BR9914256A - Derivados de ácido 2,4-pentadienóico tendo atividade seletiva para receptores de retinóide x (rxr) - Google Patents
Derivados de ácido 2,4-pentadienóico tendo atividade seletiva para receptores de retinóide x (rxr)Info
- Publication number
- BR9914256A BR9914256A BR9914256-2A BR9914256A BR9914256A BR 9914256 A BR9914256 A BR 9914256A BR 9914256 A BR9914256 A BR 9914256A BR 9914256 A BR9914256 A BR 9914256A
- Authority
- BR
- Brazil
- Prior art keywords
- formula
- rxr
- retinoid
- receptors
- acid derivatives
- Prior art date
Links
- 150000004492 retinoid derivatives Chemical class 0.000 title abstract 3
- SDVVLIIVFBKBMG-UHFFFAOYSA-N penta-2,4-dienoic acid Chemical class OC(=O)C=CC=C SDVVLIIVFBKBMG-UHFFFAOYSA-N 0.000 title 1
- SDVVLIIVFBKBMG-ONEGZZNKSA-N (E)-penta-2,4-dienoic acid Chemical class OC(=O)\C=C\C=C SDVVLIIVFBKBMG-ONEGZZNKSA-N 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000003709 fluoroalkyl group Chemical group 0.000 abstract 1
- -1 heteroaryl aryl radical Chemical class 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 150000003254 radicals Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/46—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings, e.g. cyclohexylphenylacetic acid
- C07C57/48—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings, e.g. cyclohexylphenylacetic acid having unsaturation outside the aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/46—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings, e.g. cyclohexylphenylacetic acid
- C07C57/50—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings, e.g. cyclohexylphenylacetic acid containing condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/612—Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a six-membered aromatic ring in the acid moiety
- C07C69/618—Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a six-membered aromatic ring in the acid moiety having unsaturation outside the six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/58—Ring systems containing bridged rings containing three rings
- C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
- C07C2603/74—Adamantanes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Ophthalmology & Optometry (AREA)
- Endocrinology (AREA)
- Psychiatry (AREA)
- Nutrition Science (AREA)
- Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Toxicology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrane Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/164,950 US6147224A (en) | 1998-10-01 | 1998-10-01 | 2,4-pentadienoic acid derivatives having selective activity for retinoid X (RXR) receptors |
| PCT/US1999/021712 WO2000020370A1 (en) | 1998-10-01 | 1999-09-20 | 2, 4-pentadienoic acid derivatives having selective activity for retinoid x (rxr) receptors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9914256A true BR9914256A (pt) | 2001-07-03 |
Family
ID=22596791
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9914256-2A BR9914256A (pt) | 1998-10-01 | 1999-09-20 | Derivados de ácido 2,4-pentadienóico tendo atividade seletiva para receptores de retinóide x (rxr) |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6147224A (enExample) |
| EP (2) | EP1117628B1 (enExample) |
| JP (1) | JP2002526516A (enExample) |
| KR (2) | KR20010075457A (enExample) |
| CN (1) | CN1328538A (enExample) |
| AR (1) | AR020691A1 (enExample) |
| AT (1) | ATE254593T1 (enExample) |
| AU (1) | AU757932B2 (enExample) |
| BR (1) | BR9914256A (enExample) |
| CA (1) | CA2346034A1 (enExample) |
| DE (1) | DE69912973T2 (enExample) |
| ES (1) | ES2207339T3 (enExample) |
| NZ (1) | NZ510528A (enExample) |
| TW (1) | TW580494B (enExample) |
| WO (1) | WO2000020370A1 (enExample) |
