BR9815070A - Compostos tendo efeito inibitório da cgmp-pde - Google Patents
Compostos tendo efeito inibitório da cgmp-pdeInfo
- Publication number
- BR9815070A BR9815070A BR9815070-7A BR9815070A BR9815070A BR 9815070 A BR9815070 A BR 9815070A BR 9815070 A BR9815070 A BR 9815070A BR 9815070 A BR9815070 A BR 9815070A
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- cgmp
- pde
- ring
- inhibitory effect
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/06—Peri-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Urology & Nephrology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Vascular Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Patente de Invenção: ''COMPOSTOS TENDO EFEITO INIBITóRIO DA CGMP-PDE''<D>. A presente invenção proporciona novos compostos com hetero-anel tetracíclico condensado tendo ação na inibição altamente seletiva da GMP-fosfodiesterase cíclica (aqui depois abreviada como cGMP-PDE), processos para a produção de tais compostos, agentes contendo pelo menos um de tais compostos como um ingrediente ativo e usados para prevenção e/ou tratamento de hipertensão pulmonar, doenças cardíacas isquêmicas, disfunção erétil, ou doenças contra as quais a inibição da cGMP-PDE é efetiva e intermediários úteis para a produção dos compostos com hetero-anel tetracíclico condensado. O assunto acima é obtido através dos novos compostos com hetero-anel tetracíclico condensado.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP34416497 | 1997-11-28 | ||
PCT/JP1998/005350 WO1999028319A1 (fr) | 1997-11-28 | 1998-11-27 | NOUVEAUX COMPOSES PRESENTANT UN EFFET INHIBITEUR DE cGMP-PDE |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9815070A true BR9815070A (pt) | 2000-10-03 |
Family
ID=18367131
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9815070-7A BR9815070A (pt) | 1997-11-28 | 1998-11-27 | Compostos tendo efeito inibitório da cgmp-pde |
Country Status (14)
Country | Link |
---|---|
US (1) | US6476021B1 (pt) |
EP (1) | EP1048666A4 (pt) |
KR (1) | KR20010032546A (pt) |
CN (1) | CN1284075A (pt) |
AU (1) | AU746883B2 (pt) |
BR (1) | BR9815070A (pt) |
CA (1) | CA2311947A1 (pt) |
HU (1) | HUP0100083A3 (pt) |
IL (1) | IL136340A0 (pt) |
MX (1) | MXPA00005190A (pt) |
NO (1) | NO20002696L (pt) |
PL (1) | PL340789A1 (pt) |
WO (1) | WO1999028319A1 (pt) |
ZA (1) | ZA9810766B (pt) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1090022B1 (en) | 1998-06-23 | 2003-08-06 | Glaxo Group Limited | 2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives |
AU5204800A (en) * | 1999-06-21 | 2001-01-09 | Biochemical Pharmaceutical Factory of Zhuhai Sez, The | Process for preparing sildenafil, and troche which comprises sildenafil and apomorphine |
DE19954707A1 (de) * | 1999-11-13 | 2001-05-17 | Merck Patent Gmbh | Imidazolverbindungen als Phosphodiesterase VII-Hemmer |
WO2001068648A1 (en) * | 2000-03-15 | 2001-09-20 | Aventis Pharma Deutschland Gmbh | Substituted beta-carbolines with ikb-kinase inhibiting activity |
NZ521386A (en) | 2000-03-15 | 2004-06-25 | Aventis Pharma Gmbh | Substituted beta-carbolines with lkB-kinase inhibiting activity |
AU2001255849B8 (en) | 2000-04-19 | 2006-04-27 | Lilly Icos, Llc. | PDE-V inhibitors for treatment of Parkinson's Disease |
US6271228B1 (en) * | 2000-04-28 | 2001-08-07 | Pfizer Inc. | Blood pressure stabilization during hemodialysis |
UA80258C2 (en) * | 2001-09-06 | 2007-09-10 | Biogen Inc | Methods of treating pulmonary disease |
CA2470210A1 (en) * | 2001-12-17 | 2003-06-26 | Altana Pharma Ag | Use of selective pde5 inhibitors for treating partial and global respiratory failure |
GB0202254D0 (en) * | 2002-01-31 | 2002-03-20 | Pfizer Ltd | Prevention of scarring |
