BR9307687A - Análogos de insulina - Google Patents

Análogos de insulina

Info

Publication number
BR9307687A
BR9307687A BR9307687-8A BR9307687A BR9307687A BR 9307687 A BR9307687 A BR 9307687A BR 9307687 A BR9307687 A BR 9307687A BR 9307687 A BR9307687 A BR 9307687A
Authority
BR
Brazil
Prior art keywords
insulin analogues
analogs
insulin analogs
hyperglycemia
ile
Prior art date
Application number
BR9307687-8A
Other languages
English (en)
Inventor
Ronald Eugene Chance
Li Fan
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of BR9307687A publication Critical patent/BR9307687A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Emergency Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Patente de Invenção: <B>"ANáLOGOS DE INSULINA"<D> Análogos de insulina humana contendo um resíduo Ala, Gly, Val, Leu, Ile e Pro na posição 26 da cadeia B, e opcionalmente tendo modificações em outras posições, demonstram modificadas propriedades fisico-químicas e farmacocinéticas. Estes análogos são úteis no tratamento de hiperglicemia porque eles são estáveis e demonstram uma baixa tendência de se auto-agregarem.
BR9307687-8A 1992-12-18 1993-12-15 Análogos de insulina BR9307687A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US99565992A 1992-12-18 1992-12-18
PCT/US1993/012237 WO1994014461A1 (en) 1992-12-18 1993-12-15 Insulin analogs

Publications (1)

Publication Number Publication Date
BR9307687A true BR9307687A (pt) 2002-02-19

Family

ID=25542078

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9307687-8A BR9307687A (pt) 1992-12-18 1993-12-15 Análogos de insulina

Country Status (14)

Country Link
EP (1) EP0605983A3 (pt)
JP (1) JPH08504820A (pt)
CN (1) CN1094059A (pt)
AU (1) AU680462B2 (pt)
BR (1) BR9307687A (pt)
CA (1) CA2151134A1 (pt)
CZ (1) CZ158895A3 (pt)
FI (1) FI953001A0 (pt)
HU (1) HUT71583A (pt)
MX (1) MX9307991A (pt)
NO (1) NO952336L (pt)
PL (1) PL310007A1 (pt)
WO (1) WO1994014461A1 (pt)
ZA (1) ZA939477B (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5559094A (en) * 1994-08-02 1996-09-24 Eli Lilly And Company AspB1 insulin analogs
CN1125081C (zh) * 1999-09-08 2003-10-22 中国科学院上海生物化学研究所 重组天然和新型人胰岛素及其制备方法
DE10114178A1 (de) 2001-03-23 2002-10-10 Aventis Pharma Gmbh Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität
DE10227232A1 (de) 2002-06-18 2004-01-15 Aventis Pharma Deutschland Gmbh Saure Insulinzubereitungen mit verbesserter Stabilität
LT2349324T (lt) 2008-10-17 2017-12-27 Sanofi-Aventis Deutschland Gmbh Insulino ir glp-1 agonisto derinys
ES2534191T3 (es) 2009-11-13 2015-04-20 Sanofi-Aventis Deutschland Gmbh Composición farmacéutica que comprende un agonista de GLP-1, una insulina y metionina
PL2498801T3 (pl) 2009-11-13 2018-08-31 Sanofi Aventis Deutschland Kompozycja farmaceutyczna zawierająca desPro<sup>36</sup>eksendyno-4(1-39)-Lys6-NH2 i metioninę
HUE031181T2 (en) 2010-08-30 2017-06-28 Sanofi Aventis Deutschland Use of AVE0010 for the manufacture of a medicament for the treatment of type 2 diabetes
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
CN108079281A (zh) 2011-08-29 2018-05-29 赛诺菲-安万特德国有限公司 用于2型糖尿病患者中的血糖控制的药物组合
AR087744A1 (es) 2011-09-01 2014-04-16 Sanofi Aventis Deutschland Composicion farmaceutica para uso en el tratamiento de una enfermedad neurodegenerativa
AU2013323669B2 (en) * 2012-09-26 2018-03-01 Indiana University Research And Technology Corporation Insulin analog dimers
US9950039B2 (en) 2014-12-12 2018-04-24 Sanofi-Aventis Deutschland Gmbh Insulin glargine/lixisenatide fixed ratio formulation
TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患治療
TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患之治療

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH25772A (en) * 1985-08-30 1991-10-18 Novo Industri As Insulin analogues, process for their preparation
TW222643B (pt) * 1991-06-21 1994-04-21 Lilly Co Eli

Also Published As

Publication number Publication date
NO952336D0 (no) 1995-06-13
AU680462B2 (en) 1997-07-31
AU5827994A (en) 1994-07-19
PL310007A1 (en) 1995-11-13
CA2151134A1 (en) 1994-07-07
MX9307991A (es) 1994-08-31
EP0605983A3 (en) 1995-06-07
CN1094059A (zh) 1994-10-26
NO952336L (no) 1995-06-13
FI953001A (fi) 1995-06-16
JPH08504820A (ja) 1996-05-28
HUT71583A (en) 1995-12-28
WO1994014461A1 (en) 1994-07-07
FI953001A0 (fi) 1995-06-16
EP0605983A2 (en) 1994-07-13
HU9501762D0 (en) 1995-08-28
CZ158895A3 (en) 1995-12-13
ZA939477B (en) 1995-06-19

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Legal Events

Date Code Title Description
EG Technical examination (opinion): publication of technical examination (opinion)
FC Decision: refusal