| ZA (1) | ZA200102635B (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6566372B1 (en) | 1999-08-27 | 2003-05-20 | Ligand Pharmaceuticals Incorporated | Bicyclic androgen and progesterone receptor modulator compounds and methods |
| MXPA02002032A (es) | 1999-08-27 | 2003-05-19 | Ligand Pharm Inc | Compuestos moduladores del receptor de androgeno y metodos. |
| EP1212322A2 (en) | 1999-08-27 | 2002-06-12 | Ligand Pharmaceuticals Incorporated | 8-substituted-6-trifluoromethyl-9-pyrido[3,2-g]quinoline compounds as androgen receptor modulators |
| US6593493B1 (en) | 1999-09-14 | 2003-07-15 | Ligand Pharmaceuticals, Inc. | RXR modulators with improved pharmacologic profile |
| US6906046B2 (en) | 2000-12-22 | 2005-06-14 | Celltech R & D Inc. | Pharmaceutical uses and synthesis of benzobicyclooctanes |
| CA2442366C (en) * | 2001-03-27 | 2012-09-25 | Circagen Pharmaceutical, Llc | Histone deacetylase inhibitors |
| US8026280B2 (en) | 2001-03-27 | 2011-09-27 | Errant Gene Therapeutics, Llc | Histone deacetylase inhibitors |
| US7312247B2 (en) | 2001-03-27 | 2007-12-25 | Errant Gene Therapeutics, Llc | Histone deacetylase inhibitors |
| US6495719B2 (en) | 2001-03-27 | 2002-12-17 | Circagen Pharmaceutical | Histone deacetylase inhibitors |
| US7842727B2 (en) | 2001-03-27 | 2010-11-30 | Errant Gene Therapeutics, Llc | Histone deacetylase inhibitors |
| US6388105B1 (en) * | 2001-09-27 | 2002-05-14 | Allergan Sales, Inc. | Benzofuran, indole or benzothiophene 2,4-pentadienoic acid derivatives having selective activity for retinoid X (RXR) receptors |
| US6720423B2 (en) | 2002-04-30 | 2004-04-13 | Allergan, Inc. | Dihydrobenzofuran and dihydrobenzothiophene 2,4-pentadienoic acid derivatives having selective activity for retinoid X (RXR) receptors |
| EP1511477A4 (en) | 2002-05-22 | 2008-04-09 | Errant Gene Therapeutics Llc | HISTONE DEACETYLASE INHIBITORS BASED ON ALPHA-KETO-EPOXYDE COMPOUNDS |
| JP2006508986A (ja) | 2002-11-20 | 2006-03-16 | エルラント ゲネ セラペウチクス エルエルシー | ヒストンデアセチラーゼ阻害剤による肺細胞の治療方法 |
| US6683092B1 (en) | 2003-04-09 | 2004-01-27 | Allergan, Inc. | [3-(c5-14alkyl-2-oxo-1,2,3,4-tetrahydro-quinolin-6-yl)-3-oxo-propenyl]-phenyl and [3-(c5-14alkyl-2-oxo-1,2,3,4- tetrahydro-quinolin-6-yl)-3-oxo-propenyl]-heteroaryl derivatives having anti-tumor activity |
| US6734193B1 (en) | 2003-06-03 | 2004-05-11 | Allergan, Inc. | (1,2,3,4-tetrahydroquinolin-8-yl)-heptatrienoic acid derivatives having serum glucose reducing activity |
| US6936636B2 (en) * | 2003-06-26 | 2005-08-30 | Allergan, Inc. | 5-[phenyl-tetrahydronaphthalene-2-yl dihydronaphthalen-2-yl and heteroaryl-cyclopropyl]-pentadienoic acid derivatives having serum glucose reducing activity |
| US6887896B1 (en) | 2003-10-29 | 2005-05-03 | Allergan, Inc. | 7-[(7-Alkoxy)-chrom-3-en-6-yl]-heptatrienoic acid and 7-[(3-alkoxy)-5,6-dihydronaphthalen-2-yl]-heptatrienoic acid derivatives having serum glucose reducing activity |
| LT1937244T (lt) | 2005-09-30 | 2018-11-12 | Io Therapeutics, Llc | Vėžio gydymas specifiniais rxr agonistais |
| US20070185055A1 (en) * | 2006-02-06 | 2007-08-09 | Guang Liang Jiang | Method for treating cachexia with retinoid ligands |
| CN110151745A (zh) | 2011-12-13 | 2019-08-23 | Io治疗公司 | 使用rxr激动剂的自身免疫紊乱的治疗 |
| US10653650B2 (en) | 2011-12-13 | 2020-05-19 | Io Therapeutics, Inc. | Treatment of diseases by concurrently eliciting remyelination effects and immunomodulatory effects using selective RXR agonists |
| JP6492432B2 (ja) * | 2013-07-09 | 2019-04-03 | 東ソー株式会社 | アダマンチル基を有する環状アジン化合物、その製造方法、及びそれを構成成分とする有機電界発光素子 |
| KR102149321B1 (ko) | 2015-10-31 | 2020-08-28 | 아이오 테라퓨틱스, 인크. | Rxr 아고니스트와 갑상선 호르몬의 조합을 사용한 신경계 질환의 치료 |
| NZ745704A (en) | 2016-03-10 | 2019-04-26 | Io Therapeutics Inc | Treatment of muscular disorders with combinations of rxr agonists and thyroid hormones |
| KR102549273B1 (ko) | 2016-03-10 | 2023-06-28 | 아이오 테라퓨틱스, 인크. | Rxr 작용제 및 갑상선 호르몬의 조합을 사용한 자가면역 질환의 치료 |
