BRPI0414480A - derivados de 2,4-di(hetero)-arilamino-pirimidina como inibidores de zap-70 e/ou syk - Google Patents

derivados de 2,4-di(hetero)-arilamino-pirimidina como inibidores de zap-70 e/ou syk

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Publication number
BRPI0414480A
BRPI0414480A BRPI0414480-5A BRPI0414480A BRPI0414480A BR PI0414480 A BRPI0414480 A BR PI0414480A BR PI0414480 A BRPI0414480 A BR PI0414480A BR PI0414480 A BRPI0414480 A BR PI0414480A
Authority
BR
Brazil
Prior art keywords
zap
hetero
arylamino
pyrimidine derivatives
syk inhibitors
Prior art date
Application number
BRPI0414480-5A
Other languages
English (en)
Inventor
Rolf Baenteli
Marie Claude Bernhard
Peter Buehlmayer
Nigel Graham Cooke
Rudolf Duthaler
Klaus Hinterding
Gebhard Thoma
Maurice Van Eis
Anette Von Matt
Louis Walliser
Gerhard Zenke
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BRPI0414480A publication Critical patent/BRPI0414480A/pt

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    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
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Abstract

"DERIVADOS DE 2,4-DI(HETERO)-ARILAMINOPIRIMIDINA COMO INIBIDORES DE ZAP-70 E/OU SYK". A presente invenção refere-se a derivados de pirimidina da fórmula (I) em que R¬ O¬, R¬ 1¬, R¬ 3¬ a R¬ 9¬, e Z possuem uma significação como indicado na reivindicação 1, os quais possuem propriedades farmacêuticas interessantes.
BRPI0414480-5A 2003-09-16 2004-09-15 derivados de 2,4-di(hetero)-arilamino-pirimidina como inibidores de zap-70 e/ou syk BRPI0414480A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0321710.6A GB0321710D0 (en) 2003-09-16 2003-09-16 Organic compounds
GBGB0414440.8A GB0414440D0 (en) 2003-09-16 2004-06-28 Organic compounds
PCT/EP2004/010348 WO2005026158A1 (en) 2003-09-16 2004-09-15 2,4 di (hetero) -arylamino-pyrimidine derivatives as zap-70 and/or syk inhibitors

Publications (1)

Publication Number Publication Date
BRPI0414480A true BRPI0414480A (pt) 2006-11-14

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BRPI0414480-5A BRPI0414480A (pt) 2003-09-16 2004-09-15 derivados de 2,4-di(hetero)-arilamino-pirimidina como inibidores de zap-70 e/ou syk

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US (2) US7671063B2 (pt)
EP (2) EP2266977B1 (pt)
JP (1) JP4504375B2 (pt)
KR (1) KR100813384B1 (pt)
CN (2) CN1882578B (pt)
AR (1) AR045747A1 (pt)
AT (1) ATE498623T1 (pt)
AU (1) AU2004272283B9 (pt)
BR (1) BRPI0414480A (pt)
CA (1) CA2538909A1 (pt)
DE (1) DE602004031436D1 (pt)
EC (1) ECSP066424A (pt)
ES (2) ES2361412T3 (pt)
GB (2) GB0321710D0 (pt)
IL (1) IL174217A0 (pt)
IS (1) IS8402A (pt)
MA (1) MA28076A1 (pt)
MX (1) MXPA06002966A (pt)
NO (1) NO20061656L (pt)
PE (1) PE20050429A1 (pt)
PL (1) PL1664035T3 (pt)
PT (1) PT1664035E (pt)
RU (1) RU2403251C2 (pt)
SG (1) SG132676A1 (pt)
TN (1) TNSN06083A1 (pt)
TW (1) TW200521118A (pt)
WO (1) WO2005026158A1 (pt)
ZA (1) ZA200601963B (pt)

Families Citing this family (132)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI329105B (en) 2002-02-01 2010-08-21 Rigel Pharmaceuticals Inc 2,4-pyrimidinediamine compounds and their uses
GB0206215D0 (en) * 2002-03-15 2002-05-01 Novartis Ag Organic compounds
ES2445208T3 (es) 2002-07-29 2014-02-28 Rigel Pharmaceuticals, Inc. Compuestos de 2,4-pirimidindiamina para uso en métodos para tratar o prevenir enfermedades autoinmunitarias
GB0305929D0 (en) * 2003-03-14 2003-04-23 Novartis Ag Organic compounds
KR101201603B1 (ko) 2003-07-30 2012-11-14 리겔 파마슈티칼스, 인크. 자가면역 질환의 치료 또는 예방에 사용하기 위한2,4-피리미딘디아민 화합물
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