BRPI0416931A - processo para resolver ácidos mandélicos, e, composto - Google Patents

processo para resolver ácidos mandélicos, e, composto

Info

Publication number
BRPI0416931A
BRPI0416931A BRPI0416931-0A BRPI0416931A BRPI0416931A BR PI0416931 A BRPI0416931 A BR PI0416931A BR PI0416931 A BRPI0416931 A BR PI0416931A BR PI0416931 A BRPI0416931 A BR PI0416931A
Authority
BR
Brazil
Prior art keywords
mandelic acid
acid derivatives
alkyl
solving
compound
Prior art date
Application number
BRPI0416931-0A
Other languages
English (en)
Inventor
Hans Jorgen Blixt
Bo Lars Gustaf Bosson
Roberto Giuseppe Paolo Gatti
Michael Senior William
Simone Zaramella
Kurt Vogtli
Andrea Zistler
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of BRPI0416931A publication Critical patent/BRPI0416931A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/16—Preparation of optical isomers
    • C07C231/20—Preparation of optical isomers by separation of optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/487—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to chemical modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings

Abstract

"PROCESSO PARA RESOLVER ACIDOS MANDéLICOS E COMPOSTO". A presente invenção diz respeito a um novo processo para a resolução de derivados de ácido mandélico a partir de misturas de derivados de ácido mandélico racêmico pela formação de sal com amidas cíclicas de base quiral; para os sais de amida cíclica do ácido mandélico resolvidos (ver, por exemplo, a fórmula IIa) bem como certos outros sais de amina e metálicos dos derivados de ácido mandélico, e ao uso dos derivados de ácido mandélico resolvidos como intermediários apropriados para a fabricação em larga escala de, por exemplo, compostos farmacêuticos; A fórmula IIa, em que R é selecionado a de CHF~ 2~, H, Alquila C~ 1-6~, CH~ 2~F, CHC1~ 2~ e CC1F~ 2~; e em que n é 0, 1 ou 2; R1 é H ou Alquila C~ 1-6~ e X é H, halo ou Alquila C~ 1-6~.
BRPI0416931-0A 2003-11-28 2004-11-25 processo para resolver ácidos mandélicos, e, composto BRPI0416931A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0303220A SE0303220D0 (sv) 2003-11-28 2003-11-28 New process
PCT/GB2004/004964 WO2005054168A2 (en) 2003-11-28 2004-11-25 A process for resolving, optionally substituted, mandelic acids by salt formation with a chiral base cyclic amide

Publications (1)

Publication Number Publication Date
BRPI0416931A true BRPI0416931A (pt) 2007-01-16

Family

ID=29729226

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0416931-0A BRPI0416931A (pt) 2003-11-28 2004-11-25 processo para resolver ácidos mandélicos, e, composto

Country Status (15)

