200602083A1 (ru) 2007-06-29
EA014236B1 EA014236B1 (ru) 2010-10-29

Family

ID=89986001

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200602083A EA014236B1 (ru) 2004-05-11 2005-05-11 Новые пиперазиновые производные диалкилоксиндолов

Country Status (24)

Country Link
US (1) US7786129B2 (ru)
EP (1) EP1776339B1 (ru)
JP (1) JP2007537229A (ru)
KR (1) KR20070011594A (ru)
AT (1) ATE435204T1 (ru)
AU (1) AU2005244389B2 (ru)
BG (1) BG109771A (ru)
CA (1) CA2565514A1 (ru)
CZ (1) CZ2006777A3 (ru)
DE (1) DE602005015223D1 (ru)
DK (1) DK1776339T3 (ru)
EA (1) EA014236B1 (ru)
ES (1) ES2329388T3 (ru)
HR (2) HRP20060404A2 (ru)
IL (1) IL179029A (ru)
MX (1) MXPA06013069A (ru)
NO (1) NO20065659L (ru)
NZ (1) NZ551547A (ru)
PL (1) PL1776339T3 (ru)
PT (1) PT1776339E (ru)
RS (1) RS20060623A (ru)
SI (1) SI1776339T1 (ru)
SK (1) SK51072006A3 (ru)
WO (1) WO2005109987A2 (ru)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2742936A1 (en) 2006-05-16 2014-06-18 Takeda Pharmaceutical Company Limited Fused heterocyclic compound and use thereof
EP2789338A3 (en) 2007-11-15 2015-01-14 Takeda Pharmaceutical Company Limited Condensed pyridine derivate and use thereof
HUP0900071A2 (en) * 2009-02-06 2010-10-28 Egis Gyogyszergyar Nyilvanosan Optically active 3-[(phenyl-piperazin-1-yl)alkyl]-3-alkyl-oxindole derivatives influencing the central nervous system and pharmaceutical compositions containing them
EP3733204A4 (en) 2017-12-27 2021-09-15 Takeda Pharmaceutical Company Limited THERAPEUTIC FOR EXERCISE INCONTINENCE AND STAIR INCONTINENCE

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2635104B1 (fr) * 1988-08-03 1992-04-30 Synthelabo Derives d'indolone, leur preparation et leur application en therapeutique
GB8830312D0 (en) * 1988-12-28 1989-02-22 Lundbeck & Co As H Heterocyclic compounds
WO1998008816A1 (fr) * 1996-08-26 1998-03-05 Meiji Seika Kaisha, Ltd. Derives d'indoxyle et psychotropes
AU2005240844A1 (en) * 2004-05-11 2005-11-17 Egis Gyogyszergyar Nyrt. Indol-2-one derivatives for the treatment of central nervous disorders, gastrointestinal disorders and cardiovascular disorders
NZ551542A (en) * 2004-05-11 2010-06-25 Egis Gyogyszergyar Nyrt Piperazine derivatives of alkyl oxindoles

Also Published As

Publication number Publication date
IL179029A0 (en) 2007-03-08
HRP20060404A2 (en) 2007-04-30
ES2329388T3 (es) 2009-11-25
DK1776339T3 (da) 2009-11-02
SK51072006A3 (sk) 2007-05-03
JP2007537229A (ja) 2007-12-20
EP1776339B1 (en) 2009-07-01
IL179029A (en) 2011-11-30
EA014236B1 (ru) 2010-10-29
PL1776339T3 (pl) 2009-12-31
PT1776339E (pt) 2009-09-16
AU2005244389A1 (en) 2005-11-24
KR20070011594A (ko) 2007-01-24
ATE435204T1 (de) 2009-07-15
NZ551547A (en) 2010-06-25
DE602005015223D1 (de) 2009-08-13
NO20065659L (no) 2007-01-29
HRP20090504T1 (hr) 2009-10-31
WO2005109987A3 (en) 2006-05-04
BG109771A (bg) 2008-05-30
EP1776339A2 (en) 2007-04-25
CZ2006777A3 (cs) 2007-03-14
RS20060623A (en) 2008-09-29
WO2005109987A2 (en) 2005-11-24
US7786129B2 (en) 2010-08-31
MXPA06013069A (es) 2007-03-30
WO2005109987A9 (en) 2007-03-29
AU2005244389B2 (en) 2011-09-01
CA2565514A1 (en) 2005-11-24
US20070232619A1 (en) 2007-10-04
SI1776339T1 (sl) 2009-12-31

Similar Documents

Publication Publication Date Title
CY1110977T1 (el) Υποκατεστημενα παραγωγα ινδολης για φαρμακευτικη συνθεση για θεραπεια ασθενειων του αναπνευστικου
CY1109104T1 (el) 1,2,3,4 τετρα-υποκατεστημενη ινδολη για την αντιμετωπιση ασθενειων του αναπνευστικου
NO20064325L (no) Heteroarylaminopyrazolderivativer nyttige for behandling av diabetes
SE0303180D0 (sv) Novel compounds
CY1110965T1 (el) Επιπροσθετες ετεροπολυκυκλικες ενωσεις και η χρηση τους ως ανταγωνιστες μεταβολοτροπικου υποδοχεα γλουταμικου
SE0203713D0 (sv) Novel compounds
NO20071343L (no) Substituerte fenylaminotiazoler og anvendelse derav
EA200601239A1 (ru) Замещённые хинолиновые соединения
EA200301232A1 (ru) Новые соединения арилсульфонамида и их применение для лечения ожирения, диабета типа ii и нарушений центральной нервной системы
EA200801998A1 (ru) ПИРИДИН[3,4-b]ПИРАЗИНОНЫ
DE602005012481D1 (de) 2,7-substituierte 5-amino-4-hydroxy-8-(1h-indol-5-yl)-octanamid derivate als renin inhibitoren zur behandlung von bluthochdruck
EA200700400A1 (ru) Производные n-(1h-индолил)-1н-индол-2-карбоксамидов, их получение и их применение в терапии
EA200702199A1 (ru) Новые соединения для лечения воспалительных заболеваний
EA200602083A1 (ru) Новые пиперазиновые производные диалкилоксиндолов
NO20071466L (no) 3-substituerte-5- og 6-aminoalkyl indol-2-karboksylsyreamider og relaterte analoger som inhibitorer av kaseinkinase IE
EA200970046A1 (ru) Аминопроизводные в-гомоандростанов и в-гетероандростанов
EA200602082A1 (ru) Производные индол-2-она для лечения расстройств центральной нервной системы, желудочно-кишечных расстройств и сердечно-сосудистых расстройств
EA200602084A1 (ru) Пиперазиновые производные алкилоксиндолов
ATE412634T1 (de) Piperazinderivate von alkyloxindolen
EA200500865A1 (ru) Синергетическая комбинация, включающая рофлумиласт и r,r-формотерол
DE60326348D1 (de) Makrozyclen zur behandlung von krebserkrankungen
EA200501669A1 (ru) Замещенные производные индолина и индола
UA86978C2 (en) Piperazine derivatives of dialkyl oxindoles
UA86809C2 (en) Piperazine derivatives of alkyl oxindoles
SE0301796D0 (sv) New use II

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU