BR9901403A - Biologia molecular para fabricação de isoprenóides - Google Patents

Biologia molecular para fabricação de isoprenóides

Info

Publication number
BR9901403A
BR9901403A BR9901403-3A BR9901403A BR9901403A BR 9901403 A BR9901403 A BR 9901403A BR 9901403 A BR9901403 A BR 9901403A BR 9901403 A BR9901403 A BR 9901403A
Authority
BR
Brazil
Prior art keywords
molecular biology
isoprenoid
manufacturing
isoprenoids
plasmids
Prior art date
Application number
BR9901403-3A
Other languages
English (en)
Inventor
Tatsuo Hoshino
Kazuyuki Ojima
Yutaka Setogushi
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR9901403A publication Critical patent/BR9901403A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P23/00—Preparation of compounds containing a cyclohexene ring having an unsaturated side chain containing at least ten carbon atoms bound by conjugated double bonds, e.g. carotenes

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Patente de Invenção: <B>"BIOLOGIA MOLECULAR PARA FABRICAçãO DE ISOPRENóIDES"<D>. A presente invenção é dirigida a uma codificação de seq³ência DNA isolada para uma enzima envolvida na etapa mevalonato ou a etapa de pirofosfato isopentenila para pirofosfato farnesila, vetores ou plasmídeos compreendendo tal DNA, hospedeiros transformados por quer tais DNAs ou vetores ou plasmídeos e um processo para a produção de isoprenoides e carotenóides através do uso de tais células hospedeiras transformadas.
BR9901403-3A 1998-05-06 1999-05-05 Biologia molecular para fabricação de isoprenóides BR9901403A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP98108210 1998-05-06

Publications (1)

Publication Number Publication Date
BR9901403A true BR9901403A (pt) 2000-10-17

Family

ID=8231884

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9901403-3A BR9901403A (pt) 1998-05-06 1999-05-05 Biologia molecular para fabricação de isoprenóides

Country Status (11)

Country Link
US (3) US6284506B1 (pt)
JP (2) JP2000050884A (pt)
KR (1) KR100626511B1 (pt)
CN (2) CN1262648C (pt)
AU (1) AU762939B2 (pt)
BR (1) BR9901403A (pt)
CA (1) CA2270711A1 (pt)
CL (1) CL2009002108A1 (pt)
ID (1) ID23300A (pt)
NO (1) NO992165L (pt)
TW (1) TWI250210B (pt)

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AU2001278098A1 (en) 2000-07-31 2002-02-13 Frederick M. Hahn Manipulation of genes of the mevalonate and isoprenoid pathways to create novel traits in transgenic organisms
JPWO2002031164A1 (ja) * 2000-10-06 2004-02-19 サッポロホールディングス株式会社 ファルネシルピロリン酸シンターゼタンパク質、核酸及びそのプロモーター領域
US6335190B1 (en) * 2000-10-20 2002-01-01 New England Biolabs, Inc. Method for cloning and producing the BsmI restriction endonuclease in E. coli
US6413758B1 (en) * 2000-10-20 2002-07-02 New England Biolabs, Inc. Method for cloning and expression of Bpml restriction endonuclease in E. coli
US7192751B2 (en) * 2001-12-06 2007-03-20 The Regents Of The University Of California Biosynthesis of amorpha-4,11-diene
US7172886B2 (en) * 2001-12-06 2007-02-06 The Regents Of The University Of California Biosynthesis of isopentenyl pyrophosphate
AU2003234790A1 (en) * 2002-05-10 2003-11-11 Kyowa Hakko Kogyo Co., Ltd. Process for producing mevalonic acid
US8524397B1 (en) 2004-11-08 2013-09-03 Quallion Llc Battery having high rate and high capacity capabilities
US7432076B2 (en) * 2002-09-27 2008-10-07 Dsm Ip Assets B.V. Astaxanthin production using fed-batch fermentation process by Phaffia rhodozyma
US7632317B2 (en) * 2002-11-04 2009-12-15 Quallion Llc Method for making a battery
KR101190897B1 (ko) 2003-06-12 2012-10-12 디에스엠 아이피 어셋츠 비.브이. 피드백 내성 메발로네이트 키나아제
JP4841562B2 (ja) * 2004-12-14 2011-12-21 ディーエスエム アイピー アセッツ ビー．ブイ． 改良型メバロネートキナーゼ
EP2371967B1 (en) 2005-03-18 2015-06-03 DSM IP Assets B.V. Production of carotenoids in oleaginous yeast and fungi
EP2078092A2 (en) 2006-09-28 2009-07-15 Microbia, Inc. Production of carotenoids in oleaginous yeast and fungi
KR100845582B1 (ko) * 2006-11-09 2008-07-11 부경대학교 산학협력단 이소프레노이드와 카로티노이드 생합성 유전자로 형질전환된 대장균 및 이를 이용한 아스타잔틴의 대량 생산방법
JP2009000046A (ja) * 2007-06-21 2009-01-08 Hitachi Zosen Corp トチュウのメバロン酸経路の酵素をコードする遺伝子
SG167566A1 (en) 2008-07-02 2011-01-28 Danisco Us Inc Compositions and methods for producing isoprene free of C5 hydrocarbons under decoupling conditions and/or safe operating ranges
US8232431B2 (en) * 2008-09-22 2012-07-31 The Procter & Gamble Company Specific branched surfactants and consumer products
WO2010033979A2 (en) 2008-09-22 2010-03-25 The Procter & Gamble Company Specific polybranched polyaldehydes, polyalcohols, and surfactants and consumer products based thereon
AU2010331946A1 (en) 2009-12-18 2012-06-28 Danisco Us Inc. Purification of isoprene from renewable resources
MY180803A (en) 2010-06-02 2020-12-09 Evolva Inc Recombinant production of steviol glycosides
WO2013022989A2 (en) 2011-08-08 2013-02-14 Evolva Sa Recombinant production of steviol glycosides
JP2015226469A (ja) * 2012-09-24 2015-12-17 株式会社カネカ 新規ｄｎａ、およびそれを利用したカロテノイドの製造方法
AU2014214004B2 (en) 2013-02-06 2018-05-24 Evolva Sa Methods for improved production of Rebaudioside D and Rebaudioside M
MY184253A (en) 2013-02-11 2021-03-29 Evolva Sa Efficient production of steviol glycosides in recombinant hosts
MX2015012287A (es) 2013-03-15 2015-12-16 Procter & Gamble Materiales funcionales especificos insaturados y ramificados para uso en productos para el consumidor.
JP6282813B2 (ja) * 2013-07-16 2018-02-21 住友ゴム工業株式会社 ヒドロキシメチルグルタリルＣｏＡレダクターゼの発現をｂＺＩＰ型転写因子により調整する方法、ｂＺＩＰ型転写因子をコードする遺伝子が導入されたイソプレノイド産生植物、及び該イソプレノイド産生植物を用いたポリイソプレノイドの製造方法
AU2015244729C1 (en) 2014-04-09 2021-05-27 Adeka Corporation Mutant enzyme and production method for terpenoid using said mutant enzyme
SG10201901007PA (en) 2014-08-11 2019-03-28 Evolva Sa Production of steviol glycosides in recombinant hosts
AU2015314251A1 (en) 2014-09-09 2017-03-16 Evolva Sa Production of steviol glycosides in recombinant hosts
US10364450B2 (en) 2015-01-30 2019-07-30 Evolva Sa Production of steviol glycoside in recombinant hosts
US10604743B2 (en) 2015-03-16 2020-03-31 Dsm Ip Assets B.V. UDP-glycosyltransferases
EP3332018B1 (en) 2015-08-07 2022-07-27 Evolva SA Production of steviol glycosides in recombinant hosts
MY198001A (en) 2016-04-13 2023-07-25 Evolva Sa Production of steviol glycoside in recombinant hosts
WO2017198682A1 (en) 2016-05-16 2017-11-23 Evolva Sa Production of steviol glycosides in recombinant hosts
WO2018083338A1 (en) 2016-11-07 2018-05-11 Evolva Sa Production of steviol glycosides in recombinant hosts
WO2019113387A1 (en) 2017-12-07 2019-06-13 Zymergen Inc. Engineered biosynthetic pathways for production of (6e)-8-hydroxygeraniol by fermentation
CA3086490A1 (en) 2017-12-21 2019-06-27 Zymergen Inc. Nepetalactol oxidoreductases, nepetalactol synthases, and microbes capable of producing nepetalactone
CN109777815B (zh) * 2019-03-28 2021-10-29 昆明理工大学 HMG-CoA合成酶基因RKHMGCS及其应用
CN113621631A (zh) * 2021-08-11 2021-11-09 昆明理工大学 一种甲羟戊酸激酶基因rkmk及其应用

