BRPI0008228B8 - composição farmacêutica contendo n-benzoil estaurosporina e agentes solubilizantes - Google Patents

composição farmacêutica contendo n-benzoil estaurosporina e agentes solubilizantes

Info

Publication number
BRPI0008228B8
BRPI0008228B8 BRPI0008228A BR0008228A BRPI0008228B8 BR PI0008228 B8 BRPI0008228 B8 BR PI0008228B8 BR PI0008228 A BRPI0008228 A BR PI0008228A BR 0008228 A BR0008228 A BR 0008228A BR PI0008228 B8 BRPI0008228 B8 BR PI0008228B8
Authority
BR
Brazil
Prior art keywords
benzoyl staurosporine
pharmaceutical composition
composition containing
solubilizing agents
benzoyl
Prior art date
Application number
BRPI0008228A
Other languages
English (en)
Portuguese (pt)
Other versions
BR0008228A (pt
BRPI0008228B1 (pt
Inventor
Haeberlin Barbara
Paul Matthews Graham
Original Assignee
Novartis Ag Novartis Sa Novartis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10847896&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0008228(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag Novartis Sa Novartis Inc filed Critical Novartis Ag Novartis Sa Novartis Inc
Publication of BR0008228A publication Critical patent/BR0008228A/pt
Publication of BRPI0008228B1 publication Critical patent/BRPI0008228B1/pt
Publication of BRPI0008228B8 publication Critical patent/BRPI0008228B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biophysics (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
BRPI0008228A 1999-02-16 2000-02-14 composição farmacêutica contendo n-benzoil estaurosporina e agentes solubilizantes BRPI0008228B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9903547.9A GB9903547D0 (en) 1999-02-16 1999-02-16 Organic compounds
PCT/EP2000/001196 WO2000048571A1 (en) 1999-02-16 2000-02-14 Spontaneously dispersible n-benzoyl staurosporine compositions

Publications (3)

Publication Number Publication Date
BR0008228A BR0008228A (pt) 2001-10-30
BRPI0008228B1 BRPI0008228B1 (pt) 2016-08-23
BRPI0008228B8 true BRPI0008228B8 (pt) 2021-05-25

Family

ID=10847896

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0008228A BRPI0008228B8 (pt) 1999-02-16 2000-02-14 composição farmacêutica contendo n-benzoil estaurosporina e agentes solubilizantes

Country Status (34)

Country Link
US (3) US20020061873A1 (cg-RX-API-DMAC7.html)
EP (1) EP1152750B1 (cg-RX-API-DMAC7.html)
JP (2) JP5057610B2 (cg-RX-API-DMAC7.html)
KR (2) KR100880859B1 (cg-RX-API-DMAC7.html)
CN (1) CN100367930C (cg-RX-API-DMAC7.html)
AR (2) AR022589A1 (cg-RX-API-DMAC7.html)
AT (1) ATE430554T1 (cg-RX-API-DMAC7.html)
AU (1) AU765776B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0008228B8 (cg-RX-API-DMAC7.html)
CA (1) CA2362277C (cg-RX-API-DMAC7.html)
CL (1) CL2009001682A1 (cg-RX-API-DMAC7.html)
CZ (1) CZ303979B6 (cg-RX-API-DMAC7.html)
DE (1) DE60042151D1 (cg-RX-API-DMAC7.html)
DK (1) DK1152750T3 (cg-RX-API-DMAC7.html)
EC (1) ECSP083351A (cg-RX-API-DMAC7.html)
ES (1) ES2326783T3 (cg-RX-API-DMAC7.html)
GB (1) GB9903547D0 (cg-RX-API-DMAC7.html)
HK (1) HK1045807B (cg-RX-API-DMAC7.html)
HU (1) HUP0105364A3 (cg-RX-API-DMAC7.html)
ID (1) ID30504A (cg-RX-API-DMAC7.html)
IL (3) IL144512A0 (cg-RX-API-DMAC7.html)
MY (1) MY128362A (cg-RX-API-DMAC7.html)
NO (1) NO331232B1 (cg-RX-API-DMAC7.html)
NZ (1) NZ513529A (cg-RX-API-DMAC7.html)
PE (1) PE20001499A1 (cg-RX-API-DMAC7.html)
PL (1) PL198330B1 (cg-RX-API-DMAC7.html)
PT (1) PT1152750E (cg-RX-API-DMAC7.html)
RU (1) RU2266121C2 (cg-RX-API-DMAC7.html)
SI (1) SI1152750T1 (cg-RX-API-DMAC7.html)
SK (1) SK286967B6 (cg-RX-API-DMAC7.html)
TR (1) TR200102385T2 (cg-RX-API-DMAC7.html)
TW (1) TWI240636B (cg-RX-API-DMAC7.html)
WO (1) WO2000048571A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA200106677B (cg-RX-API-DMAC7.html)

