BR9813990A - Processo para a preparação de l-carnitina a partir de crotono-betaìna - Google Patents

Processo para a preparação de l-carnitina a partir de crotono-betaìna

Info

Publication number
BR9813990A
BR9813990A BR9813990-8A BR9813990A BR9813990A BR 9813990 A BR9813990 A BR 9813990A BR 9813990 A BR9813990 A BR 9813990A BR 9813990 A BR9813990 A BR 9813990A
Authority
BR
Brazil
Prior art keywords
crotonobetaine
carnitine
reaction medium
reactor
cells
Prior art date
Application number
BR9813990-8A
Other languages
English (en)
Inventor
Hans-Peter Kleber
Manuel Canovas-Diaz
Jose Maria Obon
Jose Luis Iborra
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Publication of BR9813990A publication Critical patent/BR9813990A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/007—Carnitine; Butyrobetaine; Crotonobetaine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/848—Escherichia
    • Y10S435/849—Escherichia coli

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

Patente de Invenção: <B>"PROCESSO PARA A PREPARAçãO DE L-CARNITINA A PARTIR DE CROTONOBETAìNA"<D>. A invenção refere-se a um processo para a preparação de L(-)-carnitina. A essência da invenção consiste em preparar um processo, que de maneira economicamente vantajosa permite a síntese de L(-)-carnitina a partir de crotonobetaína, sais ou derivados de crotonobetaína mediante células imobilizadas de Escherichia coli 044 K74 em um reator de reciclagem de células que trabalha continuamente. Células em crescimento ou em repouso de E. coli são retidas em um reator de reciclagem de células que trabalha continuamente por membranas de micro- ou de ultrafiltração, que estão dispostas como módulo de membrana plana ou de fibra oca.
BR9813990-8A 1997-11-08 1998-11-09 Processo para a preparação de l-carnitina a partir de crotono-betaìna BR9813990A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19749480A DE19749480A1 (de) 1997-11-08 1997-11-08 Verfahren zur Herstellung von L-Carnitin aus Crotonobetain
PCT/EP1998/007124 WO1999024597A1 (de) 1997-11-08 1998-11-09 Verfahren zur herstellung von l-carnitin aus crotonobetain

Publications (1)

Publication Number Publication Date
BR9813990A true BR9813990A (pt) 2000-09-26

Family

ID=7848083

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9813990-8A BR9813990A (pt) 1997-11-08 1998-11-09 Processo para a preparação de l-carnitina a partir de crotono-betaìna

Country Status (15)

Country Link
US (1) US6653112B2 (pt)
EP (1) EP1049794B1 (pt)
JP (1) JP2001521760A (pt)
KR (1) KR100575297B1 (pt)
CN (1) CN1163615C (pt)
AT (1) ATE236989T1 (pt)
AU (1) AU743520B2 (pt)
BR (1) BR9813990A (pt)
CA (1) CA2314328A1 (pt)
DE (2) DE19749480A1 (pt)
DK (1) DK1049794T3 (pt)
ES (1) ES2152864B1 (pt)
HK (1) HK1031237A1 (pt)
PT (1) PT1049794E (pt)
WO (1) WO1999024597A1 (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7700074B2 (en) * 2002-02-07 2010-04-20 Pettegrew Jay W Method and system for diagnosis of neuropsychiatric disorders including chronic alcoholism
US7407778B2 (en) * 2002-02-07 2008-08-05 Pettegrew Jay W Compounds, compositions and methods for treating neuropsychiatric disorders
ES2220219B1 (es) * 2003-05-23 2005-10-01 Universidad De Murcia Procedimiento para la produccion de l-carnitina a partir de crotonobetaina, d-carnitina, sus sales y derivados, mediante celulas permeabilizadas de proteus sp. o escherichia coli.
US20060257842A1 (en) * 2003-05-29 2006-11-16 Pettegrew Jay W Cryopreservation media and molecules
EP1641806B1 (en) * 2003-05-29 2009-07-29 Jay W. Pettegrew Glycerophosphocholine and its derivatives for medical imaging of neuropsychiatric disorders
FR3025213A1 (fr) * 2014-08-28 2016-03-04 Algobiotech Procede d'induction de la synthese des phycobiliproteines
CN104928225B (zh) * 2015-05-27 2018-06-12 武汉中科光谷绿色生物技术有限公司 一种产l-肉碱的大肠杆菌基因工程菌及构建方法和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD221905B1 (de) * 1983-11-03 1987-03-18 Univ Leipzig Verfahren zur herstellung von l(-)-carnitin und seinen derivaten
FI86889C (fi) * 1984-03-29 1992-10-26 Lonza Ag Foerfarande foer framstaellning av av l-karnitin pao mikrobiologiskt saett
CH664374A5 (de) * 1985-02-27 1988-02-29 Lonza Ag Verfahren zur herstellung von l-carnitin auf mikrobiologischem weg.
US4978616A (en) * 1985-02-28 1990-12-18 Verax Corporation Fluidized cell cultivation process
DD281735A7 (de) * 1987-10-26 1990-08-22 Univ Leipzig Verfahren zur enzymatischen synthese von l(-)-carnitin
EP0320460B1 (en) * 1987-10-26 1994-04-27 Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. Process for isolating the enzyme carnitinehydrolyase from strains belonging to the family enterobacteriaceae and use of the immobilized enzyme for producing L(-)-carnitine

Also Published As

Publication number Publication date
HK1031237A1 (en) 2001-06-08
CN1163615C (zh) 2004-08-25
EP1049794A1 (de) 2000-11-08
ES2152864A1 (es) 2001-02-01
DK1049794T3 (da) 2003-07-28
AU743520B2 (en) 2002-01-31
EP1049794B1 (de) 2003-04-09
CN1278303A (zh) 2000-12-27
DE19749480A1 (de) 1999-05-20
US20030073203A1 (en) 2003-04-17
DE59807901D1 (de) 2003-05-15
US6653112B2 (en) 2003-11-25
CA2314328A1 (en) 1999-05-20
WO1999024597A1 (de) 1999-05-20
ES2152864B1 (es) 2001-09-01
AU2243699A (en) 1999-05-31
PT1049794E (pt) 2003-08-29
ATE236989T1 (de) 2003-04-15
KR20010031894A (ko) 2001-04-16
KR100575297B1 (ko) 2006-05-02
JP2001521760A (ja) 2001-11-13

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: DE ACORDO COM O ART. 36 DA LPI (LEI 9279/96) 2O, O PEDIDO VOLTA A EXAME SENDO CONSIDERADO NAO PATENTEAVEL PELAS RAZOES EXPOSTAS NO PARECER TECNICO ANTERIOR. PORTANTO, INDEFIRO O PRESENTE PEDIDO DE PATENTE COMO INVENCAO - DE ACORDO COM O ART. 8O DA LPI.

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.