BR9408025A - Compostos de peptidila e seu uso terapêutico como inibidores de metaloproteinases - Google Patents
Compostos de peptidila e seu uso terapêutico como inibidores de metaloproteinasesInfo
- Publication number
- BR9408025A BR9408025A BR9408025A BR9408025A BR9408025A BR 9408025 A BR9408025 A BR 9408025A BR 9408025 A BR9408025 A BR 9408025A BR 9408025 A BR9408025 A BR 9408025A BR 9408025 A BR9408025 A BR 9408025A
- Authority
- BR
- Brazil
- Prior art keywords
- therapeutic use
- metalloproteinase inhibitors
- peptidyl compounds
- matrix metalloproteinase
- diseases
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06043—Leu-amino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/868—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving autoimmunity, allergy, immediate hypersensitivity, delayed hypersensitivity, immunosuppression, or immunotolerance
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB939323165A GB9323165D0 (en) | 1993-11-10 | 1993-11-10 | Compounds |
PCT/GB1994/002471 WO1995013289A1 (en) | 1993-11-10 | 1994-11-10 | Peptidyl compounds and their therapeutic use as inhibitors of metalloproteinases |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9408025A true BR9408025A (pt) | 1996-12-17 |
Family
ID=10744943
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9408025A BR9408025A (pt) | 1993-11-10 | 1994-11-10 | Compostos de peptidila e seu uso terapêutico como inibidores de metaloproteinases |
Country Status (22)
Country | Link |
---|---|
US (1) | US5853623A (pt) |
EP (1) | EP0728144B1 (pt) |
JP (1) | JPH09505041A (pt) |
KR (1) | KR960705843A (pt) |
CN (1) | CN1134705A (pt) |
AT (1) | ATE188969T1 (pt) |
AU (1) | AU679286B2 (pt) |
BR (1) | BR9408025A (pt) |
CA (1) | CA2173470A1 (pt) |
CZ (1) | CZ287780B6 (pt) |
DE (1) | DE69422726T2 (pt) |
DK (1) | DK0728144T3 (pt) |
ES (1) | ES2143611T3 (pt) |
FI (1) | FI961976A0 (pt) |
GB (1) | GB9323165D0 (pt) |
GR (1) | GR3033103T3 (pt) |
HK (1) | HK1015139A1 (pt) |
HU (1) | HU217344B1 (pt) |
NO (1) | NO961888D0 (pt) |
PL (1) | PL180403B1 (pt) |
PT (1) | PT728144E (pt) |
WO (1) | WO1995013289A1 (pt) |
Families Citing this family (63)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2170158A1 (en) * | 1993-08-23 | 1995-03-02 | Roy A. Black | Inhibitors of tnf-alpha secretion |
GB9414157D0 (en) * | 1994-07-13 | 1994-08-31 | Smithkline Beecham Plc | Medical use |
GB9601042D0 (en) * | 1996-01-17 | 1996-03-20 | Smithkline Beecham Plc | Medical use |
MX9702487A (es) * | 1994-10-05 | 1998-04-30 | Darwin Discovery Ltd | Compuestos peptidilo y su uso terapeutico como inhibidores de las metaloproteasas. |
WO1996035711A1 (en) * | 1995-05-10 | 1996-11-14 | Chiroscience Limited | Peptide compounds which inhibit metalloproteinase and tnf liberation, and their therapeutic use |
EP0826000B1 (en) * | 1995-05-10 | 2002-10-23 | Darwin Discovery Limited | Peptide compounds which inhibit metalloproteinase and tnf liberation and their therapeutic uses |
CA2217859A1 (en) * | 1995-05-10 | 1996-11-14 | David Alan Owen | Peptidyl compounds which inhibit metalloproteinase and tnf liberation and their therapeutic use |