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US7795246B2 (en) 1998-08-06 2010-09-14 Cephalon, Inc. Particle-forming compositions containing fused pyrrolocarbazoles
PT1372611E (pt) * 2001-03-26 2006-08-31 Novartis Ag Composicao farmaceutica compreendendo uma estaurosporina francamente soluvel em agua, um tensioactivo et um polimero soluvel em agua
CA2444867C (en) 2001-05-16 2010-08-17 Novartis Ag Combination comprising n-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2pyrimidine-amine and a chemotherapeutic agent
DE60213842T2 (de) * 2001-10-30 2007-09-06 Novartis Ag Staurosporin-derivate als hemmer der flt3-rezeptor-tyrosinkinase-wirkung
GB0206215D0 (en) 2002-03-15 2002-05-01 Novartis Ag Organic compounds
EP1531793A1 (en) * 2002-07-23 2005-05-25 Novartis AG Ophtalmic ointment composition comprising a drug, an ointment base and a solubiling/dispersing agent
US7842791B2 (en) 2002-12-19 2010-11-30 Nancy Jean Britten Dispersible pharmaceutical compositions
TWI324604B (en) * 2003-06-18 2010-05-11 Novartis Ag New use of staurosporine derivatives
GB0512324D0 (en) 2005-06-16 2005-07-27 Novartis Ag Organic compounds
GB0419159D0 (en) * 2004-08-27 2004-09-29 Novartis Ag Organic compounds
GT200500310A (es) * 2004-11-19 2006-06-19 Compuestos organicos
JP5546860B2 (ja) * 2006-08-16 2014-07-09 ノバルティス アーゲー 高結晶性治療化合物の固体分散体を製造するための方法
FR2918566B1 (fr) 2007-07-11 2009-10-09 Pierre Fabre Medicament Sa Composition pharmaceutique stable d'un sel hydrosoluble de vinflunine.
US20090155352A1 (en) * 2007-11-20 2009-06-18 Cephalon, Inc. Microemulsion containing indolocarbazole compound and dosage forms containing the same
EP2229936B1 (en) * 2009-03-09 2015-05-06 PharmaSol GmbH Nanonized testosterone formulations for improved bioavailability
WO2011000811A2 (en) * 2009-06-30 2011-01-06 Novartis Ag Organic compounds
US20120322776A1 (en) * 2009-12-22 2012-12-20 Leo Pharma A/S Cutaneous composition comprising vitamin d analogue and a mixture of solvent and surfactants
JO3337B1 (ar) 2010-12-13 2019-03-13 Debiopharm Sa تركيبات صيدلية تشمل أليسبوريفير
US9387446B2 (en) * 2011-09-22 2016-07-12 Ariel-University Research And Development Company Ltd. Emulsions and methods of making emulsions
RU2742650C2 (ru) * 2015-12-09 2021-02-09 Фосфейдженикс Лимитед Фармацевтический состав
MX383940B (es) 2015-12-09 2025-03-14 Phosphagenics Ltd Formulación farmacéutica que contiene tocol fosfato.
IL267006B2 (en) 2016-12-21 2024-11-01 Phosphagenics Ltd Process for phosphorylation of a complex alcohol with p4o10 at high temperatures, and products thereof
WO2021097256A1 (en) 2019-11-14 2021-05-20 Cohbar, Inc. Cxcr4 antagonist peptides

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Also Published As

Publication number Publication date
TWI240636B (en) 2005-10-01
ES2326783T3 (es) 2009-10-20
NO331232B1 (no) 2011-11-07
TR200102385T2 (tr) 2002-09-23
GB9903547D0 (en) 1999-04-07
PL198330B1 (pl) 2008-06-30
JP5057610B2 (ja) 2012-10-24
US20080070897A1 (en) 2008-03-20
ATE430554T1 (de) 2009-05-15
ZA200106677B (en) 2003-01-14
IL144512A (en) 2011-03-31
ID30504A (id) 2001-12-13
WO2000048571A1 (en) 2000-08-24
SK11722001A3 (sk) 2001-12-03
DE60042151D1 (de) 2009-06-18
CZ20012931A3 (cs) 2001-11-14
KR100880859B1 (ko) 2009-01-30
ECSP083351A (es) 2008-08-29
HUP0105364A3 (en) 2003-02-28
US20020061873A1 (en) 2002-05-23
JP2012111763A (ja) 2012-06-14
BR0008228A (pt) 2001-10-30
US8722664B2 (en) 2014-05-13
MY128362A (en) 2007-01-31
IL144512A0 (en) 2002-05-23
NO20013964L (no) 2001-10-15
KR20080064914A (ko) 2008-07-09
AU3154200A (en) 2000-09-04
AU765776B2 (en) 2003-10-02
US8575147B2 (en) 2013-11-05
CN100367930C (zh) 2008-02-13
CL2009001682A1 (es) 2010-07-23
CZ303979B6 (cs) 2013-07-31
AR022589A1 (es) 2002-09-04
PL350556A1 (en) 2002-12-16
NO20013964D0 (no) 2001-08-15
SK286967B6 (sk) 2009-08-06
DK1152750T3 (da) 2009-08-24
EP1152750A1 (en) 2001-11-14
CA2362277C (en) 2010-03-30
CA2362277A1 (en) 2000-08-24
HK1045807B (zh) 2008-12-05
PT1152750E (pt) 2009-08-07
SI1152750T1 (sl) 2009-10-31
EP1152750B1 (en) 2009-05-06
RU2266121C2 (ru) 2005-12-20
HK1045807A1 (zh) 2002-12-13
CN1339963A (zh) 2002-03-13
JP2002537242A (ja) 2002-11-05
PE20001499A1 (es) 2001-01-12
IL192666A0 (en) 2009-02-11
KR20010093281A (ko) 2001-10-27
NZ513529A (en) 2003-10-31
BRPI0008228B1 (pt) 2016-08-23
HUP0105364A2 (hu) 2002-05-29
AR082579A2 (es) 2012-12-19
US20140056974A1 (en) 2014-02-27

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: ALTERADO DA INT. CL: A61K 9/107; A61K 31/553; A61K 9/107; A61K 31/553; A61K 47/10; A61K 47/34; A61K 47/44; A61P 9/00; A61P 9/10; A61P 25/00; A61P 29/00; A61P 31/00; A61P 35/00; A61P 43,00.

Ipc: A61K 9/107 (2009.01), A61K 31/553 (2009.01)

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PEDIDO DE ACORDO COM OS ARTIGOS 8O E 13 DA LPI.

B12B Appeal against refusal [chapter 12.2 patent gazette]
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