BRPI0408516A - composições autoemulsificantes, métodos de uso e preparação - Google Patents

composições autoemulsificantes, métodos de uso e preparação

Info

Publication number
BRPI0408516A
BRPI0408516A BRPI0408516-7A BRPI0408516A BRPI0408516A BR PI0408516 A BRPI0408516 A BR PI0408516A BR PI0408516 A BRPI0408516 A BR PI0408516A BR PI0408516 A BRPI0408516 A BR PI0408516A
Authority
BR
Brazil
Prior art keywords
self
emulsifying compositions
preparation
compositions
prepared
Prior art date
Application number
BRPI0408516-7A
Other languages
English (en)
Inventor
Zhi-Jian Yu
Stanley W Huth
Lauren L Crawford
James N Cook
Original Assignee
Advanced Medical Optics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Advanced Medical Optics Inc filed Critical Advanced Medical Optics Inc
Publication of BRPI0408516A publication Critical patent/BRPI0408516A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Eyeglasses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
  • Colloid Chemistry (AREA)

Abstract

"COMPOSIçõES AUTOEMULSIFICANTES, MéTODOS DE USO E PREPARAçãO". Preparação de composições autoemulsificantes que são preparadas sem homogeneização mecânica é descrita. Essas composições autoemulsificantes são preparadas usando um ou dois tensoativos. Isso prove a vantagem de uma razão de peso baixa de componente emulsificante para componente oleoso e menos preocupações com toxidez química, resultando em vantagens de conforto e segurança sobre as emulsões empregando mais de dois emulsificantes. Conseqüentemente, as composições autoemulsificantes descritas são idealmente adequadas para aplicações oftálmicas incluindo administração de agentes terapêuticos ao olho. Composições autoemulsificantes preparadas através do método descrito são descritas.
BRPI0408516-7A 2003-03-18 2004-03-17 composições autoemulsificantes, métodos de uso e preparação BRPI0408516A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/392,375 US20040185068A1 (en) 2003-03-18 2003-03-18 Self-emulsifying compositions, methods of use and preparation
PCT/US2004/008076 WO2004082625A2 (en) 2003-03-18 2004-03-17 Self-emulsifying compositions, methods of use and preparation

Publications (1)

Publication Number Publication Date
BRPI0408516A true BRPI0408516A (pt) 2006-03-07

Family

ID=32987875

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0408516-7A BRPI0408516A (pt) 2003-03-18 2004-03-17 composições autoemulsificantes, métodos de uso e preparação

Country Status (8)

