BRPI0415204A - construção de ácido nucleico, métodos de obtenção da expressão em células de mamìferos de um polipeptìdeo de interesse, e de imunização com ácido nucleico, partìculas revestidas, receptáculo de dosagem para um dispositivo de liberação mediada por partìculas, dispositivo de liberação mediada por partìculas, e, sequência de promotor quimérico isolada purificada - Google Patents

construção de ácido nucleico, métodos de obtenção da expressão em células de mamìferos de um polipeptìdeo de interesse, e de imunização com ácido nucleico, partìculas revestidas, receptáculo de dosagem para um dispositivo de liberação mediada por partìculas, dispositivo de liberação mediada por partìculas, e, sequência de promotor quimérico isolada purificada

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Publication number
BRPI0415204A
BRPI0415204A BRPI0415204-2A BRPI0415204A BRPI0415204A BR PI0415204 A BRPI0415204 A BR PI0415204A BR PI0415204 A BRPI0415204 A BR PI0415204A BR PI0415204 A BRPI0415204 A BR PI0415204A
Authority
BR
Brazil
Prior art keywords
nucleic acid
particle
delivery device
mediated delivery
promoter sequence
Prior art date
Application number
BRPI0415204-2A
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English (en)
Portuguese (pt)
Inventor
James Fuller
Original Assignee
Powderject Vaccines Inc
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34435038&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0415204(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Powderject Vaccines Inc filed Critical Powderject Vaccines Inc
Publication of BRPI0415204A publication Critical patent/BRPI0415204A/pt

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BRPI0415204-2A 2003-10-10 2004-10-11 construção de ácido nucleico, métodos de obtenção da expressão em células de mamìferos de um polipeptìdeo de interesse, e de imunização com ácido nucleico, partìculas revestidas, receptáculo de dosagem para um dispositivo de liberação mediada por partìculas, dispositivo de liberação mediada por partìculas, e, sequência de promotor quimérico isolada purificada BRPI0415204A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50993603P 2003-10-10 2003-10-10
PCT/GB2004/004279 WO2005035771A2 (en) 2003-10-10 2004-10-11 Nucleic acid constructs

Publications (1)

Publication Number Publication Date
BRPI0415204A true BRPI0415204A (pt) 2006-12-05

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BRPI0415204-2A BRPI0415204A (pt) 2003-10-10 2004-10-11 construção de ácido nucleico, métodos de obtenção da expressão em células de mamìferos de um polipeptìdeo de interesse, e de imunização com ácido nucleico, partìculas revestidas, receptáculo de dosagem para um dispositivo de liberação mediada por partìculas, dispositivo de liberação mediada por partìculas, e, sequência de promotor quimérico isolada purificada