| EP3684348A4 (en) | 2017-09-20 | 2021-08-18 | IO Therapeutics, Inc. | TREATMENT OF DISEASES WITH ETERS FROM SELECTIVE RXR AGONISTS |
| KR102715396B1 (ko) * | 2017-11-17 | 2024-10-08 | 아이오 테라퓨틱스, 인크. | 레티노이드 x 수용체 특이적 레티노이드의 제조를 위한 화합물 및 합성 방법 |
| US10966950B2 (en) | 2019-06-11 | 2021-04-06 | Io Therapeutics, Inc. | Use of an RXR agonist in treating HER2+ cancers |
| EP4444287A4 (en) | 2021-12-07 | 2025-05-28 | Io Therapeutics, Inc. | USE OF AN RXR AGONIST AND TAXANES FOR THE TREATMENT OF HER2+ CANCER |
| KR20240115316A (ko) | 2021-12-07 | 2024-07-25 | 아이오 테라퓨틱스, 인크. | 약물 내성 her2+ 암 치료에서의 rxr 작용제의 용도 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8826760D0 (en) * | 1988-11-16 | 1988-12-21 | Wellcome Found | Pesticides |
| DE617614T1 (de) * | 1991-12-18 | 1995-06-08 | Baylor College Of Medicine, Houston, Tex. | Mitteln zur modulierung von verfahren durch retinoid rezeptoren und dafür nützliche verbindungen. |
| DE69333894D1 (de) * | 1992-04-22 | 2005-12-01 | Ligand Pharm Inc | Verbindungen mit Retinoid x rezeptorselektivität |
| ES2129115T3 (es) * | 1993-01-11 | 1999-06-01 | Ligand Pharm Inc | Compuestos que tienen actividad selectiva para los receptores de retinoides x, y medios para la modulacion de procesos mediados por receptores de retinoides x. |
| US5455265A (en) * | 1993-02-11 | 1995-10-03 | Allergan, Inc. | Method of treatment with compounds having selective agonist-like activity on RXR retinoid receptors |
| KR100363545B1 (ko) * | 1994-08-10 | 2003-02-19 | 에프. 호프만-라 로슈 아게 | 레틴산x-수용체리간드 |
| IL116259A (en) * | 1994-12-19 | 2000-07-16 | American Cyanamid Co | Analogs of 9-cis retinoic acid and their use |
| US5648514A (en) * | 1994-12-29 | 1997-07-15 | Allergan | Substituted acetylenes having retinoid-like biological activity |
| US5543534A (en) * | 1994-12-29 | 1996-08-06 | Allergan | Acetylenes disubstituted with a 5 substituted tetrahydronaphthyl group and with an aryl or heteroaryl groups having retinoid-like biological activity |
| US5675033A (en) * | 1995-06-06 | 1997-10-07 | Allergan | 2,4-pentadienoic acid derivatives having retinoid-like biological activity |
| US5776699A (en) * | 1995-09-01 | 1998-07-07 | Allergan, Inc. | Method of identifying negative hormone and/or antagonist activities |
| AU726450B2 (en) * | 1995-10-06 | 2000-11-09 | Ligand Pharmaceuticals Incorporated | Dimer-selective RXR modulators and methods for their use |
| US5723666A (en) * | 1996-06-21 | 1998-03-03 | Allergan | Oxime substituted tetrahydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity |
| US5728846A (en) * | 1996-12-12 | 1998-03-17 | Allergan | Benzo 1,2-g!-chrom-3-ene and benzo 1,2-g!-thiochrom-3-ene derivatives |
| CN1337931A (zh) * | 1999-03-08 | 2002-02-27 | 巴斯利尔药物股份公司 | 类维生素a拮抗剂及其用途 |
-
1998
- 1998-10-01 US US09/164,950 patent/US6147224A/en not_active Expired - Fee Related
-
1999
- 1999-09-20 NZ NZ510528A patent/NZ510528A/xx unknown
- 1999-09-20 CA CA002346034A patent/CA2346034A1/en not_active Abandoned
- 1999-09-20 AT AT99970078T patent/ATE254593T1/de not_active IP Right Cessation
- 1999-09-20 DE DE69912973T patent/DE69912973T2/de not_active Expired - Fee Related
- 1999-09-20 JP JP2000574489A patent/JP2002526516A/ja active Pending
- 1999-09-20 WO PCT/US1999/021712 patent/WO2000020370A1/en not_active Ceased
- 1999-09-20 AU AU60513/99A patent/AU757932B2/en not_active Ceased
- 1999-09-20 EP EP99970078A patent/EP1117628B1/en not_active Expired - Lifetime
- 1999-09-20 ES ES99970078T patent/ES2207339T3/es not_active Expired - Lifetime
- 1999-09-20 KR KR1020017004018A patent/KR20010075457A/ko not_active Abandoned
- 1999-09-20 EP EP03025774A patent/EP1388534A3/en not_active Withdrawn
- 1999-09-20 BR BR9914256-2A patent/BR9914256A/pt not_active Application Discontinuation
