KR840004437A - 설타미실린의 결정형 벤젠설포네이트 염의 제조방법 - Google Patents

설타미실린의 결정형 벤젠설포네이트 염의 제조방법 Download PDF

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Publication number
KR840004437A
KR840004437A KR1019830001708A KR830001708A KR840004437A KR 840004437 A KR840004437 A KR 840004437A KR 1019830001708 A KR1019830001708 A KR 1019830001708A KR 830001708 A KR830001708 A KR 830001708A KR 840004437 A KR840004437 A KR 840004437A
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KR
South Korea
Prior art keywords
salt
sulfamicillin
formula
general formula
chlorine
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KR1019830001708A
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English (en)
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KR860001279B1 (ko
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언스트 바스 웨인 (외 1)
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윌리암 데이비스 휸
화이자 인코포레이티드
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Publication of KR840004437A publication Critical patent/KR840004437A/ko
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Publication of KR860001279B1 publication Critical patent/KR860001279B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/28—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with modified 2-carboxyl group
    • C07D499/32—Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

내용 없음

Description

설타미실린의 결정형 벤젠설포네이트 염의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (6)

  1. (a) 다음 구조식(B)의 유리염기 또는 이의 산부 가염을 일반식 4-XC6H4SO3H의 벤젠-설폰산과 적합한 용매 존재하에 접촉 반응시키거나 : (b) Y가 염소, 브롬 또는 요오드인 일반식 B·HY의 산부가염을 M이 알칼리금속 또는 알칼리 토금속 양이온인 일반식 4-XC6H4SO3M의 벤젠설폰산 염과 물존재하에서 접촉 반응시킴을 특징으로 하는 하기의 일반식(Ⅰ)을 갖는 설타미실린의 벤젠설폰산 부가염의 제조방법.
    4-XC6H4SO3H·Bn(H2O) (Ⅰ)
    상기식에서 n은 0내지 2이고, X는 수소 또는 염소이며, B는 다음 구조식을 나타낸다.
  2. 제1항에 있어서, 반응을 실온 또는 그 이하의 온도에서 수행하는 방법.
  3. 제1항에 있어서, n이 2인 방법.
  4. 제1(b)항에 있어서, Y가 염소원자이고 M이 나트륨인 방법.
  5. 제3항에 있어서, X가 수소이고 결정형 2수화 벤젠설폰산 부가염을 수득하는 방법.
  6. 제3항에 있어서, X가 염소원자이고 결정형 2수화 벤젠설폰산 염을 수득하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019830001708A 1982-04-23 1983-04-22 설타미실린의 결정형 벤젠설포네이트 염의 제조방법 KR860001279B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US371,156 1982-04-23
US06/371,156 US4432987A (en) 1982-04-23 1982-04-23 Crystalline benzenesulfonate salts of sultamicillin

Publications (2)

Publication Number Publication Date
KR840004437A true KR840004437A (ko) 1984-10-15
KR860001279B1 KR860001279B1 (ko) 1986-09-05

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019830001708A KR860001279B1 (ko) 1982-04-23 1983-04-22 설타미실린의 결정형 벤젠설포네이트 염의 제조방법

Country Status (27)

Country Link
US (1) US4432987A (ko)
EP (1) EP0092968B1 (ko)
JP (1) JPS58201792A (ko)
KR (1) KR860001279B1 (ko)
AU (1) AU536854B2 (ko)
CA (1) CA1187484A (ko)
CS (1) CS235320B2 (ko)
DD (1) DD209632A5 (ko)
DE (1) DE3362502D1 (ko)
DK (1) DK162168C (ko)
EG (1) EG16412A (ko)
ES (1) ES521728A0 (ko)
FI (1) FI76092C (ko)
GR (1) GR78582B (ko)
HK (1) HK20588A (ko)
HU (1) HU187068B (ko)
IE (1) IE54628B1 (ko)
IL (1) IL68453A (ko)
NO (1) NO156202C (ko)
NZ (1) NZ203988A (ko)
PH (1) PH18035A (ko)
PL (1) PL134978B1 (ko)
PT (1) PT76587B (ko)
SG (1) SG104087G (ko)
SU (1) SU1138030A3 (ko)
YU (1) YU43170B (ko)
ZA (1) ZA832845B (ko)