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US (1) US8663657B2 (cg-RX-API-DMAC7.html)
EP (1) EP1685251B1 (cg-RX-API-DMAC7.html)
JP (1) JP4814099B2 (cg-RX-API-DMAC7.html)
KR (2) KR101234981B1 (cg-RX-API-DMAC7.html)
CN (1) CN1890375B (cg-RX-API-DMAC7.html)
AU (1) AU2004279991B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0415204A (cg-RX-API-DMAC7.html)
CA (1) CA2542288A1 (cg-RX-API-DMAC7.html)
DK (1) DK1685251T3 (cg-RX-API-DMAC7.html)
EA (1) EA010056B1 (cg-RX-API-DMAC7.html)
ES (1) ES2457022T3 (cg-RX-API-DMAC7.html)
IL (1) IL174848A (cg-RX-API-DMAC7.html)
MX (1) MXPA06003978A (cg-RX-API-DMAC7.html)
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NZ (1) NZ546554A (cg-RX-API-DMAC7.html)
PL (1) PL1685251T3 (cg-RX-API-DMAC7.html)
PT (1) PT1685251E (cg-RX-API-DMAC7.html)
SG (1) SG147430A1 (cg-RX-API-DMAC7.html)
SI (1) SI1685251T1 (cg-RX-API-DMAC7.html)
WO (1) WO2005035771A2 (cg-RX-API-DMAC7.html)
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Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0507997D0 (en) * 2005-02-01 2005-05-25 Powderject Vaccines Inc Nucleic acid constructs
CN101365494A (zh) * 2005-10-05 2009-02-11 贝希尔治疗学股份有限公司 治疗自身免疫性疾病的组合物和方法
NZ589268A (en) 2008-07-23 2012-06-29 Boehringer Ingelheim Pharma Novel regulatory elements (polyadenylation signals and vectors comprising the signal) to improve gene expression
EP3318248B1 (en) * 2009-12-01 2019-04-10 Translate Bio, Inc. Delivery of mrna for the augmentation of proteins and enzymes in human genetic diseases
WO2012019630A1 (en) 2010-08-13 2012-02-16 Curevac Gmbh Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded protein
CN101993878B (zh) * 2010-10-14 2012-04-18 南京农业大学 一种rRNA嵌合启动子及含有该嵌合启动子的表达载体
WO2012075040A2 (en) 2010-11-30 2012-06-07 Shire Human Genetic Therapies, Inc. mRNA FOR USE IN TREATMENT OF HUMAN GENETIC DISEASES
EP2717893B1 (en) 2011-06-08 2019-05-08 Translate Bio, Inc. Lipid nanoparticle compositions and methods for mrna delivery
WO2013120499A1 (en) 2012-02-15 2013-08-22 Curevac Gmbh Nucleic acid comprising or coding for a histone stem-loop and a poly (a) sequence or a polyadenylation signal for increasing the expression of an encoded pathogenic antigen
WO2013120497A1 (en) 2012-02-15 2013-08-22 Curevac Gmbh Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded therapeutic protein
WO2013120498A1 (en) 2012-02-15 2013-08-22 Curevac Gmbh Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded allergenic antigen or an autoimmune self-antigen
WO2013120500A1 (en) 2012-02-15 2013-08-22 Curevac Gmbh Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded tumour antigen
RU2750261C2 (ru) * 2012-03-27 2021-06-25 Кьюрвак Аг Искусственные молекулы нуклеиновых кислот для улучшенной экспрессии белков и пептидов
RU2660565C2 (ru) * 2012-03-27 2018-07-06 Кьюрвак Аг Молекулы искусственной нуклеиновой кислоты, содержащие 5'utr гена top
EP2831239B1 (en) * 2012-03-27 2017-11-22 CureVac AG Artificial nucleic acid molecules
WO2013185067A1 (en) 2012-06-08 2013-12-12 Shire Human Genetic Therapies, Inc. Nuclease resistant polynucleotides and uses thereof
EP2711426B1 (en) * 2012-09-24 2015-04-08 Lonza Biologics plc Expression vectors comprising chimeric cytomegalovirus promoter and enhancer sequences
WO2014102103A2 (en) 2012-12-31 2014-07-03 Boehringer Ingelheim International Gmbh Heterologous intron within a signal peptide
WO2014102100A1 (en) 2012-12-31 2014-07-03 Boehringer Ingelheim International Gmbh Heterologous intron within an immunoglobulin domain
WO2014102104A1 (en) * 2012-12-31 2014-07-03 Boehringer Ingelheim International Gmbh Artificial introns
WO2014102101A1 (en) * 2012-12-31 2014-07-03 Boehringer Ingelheim International Gmbh Novel intron sequences
TR201901310T4 (tr) 2013-03-14 2019-02-21 Translate Bio Inc Mesajcı RNA'nın saflaştırılması yöntemleri.
LT2968586T (lt) 2013-03-14 2018-11-26 Translate Bio, Inc. Cft mrnr kompozicijos bei su jomis susiję būdai ir panaudojimai
BR112016009014B1 (pt) 2013-10-22 2024-02-06 Translate Bio, Inc USO DE COMPOSIÇÃO COMPREENDENDO mRNA PARA DEFICIÊNCIA DE ARGININOSSUCINATO SINTETASE
EP3574923A1 (en) 2013-10-22 2019-12-04 Translate Bio, Inc. Mrna therapy for phenylketonuria
US11254951B2 (en) 2014-12-30 2022-02-22 Curevac Ag Artificial nucleic acid molecules
AU2014375402B2 (en) * 2013-12-30 2020-10-01 CureVac SE Artificial nucleic acid molecules
CN103901209B (zh) * 2014-02-18 2016-05-25 王明丽 一种重组蛋白ie1包被酶标反应板的制备方法及定量检测人血浆hcmv中和抗体试剂盒
KR102739894B1 (ko) 2014-04-25 2024-12-05 샤이어 휴먼 지네틱 테라피즈 인크. 메신저 rna 의 정제 방법
SG11201609879SA (en) * 2014-06-18 2016-12-29 Agency Science Tech & Res Novel promoters for high level expression
US10611800B2 (en) 2016-03-11 2020-04-07 Pfizer Inc. Human cytomegalovirus gB polypeptide
EP3585417B1 (en) 2017-02-27 2023-02-22 Translate Bio, Inc. Method of making a codon-optimized cftr mrna
CA3063531A1 (en) 2017-05-16 2018-11-22 Translate Bio, Inc. Treatment of cystic fibrosis by delivery of codon-optimized mrna encoding cftr
WO2019060649A1 (en) * 2017-09-22 2019-03-28 Voyager Therapeutics, Inc. COMPOSITIONS AND METHODS FOR TREATING HUNTINGTON'S DISEASE
CA3108544A1 (en) 2018-08-24 2020-02-27 Translate Bio, Inc. Methods for purification of messenger rna
CA3120647A1 (en) 2018-11-21 2020-05-28 Translate Bio, Inc. Treatment of cystic fibrosis by delivery of nebulized mrna encoding cftr
US11629172B2 (en) 2018-12-21 2023-04-18 Pfizer Inc. Human cytomegalovirus gB polypeptide
TWI810589B (zh) 2020-06-21 2023-08-01 美商輝瑞股份有限公司 人巨細胞病毒糖蛋白B(gB)多肽

