BR9813988A - Anticorpos contra vasp fosforilada (fosfoproteìna estimulada por vasodilatador), céulas de hidridoma para a preparação dos mesmos e uso dos mesmos - Google Patents

Anticorpos contra vasp fosforilada (fosfoproteìna estimulada por vasodilatador), céulas de hidridoma para a preparação dos mesmos e uso dos mesmos

Info

Publication number
BR9813988A
BR9813988A BR9813988-6A BR9813988A BR9813988A BR 9813988 A BR9813988 A BR 9813988A BR 9813988 A BR9813988 A BR 9813988A BR 9813988 A BR9813988 A BR 9813988A
Authority
BR
Brazil
Prior art keywords
vasodilator
preparation
vasp
antibodies against
phosphoprotein
Prior art date
Application number
BR9813988-6A
Other languages
English (en)
Inventor
Martin Eigenthaler
Heinz Hoschuetzky
Ulrich Walter
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19749091A external-priority patent/DE19749091C1/de
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of BR9813988A publication Critical patent/BR9813988A/pt

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5064—Endothelial cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/866—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving immunoglobulin or antibody fragment, e.g. fab', fab, fv, fc, heavy chain or light chain

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Diabetes (AREA)
  • Genetics & Genomics (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)

Abstract

Patente de Invenção: <B>"ANTICORPOS CONTRA VASP FOSFORILADA (FOSFOPROTEìNA ESTIMULADA POR VASODILATADOR), CéLULAS DE HIBRIDOMA PARA A PREPARAçãO DOS MESMOS E USO DOS MESMOS"<D>. A invenção refere-se a anticorpos contra VASP (fosfoproteína estimulada por vasodilatador), que somente se liga à VASP como um antígeno quando a VASP está presente em forma fosforilada, a células de hibridoma para sua preparação e ao uso dos anticorpos ou dos fragmentos de anticorpo como agentes diagnósticos e/ou agentes terapêuticos.
BR9813988-6A 1997-11-07 1998-11-06 Anticorpos contra vasp fosforilada (fosfoproteìna estimulada por vasodilatador), céulas de hidridoma para a preparação dos mesmos e uso dos mesmos BR9813988A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19749091A DE19749091C1 (de) 1997-11-07 1997-11-07 Antikörper gegen phosphoryliertes VASP (Vasodilator-Stimuliertes Phosphoprotein), Hybridomzellen zu dessen Herstellung sowie dessen Anwendung
US7937598P 1998-03-26 1998-03-26
PCT/EP1998/007103 WO1999024473A1 (en) 1997-11-07 1998-11-06 Antibodies against phosphorylated vasp (vasodilator-stimulated phosphoprotein), hybridoma cells for their preparation, and their use

Publications (1)

Publication Number Publication Date
BR9813988A true BR9813988A (pt) 2000-09-26

Family

ID=26041380

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9813988-6A BR9813988A (pt) 1997-11-07 1998-11-06 Anticorpos contra vasp fosforilada (fosfoproteìna estimulada por vasodilatador), céulas de hidridoma para a preparação dos mesmos e uso dos mesmos

Country Status (16)