US5677282A (en) * | 1995-06-07 | 1997-10-14 | Proscript, Inc. | Amino acid amides of 1,3,4-thiadiazoles as matrix metalloproteinase |
GB9514867D0 (en) * | 1995-07-20 | 1995-09-20 | British Biotech Pharm | Metalloproteinase inhibitors |
GB2318353B (en) * | 1995-07-20 | 1999-10-06 | British Biotech Pharm | Metalloproteinase inhibitors |
JP2008024720A (ja) * | 1995-07-26 | 2008-02-07 | Mitsubishi Chemicals Corp | ペニシラミンアミド誘導体 |
DE69625506T2 (de) * | 1995-10-05 | 2003-07-24 | Darwin Discovery Ltd | Schwefelsubstituierte peptide als inhibitoren für metalloproteinasen und der tnf-freisetzung |
WO1997012861A1 (en) * | 1995-10-05 | 1997-04-10 | Chiroscience Limited | Mercaptoamide derivatives and their therapeutic use |
GB9523066D0 (en) * | 1995-11-10 | 1996-01-10 | Chiroscience Ltd | Compounds and their therapeutic use |
AU711907B2 (en) * | 1995-11-22 | 1999-10-21 | Darwin Discovery Limited | Mercaptoalkylpeptidyl compounds having an imidazole substituent and their use as inhibitors of matrix metalloproteinases (MMP) and/or tumor necrosis factor (TNF) |
JP3628335B2 (ja) | 1996-01-23 | 2005-03-09 | 塩野義製薬株式会社 | スルホン化されたアミノ酸誘導体およびそれを含有するメタロプロティナーゼ阻害剤 |
US6919375B1 (en) | 1996-01-23 | 2005-07-19 | Shionogi & Co., Ltd. | Sulfonated amino acid derivatives and metalloproteinase inhibitors containing the same |
BR9708480A (pt) * | 1996-04-04 | 1999-04-13 | Hoffmann La Roche | Uso dos derivados das tetrahidro-beta-cabolinas como agentes antimetastáticos |
GB9607120D0 (en) * | 1996-04-04 | 1996-06-12 | Chiroscience Ltd | Compounds |
GB9607119D0 (en) * | 1996-04-04 | 1996-06-12 | Chiroscience Ltd | Compounds |
GB9607249D0 (en) * | 1996-04-04 | 1996-06-12 | Chiroscience Ltd | Compounds |
GB9609702D0 (en) | 1996-05-09 | 1996-07-10 | Royal Free Hosp School Med | Anticoagulant peptides |
US5852213A (en) * | 1996-07-10 | 1998-12-22 | American Cyanamid Company | Mercaptoketones and mercaptoalcohols and a process for their preparation |
CN1230884A (zh) * | 1996-07-22 | 1999-10-06 | 孟山都公司 | 硫羟砜金属蛋白酶抑制剂 |
GB9616643D0 (en) * | 1996-08-08 | 1996-09-25 | Chiroscience Ltd | Compounds |
US6953788B1 (en) | 1996-09-19 | 2005-10-11 | Aventis Pharmaceuticals Inc. | 3-mercaptoacetylamino-1,5-substituted-2-oxo-azepan derivatives useful as inhibitors of matrix metalloproteinase |
GB9624817D0 (en) * | 1996-11-28 | 1997-01-15 | British Biotech Pharm | Metalloproteinase inhibitors |
WO1998039024A1 (en) * | 1997-03-03 | 1998-09-11 | Darwin Discovery Limited | Selective mmp inhibitors having reduced side-effects |
JP2002515901A (ja) | 1997-03-04 | 2002-05-28 | モンサント カンパニー | 芳香族スルホニルα−シクロアミノヒドロキサム酸化合物 |
US6794511B2 (en) | 1997-03-04 | 2004-09-21 | G. D. Searle | Sulfonyl aryl or heteroaryl hydroxamic acid compounds |
US6638952B1 (en) | 1997-03-04 | 2003-10-28 | Pharmacia Corporation | Aromatic sulfonyl alpha-cycloamino hydroxamic acid compounds |
US6696449B2 (en) | 1997-03-04 | 2004-02-24 | Pharmacia Corporation | Sulfonyl aryl hydroxamates and their use as matrix metalloprotease inhibitors |
