BRPI0417339A - cápsula macia de butilftalida e processo para preparação da mesma - Google Patents

cápsula macia de butilftalida e processo para preparação da mesma

Info

Publication number
BRPI0417339A
BRPI0417339A BRPI0417339-2A BRPI0417339A BRPI0417339A BR PI0417339 A BRPI0417339 A BR PI0417339A BR PI0417339 A BRPI0417339 A BR PI0417339A BR PI0417339 A BRPI0417339 A BR PI0417339A
Authority
BR
Brazil
Prior art keywords
butylphthalide
capsule
preparing
soft capsule
soft
Prior art date
Application number
BRPI0417339-2A
Other languages
English (en)
Inventor
Min Bai
Wenmin Guo
Surui Chen
Liyun Liu
Guirong Zhou
Jianquing Li
Original Assignee
Shijiazhuang Pharma Group
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shijiazhuang Pharma Group filed Critical Shijiazhuang Pharma Group
Publication of BRPI0417339A publication Critical patent/BRPI0417339A/pt
Publication of BRPI0417339B1 publication Critical patent/BRPI0417339B1/pt
Publication of BRPI0417339B8 publication Critical patent/BRPI0417339B8/pt
Publication of BRPI0417339C1 publication Critical patent/BRPI0417339C1/pt
Publication of BRPI0417339C8 publication Critical patent/BRPI0417339C8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A61K9/4825—Proteins, e.g. gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4875—Compounds of unknown constitution, e.g. material from plants or animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Botany (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Formation And Processing Of Food Products (AREA)

Abstract

"CáPSULA MACIA DE BUTILFTALIDA E PROCESSO PARA PREPARAçãO DA MESMA". A presente invenção revela uma nova cápsula macia de butilftalida e um processo para preparar a mesma. A cápsula macia de butilftalida é composta de um material da parede da cápsula e de um óleo contendo a droga, na qual o óleo contendo a droga é composto essencialmente de butilftalida e de um óleo vegetal como o diluente em uma relação de peso de aproximadamente 1:0~10. O material da parede da cápsula é composto de uma matriz da parede da cápsula, um plastificante e água em uma relação de peso de l: 0,2~0,4: 0,8~1,3. A cápsula macia de butilftalida descrita na presente invenção pode mascarar o sabor forte e especial da butilftalida, e superar as dificuldades associadas com o ingrediente ativo oleoso formulando em outra formulação oral. No momento da desintegração da cápsula macia satisfaz as exigências da farmacopéia da República Popular da China.
BRPI0417339A 2003-12-05 2004-12-03 Cápsula macia de butilftalida BRPI0417339C8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN200310119336.1 2003-12-05
CNB2003101193361A CN1257711C (zh) 2003-12-05 2003-12-05 丁苯酞软胶囊及其制备工艺
PCT/CN2004/001411 WO2005053658A1 (fr) 2003-12-05 2004-12-03 Capsule molle de butylphthalide et procede de preparation correspondant

Publications (5)

Publication Number Publication Date
BRPI0417339A true BRPI0417339A (pt) 2007-02-21
BRPI0417339B1 BRPI0417339B1 (pt) 2017-12-19
BRPI0417339B8 BRPI0417339B8 (pt) 2020-06-02
BRPI0417339C1 BRPI0417339C1 (pt) 2021-05-25
BRPI0417339C8 BRPI0417339C8 (pt) 2022-02-01

Family

ID=34638049

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0417339A BRPI0417339C8 (pt) 2003-12-05 2004-12-03 Cápsula macia de butilftalida

Country Status (15)

Country Link
US (4) US20080020034A1 (pt)
EP (1) EP1702612B1 (pt)
JP (1) JP4634394B2 (pt)
KR (1) KR100761437B1 (pt)
CN (1) CN1257711C (pt)
AT (1) ATE427104T1 (pt)
AU (1) AU2004294254B2 (pt)
BR (1) BRPI0417339C8 (pt)
CA (1) CA2549498C (pt)
DE (1) DE602004020381D1 (pt)
HK (1) HK1090302A1 (pt)
MX (1) MXPA06006401A (pt)
NO (1) NO338520B1 (pt)
RU (1) RU2322976C1 (pt)
WO (1) WO2005053658A1 (pt)