Country Link
US (2) US6649421B1 (pt)
EP (1) EP1042368B1 (pt)
JP (1) JP5031140B2 (pt)
KR (1) KR100513418B1 (pt)
CN (1) CN1188426C (pt)
AT (1) ATE248189T1 (pt)
AU (1) AU753557B2 (pt)
BR (1) BR9813988A (pt)
CA (1) CA2308604C (pt)
CZ (1) CZ299889B6 (pt)
ES (1) ES2205593T3 (pt)
HU (1) HU222411B1 (pt)
PL (1) PL195985B1 (pt)
RU (1) RU2218178C2 (pt)
TR (1) TR200001265T2 (pt)
WO (1) WO1999024473A1 (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10029210A1 (de) * 2000-06-14 2002-01-31 Vasopharm Biotech Gmbh & Co Kg Testsystem sowie dessen Verwendung
US6951947B2 (en) * 2000-07-13 2005-10-04 The Scripps Research Institute Labeled peptides, proteins and antibodies and processes and intermediates useful for their preparation
US7176037B2 (en) * 2000-07-13 2007-02-13 The Scripps Research Institute Labeled peptides, proteins and antibodies and processes and intermediates useful for their preparation
EP1182263A1 (en) * 2000-08-11 2002-02-27 Evotec OAI AG Process for detecting threonine/serine kinase activity
US20030162230A1 (en) 2000-09-27 2003-08-28 Reagan Kevin J. Method for quantifying phosphokinase activity on proteins
AU2002221132A1 (en) * 2000-12-13 2002-07-01 Taisho Pharmaceutical Co. Ltd. Novel antibody
EP1735453A2 (en) * 2004-03-12 2006-12-27 The Scripps Research Institute Fluorescent signal emitting live cell biosensor molecules and dyes for detection and quantification of protein activities
CN103102411A (zh) * 2009-06-11 2013-05-15 北京华大蛋白质研发中心有限公司 一种制备针对糖基化修饰蛋白质的单克隆抗体杂交瘤的方法
FR2946756A1 (fr) * 2009-06-12 2010-12-17 Biocytex Dosage en sang total d'un biomarqueur intracellulaire appartenant a une voie de signalisation cellulaire- utilisation pour mesurer l'activation d'une population cellulaire determinee
EP3509613A4 (en) * 2016-09-07 2020-12-02 Vanderbilt University VASOACTIVE POLYPEPTIDE FOR THE RELAXATION OF SMOOTH MUSCLES
CN112730826A (zh) * 2020-12-23 2021-04-30 中南大学湘雅三医院 一种人磷酸化血管扩张刺激磷蛋白磁微粒化学发光免疫定量检测试剂盒及其检测方法和应用
CN113238062B (zh) * 2021-07-13 2021-09-28 湖南菲思特精准医疗科技有限公司 一种用于人磷酸化血管扩张刺激磷蛋白光激化学发光均相免疫检测试剂盒及其检测方法
CN114002440B (zh) * 2021-12-30 2022-04-01 湖南菲思特精准医疗科技有限公司 一种用于人磷酸化血管扩张刺激蛋白的酶联免疫检测试剂盒及其检测方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2268684T3 (es) 1992-04-10 2007-03-16 Dana-Farber Cancer Institute, Inc. Inmunodeteccion de fosfoproteina especifica al estado de activacion.

Also Published As

Publication number Publication date
EP1042368B1 (en) 2003-08-27
AU1871299A (en) 1999-05-31
CZ20001684A3 (cs) 2000-11-15
KR100513418B1 (ko) 2005-09-09
CA2308604C (en) 2009-12-15
EP1042368A1 (en) 2000-10-11
HU222411B1 (hu) 2003-06-28
US20040063914A1 (en) 2004-04-01
CN1279691A (zh) 2001-01-10
TR200001265T2 (tr) 2000-09-21
RU2218178C2 (ru) 2003-12-10
US6649421B1 (en) 2003-11-18
HUP0004099A3 (en) 2002-01-28
CN1188426C (zh) 2005-02-09
PL340465A1 (en) 2001-02-12
CA2308604A1 (en) 1999-05-20
AU753557B2 (en) 2002-10-24
HUP0004099A1 (en) 2001-03-28
KR20010031830A (ko) 2001-04-16
WO1999024473A1 (en) 1999-05-20
PL195985B1 (pl) 2007-11-30
JP5031140B2 (ja) 2012-09-19
CZ299889B6 (cs) 2008-12-29
ATE248189T1 (de) 2003-09-15
ES2205593T3 (es) 2004-05-01
JP2001522865A (ja) 2001-11-20

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

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B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

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