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ATE90879T1 (de) * 1985-11-18 1993-07-15 Access Pharma Inc Polychelierende stoffe fuer abbildung- und spektralerhoehung (und spektrale verschiebung).
US5336762A (en) * 1985-11-18 1994-08-09 Access Pharmaceuticals, Inc. Polychelating agents for image and spectral enhancement (and spectral shift)
KR910009271B1 (ko) * 1989-06-20 1991-11-08 김영설 1,1-디옥소페닐실라노일 옥시메틸 D-6-[α-(메틸렌아미노)페닐-아세트아미도]-페니실라네이트와 그의 파라-톨루엔술폰산염
PT758651E (pt) * 1994-05-02 2002-12-31 Shionogi & Co Cristal de derivado de pirrolidiltiocarbapenem formulacao liofilizada contendo o citado cristal e processo para a producao do mesmo
JP3382159B2 (ja) * 1998-08-05 2003-03-04 株式会社東芝 情報記録媒体とその再生方法及び記録方法
UA78104C2 (en) 2002-08-29 2007-02-15 Taisho Pharmaceutical Co Ltd Benzenesulfonate salts of 4-fluoro-2-cyanopyrrolidine derivatives
US7531650B2 (en) * 2003-03-27 2009-05-12 Basilea Pharmaceutica Ag Cephalosporin salts in crystalline form
KR20060130571A (ko) * 2003-10-31 2006-12-19 알자 코포레이션 개선된 흡수를 위한 조성물 및 제형
FR2877696B1 (fr) 2004-11-09 2009-09-18 Renault Sas Dispositif et procede d'estimation en temps reel de l'angle de debut de combustion d'un moteur a combustion interne
EP2195293B1 (en) 2007-08-22 2013-10-16 AstraZeneca AB Cycloptopyl amide derivatives
EP2220050A2 (en) 2007-10-26 2010-08-25 The Regents Of The University Of California Diarylhydantoin compounds as androgen receptor modulators
UA106740C2 (uk) * 2009-01-30 2014-10-10 Глаксосмітклайн Ллс Кристалічний гідрохлорид n-{(1s)-2-аміно-1-[(3-фторфеніл)метил]етил}-5-хлор-4-(4-хлор-1-метил-1h-піразол-5-іл)-2-тіофенкарбоксаміду
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BR112012020629A2 (pt) 2010-02-18 2018-06-19 Astrazeneca Ab forma cristalina, e, método para a terapia de um distúrbio
BR112012020780A2 (pt) * 2010-02-18 2016-05-03 Astrazeneca Ab forma sólida, composição farmacêutica, e, uso de uma forma sólida.
US9518004B2 (en) * 2012-12-03 2016-12-13 Kaneka Corporation Reduced coenzyme Q10 derivative and method for production thereof
WO2015034031A1 (ja) * 2013-09-05 2015-03-12 田辺三菱製薬株式会社 新規な結晶性アリールアルキルアミン化合物およびその製造方法
SG11201702980QA (en) * 2014-10-21 2017-05-30 Ariad Pharma Inc Crystalline forms of 5-chloro-n4-[-2-(dimethylphosphoryl) phenyl]-n2-{2-methoxy-4-[4-(4-methylpiperazin-1-yl) piperidin-1-yl] pyrimidine-2,4-diamine
CN104958318A (zh) * 2015-08-04 2015-10-07 青岛蓝盛洋医药生物科技有限责任公司 一种治疗感染性疾病的药物舒巴坦钠组合物
CA3011323A1 (en) * 2016-01-22 2017-07-27 Sandoz Ag Crystalline eravacycline bis-hydrochloride
CN109563087A (zh) * 2016-07-07 2019-04-02 铁木医药有限公司 sGC刺激剂的固体形式
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Also Published As

Publication number Publication date
KR860001279B1 (ko) 1986-09-05
IE830926L (en) 1983-10-23
HK20588A (en) 1988-03-25
ZA832845B (en) 1984-11-28
IE54628B1 (en) 1989-12-20
FI76092B (fi) 1988-05-31
CS235320B2 (en) 1985-05-15
PT76587B (en) 1986-02-27
DK162168B (da) 1991-09-23
DK101783A (da) 1983-10-24
PL134978B1 (en) 1985-09-30
ES8406075A1 (es) 1984-07-01
IL68453A (en) 1986-08-31
EP0092968B1 (en) 1986-03-12
YU90483A (en) 1986-04-30
DD209632A5 (de) 1984-05-16
EG16412A (en) 1989-03-30
IL68453A0 (en) 1983-07-31
DK162168C (da) 1992-03-02
EP0092968A1 (en) 1983-11-02
SU1138030A3 (ru) 1985-01-30
FI831392A0 (fi) 1983-04-22
SG104087G (en) 1988-07-15
NO156202B (no) 1987-05-04
HU187068B (en) 1985-11-28
PH18035A (en) 1985-03-06
GR78582B (ko) 1984-09-27
JPH0119395B2 (ko) 1989-04-11
CA1187484A (en) 1985-05-21
DE3362502D1 (en) 1986-04-17
YU43170B (en) 1989-04-30
FI76092C (fi) 1988-09-09
DK101783D0 (da) 1983-02-28
PT76587A (en) 1983-05-01
PL241553A1 (en) 1983-11-21
US4432987A (en) 1984-02-21
FI831392L (fi) 1983-10-24
NO831430L (no) 1983-10-24
NZ203988A (en) 1986-01-24
JPS58201792A (ja) 1983-11-24
ES521728A0 (es) 1984-07-01
NO156202C (no) 1987-08-19
AU1387183A (en) 1983-11-17
AU536854B2 (en) 1984-05-24

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