ATE437884T1 - Glycerophosphocholin und derivate davon zur medizinischen abbildung von neuropsychiatrischen erkrankungen - Google Patents
Glycerophosphocholin und derivate davon zur medizinischen abbildung von neuropsychiatrischen erkrankungenInfo
- Publication number
- ATE437884T1 ATE437884T1 AT04753565T AT04753565T ATE437884T1 AT E437884 T1 ATE437884 T1 AT E437884T1 AT 04753565 T AT04753565 T AT 04753565T AT 04753565 T AT04753565 T AT 04753565T AT E437884 T1 ATE437884 T1 AT E437884T1
- Authority
- AT
- Austria
- Prior art keywords
- gpc
- alzheimer
- disease
- glycerophosphocholine
- derivatives
- Prior art date
Links
- SUHOQUVVVLNYQR-MRVPVSSYSA-N choline alfoscerate Chemical compound C[N+](C)(C)CCOP([O-])(=O)OC[C@H](O)CO SUHOQUVVVLNYQR-MRVPVSSYSA-N 0.000 title abstract 5
- 229960004956 glycerylphosphorylcholine Drugs 0.000 title abstract 5
- 238000002059 diagnostic imaging Methods 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 208000031124 Dementia Alzheimer type Diseases 0.000 abstract 2
- 238000003745 diagnosis Methods 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 230000002285 radioactive effect Effects 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 102000013455 Amyloid beta-Peptides Human genes 0.000 abstract 1
- 108010090849 Amyloid beta-Peptides Proteins 0.000 abstract 1
- 150000002316 glycerophosphocholines Chemical class 0.000 abstract 1
- 238000002595 magnetic resonance imaging Methods 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
- 239000002207 metabolite Substances 0.000 abstract 1
- -1 non-radioactive Chemical class 0.000 abstract 1
- 230000005298 paramagnetic effect Effects 0.000 abstract 1
- 150000003904 phospholipids Chemical class 0.000 abstract 1
- 238000002600 positron emission tomography Methods 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0404—Lipids, e.g. triglycerides; Polycationic carriers
- A61K51/0406—Amines, polyamines, e.g. spermine, spermidine, amino acids, (bis)guanidines
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2821—Alzheimer
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Radiology & Medical Imaging (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Biophysics (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47418203P | 2003-05-29 | 2003-05-29 | |
| US10/854,894 US7815894B2 (en) | 2003-05-29 | 2004-05-27 | Compounds, compositions and methods for medical imaging of neuropsychiatric disorders |
| PCT/US2004/016750 WO2004110963A2 (en) | 2003-05-29 | 2004-05-27 | Glycerophosphocholine and its derivatives for medical imaging neuropsychiatric disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE437884T1 true ATE437884T1 (de) | 2009-08-15 |
Family
ID=33457562
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04753565T ATE437884T1 (de) | 2003-05-29 | 2004-05-27 | Glycerophosphocholin und derivate davon zur medizinischen abbildung von neuropsychiatrischen erkrankungen |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7815894B2 (de) |
| EP (1) | EP1641806B1 (de) |
| CN (1) | CN1795198B (de) |
| AT (1) | ATE437884T1 (de) |
| DE (1) | DE602004022301D1 (de) |
| WO (1) | WO2004110963A2 (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8329142B2 (en) * | 2003-05-29 | 2012-12-11 | Pettegrew Jay W | Compounds, compositions and methods for medical imaging of Parkinson's disease |
| US20060257842A1 (en) * | 2003-05-29 | 2006-11-16 | Pettegrew Jay W | Cryopreservation media and molecules |
| CA2559723C (en) * | 2004-03-18 | 2010-02-23 | Transtech Pharma, Inc. | Fluorescence polarization assay related applications |
| CN102525992A (zh) * | 2012-03-09 | 2012-07-04 | 徐奎 | L-α-甘油磷酸胆碱薄膜衣片及其制备方法 |
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| US1979534A (en) * | 1931-10-15 | 1934-11-06 | Farastan Company | Disazo compound for therapeutic use |
| FR2398046A1 (fr) * | 1977-07-18 | 1979-02-16 | Inst Francais Du Petrole | Synthese enzymatique de la l-carnitine |
| US4346107A (en) * | 1979-02-12 | 1982-08-24 | Claudio Cavazza | Pharmaceutical composition comprising acyl-carnitine for the treatment of impaired cerebral metabolism |
| US4642290A (en) * | 1982-12-06 | 1987-02-10 | Sih Charles J | Process for preparing a compound for use in the production of L-carnitine |
| JPS59192095A (ja) * | 1983-04-13 | 1984-10-31 | Ajinomoto Co Inc | L−カルニチンの製造法 |