Country Link
US (1) US7960582B2 (pt)
EP (1) EP1692089A2 (pt)
JP (1) JP4906511B2 (pt)
KR (1) KR101134767B1 (pt)
CN (2) CN101407453A (pt)
AU (2) AU2004295152B2 (pt)
BR (1) BRPI0416931A (pt)
CA (1) CA2546694A1 (pt)
IL (1) IL175488A (pt)
NO (1) NO20062258L (pt)
NZ (1) NZ547354A (pt)
SE (1) SE0303220D0 (pt)
SG (2) SG148213A1 (pt)
WO (1) WO2005054168A2 (pt)
ZA (1) ZA200604192B (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR035216A1 (es) 2000-12-01 2004-05-05 Astrazeneca Ab Derivados de acido mandelico ,derivados farmaceuticamente aceptables, uso de estos derivados para la fabricacion de medicamentos, metodos de tratamiento ,procesos para la preparacion de estos derivados, y compuestos intermediarios
AR034517A1 (es) 2001-06-21 2004-02-25 Astrazeneca Ab Formulacion farmaceutica
SE0201661D0 (sv) * 2002-05-31 2002-05-31 Astrazeneca Ab New salts
US7781424B2 (en) * 2003-05-27 2010-08-24 Astrazeneca Ab Modified release pharmaceutical formulation
SE0303220D0 (sv) 2003-11-28 2003-11-28 Astrazeneca Ab New process
GB0510546D0 (en) * 2005-05-24 2005-06-29 Astrazeneca Ab New process
TW200827336A (en) 2006-12-06 2008-07-01 Astrazeneca Ab New crystalline forms
TW200900033A (en) * 2007-06-21 2009-01-01 Wen-Qing Li Automatic brewing machine
US20090061000A1 (en) * 2007-08-31 2009-03-05 Astrazeneca Ab Pharmaceutical formulation use 030
CN103450008B (zh) * 2013-09-02 2015-02-25 江苏宝众宝达药业有限公司 一种从废水中回收扁桃酸的方法
CN104447294A (zh) * 2014-11-24 2015-03-25 苏州乔纳森新材料科技有限公司 一种3-环己烯-1-甲酸的手性拆分方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1867274A (en) * 1929-11-20 1932-07-12 Lilly Co Eli Resolution of ephedrine and its homologues and of mandelic acid, and certain intermediates
JPS581105B2 (ja) * 1977-03-24 1983-01-10 日本化薬株式会社 光学活性アミノ酸−マンデル酸複合体及びその製造法
JPS5416442A (en) * 1977-07-08 1979-02-07 Sumitomo Chem Co Ltd Optical resolution of 3-pheoxymandelic acid
US4239912A (en) * 1978-12-08 1980-12-16 American Cyanamid Company Process for resolving DL-Mandelic acid with novel 2-benzylamino-1-butanols
US4260815A (en) * 1979-10-09 1981-04-07 American Cyanamid Company Process for preparing a solution of DL-mandelic acid
US4259521A (en) * 1979-10-09 1981-03-31 American Cyanamid Company Process for resolving DL-mandelic acid
JPH01221345A (ja) * 1988-02-27 1989-09-04 Ajinomoto Co Inc マンデル酸誘導体の光学分割方法
DE4137663A1 (de) * 1991-11-12 1993-05-13 Degussa Verfahren zur herstellung optisch aktiver 1,3-imidazolidin-4-one und deren verwendung
JPH11228546A (ja) * 1998-02-09 1999-08-24 Koei Chem Co Ltd 光学活性２−（Ｎ−ｔｅｒｔ−ブチルカルバモイル）ピペラジンの製造法
JP2001002641A (ja) * 1999-06-24 2001-01-09 Daito Chemix Corp 光学活性３−アミノピロリジン−２−オン誘導体の製造法
JP2001072644A (ja) * 1999-09-06 2001-03-21 Yamakawa Yakuhin Kogyo Kk 光学活性な２−クロロマンデル酸の製造方法および製造の中間体
US6642395B1 (en) 1999-11-29 2003-11-04 Mitsubishi Rayon Co., Ltd. Acetalsulfonate derivative, process for producing the same, and process for producing styrene oxide derivative
WO2002068391A1 (en) * 2000-11-20 2002-09-06 Eli Lilly And Company Process for resolving racemic mixtures of piperidine derivatives
AR035216A1 (es) * 2000-12-01 2004-05-05 Astrazeneca Ab Derivados de acido mandelico ,derivados farmaceuticamente aceptables, uso de estos derivados para la fabricacion de medicamentos, metodos de tratamiento ,procesos para la preparacion de estos derivados, y compuestos intermediarios
US7129233B2 (en) * 2000-12-01 2006-10-31 Astrazeneca Ab Mandelic acid derivatives and their use as thrombin inhibitors
AR034517A1 (es) * 2001-06-21 2004-02-25 Astrazeneca Ab Formulacion farmaceutica
SE0303220D0 (sv) 2003-11-28 2003-11-28 Astrazeneca Ab New process
GB0503672D0 (en) 2005-02-23 2005-03-30 Astrazeneca Ab New process
GB0510546D0 (en) 2005-05-24 2005-06-29 Astrazeneca Ab New process

