BR9915236A - Derivados da eritromicina, seu respectivo processo de preparação e sua respectiva aplicação enquanto medicamentos - Google Patents

Derivados da eritromicina, seu respectivo processo de preparação e sua respectiva aplicação enquanto medicamentos

Info

Publication number
BR9915236A
BR9915236A BR9915236-3A BR9915236A BR9915236A BR 9915236 A BR9915236 A BR 9915236A BR 9915236 A BR9915236 A BR 9915236A BR 9915236 A BR9915236 A BR 9915236A
Authority
BR
Brazil
Prior art keywords
medicines
preparation process
erythromycin derivatives
respective application
application
Prior art date
Application number
BR9915236-3A
Other languages
English (en)
Inventor
Constantin Agouridas
Alexis Denis
Claude Fromentin
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of BR9915236A publication Critical patent/BR9915236A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Patente de Invenção: "DERIVADOS DA ERITROMICINA, SEU RESPECTIVO PROCESSO DE PREPARAçãO E SUA RESPECTIVA APLICAçãO ENQUANTO MEDICAMENTOS". A invenção tem por objeto, a título de produtos novos, os compostos de fórmula (I) na qual X representa um átomo de hidrogênio ou um átomo de halogênio e Z representa um átomo de hidrogênio de um ácido, assim como seus sais de adição com os ácidos. Os compostos de fórmula (I) apresentam propriedades antibióticas.
BR9915236-3A 1998-11-10 1999-11-09 Derivados da eritromicina, seu respectivo processo de preparação e sua respectiva aplicação enquanto medicamentos BR9915236A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9814145A FR2785612A1 (fr) 1998-11-10 1998-11-10 Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
PCT/FR1999/002718 WO2000027857A2 (fr) 1998-11-10 1999-11-09 Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments

Publications (1)

Publication Number Publication Date
BR9915236A true BR9915236A (pt) 2002-01-08

Family

ID=9532584

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9915236-3A BR9915236A (pt) 1998-11-10 1999-11-09 Derivados da eritromicina, seu respectivo processo de preparação e sua respectiva aplicação enquanto medicamentos

Country Status (28)

Country Link
US (2) US6455505B2 (pt)
EP (1) EP1016669B1 (pt)
JP (1) JP4698783B2 (pt)
KR (1) KR100567695B1 (pt)
CN (2) CN100351238C (pt)
AR (1) AR025814A1 (pt)
AT (1) ATE232879T1 (pt)
AU (1) AU766138B2 (pt)
BR (1) BR9915236A (pt)
CA (1) CA2350651C (pt)
CZ (1) CZ20011622A3 (pt)
DE (1) DE69905447T2 (pt)
DK (1) DK1016669T3 (pt)
EA (1) EA200100533A1 (pt)
ES (1) ES2189365T3 (pt)
FR (1) FR2785612A1 (pt)
HR (1) HRP20010335B1 (pt)
HU (1) HUP0104035A3 (pt)
IL (2) IL142996A0 (pt)
NO (1) NO20012272L (pt)
NZ (1) NZ511609A (pt)
PL (1) PL348098A1 (pt)
PT (1) PT1016669E (pt)
SI (1) SI20640A (pt)
TR (1) TR200101286T2 (pt)
TW (1) TWI237027B (pt)
WO (1) WO2000027857A2 (pt)
ZA (1) ZA200103801B (pt)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1147121B1 (en) 1999-01-27 2003-12-17 Pfizer Products Inc. Ketolide antibiotics
WO2000071557A1 (en) 1999-05-24 2000-11-30 Pfizer Products Inc. 13-methyl-erythromycin derivatives
PT1167376E (pt) 2000-06-30 2004-09-30 Pfizer Prod Inc Antibioticos macrolidos
JP2004017020A (ja) * 2002-06-20 2004-01-22 Sony Corp コーティング方法および被コーティング粒子
ES2552682T3 (es) 2003-03-10 2015-12-01 Merck Sharp & Dohme Corp. Agentes antibacterianos novedosos
EP1794171A2 (en) * 2004-07-28 2007-06-13 Ranbaxy Laboratories, Ltd. Ketolide derivatives as antibacterial agents
EP1807439A2 (en) * 2004-10-25 2007-07-18 Ranbaxy Laboratories Limited Ketolide derivatives as antibacterial agents
WO2009055557A1 (en) * 2007-10-25 2009-04-30 Cempra Pharmaceuticals, Inc. Process for the preparation of macrolide antibacterial agents
WO2010048601A1 (en) 2008-10-24 2010-04-29 Cempra Pharmaceuticals, Inc. Biodefenses using triazole-containing macrolides
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
AU2010292010B2 (en) 2009-09-10 2016-01-07 Cempra Pharmaceuticals, Inc. Methods for treating malaria, tuberculosis and MAC diseases
SI2550286T1 (sl) 2010-03-22 2016-04-29 Cempra Pharmaceuticals, Inc. Kristalne oblike makrolida in njihove uporabe
RU2608390C2 (ru) 2010-05-20 2017-01-18 Семпра Фармасьютикалз, Инк. Способы получения макролидов и кетолидов, и промежуточных соединений для их получения
JP6042334B2 (ja) 2010-09-10 2016-12-14 センプラ ファーマシューティカルズ，インコーポレイテッド 疾患治療のための水素結合形成フルオロケトライド
RU2658050C2 (ru) 2012-03-27 2018-06-19 Семпра Фармасьютикалз, Инк. Парентеральные составы для введения макролидных антибиотиков
US9861616B2 (en) 2013-03-14 2018-01-09 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
CN105188712A (zh) 2013-03-15 2015-12-23 森普拉制药公司 用于制备大环内酯抗菌剂的收敛方法
AU2014248014B2 (en) * 2013-04-04 2018-11-08 President And Fellows Of Harvard College Macrolides and methods of their preparation and use
CA2963815A1 (en) 2014-10-08 2016-04-14 President And Fellows Of Harvard College 14-membered ketolides and methods of their preparation and use
US10640528B2 (en) 2015-03-25 2020-05-05 President And Fellows Of Havard College Macrolides with modified desosamine sugars and uses thereof
EP3190122A1 (en) * 2016-01-08 2017-07-12 LEK Pharmaceuticals d.d. A novel synthetic pathway towards solithromycin and purification thereof
CN106432383A (zh) * 2016-09-14 2017-02-22 重庆两江药物研发中心有限公司 索利霉素及其中间体的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5671074A (en) * 1979-11-12 1981-06-13 Takeda Chem Ind Ltd 1,2-disubstituted-4-halogenoimidazole-5-acetic acid derivative
IL114589A (en) * 1990-11-21 1999-12-22 Roussel Uclaf Intermediates for the preparation of the history of erythromycin
FR2669337B1 (fr) * 1990-11-21 1995-03-24 Roussel Uclaf Nouveaux derives descladinosyles de l'erythromycine, leur procede de preparation et leur application comme medicaments.
FR2697524B1 (fr) * 1992-11-05 1994-12-23 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
US5527780A (en) * 1992-11-05 1996-06-18 Roussel Uclaf Erythromycin derivatives
FR2719587B1 (fr) * 1994-05-03 1996-07-12 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR2727969B1 (fr) * 1994-12-09 1997-01-17 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2742757B1 (fr) * 1995-12-22 1998-01-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
KR100576988B1 (ko) * 1996-09-04 2006-05-10 아보트 러보러터리즈 항균 활성을 지닌 6-ｏ-치환된 케톨라이드
US6165986A (en) * 1997-03-10 2000-12-26 Taisho Pharmaceutical Co., Ltd. Erythromycin a derivatives

Also Published As

Publication number Publication date
EP1016669A1 (fr) 2000-07-05
HRP20010335A2 (en) 2002-06-30
HUP0104035A3 (en) 2003-12-29
TWI237027B (en) 2005-08-01
DE69905447D1 (de) 2003-03-27
CA2350651C (fr) 2010-07-20
PT1016669E (pt) 2003-07-31
NO20012272L (no) 2001-07-10
KR100567695B1 (ko) 2006-04-05
AR025814A1 (es) 2002-12-18
WO2000027857A3 (fr) 2000-08-17
NZ511609A (en) 2003-07-25
AU766138B2 (en) 2003-10-09
TR200101286T2 (tr) 2001-09-21
JP2000143689A (ja) 2000-05-26
JP4698783B2 (ja) 2011-06-08
US6407257B1 (en) 2002-06-18
CN100351238C (zh) 2007-11-28
CN1240708C (zh) 2006-02-08
CN1814592A (zh) 2006-08-09
WO2000027857A2 (fr) 2000-05-18
CN1333782A (zh) 2002-01-30
KR20010080970A (ko) 2001-08-25
ATE232879T1 (de) 2003-03-15
CA2350651A1 (fr) 2000-05-18
FR2785612A1 (fr) 2000-05-12
NO20012272D0 (no) 2001-05-09
AU1052600A (en) 2000-05-29
SI20640A (sl) 2002-02-28
ES2189365T3 (es) 2003-07-01
CZ20011622A3 (cs) 2001-09-12
HRP20010335B1 (en) 2003-08-31
US20020013281A1 (en) 2002-01-31
IL142996A0 (en) 2002-04-21
US20020028781A1 (en) 2002-03-07
PL348098A1 (en) 2002-05-06
DK1016669T3 (da) 2003-05-26
DE69905447T2 (de) 2003-07-24
EP1016669B1 (fr) 2003-02-19
IL142996A (en) 2006-12-10
ZA200103801B (en) 2002-05-10
EA200100533A1 (ru) 2001-10-22
US6455505B2 (en) 2002-09-24
HUP0104035A2 (hu) 2002-02-28

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Legal Events

Date Code Title Description
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07F Notification of approval that there is no relation to art. 229 of lpi (pipeline patents) [chapter 7.6 patent gazette]

Free format text: NOTIFICACAO DE NAO ANUENCIA RELACIONADA COM O ART. 229 DA LPI

B09A Decision: intention to grant [chapter 9.1 patent gazette]
B11D Dismissal acc. art. 38, par 2 of ipl - failure to pay fee after grant in time