CA2542288A1 - Chimeric promoter comprising hcmv major immediate early gene exons and a heterologous intron - Google Patents
Chimeric promoter comprising hcmv major immediate early gene exons and a heterologous intron Download PDFInfo
- Publication number
- CA2542288A1 CA2542288A1 CA002542288A CA2542288A CA2542288A1 CA 2542288 A1 CA2542288 A1 CA 2542288A1 CA 002542288 A CA002542288 A CA 002542288A CA 2542288 A CA2542288 A CA 2542288A CA 2542288 A1 CA2542288 A1 CA 2542288A1
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- Prior art keywords
- sequence
- nucleic acid
- acid construct
- antigen
- intron
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- C12N2710/16011—Herpesviridae
- C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
- C12N2710/16722—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/15—Vector systems having a special element relevant for transcription chimeric enhancer/promoter combination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/42—Vector systems having a special element relevant for transcription being an intron or intervening sequence for splicing and/or stability of RNA
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/60—Vector systems having a special element relevant for transcription from viruses
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50993603P | 2003-10-10 | 2003-10-10 | |
| US60/509,936 | 2003-10-10 | ||
| PCT/GB2004/004279 WO2005035771A2 (en) | 2003-10-10 | 2004-10-11 | Nucleic acid constructs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2542288A1 true CA2542288A1 (en) | 2005-04-21 |
Family
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| CA002542288A Abandoned CA2542288A1 (en) | 2003-10-10 | 2004-10-11 | Chimeric promoter comprising hcmv major immediate early gene exons and a heterologous intron |
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| GB0507997D0 (en) * | 2005-02-01 | 2005-05-25 | Powderject Vaccines Inc | Nucleic acid constructs |
| JP2009511014A (ja) * | 2005-10-05 | 2009-03-19 | ベイヒル セラピューティクス インコーポレーティッド | 自己免疫疾患の処置のための組成物および方法 |
| AR072531A1 (es) | 2008-07-23 | 2010-09-01 | Boehringer Ingelheim Pharma | SENAL DE POLIADENILACIoN |
| US20110244026A1 (en) | 2009-12-01 | 2011-10-06 | Braydon Charles Guild | Delivery of mrna for the augmentation of proteins and enzymes in human genetic diseases |
| WO2012019630A1 (en) | 2010-08-13 | 2012-02-16 | Curevac Gmbh | Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded protein |
| CN101993878B (zh) * | 2010-10-14 | 2012-04-18 | 南京农业大学 | 一种rRNA嵌合启动子及含有该嵌合启动子的表达载体 |
| WO2012075040A2 (en) | 2010-11-30 | 2012-06-07 | Shire Human Genetic Therapies, Inc. | mRNA FOR USE IN TREATMENT OF HUMAN GENETIC DISEASES |
| LT2717893T (lt) | 2011-06-08 | 2019-08-12 | Translate Bio, Inc. | Lipidų nanodalelių kompozicijos ir mrnr pristatymo būdai |
| WO2013120499A1 (en) | 2012-02-15 | 2013-08-22 | Curevac Gmbh | Nucleic acid comprising or coding for a histone stem-loop and a poly (a) sequence or a polyadenylation signal for increasing the expression of an encoded pathogenic antigen |
| WO2013120497A1 (en) | 2012-02-15 | 2013-08-22 | Curevac Gmbh | Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded therapeutic protein |
| WO2013120498A1 (en) | 2012-02-15 | 2013-08-22 | Curevac Gmbh | Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded allergenic antigen or an autoimmune self-antigen |
| WO2013120500A1 (en) | 2012-02-15 | 2013-08-22 | Curevac Gmbh | Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded tumour antigen |
| MX2019002345A (es) * | 2012-03-27 | 2022-08-24 | Curevac Ag | Moleculas artificiales de acido nucleico para la expresion mejorada de proteina o peptido. |
