BR9908178A - Processos para tratamento de diabetes usando análogos peptìdios de insulina - Google Patents
Processos para tratamento de diabetes usando análogos peptìdios de insulinaInfo
- Publication number
- BR9908178A BR9908178A BR9908178-4A BR9908178A BR9908178A BR 9908178 A BR9908178 A BR 9908178A BR 9908178 A BR9908178 A BR 9908178A BR 9908178 A BR9908178 A BR 9908178A
- Authority
- BR
- Brazil
- Prior art keywords
- peptide analogs
- processes
- treating diabetes
- insulin peptide
- insulin
- Prior art date
Links
- 108090001061 Insulin Proteins 0.000 title abstract 3
- 206010012601 diabetes mellitus Diseases 0.000 title abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 4
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 2
- 102000004877 Insulin Human genes 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 229940125396 insulin Drugs 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Endocrinology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2815698A | 1998-02-23 | 1998-02-23 | |
| PCT/US1999/003915 WO1999042482A1 (en) | 1998-02-23 | 1999-02-23 | Methods for treatment of diabetes using peptide analogues of insulin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9908178A true BR9908178A (pt) | 2002-01-15 |
Family
ID=21841884
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9908178-4A BR9908178A (pt) | 1998-02-23 | 1999-02-23 | Processos para tratamento de diabetes usando análogos peptìdios de insulina |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6197926B1 (https=) |
| EP (1) | EP1056776A1 (https=) |
| JP (1) | JP2002504491A (https=) |
| KR (1) | KR20010041238A (https=) |
| CN (1) | CN1241942C (https=) |
| AP (1) | AP2000001888A0 (https=) |
| AU (1) | AU741037B2 (https=) |
| BR (1) | BR9908178A (https=) |
| CA (1) | CA2321929A1 (https=) |
| EA (1) | EA003944B1 (https=) |
| HU (1) | HUP0100928A3 (https=) |
| ID (1) | ID26788A (https=) |
| IL (1) | IL137904A0 (https=) |
| NO (1) | NO20004198L (https=) |
| NZ (1) | NZ506447A (https=) |
| OA (1) | OA11453A (https=) |
| PL (1) | PL342517A1 (https=) |
| SK (1) | SK12412000A3 (https=) |
| TR (1) | TR200003048T2 (https=) |
| WO (1) | WO1999042482A1 (https=) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6562942B1 (en) * | 1999-02-23 | 2003-05-13 | Neurocrine Biosciences, Inc. | Methods for treatment of diabetes using peptide analogues of insulin |
| CN1125081C (zh) * | 1999-09-08 | 2003-10-22 | 中国科学院上海生物化学研究所 | 重组天然和新型人胰岛素及其制备方法 |
| WO2001085154A2 (en) * | 2000-05-12 | 2001-11-15 | Oregon Health Sciences University | Method of treating immune pathologies with low dose estrogen |
| US7462486B2 (en) * | 2000-05-12 | 2008-12-09 | Oregon Health & Science University | Methods of selecting T cell receptor V peptides for therapeutic use |
| US20020103131A1 (en) * | 2001-01-26 | 2002-08-01 | Jacobson Jill D. | Prevention of diabetes by administration of GnRH antagonists |
| US20070172453A1 (en) * | 2002-08-30 | 2007-07-26 | Vincent Geenen | Tolerogenic approach for type 1 diabetes |
| US20040138116A1 (en) * | 2002-08-30 | 2004-07-15 | Vincent Geenen | Tolerogenic approach for type 1 diabetes |
| US8987263B2 (en) | 2002-10-10 | 2015-03-24 | Meir Shinitzky | Basic esters of fatty alcohols and their use as anti-inflammatory or immunomodulatory agents |
| CA2527830A1 (en) * | 2003-06-02 | 2004-12-23 | Mercia Pharma, Inc. | Therapeutic vaccine compositions for the treatment of type 1 diabetes |
