IL136340A0 - NOVEL COMPOUNDS HAVING cGMP-PDE INHIBITORY EFFECT - Google Patents
NOVEL COMPOUNDS HAVING cGMP-PDE INHIBITORY EFFECTInfo
- Publication number
- IL136340A0 IL136340A0 IL13634098A IL13634098A IL136340A0 IL 136340 A0 IL136340 A0 IL 136340A0 IL 13634098 A IL13634098 A IL 13634098A IL 13634098 A IL13634098 A IL 13634098A IL 136340 A0 IL136340 A0 IL 136340A0
- Authority
- IL
- Israel
- Prior art keywords
- cgmp
- inhibitory effect
- novel compounds
- pde inhibitory
- pde
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/06—Peri-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Vascular Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Urology & Nephrology (AREA)
- Pharmacology & Pharmacy (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP34416497 | 1997-11-28 | ||
| PCT/JP1998/005350 WO1999028319A1 (fr) | 1997-11-28 | 1998-11-27 | NOUVEAUX COMPOSES PRESENTANT UN EFFET INHIBITEUR DE cGMP-PDE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL136340A0 true IL136340A0 (en) | 2001-05-20 |
Family
ID=18367131
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL13634098A IL136340A0 (en) | 1997-11-28 | 1998-11-27 | NOVEL COMPOUNDS HAVING cGMP-PDE INHIBITORY EFFECT |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US6476021B1 (pt) |
| EP (1) | EP1048666A4 (pt) |
| KR (1) | KR20010032546A (pt) |
| CN (1) | CN1284075A (pt) |
| AU (1) | AU746883B2 (pt) |
| BR (1) | BR9815070A (pt) |
| CA (1) | CA2311947A1 (pt) |
| HU (1) | HUP0100083A3 (pt) |
| IL (1) | IL136340A0 (pt) |
| MX (1) | MXPA00005190A (pt) |
| NO (1) | NO20002696L (pt) |
| PL (1) | PL340789A1 (pt) |
| WO (1) | WO1999028319A1 (pt) |
| ZA (1) | ZA9810766B (pt) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA200001224A1 (ru) | 1998-06-23 | 2001-08-27 | Глаксо Груп Лимитед | Производные 2-(пурин-9-ил)-тетрагидрофуран-3,4-диола |
| WO2000078760A1 (fr) * | 1999-06-21 | 2000-12-28 | The Biochemical Pharmaceutical Factory Of Zhuhai Sez | Procede de preparation de sildenafil, agent et procede d'obtention d'un comprime mixte a base de sildenafil et de chlorhydrate d'apomorphine |
| DE19954707A1 (de) * | 1999-11-13 | 2001-05-17 | Merck Patent Gmbh | Imidazolverbindungen als Phosphodiesterase VII-Hemmer |
| EP1268477B1 (en) * | 2000-03-15 | 2010-04-21 | Sanofi-Aventis Deutschland GmbH | Substituted beta-carbolines with ikb-kinase inhibiting activity |
| PL357284A1 (en) * | 2000-03-15 | 2004-07-26 | Aventis Pharma Deutschland Gmbh | Substituted beta-carbolines with ikb-kinase inhibiting activity |
| US20020006926A1 (en) | 2000-04-19 | 2002-01-17 | Roylance H. H. | Use of cyclic GMP-specific phosphodiesterase inhibitors for treatment of parkinson's disease |
| US6271228B1 (en) * | 2000-04-28 | 2001-08-07 | Pfizer Inc. | Blood pressure stabilization during hemodialysis |
| UA80258C2 (en) * | 2001-09-06 | 2007-09-10 | Biogen Inc | Methods of treating pulmonary disease |
| WO2003051346A2 (en) * | 2001-12-17 | 2003-06-26 | Altana Pharma Ag | Use of selective pde5 inhibitors for treating partial and global respiratory failure |
| GB0202254D0 (en) * | 2002-01-31 | 2002-03-20 | Pfizer Ltd | Prevention of scarring |
| US8133903B2 (en) | 2003-10-21 | 2012-03-13 | Los Angeles Biomedical Research Institute at Harbor—UCLA Medical Center | Methods of use of inhibitors of phosphodiesterases and modulators of nitric oxide, reactive oxygen species, and metalloproteinases in the treatment of peyronie's disease, arteriosclerosis and other fibrotic diseases |