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3431140A1 (de) * 1984-08-24 1986-03-06 Behringwerke Ag, 3550 Marburg Enhancer fuer eukaryotische expressionssysteme
US5100792A (en) * 1984-11-13 1992-03-31 Cornell Research Foundation, Inc. Method for transporting substances into living cells and tissues
US5168062A (en) * 1985-01-30 1992-12-01 University Of Iowa Research Foundation Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence
GB8717430D0 (en) 1987-07-23 1987-08-26 Celltech Ltd Recombinant dna product
TW404844B (en) * 1993-04-08 2000-09-11 Oxford Biosciences Ltd Needleless syringe
DE69529495T2 (de) * 1994-01-21 2003-06-12 Powderject Vaccines, Inc. Gasbetätigtes element zum austragen von genmaterial
DE69536091D1 (de) 1994-01-27 2010-09-09 Univ Massachusetts Medical Immunisierung durch Impfung von DNS Transkriptionseinheit
EP0836482B1 (en) * 1995-05-24 2002-11-13 Hawaii Biotechnology Group, Inc. Subunit vaccine against flavivirus infection
US6110707A (en) * 1996-01-19 2000-08-29 Board Of Regents, The University Of Texas System Recombinant expression of proteins from secretory cell lines
GB9715064D0 (en) * 1997-07-17 1997-09-24 Ppl Therapeutics Scotland Ltd Protein expression
US20020106635A1 (en) 1998-05-27 2002-08-08 Bruce Freimark Cytokine resistant cytomegalovirus promoter mutants and related products and methods
EP1123396B1 (en) 1998-10-19 2006-03-08 Powderject Vaccines, Inc. Minimal promoters and uses thereof
JP2003522159A (ja) 2000-02-08 2003-07-22 ザ ユニバーシティ オブ ヴァージニア パテント ファウンデーション 抗C3b(i)抗体を用いる感染の予防および治療のための方法
GB0027088D0 (en) * 2000-11-06 2000-12-20 Glaxo Group Ltd DNA expression vectors
US20030124523A1 (en) * 2000-06-22 2003-07-03 Asselbergs Fredericus Alphonsus Maria Organic compounds
ATE323166T1 (de) * 2000-10-13 2006-04-15 Chiron Corp Fragmente der intron a von citomegalovirus
KR20040045391A (ko) 2000-11-27 2004-06-01 파우더젝트 백신, 인코포레이티드 핵산 어쥬번트
US7320793B2 (en) * 2001-01-19 2008-01-22 Cytos Biotechnology Ag Molecular antigen array
EP1392357A2 (en) 2001-05-18 2004-03-03 Powderject Vaccines, Inc. Vaccine composition
GB0118367D0 (en) 2001-07-27 2001-09-19 Glaxosmithkline Biolog Sa Novel use
AU2004280630A1 (en) 2003-10-10 2005-04-21 Powderject Vaccines, Inc. Method
GB0507997D0 (en) * 2005-02-01 2005-05-25 Powderject Vaccines Inc Nucleic acid constructs

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SG147430A1 (en) 2008-11-28
WO2005035771A3 (en) 2005-08-25
NZ546554A (en) 2009-04-30
US20080160048A1 (en) 2008-07-03
ZA200603685B (en) 2007-09-26
IL174848A0 (en) 2006-08-20
WO2005035771A2 (en) 2005-04-21
SI1685251T1 (sl) 2014-05-30
AU2004279991B2 (en) 2010-11-25
EP1685251B1 (en) 2014-03-05
PL1685251T3 (pl) 2014-07-31
KR101225395B1 (ko) 2013-01-28
AU2004279991A1 (en) 2005-04-21
NO20062080L (no) 2006-05-09
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EA010056B1 (ru) 2008-06-30
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US8663657B2 (en) 2014-03-04
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IL174848A (en) 2011-06-30
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