EA010056B1 - Конструкции нуклеиновых кислот - Google Patents

Конструкции нуклеиновых кислот Download PDF

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Publication number
EA010056B1
EA010056B1 EA200600746A EA200600746A EA010056B1 EA 010056 B1 EA010056 B1 EA 010056B1 EA 200600746 A EA200600746 A EA 200600746A EA 200600746 A EA200600746 A EA 200600746A EA 010056 B1 EA010056 B1 EA 010056B1
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EA
Eurasian Patent Office
Prior art keywords
sequence
nucleic acid
promoter
intron
early
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EA200600746A
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English (en)
Russian (ru)
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EA200600746A1 (ru
Inventor
Джеймс Фуллер
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Паудерджект Вэксинс, Инк.
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Application filed by Паудерджект Вэксинс, Инк. filed Critical Паудерджект Вэксинс, Инк.
Publication of EA200600746A1 publication Critical patent/EA200600746A1/ru
Publication of EA010056B1 publication Critical patent/EA010056B1/ru

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    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
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    • C12N2830/60Vector systems having a special element relevant for transcription from viruses

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EA200600746A 2003-10-10 2004-10-11 Конструкции нуклеиновых кислот EA010056B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50993603P 2003-10-10 2003-10-10
PCT/GB2004/004279 WO2005035771A2 (en) 2003-10-10 2004-10-11 Nucleic acid constructs

Publications (2)

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EA200600746A1 EA200600746A1 (ru) 2006-10-27
EA010056B1 true EA010056B1 (ru) 2008-06-30

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EP (1) EP1685251B1 (cg-RX-API-DMAC7.html)
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KR (2) KR101234981B1 (cg-RX-API-DMAC7.html)
CN (1) CN1890375B (cg-RX-API-DMAC7.html)
AU (1) AU2004279991B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0415204A (cg-RX-API-DMAC7.html)
CA (1) CA2542288A1 (cg-RX-API-DMAC7.html)
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EA (1) EA010056B1 (cg-RX-API-DMAC7.html)
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IL (1) IL174848A (cg-RX-API-DMAC7.html)
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PL (1) PL1685251T3 (cg-RX-API-DMAC7.html)
PT (1) PT1685251E (cg-RX-API-DMAC7.html)
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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2651498C2 (ru) * 2012-03-27 2018-04-19 Кьюрвак Аг Молекулы искусственной нуклеиновой кислоты
RU2658490C2 (ru) * 2012-03-27 2018-06-21 Кьюрвак Аг Искусственные молекулы нуклеиновых кислот для улучшенной экспрессии белков или пептидов
RU2660565C2 (ru) * 2012-03-27 2018-07-06 Кьюрвак Аг Молекулы искусственной нуклеиновой кислоты, содержащие 5'utr гена top
RU2717986C2 (ru) * 2013-12-30 2020-03-27 Куревак Аг Искусственные молекулы нуклеиновой кислоты
US11254951B2 (en) 2014-12-30 2022-02-22 Curevac Ag Artificial nucleic acid molecules