| US7662831B2 (en) * | 2006-07-27 | 2010-02-16 | Wyeth Llc | Tetracyclic indoles as potassium channel modulators |
| US7601856B2 (en) * | 2006-07-27 | 2009-10-13 | Wyeth | Benzofurans as potassium ion channel modulators |
| WO2017168174A1 (en) | 2016-04-02 | 2017-10-05 | N4 Pharma Uk Limited | New pharmaceutical forms of sildenafil |
| CN115872991B (zh) * | 2021-09-26 | 2024-08-23 | 深圳大学 | β-咔伯啉生物碱类化合物及其药用组合物、制备方法和应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CS261338B1 (cs) * | 1987-09-17 | 1989-06-15 | Viktor Zikan | Způsob přípravy 10-nitro-4-oxo-4H-chino/2,3,4-i,j//1,4/benzoxazinových derivátů |
| GB9126260D0 (en) * | 1991-12-11 | 1992-02-12 | Pfizer Ltd | Therapeutic agents |
| PH31122A (en) * | 1993-03-31 | 1998-02-23 | Eisai Co Ltd | Nitrogen-containing fused-heterocycle compounds. |
| JPH0710843A (ja) * | 1993-03-31 | 1995-01-13 | Eisai Co Ltd | 含窒素縮合複素環化合物 |
| EP0722936B1 (en) * | 1994-08-09 | 2004-05-19 | Eisai Co., Ltd. | Fused pyridazine compound |
| GB9423910D0 (en) * | 1994-11-26 | 1995-01-11 | Pfizer Ltd | Therapeutic agents |
| JP3713783B2 (ja) * | 1995-01-20 | 2005-11-09 | 大正製薬株式会社 | １Ｈ−ピラゾロ［３，４−ｄ］ピリミジン−４−オン誘導体 |
| EP0985671B1 (en) * | 1996-05-31 | 2003-04-02 | Mochida Pharmaceutical Co., Ltd. | PYRIDOCARBAZOLE DERIVATIVES HAVING cGMP-PDE INHIBITORY EFFECT |
| EP0992240A4 (en) * | 1997-05-29 | 2003-04-16 | Mochida Pharm Co Ltd | THERAPEUTIC AGENT FOR TREATING ANERECTION |
| WO1999026946A1 (fr) * | 1997-11-26 | 1999-06-03 | Mochida Pharmaceutical Co., Ltd. | DERIVES DE PYRIDOCARBAZOLE A ACTIVITE INHIBITRICE SUR LA cGMP-PDE |
-
1998
- 1998-11-25 ZA ZA9810766A patent/ZA9810766B/xx unknown
- 1998-11-27 BR BR9815070-7A patent/BR9815070A/pt not_active IP Right Cessation
- 1998-11-27 CN CN98813341A patent/CN1284075A/zh active Pending
- 1998-11-27 PL PL98340789A patent/PL340789A1/xx not_active Application Discontinuation
- 1998-11-27 IL IL13634098A patent/IL136340A0/xx unknown
- 1998-11-27 CA CA002311947A patent/CA2311947A1/en not_active Abandoned
- 1998-11-27 HU HU0100083A patent/HUP0100083A3/hu unknown
- 1998-11-27 WO PCT/JP1998/005350 patent/WO1999028319A1/ja not_active Application Discontinuation
- 1998-11-27 AU AU12617/99A patent/AU746883B2/en not_active Ceased
- 1998-11-27 EP EP98955965A patent/EP1048666A4/en not_active Withdrawn
- 1998-11-27 KR KR1020007005789A patent/KR20010032546A/ko not_active Application Discontinuation
- 1998-11-27 MX MXPA00005190A patent/MXPA00005190A/es unknown
-
2000
- 2000-05-26 NO NO20002696A patent/NO20002696L/no not_active Application Discontinuation
- 2000-05-26 US US09/580,657 patent/US6476021B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2311947A1 (en) | 1999-06-10 |
| HUP0100083A2 (hu) | 2001-08-28 |
| MXPA00005190A (es) | 2002-04-24 |
| WO1999028319A1 (fr) | 1999-06-10 |
| EP1048666A4 (en) | 2001-10-31 |
| ZA9810766B (en) | 1999-05-25 |
| HUP0100083A3 (en) | 2002-01-28 |
| PL340789A1 (en) | 2001-02-26 |
| US6476021B1 (en) | 2002-11-05 |
| EP1048666A1 (en) | 2000-11-02 |
| NO20002696L (no) | 2000-07-24 |
| KR20010032546A (ko) | 2001-04-25 |
| CN1284075A (zh) | 2001-02-14 |
| BR9815070A (pt) | 2000-10-03 |
| AU1261799A (en) | 1999-06-16 |
| AU746883B2 (en) | 2002-05-02 |
| NO20002696D0 (no) | 2000-05-26 |
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