BRPI0418029B8 - formulação farmacêutica líquida, estável, adequada para administração parentérica que compreende um anticorpo agonista de cd40 - Google Patents
formulação farmacêutica líquida, estável, adequada para administração parentérica que compreende um anticorpo agonista de cd40Info
- Publication number
- BRPI0418029B8 BRPI0418029B8 BRPI0418029A BRPI0418029A BRPI0418029B8 BR PI0418029 B8 BRPI0418029 B8 BR PI0418029B8 BR PI0418029 A BRPI0418029 A BR PI0418029A BR PI0418029 A BRPI0418029 A BR PI0418029A BR PI0418029 B8 BRPI0418029 B8 BR PI0418029B8
- Authority
- BR
- Brazil
- Prior art keywords
- agonist antibody
- parenteral administration
- pharmaceutical formulation
- liquid pharmaceutical
- stable liquid
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/74—Inducing cell proliferation
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53163903P | 2003-12-22 | 2003-12-22 | |
| PCT/IB2004/004103 WO2005063289A1 (en) | 2003-12-22 | 2004-12-09 | Cd40 antibody formulation and methods |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BRPI0418029A BRPI0418029A (pt) | 2007-04-17 |
| BRPI0418029B1 BRPI0418029B1 (pt) | 2018-12-26 |
| BRPI0418029B8 true BRPI0418029B8 (pt) | 2021-05-25 |
Family
ID=34738672
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0418029A BRPI0418029B8 (pt) | 2003-12-22 | 2004-12-09 | formulação farmacêutica líquida, estável, adequada para administração parentérica que compreende um anticorpo agonista de cd40 |
Country Status (20)
| Country | Link |
|---|---|
| US (4) | US20050136055A1 (OSRAM) |
| EP (3) | EP3081933A1 (OSRAM) |
| JP (3) | JP2007515469A (OSRAM) |
| KR (2) | KR20080023766A (OSRAM) |
| CN (2) | CN102552905A (OSRAM) |
| AU (1) | AU2004308749B2 (OSRAM) |
| BR (1) | BRPI0418029B8 (OSRAM) |
| CA (2) | CA2704300A1 (OSRAM) |
| DK (1) | DK2218461T3 (OSRAM) |
| ES (1) | ES2580002T3 (OSRAM) |
| HU (1) | HUE027717T2 (OSRAM) |
| IL (2) | IL175540A (OSRAM) |
| NO (1) | NO343797B1 (OSRAM) |
| NZ (2) | NZ583179A (OSRAM) |
| PL (1) | PL2218461T3 (OSRAM) |
| RU (1) | RU2355421C2 (OSRAM) |
| SI (1) | SI2218461T1 (OSRAM) |
| TW (1) | TWI359671B (OSRAM) |
| WO (1) | WO2005063289A1 (OSRAM) |
| ZA (1) | ZA200603804B (OSRAM) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6946129B1 (en) | 1999-06-08 | 2005-09-20 | Seattle Genetics, Inc. | Recombinant anti-CD40 antibody and uses thereof |
| US7658924B2 (en) * | 2001-10-11 | 2010-02-09 | Amgen Inc. | Angiopoietin-2 specific binding agents |
| WO2007075326A2 (en) * | 2005-12-09 | 2007-07-05 | Seattle Genetics, Inc. | Methods of using cd40 binding agents |
| CN101479375B (zh) | 2006-05-03 | 2016-03-30 | 科罗拉多州立大学董事会 | Cd40激动剂抗体/1型干扰素协同佐剂组合、包含前述的结合物及其作为增强细胞免疫的治疗剂的用途 |
| US20090074711A1 (en) * | 2006-09-07 | 2009-03-19 | University Of Southhampton | Human therapies using chimeric agonistic anti-human cd40 antibody |
| ES2659517T3 (es) | 2007-05-30 | 2018-03-16 | Xencor, Inc. | Métodos y composiciones para inhibir células que expresan CD32B |
| JO2913B1 (en) * | 2008-02-20 | 2015-09-15 | امجين إنك, | Antibodies directed towards angiopoietin-1 and angiopoietin-2 proteins and their uses |
| US20110311525A1 (en) * | 2008-08-29 | 2011-12-22 | Academisch Ziekenhuis Leiden H.O.D.N. Lumc | Delivery of a cd40 agonist to a tumor draining lymph node of a subject |
| US9561214B2 (en) * | 2008-10-16 | 2017-02-07 | Array Biopharma Inc. | Method of treatment using inhibitors of mitosis |
| WO2011101332A1 (en) | 2010-02-16 | 2011-08-25 | Proyecto De Biomedicina Cima, S.L. | Compositions based on the fibronectin extracellular domain a for the treatment of melanoma |
| WO2012123269A1 (en) | 2011-03-11 | 2012-09-20 | Proyecto De Biomedicina Cima, S.L. | Immunogenic compositions and methods for their use |
| EP2505640A1 (en) | 2011-03-29 | 2012-10-03 | Neo Virnatech, S.L. | Vaccine compositions for birnavirus-borne diseases |
| AU2012249454B2 (en) | 2011-04-29 | 2016-03-24 | Apexigen, Inc. | Anti-CD40 antibodies and methods of use |
| NZ701324A (en) | 2012-05-04 | 2016-09-30 | Pfizer | Prostate-associated antigens and vaccine-based immunotherapy regimens |
| FR2994390B1 (fr) | 2012-08-10 | 2014-08-15 | Adocia | Procede d'abaissement de la viscosite de solutions de proteines a concentration elevee |
| US9676861B2 (en) | 2012-10-30 | 2017-06-13 | Apexigen, Inc. | Anti-CD40 antibodies and methods of use |
| US9856319B2 (en) | 2012-12-28 | 2018-01-02 | Abbvie Inc. | Monovalent binding proteins |
| US10533054B2 (en) | 2013-01-31 | 2020-01-14 | Thomas Jefferson University | Agonist fusion protein for CD40 and OX40 and methods of stimulating the immune system |
| KR102564207B1 (ko) | 2013-08-08 | 2023-08-10 | 싸이튠 파마 | Il―15 및 il―15r 알파 스시 도메인 기반 모듈로카인 |
| CN107073118B (zh) | 2014-10-29 | 2022-03-01 | 西雅图基因公司 | 非岩藻糖基化抗cd40抗体的剂量和给药 |
| AU2016291817A1 (en) | 2015-07-16 | 2018-02-22 | Biolinerx Ltd. | Compositions and methods for treating cancer |
| CN108778301A (zh) | 2016-03-10 | 2018-11-09 | 永恒生物科技股份有限公司 | 通过联合疗法来治疗实体瘤或淋巴瘤的方法 |
| EP4371570A3 (en) | 2016-06-08 | 2024-07-17 | Xencor, Inc. | Treatment of igg4-related diseases with anti-cd19 antibodies crossbinding to cd32b |
| CA3026474A1 (en) | 2016-06-20 | 2017-12-28 | Kymab Limited | Anti-pd-l1 and il-2 cytokines |
| CA3042867A1 (en) | 2016-11-04 | 2018-05-11 | Memorial Sloan Kettering Cancer Center | Bi-specific activators for tumor therapy |
| WO2018088850A2 (ko) * | 2016-11-11 | 2018-05-17 | 다이노나(주) | Cd40에 특이적으로 결합하는 항체 및 그의 용도 |
| WO2018162450A1 (en) | 2017-03-06 | 2018-09-13 | Fundación Para La Investigación Médica Aplicada | New inmunostimulatory compositions comprising an entity of cold inducible rna-binding protein with an antigen for the activation of dendritic cells |
| CN111344304B (zh) * | 2017-06-01 | 2023-09-01 | Pb免疫治疗公司 | 新型抗cd40抗体及其用途 |
| EP3418302A1 (en) * | 2017-06-19 | 2018-12-26 | F. Hoffmann-La Roche AG | Administration routes for immune agonists |
| CN110506058A (zh) * | 2017-06-02 | 2019-11-26 | 豪夫迈·罗氏有限公司 | 免疫激动剂的施用路径 |
| CA3097007A1 (en) * | 2018-04-20 | 2019-10-24 | Lyvgen Biopharma Co., Ltd. | Anti-cd40 antibodies and uses thereof |
| AU2019287765A1 (en) | 2018-06-15 | 2021-01-07 | Flagship Pioneering Innovations V, Inc. | Increasing immune activity through modulation of postcellular signaling factors |
| AU2019349874A1 (en) * | 2018-09-28 | 2021-04-29 | Lyvgen Biopharma Holdings Limited | Anti-CD40 binding molecules having engineered Fc domains and therapeutic uses thereof |
| CN116063495A (zh) * | 2018-09-28 | 2023-05-05 | 礼进生物医药科技(上海)有限公司 | 具有经过工程化的Fc结构域的抗CD40结合分子及其治疗用途 |
| KR20210097750A (ko) * | 2018-11-30 | 2021-08-09 | 지앙수 헨그루이 메디슨 컴퍼니 리미티드 | Cd40 항체 약학 조성물 및 이의 용도 |
| MX2021008305A (es) | 2019-01-11 | 2021-08-24 | Novartis Ag | Anticuerpos anti-cd40 para el uso en el tratamiento de hidradenitis supurativa. |
| MA55805A (fr) | 2019-05-03 | 2022-03-09 | Flagship Pioneering Innovations V Inc | Métodes de modulation de l'activité immunitaire |