| US8053197B2 (en) * | 2004-07-30 | 2011-11-08 | Oregon Health & Science University | Methods for detecting and treating autoimmune disorders |
| US7833513B2 (en) | 2004-12-03 | 2010-11-16 | Rhode Island Hospital | Treatment of Alzheimer's Disease |
| DE102008003566A1 (de) * | 2008-01-09 | 2009-07-16 | Sanofi-Aventis Deutschland Gmbh | Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil |
| MY152979A (en) | 2008-01-09 | 2014-12-15 | Sanofi Aventis Deutschland | Novel insulin derivatives having an extremely delayed time-action profile |
| EP2249853A4 (en) | 2008-01-30 | 2012-12-26 | Univ Indiana Res & Tech Corp | ESTER BASED PEPTIDE PRODRUGS |
| RS59913B1 (sr) | 2008-10-17 | 2020-03-31 | Sanofi Aventis Deutschland | Kombinacija insulina i glp-1-agonista |
| JP5789515B2 (ja) * | 2008-12-19 | 2015-10-07 | インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ | インスリン類似体 |
| AU2009335715B2 (en) | 2008-12-19 | 2016-09-15 | Indiana University Research And Technology Corporation | Amide-based insulin prodrugs |
| US12370251B2 (en) | 2009-11-05 | 2025-07-29 | Mercia Pharma, Inc. | Adjuvanted nanoparticulate influenza vaccine |
| PT3345593T (pt) | 2009-11-13 | 2023-11-27 | Sanofi Aventis Deutschland | Composição farmacêutica compreendendo despro36exendina- 4(1-39)-lys6-nh2 e metionina |
| MY180661A (en) | 2009-11-13 | 2020-12-04 | Sanofi Aventis Deutschland | Pharmaceutical composition comprising a glp-1 agonist, an insulin and methionine |
| US20110311536A1 (en) * | 2010-06-11 | 2011-12-22 | Dana-Farber Cancer Institute, Inc. | Prevention of type 1 diabetes by treg vaccination with an insulin mimetope |
| JP5969469B2 (ja) | 2010-06-16 | 2016-08-17 | インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ | インスリン受容体に対して高い活性を示す単鎖インスリンアゴニスト |
| EP2585102B1 (en) | 2010-06-24 | 2015-05-06 | Indiana University Research and Technology Corporation | Amide-based insulin prodrugs |
| PL2611458T3 (pl) | 2010-08-30 | 2017-02-28 | Sanofi-Aventis Deutschland Gmbh | Zastosowanie AVE0010 do produkcji leku do leczenia cukrzycy typu 2 |
| US9821032B2 (en) | 2011-05-13 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin |
| UA113626C2 (xx) * | 2011-06-02 | 2017-02-27 | Композиція для лікування діабету, що містить кон'югат інсуліну тривалої дії та кон'югат інсулінотропного пептиду тривалої дії | |
| TWI559929B (en) | 2011-09-01 | 2016-12-01 | Sanofi Aventis Deutschland | Pharmaceutical composition for use in the treatment of a neurodegenerative disease |
| BR112014015156A2 (pt) | 2011-12-20 | 2020-10-27 | Indiana University Research And Technology Corporation | análogos de insulina à base de ctp, seus métodos de produção e uso no tratamento de hiperglicemia, bem como sequência de ácido nucleico e célula hospedeira |
| EP3395358B1 (en) | 2012-09-26 | 2019-11-06 | Indiana University Research and Technology Corporation | Insulin analog dimers |
| JP6538645B2 (ja) | 2013-03-14 | 2019-07-03 | インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ | インスリン‐インクレチン複合物 |
| JP6701208B2 (ja) | 2014-09-24 | 2020-05-27 | インディアナ ユニヴァーシティ リサーチ アンド テクノロジー コーポレイション | 脂質化アミド系インスリンプロドラッグ |
| CN108271356A (zh) | 2014-09-24 | 2018-07-10 | 印第安纳大学研究及科技有限公司 | 肠降血糖素-胰岛素缀合物 |
| EP3229828B1 (en) | 2014-12-12 | 2023-04-05 | Sanofi-Aventis Deutschland GmbH | Insulin glargine/lixisenatide fixed ratio formulation |