Country Link
US (2) US20040185068A1 (pt)
EP (1) EP1603607A2 (pt)
JP (1) JP2006526579A (pt)
CN (1) CN1791383A (pt)
AU (1) AU2004222295B2 (pt)
BR (1) BRPI0408516A (pt)
CA (1) CA2519300A1 (pt)
WO (1) WO2004082625A2 (pt)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8858961B2 (en) 2000-07-14 2014-10-14 Allergan, Inc. Compositions containing alpha-2-adrenergic agonist components
AU2011250793B2 (en) * 2000-07-14 2012-11-29 Allergan, Inc. Compositions containing alpha-2-adrenergic agonist components
US20050026924A1 (en) * 2000-07-14 2005-02-03 Allergan, Inc. Compositions containing alpha-2-adrenergic agonist components
US20060251685A1 (en) * 2003-03-18 2006-11-09 Zhi-Jian Yu Stable ophthalmic oil-in-water emulsions with Omega-3 fatty acids for alleviating dry eye
US20040185068A1 (en) * 2003-03-18 2004-09-23 Zhi-Jian Yu Self-emulsifying compositions, methods of use and preparation
US20050196370A1 (en) * 2003-03-18 2005-09-08 Zhi-Jian Yu Stable ophthalmic oil-in-water emulsions with sodium hyaluronate for alleviating dry eye
JP5318850B2 (ja) * 2003-12-26 2013-10-16 ロート製薬株式会社 粘度低下が防止された組成物
JP5382973B2 (ja) * 2003-12-26 2014-01-08 ロート製薬株式会社 粘度低下が防止された組成物
JP5382972B2 (ja) * 2003-12-26 2014-01-08 ロート製薬株式会社 粘度低下が防止された組成物
DE602005020912D1 (de) * 2004-03-18 2010-06-10 Galderma Sa Ivermectin enthaltende creme
WO2005110439A2 (en) * 2004-05-07 2005-11-24 S.K. Pharmaceuticals, Inc. Stabilized hyaluronan preparations and related methods
US8288362B2 (en) 2004-05-07 2012-10-16 S.K. Pharmaceuticals, Inc. Stabilized glycosaminoglycan preparations and related methods
MX2007000208A (es) * 2004-07-01 2007-08-07 Schepens Eye Res Inst Composiciones y metodos para tratar trastornos y condiciones del ojo.
US20070265341A1 (en) * 2004-07-01 2007-11-15 The Schepens Eye Research Institute Inc. Compositions and methods for treating eye disorders and conditions
JP4999304B2 (ja) * 2004-09-27 2012-08-15 ロート製薬株式会社 ヒアルロン酸又はその塩を含有する粘膜適用組成物
US9161905B2 (en) * 2005-01-12 2015-10-20 Ocular Research Of Boston, Inc. Dry eye treatment
US7288520B2 (en) * 2005-07-13 2007-10-30 Allergan, Inc. Cyclosporin compositions
US8288348B2 (en) 2005-07-13 2012-10-16 Allergan, Inc. Cyclosporin compositions
US7202209B2 (en) 2005-07-13 2007-04-10 Allergan, Inc. Cyclosporin compositions
US7297679B2 (en) 2005-07-13 2007-11-20 Allergan, Inc. Cyclosporin compositions
US20070015691A1 (en) * 2005-07-13 2007-01-18 Allergan, Inc. Cyclosporin compositions
US7501393B2 (en) * 2005-07-27 2009-03-10 Allergan, Inc. Pharmaceutical compositions comprising cyclosporins
US7745400B2 (en) * 2005-10-14 2010-06-29 Gregg Feinerman Prevention and treatment of ocular side effects with a cyclosporin
US9839667B2 (en) 2005-10-14 2017-12-12 Allergan, Inc. Prevention and treatment of ocular side effects with a cyclosporin
US20070087962A1 (en) * 2005-10-17 2007-04-19 Allergan, Inc. Pharmaceutical compositions comprising cyclosporins
US20070138439A1 (en) * 2005-12-21 2007-06-21 3M Innovative Properties Company Denaturant for ethanol
US20070148127A1 (en) * 2005-12-22 2007-06-28 Heiler David J Antimicrobial ophthalmic treatment system and method
US7767217B2 (en) * 2006-03-14 2010-08-03 Foresight Biotherapeutics Ophthalmic compositions comprising povidone-iodine
US20070264226A1 (en) * 2006-05-10 2007-11-15 Karagoezian Hampar L Synergistically enhanced disinfecting solutions
WO2008120249A1 (en) * 2007-03-30 2008-10-09 Sifi S.P.A. Pharmaceutical formulations based on apolar and polar lipids for ophthalmic use
EP1985298A1 (en) * 2007-04-24 2008-10-29 Azad Pharma AG Ophtalmic oil-in-water emulsions containing prostaglandins
EP2164466A1 (en) * 2007-06-01 2010-03-24 Novo Nordisk A/S Spontaneously dispersible preconcentrates including a peptide drug in a solid or semisolid carrier
