ES2152864B1 - Procedimiento para la fabricacion de l-carnitina a partir de crotonobetaina. - Google Patents
Procedimiento para la fabricacion de l-carnitina a partir de crotonobetaina.Info
- Publication number
- ES2152864B1 ES2152864B1 ES009802324A ES9802324A ES2152864B1 ES 2152864 B1 ES2152864 B1 ES 2152864B1 ES 009802324 A ES009802324 A ES 009802324A ES 9802324 A ES9802324 A ES 9802324A ES 2152864 B1 ES2152864 B1 ES 2152864B1
- Authority
- ES
- Spain
- Prior art keywords
- crotonobetaine
- carnitine
- reaction medium
- reactor
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/007—Carnitine; Butyrobetaine; Crotonobetaine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/848—Escherichia
- Y10S435/849—Escherichia coli
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Abstract
Procedimiento para la fabricación de L-carnitina a partir de crotonobetaína. Consiste en la obtención de una manera económicamente ventajosa, de L-carnitina a partir de crotonobetaína, sales de crotonobetaína o derivados a través de células inmovilizadas de Escherichia coli 044 K74 en un reactor de reciclado de células que funciona de forma continua. Las células en crecimiento o en reposo de E. coli son retenidas en un reactor de reciclado de células que funciona de forma continua, por medio de membranas de micro o ultrafiltración, que están dispuestas como módulo de membrana plana o de fibras huecas. La L-carnitina tiene numerosas aplicaciones clínicas, entre las que destacan la profilaxis y tratamiento de las enfermedades cardíacas.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19749480A DE19749480A1 (de) | 1997-11-08 | 1997-11-08 | Verfahren zur Herstellung von L-Carnitin aus Crotonobetain |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2152864A1 ES2152864A1 (es) | 2001-02-01 |
| ES2152864B1 true ES2152864B1 (es) | 2001-09-01 |
Family
ID=7848083
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES009802324A Expired - Fee Related ES2152864B1 (es) | 1997-11-08 | 1998-11-05 | Procedimiento para la fabricacion de l-carnitina a partir de crotonobetaina. |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6653112B2 (es) |
| EP (1) | EP1049794B1 (es) |
| JP (1) | JP2001521760A (es) |
| KR (1) | KR100575297B1 (es) |
| CN (1) | CN1163615C (es) |
| AT (1) | ATE236989T1 (es) |
| AU (1) | AU743520B2 (es) |
| BR (1) | BR9813990A (es) |
| CA (1) | CA2314328A1 (es) |
| DE (2) | DE19749480A1 (es) |
| DK (1) | DK1049794T3 (es) |
| ES (1) | ES2152864B1 (es) |
| HK (1) | HK1031237A1 (es) |
| PT (1) | PT1049794E (es) |
| WO (1) | WO1999024597A1 (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7407778B2 (en) * | 2002-02-07 | 2008-08-05 | Pettegrew Jay W | Compounds, compositions and methods for treating neuropsychiatric disorders |
| US7700074B2 (en) * | 2002-02-07 | 2010-04-20 | Pettegrew Jay W | Method and system for diagnosis of neuropsychiatric disorders including chronic alcoholism |
| ES2220219B1 (es) * | 2003-05-23 | 2005-10-01 | Universidad De Murcia | Procedimiento para la produccion de l-carnitina a partir de crotonobetaina, d-carnitina, sus sales y derivados, mediante celulas permeabilizadas de proteus sp. o escherichia coli. |
| DE602004022301D1 (de) * | 2003-05-29 | 2009-09-10 | Jay W Pettegrew | Glycerophosphocholin und derivate davon zur medizinischen abbildung von neuropsychiatrischen erkrankungen |
| US20060257842A1 (en) * | 2003-05-29 | 2006-11-16 | Pettegrew Jay W | Cryopreservation media and molecules |