| SG10201607966UA (en) * | 2012-03-27 | 2016-11-29 | Curevac Ag | Artificial nucleic acid molecules comprising a 5'top utr |
| CA2866955A1 (en) * | 2012-03-27 | 2013-10-03 | Curevac Gmbh | Artificial nucleic acid molecules |
| US20150267192A1 (en) | 2012-06-08 | 2015-09-24 | Shire Human Genetic Therapies, Inc. | Nuclease resistant polynucleotides and uses thereof |
| DK2711426T3 (en) | 2012-09-24 | 2015-07-13 | Lonza Biologics Plc | Expression vectors comprising chimeric cytomegalovirus promoter and enhancer sequences |
| WO2014102101A1 (en) * | 2012-12-31 | 2014-07-03 | Boehringer Ingelheim International Gmbh | Novel intron sequences |
| WO2014102100A1 (en) | 2012-12-31 | 2014-07-03 | Boehringer Ingelheim International Gmbh | Heterologous intron within an immunoglobulin domain |
| EP2938728B1 (en) * | 2012-12-31 | 2020-12-09 | Boehringer Ingelheim International GmbH | Artificial introns |
| WO2014102103A2 (en) | 2012-12-31 | 2014-07-03 | Boehringer Ingelheim International Gmbh | Heterologous intron within a signal peptide |
| AU2014236305B2 (en) | 2013-03-14 | 2019-01-17 | Ethris Gmbh | CFTR mRNA compositions and related methods and uses |
| MX2015012865A (es) | 2013-03-14 | 2016-07-21 | Shire Human Genetic Therapies | Metodos para purificacion de arn mensajero. |
| EP3574923A1 (en) | 2013-10-22 | 2019-12-04 | Translate Bio, Inc. | Mrna therapy for phenylketonuria |
| ES2954366T3 (es) | 2013-10-22 | 2023-11-21 | Translate Bio Inc | Terapia de ácido ribonucleico mensajero para la deficiencia de argininosuccinato sintetasa |
| US11254951B2 (en) | 2014-12-30 | 2022-02-22 | Curevac Ag | Artificial nucleic acid molecules |
| JP6704850B2 (ja) * | 2013-12-30 | 2020-06-03 | キュアバック アーゲー | 人工核酸分子 |
| CN103901209B (zh) * | 2014-02-18 | 2016-05-25 | 王明丽 | 一种重组蛋白ie1包被酶标反应板的制备方法及定量检测人血浆hcmv中和抗体试剂盒 |
| MX373952B (es) | 2014-04-25 | 2020-07-13 | Shire Human Genetic Therapies | Métodos de purificación de arn mensajero. |
| CN106459999B (zh) * | 2014-06-18 | 2024-10-11 | 新加坡科技研究局 | 用于高水平表达的新型启动子 |
| US10611800B2 (en) | 2016-03-11 | 2020-04-07 | Pfizer Inc. | Human cytomegalovirus gB polypeptide |
| US11253605B2 (en) | 2017-02-27 | 2022-02-22 | Translate Bio, Inc. | Codon-optimized CFTR MRNA |
| MA49138A (fr) | 2017-05-16 | 2020-03-25 | Translate Bio Inc | Traitement de la fibrose kystique par administration d'arnm à codons optimisés codant pour la cftr |
| US20200377887A1 (en) * | 2017-09-22 | 2020-12-03 | Voyager Therapeutics, Inc. | Compositions and methods of treating huntington's disease |
| CN112930396B (zh) | 2018-08-24 | 2024-05-24 | 川斯勒佰尔公司 | 用于纯化信使rna的方法 |
| AU2019384557B2 (en) | 2018-11-21 | 2025-07-17 | Translate Bio, Inc. | Treatment of cystic fibrosis by delivery of nebulized mRNA encoding CFTR |
| US11629172B2 (en) | 2018-12-21 | 2023-04-18 | Pfizer Inc. | Human cytomegalovirus gB polypeptide |
| TWI810589B (zh) | 2020-06-21 | 2023-08-01 | 美商輝瑞股份有限公司 | 人巨細胞病毒糖蛋白Ｂ（ｇＢ）多肽 |
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| DE3431140A1 (de) * | 1984-08-24 | 1986-03-06 | Behringwerke Ag, 3550 Marburg | Enhancer fuer eukaryotische expressionssysteme |
| US5100792A (en) * | 1984-11-13 | 1992-03-31 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues |
| US5168062A (en) * | 1985-01-30 | 1992-12-01 | University Of Iowa Research Foundation | Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence |
| GB8717430D0 (en) | 1987-07-23 | 1987-08-26 | Celltech Ltd | Recombinant dna product |
| TW360548B (en) * | 1993-04-08 | 1999-06-11 | Powderject Res Ltd | Products for therapeutic use |
| CA2158733C (en) * | 1994-01-21 | 2007-01-16 | Dennis E. Mccabe | Gas driven gene delivery instrument |