Also Published As

Publication number Publication date
WO2005054168A2 (en) 2005-06-16
AU2004295152B2 (en) 2009-07-02
KR20060109965A (ko) 2006-10-23
JP2007513885A (ja) 2007-05-31
IL175488A (en) 2012-02-29
WO2005054168A3 (en) 2005-10-27
KR101134767B1 (ko) 2012-04-13
SG148213A1 (en) 2008-12-31
JP4906511B2 (ja) 2012-03-28
CA2546694A1 (en) 2005-06-16
EP1692089A2 (en) 2006-08-23
US20080312457A1 (en) 2008-12-18
IL175488A0 (en) 2006-09-05
NZ547354A (en) 2010-02-26
SE0303220D0 (sv) 2003-11-28
CN101407453A (zh) 2009-04-15
CN1886359A (zh) 2006-12-27
ZA200604192B (en) 2007-11-28
NO20062258L (no) 2006-08-23
CN100448834C (zh) 2009-01-07
AU2009208107A1 (en) 2009-09-03
AU2004295152A1 (en) 2005-06-16
US7960582B2 (en) 2011-06-14
SG148212A1 (en) 2008-12-31

Similar Documents

Publication Publication Date Title
BRPI0416931A (pt) processo para resolver ácidos mandélicos, e, composto
TW200722415A (en) New process
HRP20040690B1 (en) Novel fluorene carboxylic acid esters, methods for the production thereof, and use of the same as pharmaceuticals
DE602006008962D1 (de) Verfahren zur herstellung von valsartan
BR112014009302B1 (pt) processo para preparar derivados de quinolina
AR049401A1 (es) Aza-biciclononanos
EP1712549A4 (en) OPTICALLY ACTIVE QUATERNARY AMMONIUM SALT HAVING AXIAL ASYMMETRY AND PROCESS FOR PRODUCTION OF ALPHA-AMINO ACID AND ITS DERIVATIVE THEREOF
HRP20050543A2 (en) Substituted indolepyridinium as anti-infective compounds
BRPI0415220A (pt) processo de produção de amida carboxìlica e derivados da mesma
EA200501477A1 (ru) Производные пиперидинил- и пиперазинилалкилкарбаматов, способы их получения и применение их в терапии
BR112012028637A2 (pt) composição de gasolina, pacote de aditivo, uso de aditivo e método
BRPI0500480B8 (pt) processo para a síntese de ivabradina bem como processos para a resolução de amina e para a síntese de composto relacionado com a síntese de ivabradina
AR048465A1 (es) Derivados de acidos carboxilicos
AR044694A1 (es) Proceso y compuestos intermedios para la preparacion de (1r, 2s,5s) - 3 azabiciclo [3,1,0] hexano-2- carboxamida, n- [3- amino-1- (ciclobutilmetil) - 2, 3 - dioxopropil] -3- [ (2s) - 2 - [[ [ 1,1- dimetiletil] amino] carbonilamino] -3,3-dimetil -1- oxobutil]-6,6 dimetilo
FI117436B (fi) Menetelmä levobupivakaiinin ja sen analogien optisesti rikastuneen muodon rasemisoimiseksi
BRPI0500590B8 (pt) processo para a síntese de compostos de 1,3,4,5-tetraidro-2h-3-benzazepin-2-ona, e aplicação na síntese de ivabradina e sais de adição desta com um ácido farmaceuticamente aceitável
BRPI0513299A (pt) processo para preparação de ésteres de ácido 4, 4-difluoro-3-oxobutanóico
Shah et al. Catalyst-free, facile, and an efficient synthesis of α-aminonitriles employing Zn (CN) 2 as an ecofriendly cyanating agent
US5491263A (en) Aminoethylation process for production of substituted ethylene diamines
RS54082B1 (en) PROCEDURE FOR ENZYMIC SYNTHESIS (7S) -1- (3,4-DIMETOXYBICYCLO [4.2.0] OCTA-1,3,5-TRIEN-7-IL) N-METHYL METHANAMINE AND APPLICATION IN THE SYNTHESIS OF IVABRADINE AND ITS SALTS
BR0214150A (pt) Processo para a preparação de amidas de acidos alfa-hidroxicarboxìlicos
BRPI0409016A (pt) processos para preparação de um produto de reação, de uma composição farmacêutica, de uma composição agroquìmica, de uma composição de limpeza, de uma composição de tinta e de um refrigerante ou lubrificante
BR0314954A (pt) Derivados cìclicos de ácido nitrometilacético
CN103073483A (zh) 一种甲哌卡因及其光学对映体的制备方法
AR044341A1 (es) Proceso para la sintesis de intermediarios de inhibidores de betalactamasa

Legal Events

Date Code Title Description
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B11D Dismissal acc. art. 38, par 2 of ipl - failure to pay fee after grant in time