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US5460949A (en) 1990-11-15 1995-10-24 Amoco Corporation Method and composition for increasing the accumulation of squalene and specific sterols in yeast
JP2754975B2 (ja) 1991-10-01 1998-05-20 トヨタ自動車株式会社 ファルネシル二リン酸合成酵素およびそれをコードするｄｎａ配列
FR2687284B1 (fr) 1992-02-14 1995-06-23 Verneuil Rech Plante portant des genes codant pour des enzymes de la voie de biosynthese des phytosterols, et procede d'obtention.
NZ248628A (en) 1992-09-11 1996-02-27 Gist Brocades Nv Transformed phaffia (yeast) strains and methods and vectors used
JP2000507087A (ja) 1995-12-22 2000-06-13 ギスト ブロカデス ベスローテン ファンノートシャップ ファフィア株を形質転換する改良法、そのようにして得られた形質転換したファフィア株及び前記方法における組換えｄｎａ
JPH10248575A (ja) 1997-03-12 1998-09-22 Kirin Brewery Co Ltd カロチノイド生産の増量に有用な遺伝子、およびカロチノイドの製造法

Also Published As

Publication number Publication date
US20030190734A1 (en) 2003-10-09
TWI250210B (en) 2006-03-01
US6586202B2 (en) 2003-07-01
KR19990088053A (ko) 1999-12-27
ID23300A (id) 2000-04-05
CN100487120C (zh) 2009-05-13
AU762939B2 (en) 2003-07-10
CN1970770A (zh) 2007-05-30
JP2010104378A (ja) 2010-05-13
KR100626511B1 (ko) 2006-09-20
US20030054523A1 (en) 2003-03-20
CL2009002108A1 (es) 2010-04-09
CA2270711A1 (en) 1999-11-06
CN1262648C (zh) 2006-07-05
AU2696299A (en) 1999-11-18
JP2000050884A (ja) 2000-02-22
NO992165D0 (no) 1999-05-04
US6872556B2 (en) 2005-03-29
US6284506B1 (en) 2001-09-04
CN1234445A (zh) 1999-11-10
NO992165L (no) 1999-11-08

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Legal Events

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B25A Requested transfer of rights approved

Free format text: DSM IP ASSETS B.V. (NL)

B07A Technical examination (opinion): publication of technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: PORTANTO, INDEFIRO O PRESENTE PEDIDO DE PATENTE COMO INVENCAO DE ACORDO COM O ARTS. 8O, 10 (IX), 11, 18(III) E 25.

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.