| DE69536091D1 (de) | 1994-01-27 | 2010-09-09 | Univ Massachusetts Medical | Immunisierung durch Impfung von DNS Transkriptionseinheit |
| ES2184869T3 (es) * | 1995-05-24 | 2003-04-16 | Hawaii Biotech Group | Vacuna sub-unitaria contra la infeccion por flavivirus. |
| US6110707A (en) * | 1996-01-19 | 2000-08-29 | Board Of Regents, The University Of Texas System | Recombinant expression of proteins from secretory cell lines |
| GB9715064D0 (en) * | 1997-07-17 | 1997-09-24 | Ppl Therapeutics Scotland Ltd | Protein expression |
| US20020106635A1 (en) | 1998-05-27 | 2002-08-08 | Bruce Freimark | Cytokine resistant cytomegalovirus promoter mutants and related products and methods |
| CA2347369A1 (en) | 1998-10-19 | 2000-04-27 | Powderject Vaccines, Inc. | Minimal promoters and uses thereof |
| JP2003522159A (ja) | 2000-02-08 | 2003-07-22 | ザ ユニバーシティ オブ ヴァージニア パテント ファウンデーション | 抗Ｃ３ｂ（ｉ）抗体を用いる感染の予防および治療のための方法 |
| GB0027088D0 (en) * | 2000-11-06 | 2000-12-20 | Glaxo Group Ltd | DNA expression vectors |
| US20030124523A1 (en) * | 2000-06-22 | 2003-07-03 | Asselbergs Fredericus Alphonsus Maria | Organic compounds |
| DE60118798T2 (de) * | 2000-10-13 | 2007-04-12 | Chiron Corp., Emeryville | Fragmente des introns a des cytomegalovirus |
| WO2003004055A2 (en) | 2000-11-27 | 2003-01-16 | Powderject Vaccines, Inc. | Nucleic acid adjuvants |
| US7264810B2 (en) * | 2001-01-19 | 2007-09-04 | Cytos Biotechnology Ag | Molecular antigen array |
| US20030124718A1 (en) | 2001-05-18 | 2003-07-03 | Deborah Fuller | Vaccine composition |
| GB0118367D0 (en) | 2001-07-27 | 2001-09-19 | Glaxosmithkline Biolog Sa | Novel use |
| NZ547042A (en) | 2003-10-10 | 2010-05-28 | Powderject Vaccines Inc | Method for eliciting a T-cell response |
| GB0507997D0 (en) * | 2005-02-01 | 2005-05-25 | Powderject Vaccines Inc | Nucleic acid constructs |
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- 2004-10-11 CA CA002542288A patent/CA2542288A1/en not_active Abandoned
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- 2004-10-11 NZ NZ546554A patent/NZ546554A/en not_active IP Right Cessation
- 2004-10-11 SI SI200432144T patent/SI1685251T1/sl unknown
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Also Published As
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| NO20062080L (no) | 2006-05-09 |
| JP2007509607A (ja) | 2007-04-19 |
| ZA200603685B (en) | 2007-09-26 |
| KR101234981B1 (ko) | 2013-02-21 |
| IL174848A (en) | 2011-06-30 |
| EA010056B1 (ru) | 2008-06-30 |
| KR20060125742A (ko) | 2006-12-06 |
| WO2005035771A3 (en) | 2005-08-25 |
| EP1685251A2 (en) | 2006-08-02 |
| PL1685251T3 (pl) | 2014-07-31 |
| ES2457022T3 (es) | 2014-04-24 |
| EP1685251B1 (en) | 2014-03-05 |
| NZ546554A (en) | 2009-04-30 |
| MXPA06003978A (es) | 2006-06-27 |
| JP4814099B2 (ja) | 2011-11-09 |
| DK1685251T3 (en) | 2014-03-24 |
| KR20110120364A (ko) | 2011-11-03 |
| SG147430A1 (en) | 2008-11-28 |
| BRPI0415204A (pt) | 2006-12-05 |
| US20080160048A1 (en) | 2008-07-03 |
| CN1890375A (zh) | 2007-01-03 |
| US8663657B2 (en) | 2014-03-04 |
| IL174848A0 (en) | 2006-08-20 |
| CN1890375B (zh) | 2011-12-07 |
| KR101225395B1 (ko) | 2013-01-28 |
| SI1685251T1 (sl) | 2014-05-30 |
| WO2005035771A2 (en) | 2005-04-21 |
| AU2004279991B2 (en) | 2010-11-25 |
| EA200600746A1 (ru) | 2006-10-27 |
| AU2004279991A1 (en) | 2005-04-21 |
| PT1685251E (pt) | 2014-04-15 |
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Legal Events
| Date | Code | Title | Description |
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| EEER | Examination request | ||
| FZDE | Discontinued |
Effective date: 20170315 |