DK1049794T3 - Fremgangsmåde til fremstilling af L-carnitin af crotonobetain - Google Patents

Fremgangsmåde til fremstilling af L-carnitin af crotonobetain

Info

Publication number
DK1049794T3
DK1049794T3 DK98963424T DK98963424T DK1049794T3 DK 1049794 T3 DK1049794 T3 DK 1049794T3 DK 98963424 T DK98963424 T DK 98963424T DK 98963424 T DK98963424 T DK 98963424T DK 1049794 T3 DK1049794 T3 DK 1049794T3
Authority
DK
Denmark
Prior art keywords
crotonobetaine
carnitine
reaction medium
reactor
cells
Prior art date
Application number
DK98963424T
Other languages
English (en)
Inventor
Hans-Peter Kleber
Manuel Canovas-Diaz
Jose Maria Obon
Jose Luis Iborra
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Application granted granted Critical
Publication of DK1049794T3 publication Critical patent/DK1049794T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/007—Carnitine; Butyrobetaine; Crotonobetaine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/848—Escherichia
    • Y10S435/849—Escherichia coli

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
DK98963424T 1997-11-08 1998-11-09 Fremgangsmåde til fremstilling af L-carnitin af crotonobetain DK1049794T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19749480A DE19749480A1 (de) 1997-11-08 1997-11-08 Verfahren zur Herstellung von L-Carnitin aus Crotonobetain
PCT/EP1998/007124 WO1999024597A1 (de) 1997-11-08 1998-11-09 Verfahren zur herstellung von l-carnitin aus crotonobetain

Publications (1)

Publication Number Publication Date
DK1049794T3 true DK1049794T3 (da) 2003-07-28

Family

ID=7848083

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98963424T DK1049794T3 (da) 1997-11-08 1998-11-09 Fremgangsmåde til fremstilling af L-carnitin af crotonobetain

Country Status (15)

Country Link
US (1) US6653112B2 (da)
EP (1) EP1049794B1 (da)
JP (1) JP2001521760A (da)
KR (1) KR100575297B1 (da)
CN (1) CN1163615C (da)
AT (1) ATE236989T1 (da)
AU (1) AU743520B2 (da)
BR (1) BR9813990A (da)
CA (1) CA2314328A1 (da)
DE (2) DE19749480A1 (da)
DK (1) DK1049794T3 (da)
ES (1) ES2152864B1 (da)
HK (1) HK1031237A1 (da)
PT (1) PT1049794E (da)
WO (1) WO1999024597A1 (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7407778B2 (en) * 2002-02-07 2008-08-05 Pettegrew Jay W Compounds, compositions and methods for treating neuropsychiatric disorders
US7700074B2 (en) * 2002-02-07 2010-04-20 Pettegrew Jay W Method and system for diagnosis of neuropsychiatric disorders including chronic alcoholism
ES2220219B1 (es) * 2003-05-23 2005-10-01 Universidad De Murcia Procedimiento para la produccion de l-carnitina a partir de crotonobetaina, d-carnitina, sus sales y derivados, mediante celulas permeabilizadas de proteus sp. o escherichia coli.
ATE437884T1 (de) * 2003-05-29 2009-08-15 Jay W Pettegrew Glycerophosphocholin und derivate davon zur medizinischen abbildung von neuropsychiatrischen erkrankungen
US20060257842A1 (en) * 2003-05-29 2006-11-16 Pettegrew Jay W Cryopreservation media and molecules
FR3025213A1 (fr) * 2014-08-28 2016-03-04 Algobiotech Procede d'induction de la synthese des phycobiliproteines
CN104928225B (zh) * 2015-05-27 2018-06-12 武汉中科光谷绿色生物技术有限公司 一种产l-肉碱的大肠杆菌基因工程菌及构建方法和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD221905B1 (de) * 1983-11-03 1987-03-18 Univ Leipzig Verfahren zur herstellung von l(-)-carnitin und seinen derivaten
FI86889C (fi) * 1984-03-29 1992-10-26 Lonza Ag Foerfarande foer framstaellning av av l-karnitin pao mikrobiologiskt saett
CH664374A5 (de) * 1985-02-27 1988-02-29 Lonza Ag Verfahren zur herstellung von l-carnitin auf mikrobiologischem weg.
US4978616A (en) * 1985-02-28 1990-12-18 Verax Corporation Fluidized cell cultivation process
DD281735A7 (de) * 1987-10-26 1990-08-22 Univ Leipzig Verfahren zur enzymatischen synthese von l(-)-carnitin
EP0320460B1 (en) * 1987-10-26 1994-04-27 Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. Process for isolating the enzyme carnitinehydrolyase from strains belonging to the family enterobacteriaceae and use of the immobilized enzyme for producing L(-)-carnitine

Also Published As

Publication number Publication date
AU2243699A (en) 1999-05-31
EP1049794A1 (de) 2000-11-08
ES2152864B1 (es) 2001-09-01
WO1999024597A1 (de) 1999-05-20
KR20010031894A (ko) 2001-04-16
EP1049794B1 (de) 2003-04-09
JP2001521760A (ja) 2001-11-13
PT1049794E (pt) 2003-08-29
CA2314328A1 (en) 1999-05-20
US20030073203A1 (en) 2003-04-17
CN1163615C (zh) 2004-08-25
DE19749480A1 (de) 1999-05-20
HK1031237A1 (en) 2001-06-08
DE59807901D1 (de) 2003-05-15
AU743520B2 (en) 2002-01-31
KR100575297B1 (ko) 2006-05-02
ES2152864A1 (es) 2001-02-01
US6653112B2 (en) 2003-11-25
ATE236989T1 (de) 2003-04-15
CN1278303A (zh) 2000-12-27
BR9813990A (pt) 2000-09-26

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