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CN100471494C (zh) * 2005-12-24 2009-03-25 石药集团中奇制药技术（石家庄）有限公司 丁苯酞滴丸及制备方法
US8026393B2 (en) * 2006-01-24 2011-09-27 Sucampo Ag Soft-gelatin capsule formulation
CN101342152B (zh) * 2007-07-10 2010-10-13 石药集团中奇制药技术（石家庄）有限公司 丁苯酞片及其制备方法
US8726005B2 (en) 2009-12-10 2014-05-13 George Mason Intellectual Properties, Inc. Website matching based on network traffic
CN102058560B (zh) * 2010-12-30 2013-07-24 张家界茅岩莓有限公司 一种二氢杨梅素软胶囊及制备方法
CN102178643B (zh) * 2011-04-29 2014-05-14 石药集团恩必普药业有限公司 一种丁苯酞或其衍生物的微乳透皮凝胶剂及其制备方法
CN103169685B (zh) * 2011-12-23 2018-03-06 石药集团中奇制药技术（石家庄）有限公司 一种丁苯酞控释制剂及其制备方法
CN107648222A (zh) * 2012-06-06 2018-02-02 石药集团中奇制药技术（石家庄）有限公司 一种丁苯酞药物活性组合物及其制备方法
CN102716103B (zh) * 2012-07-02 2013-12-18 西安力邦制药有限公司 2,2′,6,6′-四异丙基-4,4′-二联苯酚软胶囊制剂及其制备方法
CN109939102B (zh) * 2013-06-13 2022-05-17 石药集团中奇制药技术（石家庄）有限公司 一种包含丁苯酞和冰片的药物组合物及其应用
CN106606498A (zh) * 2016-07-25 2017-05-03 山东诚创医药技术开发有限公司 一种丁苯酞软胶囊
CN106580959B (zh) * 2017-01-10 2019-04-23 山东省立医院 一种缓解急性缺血性脑卒中的丁苯酞尼群地平软胶囊
CN109432042B (zh) * 2018-12-24 2022-04-22 石药集团恩必普药业有限公司 一种软胶囊囊壳及其制备方法
CN112336700B (zh) * 2019-08-08 2023-12-01 河北菲尼斯生物技术有限公司 一种稳定的含丁苯酞药物及其制备方法
CN114073694B (zh) * 2020-08-14 2024-03-12 北京科莱博医药开发有限责任公司 丁苯酞制剂及其制备方法
KR102294072B1 (ko) 2020-11-19 2021-08-26 (주)알피바이오 식물성 츄어블 연질캡슐용 조성물 및 이를 통해 형성된 식물성 츄어블 연질캡슐
KR102523186B1 (ko) 2020-11-19 2023-04-18 (주)알피바이오 동물성 츄어블 연질캡슐용 조성물 및 이를 통해 형성된 동물성 츄어블 연질캡슐
CN113975242A (zh) * 2021-10-14 2022-01-28 山东诚创蓝海医药科技有限公司 一种提高口服生物利用度的丁苯酞软胶囊
CN115469039B (zh) * 2022-10-28 2024-04-26 成都施贝康生物医药科技有限公司 一种丁苯酞及其有关物质检测方法
CN115453014B (zh) * 2022-10-28 2024-04-19 成都施贝康生物医药科技有限公司 一种丁苯酞及其有关物质的检测方法

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Also Published As

Publication number Publication date
EP1702612A4 (en) 2006-12-20
CN1257711C (zh) 2006-05-31
DE602004020381D1 (de) 2009-05-14
RU2006122207A (ru) 2008-01-10
JP4634394B2 (ja) 2011-02-16
AU2004294254A1 (en) 2005-06-16
US20080305163A1 (en) 2008-12-11
US20080020034A1 (en) 2008-01-24
BRPI0417339B8 (pt) 2020-06-02
NO20062895L (no) 2006-09-04
MXPA06006401A (es) 2007-11-13
CN1623542A (zh) 2005-06-08
EP1702612B1 (en) 2009-04-01
AU2004294254B2 (en) 2008-02-07
CA2549498A1 (en) 2005-06-16
BRPI0417339B1 (pt) 2017-12-19
BRPI0417339C8 (pt) 2022-02-01
WO2005053658A1 (fr) 2005-06-16
KR20060105013A (ko) 2006-10-09
BRPI0417339C1 (pt) 2021-05-25
KR100761437B1 (ko) 2007-10-04
WO2005053658A8 (fr) 2005-10-13
US8609137B2 (en) 2013-12-17
EP1702612A1 (en) 2006-09-20
US20070134316A1 (en) 2007-06-14
US20120052117A1 (en) 2012-03-01
HK1090302A1 (en) 2006-12-22
ATE427104T1 (de) 2009-04-15
JP2007513097A (ja) 2007-05-24
RU2322976C1 (ru) 2008-04-27
CA2549498C (en) 2011-07-12
NO338520B1 (no) 2016-08-29

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