US20090036404A1 (en) * 2007-08-02 2009-02-05 Macleod Steven K Ophthalmic compositions comprising a carboxyl-modified fructan or a salt thereof
AU2008344909B2 (en) * 2007-10-16 2013-06-06 Sun Pharma Advanced Research Company Limited Ophthalmic composition comprising a prostaglandin
CN103462892A (zh) * 2007-11-28 2013-12-25 联邦科学和工业研究组织 纳米乳剂
US20130059796A1 (en) * 2007-12-13 2013-03-07 Allergan, Inc Cyclosporin compositions
US9314524B2 (en) * 2007-12-31 2016-04-19 Calla Therapeutics Llc Topical formulations of Flucytosine
JP5749155B2 (ja) 2008-03-18 2015-07-15 ノボ・ノルデイスク・エー／エス プロテアーゼ安定化アシル化インスリンアナログ
WO2010091362A2 (en) * 2009-02-06 2010-08-12 Mesh Therapeutics, Llc Topical formulations comprising ion channel modulators
US20100273730A1 (en) * 2009-04-27 2010-10-28 Innopharmax, Inc. Self-emulsifying pharmaceutical compositions of hydrophilic drugs and preparation thereof
NO2437762T3 (pt) 2009-06-05 2018-01-06
KR101690817B1 (ko) * 2009-06-30 2016-12-28 라이온 가부시키가이샤 안과용 조성물
WO2011047259A1 (en) 2009-10-16 2011-04-21 Glaxosmithkline Llc Compositions
CN104688687A (zh) 2009-12-03 2015-06-10 诺华股份有限公司 疫苗佐剂制备中的亲水过滤
DE102009056884B4 (de) 2009-12-03 2021-03-18 Novartis Ag Impfstoff-Adjuvantien und verbesserte Verfahren zur Herstellung derselben
BR112012013426B8 (pt) * 2009-12-03 2021-05-25 Novartis Ag métodos para a fabricação de uma emulsão de óleo-em-água, para preparar uma composição de vacina e para preparar um kit de vacina
DE102009056883B4 (de) 2009-12-03 2012-08-16 Novartis Ag Impfstoff-Adjuvantien und verbesserte Verfahren zur Herstellung derselben
CL2012001399A1 (es) 2009-12-03 2013-03-08 Novartis Ag Metodo para fabricar adyuvante para vacuna (emulsion aceite/agua con escualeno, polisorbato 80 y trioleato de sorbitan), que comprende (i) formar primera emulsion en homogenizador desde un contendor a otro para formar segunda emulsion, (ii) y microfluidizar primera emulsion para formar segunda emulsion.
KR101523215B1 (ko) 2009-12-03 2015-05-27 노파르티스 아게 에멀션 미세 액화 및/또는 균질화 동안 성분들의 순환
IT1404931B1 (it) * 2010-06-11 2013-12-09 Medivis S R L Composizioni oftalmiche per la somministrazione di principi attivi liposolubili .
EP2621281A1 (de) 2010-10-01 2013-08-07 Elektra Management s.r.o. Lösung von guanidinium-verbindungen, verfahren unter einsatz dieser lösung sowie deren verwendung
MX2014012096A (es) 2012-04-11 2014-11-21 Novo Nordisk As Formulaciones de insulina.
US9132106B2 (en) * 2013-03-14 2015-09-15 Abbott Medical Optics Inc. Synergistic ophthalmic compositions for disinfecting contact lenses
US9089562B2 (en) * 2013-08-28 2015-07-28 Presbyopia Therapies Llc Compositions and methods for the treatment of presbyopia
RU2746083C2 (ru) 2015-03-05 2021-04-06 Аллерган, Инк. Самоэмульгирующиеся системы доставки лекарств (sedds) для доставки офтальмологического лекарства
US20180098937A1 (en) * 2016-10-12 2018-04-12 Ps Therapies Ltd Artificial tear, contact lens and drug vehicle compositions and methods of use thereof
US11583496B2 (en) * 2016-10-12 2023-02-21 PS Therapy Inc. Drug vehicle compositions and methods of use thereof
US20200397727A1 (en) * 2016-10-12 2020-12-24 Ps Therapies Ltd Drug vehicle compositions and methods of use thereof
US20190262290A1 (en) * 2016-10-12 2019-08-29 Ps Therapies Ltd Drug vehicle compositions and methods of use thereof
ES2886837T3 (es) 2016-12-16 2021-12-21 Novo Nordisk As Composiciones farmacéuticas que contienen insulina
JP7490570B2 (ja) 2018-04-27 2024-05-27 アラーガン、インコーポレイテッド 抗微生物有効性の増強及び毒性の減少を有する亜塩素酸ナトリウム組成物
JP6730500B2 (ja) * 2018-10-01 2020-07-29 千寿製薬株式会社 水性液剤
WO2021262184A1 (en) * 2020-06-26 2021-12-30 Renden Tashiro Disinfectant solution and article coated with disinfectant solution
CN112842936A (zh) * 2021-03-15 2021-05-28 傅博 一种眼部清洁液及其制备方法