| FR3025213A1 (fr) * | 2014-08-28 | 2016-03-04 | Algobiotech | Procede d'induction de la synthese des phycobiliproteines |
| CN104928225B (zh) * | 2015-05-27 | 2018-06-12 | 武汉中科光谷绿色生物技术有限公司 | 一种产l-肉碱的大肠杆菌基因工程菌及构建方法和应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DD221905B1 (de) * | 1983-11-03 | 1987-03-18 | Univ Leipzig | Verfahren zur herstellung von l(-)-carnitin und seinen derivaten |
| FI86889C (fi) * | 1984-03-29 | 1992-10-26 | Lonza Ag | Foerfarande foer framstaellning av av l-karnitin pao mikrobiologiskt saett |
| CH664374A5 (de) * | 1985-02-27 | 1988-02-29 | Lonza Ag | Verfahren zur herstellung von l-carnitin auf mikrobiologischem weg. |
| US4978616A (en) * | 1985-02-28 | 1990-12-18 | Verax Corporation | Fluidized cell cultivation process |
| DD281735A7 (de) * | 1987-10-26 | 1990-08-22 | Univ Leipzig | Verfahren zur enzymatischen synthese von l(-)-carnitin |
| EP0320460B1 (en) * | 1987-10-26 | 1994-04-27 | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. | Process for isolating the enzyme carnitinehydrolyase from strains belonging to the family enterobacteriaceae and use of the immobilized enzyme for producing L(-)-carnitine |
-
1997
- 1997-11-08 DE DE19749480A patent/DE19749480A1/de not_active Ceased
-
1998
- 1998-11-05 ES ES009802324A patent/ES2152864B1/es not_active Expired - Fee Related
- 1998-11-09 KR KR1020007004992A patent/KR100575297B1/ko not_active IP Right Cessation
- 1998-11-09 US US09/530,783 patent/US6653112B2/en not_active Expired - Fee Related
- 1998-11-09 AU AU22436/99A patent/AU743520B2/en not_active Ceased
- 1998-11-09 DK DK98963424T patent/DK1049794T3/da active
- 1998-11-09 DE DE59807901T patent/DE59807901D1/de not_active Expired - Fee Related
- 1998-11-09 CA CA002314328A patent/CA2314328A1/en not_active Abandoned
- 1998-11-09 PT PT98963424T patent/PT1049794E/pt unknown
- 1998-11-09 JP JP2000519591A patent/JP2001521760A/ja active Pending
- 1998-11-09 AT AT98963424T patent/ATE236989T1/de not_active IP Right Cessation
- 1998-11-09 WO PCT/EP1998/007124 patent/WO1999024597A1/de active IP Right Grant
- 1998-11-09 BR BR9813990-8A patent/BR9813990A/pt not_active Application Discontinuation
- 1998-11-09 EP EP98963424A patent/EP1049794B1/de not_active Expired - Lifetime
- 1998-11-09 CN CNB988108542A patent/CN1163615C/zh not_active Expired - Fee Related
-
2000
- 2000-12-14 HK HK00108094A patent/HK1031237A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1049794B1 (de) | 2003-04-09 |
| AU2243699A (en) | 1999-05-31 |
| ES2152864A1 (es) | 2001-02-01 |
| PT1049794E (pt) | 2003-08-29 |
| KR20010031894A (ko) | 2001-04-16 |
| US6653112B2 (en) | 2003-11-25 |
| JP2001521760A (ja) | 2001-11-13 |
| BR9813990A (pt) | 2000-09-26 |
| KR100575297B1 (ko) | 2006-05-02 |
| DK1049794T3 (da) | 2003-07-28 |
| HK1031237A1 (en) | 2001-06-08 |
| US20030073203A1 (en) | 2003-04-17 |
| CN1163615C (zh) | 2004-08-25 |
| WO1999024597A1 (de) | 1999-05-20 |
| CN1278303A (zh) | 2000-12-27 |
| ATE236989T1 (de) | 2003-04-15 |
| CA2314328A1 (en) | 1999-05-20 |
| AU743520B2 (en) | 2002-01-31 |
| EP1049794A1 (de) | 2000-11-08 |
| DE19749480A1 (de) | 1999-05-20 |
| DE59807901D1 (de) | 2003-05-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EC2A | Search report published |
Date of ref document: 20010201 Kind code of ref document: A1 Effective date: 20010201 |
|
| FD2A | Announcement of lapse in spain |
Effective date: 20190226 |