BR9815711B1

BR9815711B1 - Composto antibiótico derivado de esteróide

Composto antibiótico derivado de esteróide Download PDF

Info

Publication number: BR9815711B1
Authority: BR; Brazil
Prior art keywords: compound; mmol; nmr; mhz; added
Prior art date: 1998-03-06

Application number

BRPI9815711-6A

Other languages

English (en)

Portuguese (pt)

Other versions

BR9815711A (pt

Inventor

Paul B Savage

Chunhong Li

Original Assignee

Univ Brigham Young

Priority date

1998-03-06

Filing date

1998-03-06

Publication date

2014-10-29

1998-03-06 Application filed by Univ Brigham Young filed Critical Univ Brigham Young

2001-11-13 Publication of BR9815711A publication Critical patent/BR9815711A/pt

2014-10-29 Publication of BR9815711B1 publication Critical patent/BR9815711B1/pt

Links

150000001875 compounds Chemical class 0.000 title claims description 135
150000003431 steroids Chemical class 0.000 title abstract description 29
230000003115 biocidal effect Effects 0.000 title description 16
241000894006 Bacteria Species 0.000 abstract description 37
239000003242 anti bacterial agent Substances 0.000 abstract description 33
229940088710 antibiotic agent Drugs 0.000 abstract description 26
YJQPYGGHQPGBLI-UHFFFAOYSA-N Novobiocin Natural products O1C(C)(C)C(OC)C(OC(N)=O)C(O)C1OC1=CC=C(C(O)=C(NC(=O)C=2C=C(CC=C(C)C)C(O)=CC=2)C(=O)O2)C2=C1C YJQPYGGHQPGBLI-UHFFFAOYSA-N 0.000 abstract description 6
229960002950 novobiocin Drugs 0.000 abstract description 6
YJQPYGGHQPGBLI-KGSXXDOSSA-N novobiocin Chemical compound O1C(C)(C)[C@H](OC)[C@@H](OC(N)=O)[C@@H](O)[C@@H]1OC1=CC=C(C(O)=C(NC(=O)C=2C=C(CC=C(C)C)C(O)=CC=2)C(=O)O2)C2=C1C YJQPYGGHQPGBLI-KGSXXDOSSA-N 0.000 abstract description 6
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 126
239000011734 sodium Substances 0.000 description 110
HEDRZPFGACZZDS-MICDWDOJSA-N Trichloro(2H)methane Chemical compound [2H]C(Cl)(Cl)Cl HEDRZPFGACZZDS-MICDWDOJSA-N 0.000 description 106
239000000203 mixture Substances 0.000 description 86
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 82
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238000005481 NMR spectroscopy Methods 0.000 description 54
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239000011159 matrix material Substances 0.000 description 48
PJUIMOJAAPLTRJ-UHFFFAOYSA-N monothioglycerol Chemical compound OCC(O)CS PJUIMOJAAPLTRJ-UHFFFAOYSA-N 0.000 description 48
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