US8133903B2 (en) | 2003-10-21 | 2012-03-13 | Los Angeles Biomedical Research Institute at Harbor—UCLA Medical Center | Methods of use of inhibitors of phosphodiesterases and modulators of nitric oxide, reactive oxygen species, and metalloproteinases in the treatment of peyronie's disease, arteriosclerosis and other fibrotic diseases |
US7601856B2 (en) * | 2006-07-27 | 2009-10-13 | Wyeth | Benzofurans as potassium ion channel modulators |
US7662831B2 (en) * | 2006-07-27 | 2010-02-16 | Wyeth Llc | Tetracyclic indoles as potassium channel modulators |
WO2017168174A1 (en) | 2016-04-02 | 2017-10-05 | N4 Pharma Uk Limited | New pharmaceutical forms of sildenafil |
CN115872991A (zh) * | 2021-09-26 | 2023-03-31 | 深圳大学 | β-咔伯啉生物碱类化合物及其药用组合物、制备方法和应用 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CS261338B1 (cs) * | 1987-09-17 | 1989-06-15 | Viktor Zikan | Způsob přípravy 10-nitro-4-oxo-4H-chino/2,3,4-i,j//1,4/benzoxazinových derivátů |
GB9126260D0 (en) * | 1991-12-11 | 1992-02-12 | Pfizer Ltd | Therapeutic agents |
PH31122A (en) * | 1993-03-31 | 1998-02-23 | Eisai Co Ltd | Nitrogen-containing fused-heterocycle compounds. |
JPH0710843A (ja) * | 1993-03-31 | 1995-01-13 | Eisai Co Ltd | 含窒素縮合複素環化合物 |
ES2224130T3 (es) * | 1994-08-09 | 2005-03-01 | Eisai Co., Ltd. | Compuesto de piridazina condensada. |
GB9423910D0 (en) * | 1994-11-26 | 1995-01-11 | Pfizer Ltd | Therapeutic agents |
JP3713783B2 (ja) * | 1995-01-20 | 2005-11-09 | 大正製薬株式会社 | 1H−ピラゾロ[3,4−d]ピリミジン−4−オン誘導体 |
WO1997045427A1 (fr) * | 1996-05-31 | 1997-12-04 | Mochida Pharmaceutical Co., Ltd. | DERIVES DE PYRIDOCARBAZOLE AYANT UN EFFET INHIBITEUR DE cGMP-PDE |
CN1309561A (zh) * | 1997-05-29 | 2001-08-22 | 持田制药株式会社 | 勃起机能障碍治疗剂 |
WO1999026946A1 (fr) * | 1997-11-26 | 1999-06-03 | Mochida Pharmaceutical Co., Ltd. | DERIVES DE PYRIDOCARBAZOLE A ACTIVITE INHIBITRICE SUR LA cGMP-PDE |
-
1998
- 1998-11-25 ZA ZA9810766A patent/ZA9810766B/xx unknown
- 1998-11-27 WO PCT/JP1998/005350 patent/WO1999028319A1/ja not_active Application Discontinuation
- 1998-11-27 EP EP98955965A patent/EP1048666A4/en not_active Withdrawn
- 1998-11-27 KR KR1020007005789A patent/KR20010032546A/ko not_active Application Discontinuation
- 1998-11-27 BR BR9815070-7A patent/BR9815070A/pt not_active IP Right Cessation
- 1998-11-27 CA CA002311947A patent/CA2311947A1/en not_active Abandoned
- 1998-11-27 MX MXPA00005190A patent/MXPA00005190A/es unknown
- 1998-11-27 HU HU0100083A patent/HUP0100083A3/hu unknown
- 1998-11-27 PL PL98340789A patent/PL340789A1/xx not_active Application Discontinuation
- 1998-11-27 CN CN98813341A patent/CN1284075A/zh active Pending
- 1998-11-27 AU AU12617/99A patent/AU746883B2/en not_active Ceased
- 1998-11-27 IL IL13634098A patent/IL136340A0/xx unknown
-
2000
- 2000-05-26 NO NO20002696A patent/NO20002696L/no not_active Application Discontinuation
- 2000-05-26 US US09/580,657 patent/US6476021B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
AU1261799A (en) | 1999-06-16 |
US6476021B1 (en) | 2002-11-05 |
MXPA00005190A (es) | 2002-04-24 |
ZA9810766B (en) | 1999-05-25 |
EP1048666A1 (en) | 2000-11-02 |
HUP0100083A3 (en) | 2002-01-28 |
IL136340A0 (en) | 2001-05-20 |
HUP0100083A2 (hu) | 2001-08-28 |
NO20002696D0 (no) | 2000-05-26 |
CA2311947A1 (en) | 1999-06-10 |
KR20010032546A (ko) | 2001-04-25 |
WO1999028319A1 (fr) | 1999-06-10 |
PL340789A1 (en) | 2001-02-26 |
AU746883B2 (en) | 2002-05-02 |
NO20002696L (no) | 2000-07-24 |
EP1048666A4 (en) | 2001-10-31 |
CN1284075A (zh) | 2001-02-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 5O, 6O, 7O E 8O ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1910 DE 14/08/2007. |