| CN115052625B (zh) | 2019-12-03 | 2024-11-01 | 埃沃特克国际有限责任公司 | 干扰素相关抗原结合蛋白及其用途 |
| EP4076434A1 (en) | 2019-12-17 | 2022-10-26 | Flagship Pioneering Innovations V, Inc. | Combination anti-cancer therapies with inducers of iron-dependent cellular disassembly |
| WO2021168274A1 (en) | 2020-02-21 | 2021-08-26 | Silverback Therapeutics, Inc. | Nectin-4 antibody conjugates and uses thereof |
| JP2023527916A (ja) * | 2020-06-04 | 2023-06-30 | セルヴァックス ピーティーワイ リミテッド | アゴニスト抗cd40抗体 |
| CA3184366A1 (en) | 2020-06-29 | 2022-01-06 | Darby Rye Schmidt | Viruses engineered to promote thanotransmission and their use in treating cancer |
| TW202216211A (zh) | 2020-07-01 | 2022-05-01 | 美商希沃爾拜克治療公司 | 抗asgr1抗體共軛物及其用途 |
| JP2023538105A (ja) * | 2020-08-21 | 2023-09-06 | ウーシー・バイオロジクス・(シャンハイ)・カンパニー・リミテッド | Cd40アゴニスト抗体及び使用方法 |
| JP2024512669A (ja) | 2021-03-31 | 2024-03-19 | フラグシップ パイオニアリング イノベーションズ ブイ,インコーポレーテッド | タノトランスミッションポリペプチド及び癌の処置におけるそれらの使用 |
| AU2022303363A1 (en) | 2021-06-29 | 2024-01-18 | Flagship Pioneering Innovations V, Inc. | Immune cells engineered to promote thanotransmission and uses thereof |
| EP4598946A1 (en) | 2022-10-05 | 2025-08-13 | Flagship Pioneering Innovations V, Inc. | Nucleic acid molecules encoding trif and additionalpolypeptides and their use in treating cancer |
| US20240269251A1 (en) | 2023-01-09 | 2024-08-15 | Flagship Pioneering Innovations V, Inc. | Genetic switches and their use in treating cancer |
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| US5247069A (en) * | 1986-06-13 | 1993-09-21 | Oncogen | Ligands and methods for augmenting B-cell proliferation |
| JP2547556B2 (ja) * | 1987-02-06 | 1996-10-23 | 株式会社 ミドリ十字 | r−グロブリンの液状製剤 |
| SE8701004D0 (sv) | 1987-03-11 | 1987-03-11 | Astra Ab | Method for therapy of leukemias and certain other malignancies |
| JPH03204821A (ja) * | 1989-12-28 | 1991-09-06 | Green Cross Corp:The | モノクローナル抗体含有水溶液の加熱処理方法 |
| CA2089229C (en) * | 1992-02-14 | 2010-04-13 | Alejandro A. Aruffo | Cd40cr receptor and ligands therefor |
| WO1994004570A1 (en) | 1992-08-21 | 1994-03-03 | Schering Corporation | Cd40 ligand, anti cd40 antibodies, and soluble cd40 |
| PT724456E (pt) * | 1993-10-01 | 2004-04-30 | Immunex Corp | Anticorpos contra cd4 |
| DE69433820T2 (de) * | 1993-12-23 | 2005-06-23 | Immunex Corp., Seattle | Verwendung von löslichen oligomerischen cd40 liganden oder monoklonalen antikörpern zur herstellung eines arzneimitells zur vorbeugung oder behandlung von neoplastischen krankheiten |
| GB9425060D0 (en) | 1994-12-13 | 1995-02-08 | Univ Birmingham | Carcinoma treatment |
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| JP4817503B2 (ja) * | 1999-06-01 | 2011-11-16 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | Vla−1に対するブロッキングモノクローナル抗体および炎症性障害の処置のためのその使用 |
| US6358670B1 (en) * | 1999-12-28 | 2002-03-19 | Electron Vision Corporation | Enhancement of photoresist plasma etch resistance via electron beam surface cure |
| JP4516711B2 (ja) * | 1999-12-28 | 2010-08-04 | 中外製薬株式会社 | 安定な抗体組成物及び注射製剤 |
| JP2003524644A (ja) | 2000-02-01 | 2003-08-19 | タノックス インコーポレイテッド | Cd40−結合性apc−活性化分子 |
| KR20020091170A (ko) * | 2000-03-31 | 2002-12-05 | 아이덱 파마슈티칼즈 코포레이션 | B 세포 림프종의 치료를 위한 항-사이토카인 항체 또는길항제 및 항-cd20의 조합된 사용 |
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| ATE541860T1 (de) * | 2000-10-02 | 2012-02-15 | Novartis Vaccines & Diagnostic | Humane antikörper gegen cd40 zur therapie von b- zell tumoren |