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0507997D0 (en) * 2005-02-01 2005-05-25 Powderject Vaccines Inc Nucleic acid constructs
CN101365494A (zh) * 2005-10-05 2009-02-11 贝希尔治疗学股份有限公司 治疗自身免疫性疾病的组合物和方法
NZ589268A (en) 2008-07-23 2012-06-29 Boehringer Ingelheim Pharma Novel regulatory elements (polyadenylation signals and vectors comprising the signal) to improve gene expression
EP3318248B1 (en) * 2009-12-01 2019-04-10 Translate Bio, Inc. Delivery of mrna for the augmentation of proteins and enzymes in human genetic diseases
WO2012019630A1 (en) 2010-08-13 2012-02-16 Curevac Gmbh Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded protein
CN101993878B (zh) * 2010-10-14 2012-04-18 南京农业大学 一种rRNA嵌合启动子及含有该嵌合启动子的表达载体
WO2012075040A2 (en) 2010-11-30 2012-06-07 Shire Human Genetic Therapies, Inc. mRNA FOR USE IN TREATMENT OF HUMAN GENETIC DISEASES
EP2717893B1 (en) 2011-06-08 2019-05-08 Translate Bio, Inc. Lipid nanoparticle compositions and methods for mrna delivery
WO2013120499A1 (en) 2012-02-15 2013-08-22 Curevac Gmbh Nucleic acid comprising or coding for a histone stem-loop and a poly (a) sequence or a polyadenylation signal for increasing the expression of an encoded pathogenic antigen
WO2013120497A1 (en) 2012-02-15 2013-08-22 Curevac Gmbh Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded therapeutic protein
WO2013120498A1 (en) 2012-02-15 2013-08-22 Curevac Gmbh Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded allergenic antigen or an autoimmune self-antigen
WO2013120500A1 (en) 2012-02-15 2013-08-22 Curevac Gmbh Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded tumour antigen
WO2013185067A1 (en) 2012-06-08 2013-12-12 Shire Human Genetic Therapies, Inc. Nuclease resistant polynucleotides and uses thereof
EP2711426B1 (en) * 2012-09-24 2015-04-08 Lonza Biologics plc Expression vectors comprising chimeric cytomegalovirus promoter and enhancer sequences
WO2014102103A2 (en) 2012-12-31 2014-07-03 Boehringer Ingelheim International Gmbh Heterologous intron within a signal peptide
WO2014102100A1 (en) 2012-12-31 2014-07-03 Boehringer Ingelheim International Gmbh Heterologous intron within an immunoglobulin domain
WO2014102104A1 (en) * 2012-12-31 2014-07-03 Boehringer Ingelheim International Gmbh Artificial introns
WO2014102101A1 (en) * 2012-12-31 2014-07-03 Boehringer Ingelheim International Gmbh Novel intron sequences
TR201901310T4 (tr) 2013-03-14 2019-02-21 Translate Bio Inc Mesajcı RNA'nın saflaştırılması yöntemleri.
LT2968586T (lt) 2013-03-14 2018-11-26 Translate Bio, Inc. Cft mrnr kompozicijos bei su jomis susiję būdai ir panaudojimai
BR112016009014B1 (pt) 2013-10-22 2024-02-06 Translate Bio, Inc USO DE COMPOSIÇÃO COMPREENDENDO mRNA PARA DEFICIÊNCIA DE ARGININOSSUCINATO SINTETASE
EP3574923A1 (en) 2013-10-22 2019-12-04 Translate Bio, Inc. Mrna therapy for phenylketonuria
CN103901209B (zh) * 2014-02-18 2016-05-25 王明丽 一种重组蛋白ie1包被酶标反应板的制备方法及定量检测人血浆hcmv中和抗体试剂盒
KR102739894B1 (ko) 2014-04-25 2024-12-05 샤이어 휴먼 지네틱 테라피즈 인크. 메신저 rna 의 정제 방법
SG11201609879SA (en) * 2014-06-18 2016-12-29 Agency Science Tech & Res Novel promoters for high level expression
US10611800B2 (en) 2016-03-11 2020-04-07 Pfizer Inc. Human cytomegalovirus gB polypeptide
EP3585417B1 (en) 2017-02-27 2023-02-22 Translate Bio, Inc. Method of making a codon-optimized cftr mrna
CA3063531A1 (en) 2017-05-16 2018-11-22 Translate Bio, Inc. Treatment of cystic fibrosis by delivery of codon-optimized mrna encoding cftr
WO2019060649A1 (en) * 2017-09-22 2019-03-28 Voyager Therapeutics, Inc. COMPOSITIONS AND METHODS FOR TREATING HUNTINGTON'S DISEASE
CA3108544A1 (en) 2018-08-24 2020-02-27 Translate Bio, Inc. Methods for purification of messenger rna
CA3120647A1 (en) 2018-11-21 2020-05-28 Translate Bio, Inc. Treatment of cystic fibrosis by delivery of nebulized mrna encoding cftr
US11629172B2 (en) 2018-12-21 2023-04-18 Pfizer Inc. Human cytomegalovirus gB polypeptide
TWI810589B (zh) 2020-06-21 2023-08-01 美商輝瑞股份有限公司 人巨細胞病毒糖蛋白B(gB)多肽

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999003981A1 (en) * 1997-07-17 1999-01-28 Ppl Therapeutics (Scotland) Limited Nucleic acid expression constructs incorporating a heterologous intron whose natural position is within the 5'untranslated region of its gene
CA2425852A1 (en) * 2000-10-13 2002-04-18 Chiron Corporation Cytomegalovirus intron a fragments
WO2002036792A2 (en) * 2000-11-06 2002-05-10 Glaxo Group Limited Dna expression vectors
WO2003011334A1 (en) * 2001-07-27 2003-02-13 Glaxosmithkline Biologicals S.A. Vaccine comprising gp120 and nef and/or tat for the immunisation against hiv