- 1999-09-20 CN CN99813787A patent/CN1328538A/zh active Pending
- 1999-10-01 AR ARP990104996A patent/AR020691A1/es not_active Application Discontinuation
- 1999-10-12 TW TW088116960A patent/TW580494B/zh not_active IP Right Cessation
-
2001
- 2001-03-30 ZA ZA200102635A patent/ZA200102635B/en unknown
-
2006
- 2006-09-20 KR KR1020060091029A patent/KR20060118367A/ko not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| NZ510528A (en) | 2003-04-29 |
| EP1117628A1 (en) | 2001-07-25 |
| EP1117628B1 (en) | 2003-11-19 |
| KR20060118367A (ko) | 2006-11-23 |
| EP1388534A3 (en) | 2004-02-25 |
| JP2002526516A (ja) | 2002-08-20 |
| DE69912973T2 (de) | 2004-07-22 |
| EP1388534A2 (en) | 2004-02-11 |
| AR020691A1 (es) | 2002-05-22 |
| CA2346034A1 (en) | 2000-04-13 |
| AU6051399A (en) | 2000-04-26 |
| ZA200102635B (en) | 2002-10-18 |
| CN1328538A (zh) | 2001-12-26 |
| KR20010075457A (ko) | 2001-08-09 |
| US6147224A (en) | 2000-11-14 |
| AU757932B2 (en) | 2003-03-13 |
| TW580494B (en) | 2004-03-21 |
| ES2207339T3 (es) | 2004-05-16 |
| DE69912973D1 (de) | 2003-12-24 |
| ATE254593T1 (de) | 2003-12-15 |
| HK1039477A1 (en) | 2002-04-26 |
| WO2000020370A1 (en) | 2000-04-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP1388534A3 (en) | 2,4-pentadienoic acid derivatives having selective activity for retinoid X (RXR) receptors | |
| BR0307599A (pt) | Derivados de sulfonilamino como inibidores de histona deacetilase | |
| BR0115580A (pt) | Derivados de 3-aroilindol e a utilizaçao dos mesmos como agonistas dos receptores cb2 | |
| NO892982D0 (no) | Tetrahydro-1-benz-(c,d)-indolpropionsyre-sulfonamider. | |
| BR9909423A (pt) | Composição e método para produzir politioéteres tendo cadeias de metila pendentes | |
| ATE270103T1 (de) | Aminophenoxyessigsäure derivate als neuroschützende mittel | |
| EP1362846A4 (en) | AMINOETHANOL DERIVATIVES | |
| BR0307607A (pt) | Derivados de carbonilamino como inibidores de histona desacetilase | |
| BR9803883A (pt) | Derivado de amida. | |
| DK1117648T3 (da) | Tetrahydroquinolinderivater med selektiv virkning for retinoid X receptorer | |
| BR0001509A (pt) | Derivados de oxima e o seu uso como ácidos latentes | |
| NO963370D0 (no) | Nye mercaptoacetylamido-1,3,4,5-tetrahydro-benzo[cÅazepin-3-on-disulfidderivater som er anvendbare som inhibitorer av enkefalinase og ACE | |
| BR9900788A (pt) | Compostos ésteres. | |
| BR9810163A (pt) | Compostos ou suas composições | |
| DE3665711D1 (de) | Novel guanidinomethylbenzoic acid derivatives | |
| AR016175A1 (es) | Compuestos derivados del acido dihidroxihexanoico, su uso para la preparacion de medicamentos y composiciones de los mismos. | |
| KR890000457A (ko) | 티오펜 유도체 | |
| ES2186322T3 (es) | Derivados de acido perfluor-n-alcanosulfonico. | |
| BR0107886A (pt) | Derivados do ácido isotiazolcarboxìlico e seu uso como microbicidas | |
| MX7122E (es) | Procedimiento para la preparacion de derivados de tiometilpiridina | |
| DE69633059D1 (de) | Neue naphthyridinderivate. | |
| BR0008589A (pt) | Composto de tipirano, processo para sua preparação e seu uso | |
| BRPI9710537B8 (pt) | derivados da eritromicina, composições farmacêuticas, bem como processo para preparação dos mesmos. | |
| FI963168A0 (fi) | Enkefalinaasin inhibiittoreina käyttökelpoisia uusia indaani-2-merkaptoasetyyliamiddisulfidijohdannaisia | |
| BR9910418A (pt) | Barra de limpeza pessoal translúcida e processo para fabricação da mesma |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25A | Requested transfer of rights approved |
Free format text: ALLERGAN SALES, LLC (US) |
|
| B25A | Requested transfer of rights approved |
Free format text: ALLERGAN, INC (US) |
|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: INDEFIRO O PRESENTE PEDIDO DE PATENTE DE ACORDO COM ART. 8O DA LPI |