| JP4340062B2 (ja) * | 2000-10-12 | 2009-10-07 | ジェネンテック・インコーポレーテッド | 粘度の減少した濃縮タンパク質製剤 |
| IL149701A0 (en) * | 2001-05-23 | 2002-11-10 | Pfizer Prod Inc | Use of anti-ctla-4 antibodies |
| US20030113316A1 (en) * | 2001-07-25 | 2003-06-19 | Kaisheva Elizabet A. | Stable lyophilized pharmaceutical formulation of IgG antibodies |
| EP1441589B1 (en) * | 2001-11-08 | 2012-05-09 | Abbott Biotherapeutics Corp. | Stable liquid pharmaceutical formulation of igg antibodies |
| AR039067A1 (es) * | 2001-11-09 | 2005-02-09 | Pfizer Prod Inc | Anticuerpos para cd40 |
| US7771951B2 (en) * | 2001-12-03 | 2010-08-10 | Amgen Fremont Inc. | Antibody categorization based on binding characteristics |
| US7115108B2 (en) | 2002-04-02 | 2006-10-03 | Becton, Dickinson And Company | Method and device for intradermally delivering a substance |
| US20080009439A1 (en) * | 2002-11-05 | 2008-01-10 | Alsobrook John P | Compositions and Methods of Use for a Fibroblast Growth Factor |
| HN2004000285A (es) * | 2003-08-04 | 2006-04-27 | Pfizer Prod Inc | ANTICUERPOS DIRIGIDOS A c-MET |
-
2004
- 2004-12-02 US US11/001,980 patent/US20050136055A1/en not_active Abandoned
- 2004-12-09 EP EP16164228.5A patent/EP3081933A1/en not_active Withdrawn
- 2004-12-09 NZ NZ583179A patent/NZ583179A/en not_active IP Right Cessation
- 2004-12-09 CA CA2704300A patent/CA2704300A1/en not_active Abandoned
- 2004-12-09 RU RU2006120950/14A patent/RU2355421C2/ru active
- 2004-12-09 NZ NZ547162A patent/NZ547162A/en not_active IP Right Cessation
- 2004-12-09 KR KR1020087004912A patent/KR20080023766A/ko not_active Ceased
- 2004-12-09 ES ES10162787.5T patent/ES2580002T3/es not_active Expired - Lifetime
- 2004-12-09 EP EP04801378A patent/EP1706143A1/en not_active Ceased
- 2004-12-09 CN CN2012100028652A patent/CN102552905A/zh active Pending
- 2004-12-09 KR KR1020067012364A patent/KR100847944B1/ko not_active Expired - Fee Related
- 2004-12-09 HU HUE10162787A patent/HUE027717T2/en unknown
- 2004-12-09 JP JP2006546357A patent/JP2007515469A/ja active Pending
- 2004-12-09 CN CNA2004800385418A patent/CN1897971A/zh active Pending
- 2004-12-09 CA CA2549652A patent/CA2549652C/en not_active Expired - Lifetime
- 2004-12-09 AU AU2004308749A patent/AU2004308749B2/en not_active Ceased
- 2004-12-09 DK DK10162787.5T patent/DK2218461T3/en active
- 2004-12-09 BR BRPI0418029A patent/BRPI0418029B8/pt not_active IP Right Cessation
- 2004-12-09 EP EP10162787.5A patent/EP2218461B1/en not_active Expired - Lifetime
- 2004-12-09 PL PL10162787.5T patent/PL2218461T3/pl unknown
- 2004-12-09 SI SI200432321A patent/SI2218461T1/sl unknown
- 2004-12-09 WO PCT/IB2004/004103 patent/WO2005063289A1/en not_active Ceased
- 2004-12-21 TW TW093139794A patent/TWI359671B/zh not_active IP Right Cessation
-
2006
- 2006-05-10 IL IL175540A patent/IL175540A/en active IP Right Grant
- 2006-05-12 ZA ZA200603804A patent/ZA200603804B/en unknown
- 2006-07-20 NO NO20063373A patent/NO343797B1/no not_active IP Right Cessation
-
2009
- 2009-07-14 US US12/502,587 patent/US20090311254A1/en not_active Abandoned
- 2009-10-11 IL IL201409A patent/IL201409A0/en unknown
-
2010
- 2010-12-23 US US12/978,272 patent/US20110104182A1/en not_active Abandoned
-
2011
- 2011-04-28 JP JP2011100868A patent/JP5634321B2/ja not_active Expired - Fee Related
-
2012
- 2012-03-19 US US13/424,260 patent/US20120263732A1/en not_active Abandoned
-
2014
- 2014-06-12 JP JP2014121342A patent/JP2014205692A/ja active Pending
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