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3431140A1 (de) * 1984-08-24 1986-03-06 Behringwerke Ag, 3550 Marburg Enhancer fuer eukaryotische expressionssysteme
US5100792A (en) * 1984-11-13 1992-03-31 Cornell Research Foundation, Inc. Method for transporting substances into living cells and tissues
US5168062A (en) * 1985-01-30 1992-12-01 University Of Iowa Research Foundation Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence
GB8717430D0 (en) 1987-07-23 1987-08-26 Celltech Ltd Recombinant dna product
TW404844B (en) * 1993-04-08 2000-09-11 Oxford Biosciences Ltd Needleless syringe
DE69529495T2 (de) * 1994-01-21 2003-06-12 Powderject Vaccines, Inc. Gasbetätigtes element zum austragen von genmaterial
DE69536091D1 (de) 1994-01-27 2010-09-09 Univ Massachusetts Medical Immunisierung durch Impfung von DNS Transkriptionseinheit
EP0836482B1 (en) * 1995-05-24 2002-11-13 Hawaii Biotechnology Group, Inc. Subunit vaccine against flavivirus infection
US6110707A (en) * 1996-01-19 2000-08-29 Board Of Regents, The University Of Texas System Recombinant expression of proteins from secretory cell lines
US20020106635A1 (en) 1998-05-27 2002-08-08 Bruce Freimark Cytokine resistant cytomegalovirus promoter mutants and related products and methods
EP1123396B1 (en) 1998-10-19 2006-03-08 Powderject Vaccines, Inc. Minimal promoters and uses thereof
JP2003522159A (ja) 2000-02-08 2003-07-22 ザ ユニバーシティ オブ ヴァージニア パテント ファウンデーション 抗C3b(i)抗体を用いる感染の予防および治療のための方法
US20030124523A1 (en) * 2000-06-22 2003-07-03 Asselbergs Fredericus Alphonsus Maria Organic compounds
KR20040045391A (ko) 2000-11-27 2004-06-01 파우더젝트 백신, 인코포레이티드 핵산 어쥬번트
US7320793B2 (en) * 2001-01-19 2008-01-22 Cytos Biotechnology Ag Molecular antigen array
EP1392357A2 (en) 2001-05-18 2004-03-03 Powderject Vaccines, Inc. Vaccine composition
AU2004280630A1 (en) 2003-10-10 2005-04-21 Powderject Vaccines, Inc. Method
GB0507997D0 (en) * 2005-02-01 2005-05-25 Powderject Vaccines Inc Nucleic acid constructs

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999003981A1 (en) * 1997-07-17 1999-01-28 Ppl Therapeutics (Scotland) Limited Nucleic acid expression constructs incorporating a heterologous intron whose natural position is within the 5'untranslated region of its gene
CA2425852A1 (en) * 2000-10-13 2002-04-18 Chiron Corporation Cytomegalovirus intron a fragments
WO2002036792A2 (en) * 2000-11-06 2002-05-10 Glaxo Group Limited Dna expression vectors
WO2003011334A1 (en) * 2001-07-27 2003-02-13 Glaxosmithkline Biologicals S.A. Vaccine comprising gp120 and nef and/or tat for the immunisation against hiv

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
LOSER P. et al. Evaluation of promoters for use in hepatic gene therapy, Biol. Chem. HOPPE Seyler. 1996 Mar; 377 (3): 187-93, referat [on-layn] [naydeno 20.09. 2006]. Naydeno iz bazy dannykh PubMed, PMID: 8722320 *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2651498C2 (ru) * 2012-03-27 2018-04-19 Кьюрвак Аг Молекулы искусственной нуклеиновой кислоты
RU2658490C2 (ru) * 2012-03-27 2018-06-21 Кьюрвак Аг Искусственные молекулы нуклеиновых кислот для улучшенной экспрессии белков или пептидов
RU2660565C2 (ru) * 2012-03-27 2018-07-06 Кьюрвак Аг Молекулы искусственной нуклеиновой кислоты, содержащие 5'utr гена top
US10080809B2 (en) 2012-03-27 2018-09-25 Curevac Ag Artificial nucleic acid molecules comprising a 5′TOP UTR
RU2750261C2 (ru) * 2012-03-27 2021-06-25 Кьюрвак Аг Искусственные молекулы нуклеиновых кислот для улучшенной экспрессии белков и пептидов
RU2717986C2 (ru) * 2013-12-30 2020-03-27 Куревак Аг Искусственные молекулы нуклеиновой кислоты
US11254951B2 (en) 2014-12-30 2022-02-22 Curevac Ag Artificial nucleic acid molecules

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