| US4542098A (en) * | 1983-05-06 | 1985-09-17 | Institut Francais Du Petrole | Production of glucose dehydrogenase and use of the resultant enzyme in the enzymatic synthesis of L-carnitine |
| DD221905B1 (de) * | 1983-11-03 | 1987-03-18 | Univ Leipzig | Verfahren zur herstellung von l(-)-carnitin und seinen derivaten |
| FI86889C (fi) * | 1984-03-29 | 1992-10-26 | Lonza Ag | Foerfarande foer framstaellning av av l-karnitin pao mikrobiologiskt saett |
| IT1177874B (it) * | 1984-07-04 | 1987-08-26 | Sigma Tau Ind Farmaceuti | Estere della acetil carnitina,procedimenti per la sua preparazione e composizioni farmaceutiche che lo contengono |
| CH664374A5 (de) * | 1985-02-27 | 1988-02-29 | Lonza Ag | Verfahren zur herstellung von l-carnitin auf mikrobiologischem weg. |
| US4933156A (en) * | 1987-04-08 | 1990-06-12 | Salutar, Inc. | Amyloidosis and Alzheimer's disease diagnostic assay and reagents therefor |
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| US4996041A (en) * | 1988-08-19 | 1991-02-26 | Toshiyuki Arai | Method for introducing oxygen-17 into tissue for imaging in a magnetic resonance imaging system |
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| US5066583A (en) * | 1988-12-21 | 1991-11-19 | Wisconsin Alumni Research Foundation | Method for distinguishing alcoholics from non-alcoholics |
| JP3059735B2 (ja) * | 1989-10-13 | 2000-07-04 | 旭化成工業株式会社 | L―カルニチンデヒドロゲナーゼおよびその製造法 |
| US5773024A (en) * | 1989-12-22 | 1998-06-30 | Imarx Pharmaceutical Corp. | Container with multi-phase composition for use in diagnostic and therapeutic applications |
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| US5668117A (en) * | 1991-02-22 | 1997-09-16 | Shapiro; Howard K. | Methods of treating neurological diseases and etiologically related symptomology using carbonyl trapping agents in combination with previously known medicaments |
| AU654013B2 (en) * | 1991-03-13 | 1994-10-20 | Regents Of The University Of Minnesota | 2-hydroxy-3(4-iodophenyl)-1-(4-phenylpiperidinyl) propane |
| GB9108756D0 (en) * | 1991-04-24 | 1991-06-12 | Ici Plc | Production of polyalkanoate in plants |
| US5276059A (en) * | 1992-07-10 | 1994-01-04 | The United States Of America As Represented By The Department Of Health And Human Services | Inhibition of diseases associated with amyloid formation |
| WO1994009371A1 (en) * | 1992-10-09 | 1994-04-28 | Massachusetts Institute Of Technology | Antemortem diagnostic test for alzheimer's disease |
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| EP0770400B1 (de) * | 1995-10-31 | 2003-02-26 | Japan Science and Technology Corporation | Am sekundären Kohlenstoffatom markiertes Acyl-L-Carnitin und diagnostische Mittel es enthaltend |
| DE69721542D1 (de) * | 1996-06-14 | 2003-06-05 | Mclean Hospital Corp | In vitro h-nmr-nachweis der häufigkeit und menge von alkoholeinnahme |
| IT1290801B1 (it) * | 1996-07-05 | 1998-12-11 | Mendes Srl | Uso della acetil l-carnitina, della isovaleril l-carnitina, della propionil l-carnitina o dei loro sali farmacologicamente accettabili |
| US6380252B1 (en) * | 1996-07-05 | 2002-04-30 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Use of L-acetylcarnitine, L-isovalerylcarnitine, L-propionylcarnitine for increasing the levels of IGF-1 |
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-
2004
- 2004-05-27 DE DE602004022301T patent/DE602004022301D1/de not_active Expired - Lifetime
- 2004-05-27 WO PCT/US2004/016750 patent/WO2004110963A2/en not_active Ceased
- 2004-05-27 AT AT04753565T patent/ATE437884T1/de not_active IP Right Cessation
- 2004-05-27 US US10/854,894 patent/US7815894B2/en not_active Expired - Fee Related
- 2004-05-27 CN CN200480014302.9A patent/CN1795198B/zh not_active Expired - Fee Related
- 2004-05-27 EP EP04753565A patent/EP1641806B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CN1795198A (zh) | 2006-06-28 |
| EP1641806B1 (de) | 2009-07-29 |
| CN1795198B (zh) | 2011-08-17 |
| WO2004110963A3 (en) | 2005-03-10 |
| US20040241090A1 (en) | 2004-12-02 |
| US7815894B2 (en) | 2010-10-19 |
| DE602004022301D1 (de) | 2009-09-10 |
| EP1641806A2 (de) | 2006-04-05 |
| WO2004110963A2 (en) | 2004-12-23 |
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| ATE437884T1 (de) | Glycerophosphocholin und derivate davon zur medizinischen abbildung von neuropsychiatrischen erkrankungen | |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |