BR9804722A - Processo para a c-alquilação de ésteres de ácido malónico - Google Patents
Processo para a c-alquilação de ésteres de ácido malónicoInfo
- Publication number
- BR9804722A BR9804722A BR9804722-1A BR9804722A BR9804722A BR 9804722 A BR9804722 A BR 9804722A BR 9804722 A BR9804722 A BR 9804722A BR 9804722 A BR9804722 A BR 9804722A
- Authority
- BR
- Brazil
- Prior art keywords
- malonic acid
- alkylation
- acid esters
- reacted
- hydroxide
- Prior art date
Links
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical class OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 title abstract 7
- 238000005804 alkylation reaction Methods 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 2
- 239000003444 phase transfer catalyst Substances 0.000 abstract 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 abstract 2
- 150000001350 alkyl halides Chemical class 0.000 abstract 1
- 150000003983 crown ethers Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 239000012442 inert solvent Substances 0.000 abstract 1
- 229910000027 potassium carbonate Inorganic materials 0.000 abstract 1
- 150000005621 tetraalkylammonium salts Chemical class 0.000 abstract 1
- 125000005497 tetraalkylphosphonium group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/34—Esters of acyclic saturated polycarboxylic acids having an esterified carboxyl group bound to an acyclic carbon atom
- C07C69/38—Malonic acid esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
- C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Patente de Invenção: <B>"PROCESSO PARA A C-ALQUILAçãO DE éSTERES DE áCIDO MALÈNICO"<D>. A invenção refere-se a um processo para a C-alquilação de dialquilésteres de ácido malónico, no qual dialquiléster de ácido malónico é reagido, em presença de carbonato de potássia como aceptor de ácido halogenídrico, em um solvente inerte, com um halogeneto de alquila ou com um dihalogeneto de 1,2-alquileno, e, nesse caso, apenas então, é adicionado um catalisador de transferência de fase, quando o dialquiléster de ácido malónico estiver reagido em 50 até 80%. O catalisador de transferência de fase pode ser, por exemplo, um sal ou hidróxido de tetraalquilamónio, um sal ou hidróxido de tetraalquilfosfónio ou um éter coroa.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19752041A DE19752041A1 (de) | 1997-11-24 | 1997-11-24 | Verfahren zur C-Alkylierung von Malonsäureestern |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9804722A true BR9804722A (pt) | 1999-12-21 |
Family
ID=7849674
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9804722-1A BR9804722A (pt) | 1997-11-24 | 1998-11-20 | Processo para a c-alquilação de ésteres de ácido malónico |
Country Status (11)
Country | Link |
---|---|
US (1) | US6262298B1 (pt) |
EP (1) | EP0918047B1 (pt) |
JP (1) | JP3522554B2 (pt) |
KR (1) | KR100425871B1 (pt) |
CN (1) | CN1113847C (pt) |
AT (1) | ATE215927T1 (pt) |
AU (1) | AU740587B2 (pt) |
BR (1) | BR9804722A (pt) |
DE (2) | DE19752041A1 (pt) |
HU (1) | HUP9802711A2 (pt) |
TW (1) | TW496861B (pt) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19963115B4 (de) * | 1999-12-24 | 2009-04-09 | Evonik Degussa Gmbh | Verfahren zur Herstellung von Cyclopropan-1,1-dicarbonsäurediestern |
EP1384706A1 (de) * | 2002-07-24 | 2004-01-28 | Degussa AG | Verfahren zur Monoalkylierung C-H-acider Methylengruppen |
JP2011042580A (ja) * | 2007-12-20 | 2011-03-03 | Kuraray Co Ltd | 1,1,3,4−ブタンテトラカルボン酸エステルの製造方法 |
CN102527523A (zh) * | 2010-12-07 | 2012-07-04 | 沈阳有色金属研究院 | 一种有色金属氧化矿螯合捕收剂及其制备方法 |
WO2013134424A1 (en) | 2012-03-06 | 2013-09-12 | Lygos, Inc. | Recombinant host cells for the production of malonate |
CN103382152A (zh) * | 2012-12-07 | 2013-11-06 | 苏州百灵威超精细材料有限公司 | α-酮酸酯的制备方法 |
CN105566111A (zh) * | 2014-10-09 | 2016-05-11 | 安徽扬子化工有限公司 | 一种3-四氢呋喃甲醇中间体的合成方法 |
CN104803857B (zh) * | 2015-03-18 | 2017-03-01 | 苏州纳驰生物科技有限公司 | 西他沙星三元环中间体制备方法 |
CN108047028A (zh) * | 2017-12-15 | 2018-05-18 | 中国石油大学(华东) | 一种电容级2,7-二丁基辛二酸的制备方法 |
CN109593047B (zh) * | 2018-11-21 | 2022-12-27 | 沈阳新地药业有限公司 | 一种活泼亚甲基碳-烷基化的连续制备方法 |
CN111269083B (zh) * | 2020-02-24 | 2023-08-25 | 珠海市柏瑞医药科技有限公司 | 一种格尔伯特酸的合成方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH06234705A (ja) * | 1993-02-12 | 1994-08-23 | Nippon Synthetic Chem Ind Co Ltd:The | 1,1−シクロプロパンジカルボン酸ジエステルの製造法 |
DE4326917C1 (de) * | 1993-08-11 | 1995-02-23 | Huels Chemische Werke Ag | Verfahren zur Herstellung von Cyclopropan-1,1-dicarbonsäureestern |
-
1997
- 1997-11-24 DE DE19752041A patent/DE19752041A1/de not_active Withdrawn
-
1998
- 1998-10-12 DE DE59803710T patent/DE59803710D1/de not_active Expired - Lifetime
- 1998-10-12 AT AT98119192T patent/ATE215927T1/de not_active IP Right Cessation
- 1998-10-12 EP EP98119192A patent/EP0918047B1/de not_active Expired - Lifetime
- 1998-11-18 TW TW087119089A patent/TW496861B/zh not_active IP Right Cessation
- 1998-11-20 BR BR9804722-1A patent/BR9804722A/pt not_active IP Right Cessation
- 1998-11-23 HU HU9802711A patent/HUP9802711A2/hu unknown
- 1998-11-23 AU AU94076/98A patent/AU740587B2/en not_active Ceased
- 1998-11-23 KR KR10-1998-0050136A patent/KR100425871B1/ko not_active IP Right Cessation
- 1998-11-23 CN CN98122634A patent/CN1113847C/zh not_active Expired - Fee Related
- 1998-11-24 JP JP33269598A patent/JP3522554B2/ja not_active Expired - Fee Related
- 1998-11-24 US US09/198,581 patent/US6262298B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
KR100425871B1 (ko) | 2004-06-23 |
HU9802711D0 (en) | 1999-01-28 |
TW496861B (en) | 2002-08-01 |
EP0918047A1 (de) | 1999-05-26 |
KR19990045496A (ko) | 1999-06-25 |
US6262298B1 (en) | 2001-07-17 |
JPH11228497A (ja) | 1999-08-24 |
HUP9802711A2 (hu) | 1999-12-28 |
EP0918047B1 (de) | 2002-04-10 |
DE59803710D1 (de) | 2002-05-16 |
ATE215927T1 (de) | 2002-04-15 |
CN1113847C (zh) | 2003-07-09 |
CN1222502A (zh) | 1999-07-14 |
JP3522554B2 (ja) | 2004-04-26 |
AU740587B2 (en) | 2001-11-08 |
AU9407698A (en) | 1999-06-17 |
DE19752041A1 (de) | 1999-05-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Transfer |
Free format text: DEGUSSA - HUELS AKTIENGESELLSCHAFT (DE) |
|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 4A,5A,6A,7A E 8A ANUIDADES |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1912 DE 28/08/2007. |