| TWI748945B (zh) | 2015-03-13 | 2021-12-11 | 德商賽諾菲阿凡提斯德意志有限公司 | 第２型糖尿病病患治療 |
| TW201705975A (zh) | 2015-03-18 | 2017-02-16 | 賽諾菲阿凡提斯德意志有限公司 | 第２型糖尿病病患之治療 |
| CN111925420B (zh) * | 2019-12-11 | 2022-04-01 | 山东大学 | 一种多肽作为嗅觉受体Olfr109激动剂配体的应用 |
| USD1043348S1 (en) * | 2021-09-24 | 2024-09-24 | H.J. Heinz Company Brands Llc | Bottle |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5008241A (en) * | 1985-03-12 | 1991-04-16 | Novo Nordisk A/S | Novel insulin peptides |
| PH25772A (en) * | 1985-08-30 | 1991-10-18 | Novo Industri As | Insulin analogues, process for their preparation |
| US5559094A (en) * | 1994-08-02 | 1996-09-24 | Eli Lilly And Company | AspB1 insulin analogs |
| US5594100A (en) * | 1995-02-22 | 1997-01-14 | Regents Of The University Of Colorado | Epitope for prevention of type I diabetes |
| EP0835129B1 (en) * | 1995-06-30 | 2003-10-29 | Novo Nordisk A/S | Prevention of a disease having the characteristics of diabetes |
-
1999
- 1999-02-23 WO PCT/US1999/003915 patent/WO1999042482A1/en not_active Ceased
- 1999-02-23 IL IL13790499A patent/IL137904A0/xx unknown
- 1999-02-23 HU HU0100928A patent/HUP0100928A3/hu unknown
- 1999-02-23 JP JP2000532434A patent/JP2002504491A/ja active Pending
- 1999-02-23 CA CA002321929A patent/CA2321929A1/en not_active Abandoned
- 1999-02-23 AP APAP/P/2000/001888A patent/AP2000001888A0/en unknown
- 1999-02-23 TR TR2000/03048T patent/TR200003048T2/xx unknown
- 1999-02-23 EP EP99908385A patent/EP1056776A1/en not_active Withdrawn
- 1999-02-23 SK SK1241-2000A patent/SK12412000A3/sk unknown
- 1999-02-23 AU AU27831/99A patent/AU741037B2/en not_active Ceased
- 1999-02-23 KR KR1020007009330A patent/KR20010041238A/ko not_active Abandoned
- 1999-02-23 US US09/255,668 patent/US6197926B1/en not_active Expired - Fee Related
- 1999-02-23 EA EA200000872A patent/EA003944B1/ru not_active IP Right Cessation
- 1999-02-23 CN CNB998042765A patent/CN1241942C/zh not_active Expired - Fee Related
- 1999-02-23 ID IDW20001917A patent/ID26788A/id unknown
- 1999-02-23 BR BR9908178-4A patent/BR9908178A/pt not_active IP Right Cessation
- 1999-02-23 PL PL99342517A patent/PL342517A1/xx not_active Application Discontinuation
- 1999-02-23 NZ NZ506447A patent/NZ506447A/xx unknown
-
2000
- 2000-08-22 NO NO20004198A patent/NO20004198L/no unknown
- 2000-08-22 OA OA1200000229A patent/OA11453A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SK12412000A3 (sk) | 2002-05-09 |
| EP1056776A1 (en) | 2000-12-06 |
| US6197926B1 (en) | 2001-03-06 |
| WO1999042482A1 (en) | 1999-08-26 |
| HUP0100928A3 (en) | 2001-11-28 |
| OA11453A (en) | 2003-12-08 |
| JP2002504491A (ja) | 2002-02-12 |
| HUP0100928A2 (hu) | 2001-08-28 |
| TR200003048T2 (tr) | 2000-12-21 |
| KR20010041238A (ko) | 2001-05-15 |
| NO20004198L (no) | 2000-10-20 |
| AU2783199A (en) | 1999-09-06 |
| CN1294597A (zh) | 2001-05-09 |
| AP2000001888A0 (en) | 2000-09-30 |
| ID26788A (id) | 2001-02-08 |
| EA003944B1 (ru) | 2003-10-30 |
| CA2321929A1 (en) | 1999-08-26 |
| NO20004198D0 (no) | 2000-08-22 |
| CN1241942C (zh) | 2006-02-15 |
| IL137904A0 (en) | 2001-10-31 |
| PL342517A1 (en) | 2001-06-18 |
| EA200000872A1 (ru) | 2001-02-26 |
| NZ506447A (en) | 2002-11-26 |
| AU741037B2 (en) | 2001-11-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 9A E 10A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 1990 DE 25/02/2009. |