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4818614A (en) * 1985-07-29 1989-04-04 Shiseido Company Ltd. Modified powder
KR920003601B1 (ko) * 1987-09-03 1992-05-04 유니버시티 어브 죠지아 리서취 화운데이션 인코포레이티드 점안 싸이클로스포린(cyclosporin)의 조성물
US5407683A (en) * 1990-06-01 1995-04-18 Research Corporation Technologies, Inc. Pharmaceutical solutions and emulsions containing taxol
IL101007A (en) * 1992-02-18 1997-08-14 Pharmos Ltd Dry stable compositions prepared by lyophilization
DE4206154A1 (de) * 1992-02-28 1993-09-02 Wella Ag Verfahren zur gewinnung von apfelwachs, durch diese verfahren erhaeltliches apfelwachs sowie apfelwachshaltige kosmetische mittel
IL101241A (en) * 1992-03-16 1997-11-20 Yissum Res Dev Co Pharmaceutical or cosmetic composition comprising stabilized oil-in-water type emulsion as carrier
IL103907A0 (en) * 1992-11-27 1993-04-04 Pharmos Corp Ophthalmic compositions
EP0656779B1 (en) * 1992-08-28 2000-04-12 Pharmos Corporation Submicron emulsions as ocular drug delivery vehicles
DE59308338D1 (de) * 1992-10-31 1998-05-07 Goldschmidt Ag Th Kosmetische oder pharmazeutische Zubereitungen
GB9514878D0 (en) * 1995-07-20 1995-09-20 Danbiosyst Uk Vitamin E as a solubilizer for drugs contained in lipid vehicles
US5679327A (en) * 1995-08-25 1997-10-21 Johnson Products Co., Inc. Hair straightening emulsion
US6458373B1 (en) * 1997-01-07 2002-10-01 Sonus Pharmaceuticals, Inc. Emulsion vehicle for poorly soluble drugs
GB2326337A (en) * 1997-06-20 1998-12-23 Phares Pharma Holland Homogeneous lipid compositions for drug delivery
DE69823663T2 (de) * 1997-07-29 2005-05-19 Pharmacia & Upjohn Co., Kalamazoo Selbstemulgierbare formulierung enthaltend lipophile verbindungen
ATE215370T1 (de) * 1997-07-29 2002-04-15 Upjohn Co Selbstemulgierende formulierung enthaltend lipophile verbindungen
FR2767069B1 (fr) * 1997-08-08 1999-09-17 Ard Sa Composition emulsionnante a base de polyglycosides et d'alcool gras
US6979456B1 (en) * 1998-04-01 2005-12-27 Jagotec Ag Anticancer compositions
WO1999056727A2 (en) * 1998-05-07 1999-11-11 Elan Corporation, Plc Solvent/cosolvent free microemulsion and emulsion preconcentrate drug delivery systems
FR2787027B1 (fr) * 1998-12-14 2001-01-12 Oreal Nanoemulsion a base d'esters gras de sucre ou d'ethers gras de sucre et ses utilisations dans les domaines cosmetique, dermatologique et/ou ophtalmologique
US6309663B1 (en) * 1999-08-17 2001-10-30 Lipocine Inc. Triglyceride-free compositions and methods for enhanced absorption of hydrophilic therapeutic agents
US6506394B1 (en) * 1999-06-30 2003-01-14 Kimberly-Clark Worldwide, Inc. Delivery of a botanical extract to a treated substrate for transfer to skin
WO2001028519A1 (de) * 1999-10-20 2001-04-26 Vesifact Ag Mikroemulsion-prekonzentrate und mikroemulsionen
GB0008785D0 (en) * 2000-04-10 2000-05-31 Novartis Ag Organic compounds
US20030185878A1 (en) * 2000-06-23 2003-10-02 Tetsuo Hoshino Process for producing phospholipid-containing drug
FR2819427B1 (fr) * 2001-01-18 2003-04-11 Oreal Nanoemulsion translucide, son procede de fabrication et ses utilisations dans les domaines cosmetique, dermatologique et/ou ophtalmologique
US7235230B2 (en) * 2001-10-24 2007-06-26 Clariant Finance (Bvi) Limited Leave-on compositions for personal care
US6656460B2 (en) * 2001-11-01 2003-12-02 Yissum Research Development Method and composition for dry eye treatment
WO2003041632A2 (en) * 2001-11-14 2003-05-22 Texas Tech University Eutectic-based self-nanoemulsified drug delivery system
US20030165545A1 (en) * 2002-01-30 2003-09-04 Allergan, Inc. Ophthalmic compositions including oil-in-water emulsions, and methods for making and using same
US20040115287A1 (en) * 2002-12-17 2004-06-17 Lipocine, Inc. Hydrophobic active agent compositions and methods
US20040137079A1 (en) * 2003-01-08 2004-07-15 Cook James N. Contact lens and eye drop rewetter compositions and methods
US20050196370A1 (en) * 2003-03-18 2005-09-08 Zhi-Jian Yu Stable ophthalmic oil-in-water emulsions with sodium hyaluronate for alleviating dry eye
US20040185068A1 (en) * 2003-03-18 2004-09-23 Zhi-Jian Yu Self-emulsifying compositions, methods of use and preparation

Also Published As

Publication number Publication date
JP2006526579A (ja) 2006-11-24
EP1603607A2 (en) 2005-12-14
US20040185068A1 (en) 2004-09-23
AU2004222295A1 (en) 2004-09-30
WO2004082625A2 (en) 2004-09-30
US20040191284A1 (en) 2004-09-30
CN1791383A (zh) 2006-06-21
CA2519300A1 (en) 2004-09-30
AU2004222295B2 (en) 2008-07-17
WO2004082625A3 (en) 2004-11-18

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Legal Events

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2129 DE 25/10/2011.