US7115632B1 (en) | 1999-05-12 | 2006-10-03 | G. D. Searle & Co. | Sulfonyl aryl or heteroaryl hydroxamic acid compounds |
WO1998039316A1 (en) | 1997-03-04 | 1998-09-11 | Monsanto Company | N-hydroxy 4-sulfonyl butanamide compounds |
US6362183B1 (en) | 1997-03-04 | 2002-03-26 | G. D. Searle & Company | Aromatic sulfonyl alpha-hydroxy hydroxamic acid compounds |
US6034136A (en) | 1997-03-20 | 2000-03-07 | Novartis Ag | Certain cyclic thio substituted acylaminoacid amide derivatives |
US5756545A (en) * | 1997-04-21 | 1998-05-26 | Warner-Lambert Company | Biphenysulfonamide matrix metal alloproteinase inhibitors |
WO1999007679A1 (en) * | 1997-08-08 | 1999-02-18 | Chiroscience Limited | Peptidyl compounds having mmp and tnf inhibitory activity |
US20010039287A1 (en) | 1997-11-14 | 2001-11-08 | Thomas E Barta | Aromatic sulfone hydroxamic acid metalloprotease inhibitor |
US6750228B1 (en) | 1997-11-14 | 2004-06-15 | Pharmacia Corporation | Aromatic sulfone hydroxamic acid metalloprotease inhibitor |
CN1279669A (zh) | 1997-11-14 | 2001-01-10 | G·D·瑟尔公司 | 芳族砜异羟肟酸金属蛋白酶抑制剂 |
US6329418B1 (en) | 1998-04-14 | 2001-12-11 | The Procter & Gamble Company | Substituted pyrrolidine hydroxamate metalloprotease inhibitors |
AUPP508798A0 (en) * | 1998-08-05 | 1998-08-27 | Biotech Australia Pty Limited | Method of treating psoriasis |
US6858598B1 (en) | 1998-12-23 | 2005-02-22 | G. D. Searle & Co. | Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia |
US6329550B1 (en) | 1998-12-31 | 2001-12-11 | Aventis Pharmaceuticals Inc. | Amidomalonamides useful as inhibitors of MMP of matrix metalloproteinase |
ES2203226T3 (es) * | 1998-12-31 | 2004-04-01 | Aventis Pharmaceuticals Inc. | Amidomalonamidas y su uso como inhibidores de las metaloproteinasas de la matriz. |
EA005500B1 (ru) | 1999-02-08 | 2005-02-24 | Дж.Д. Сирл Ллк | Сульфаматогидроксамовая кислота как ингибитор металлопротеаз |
US6800646B1 (en) | 1999-02-08 | 2004-10-05 | Pharmacia Corporation | Sulfamato hydroxamic acid metalloprotease inhibitor |
CA2374555A1 (en) * | 1999-06-15 | 2000-12-21 | Merck & Co., Inc. | Thiol derivative, metallo-beta-lactamase inhibitors |
US6869951B1 (en) | 1999-07-16 | 2005-03-22 | Pharmacia Corporation | Method of changing conformation of a matrix metalloproteinase |
US6696456B1 (en) * | 1999-10-14 | 2004-02-24 | The Procter & Gamble Company | Beta disubstituted metalloprotease inhibitors |
AU2001245862A1 (en) * | 2000-03-21 | 2001-10-03 | The Procter & Gamble Company | Difluorobutyric acid metalloprotease inhibitors |
CN1425004A (zh) | 2000-03-21 | 2003-06-18 | 宝洁公司 | 含杂环侧链的n-取代的金属蛋白酶抑制剂 |
BR0109354A (pt) * | 2000-03-21 | 2003-04-15 | Procter & Gamble | Inibidores de metaloproteases os quais contêm cadeias laterais carbocìclicas |
US6683093B2 (en) | 2000-05-12 | 2004-01-27 | Pharmacia Corporation | Aromatic sulfone hydroxamic acids and their use as protease inhibitors |
FR2823212B1 (fr) * | 2001-04-10 | 2005-12-02 | Inst Nat Sante Rech Med | Inhibiteurs de la toxine botulique de type b |
HUP0304069A2 (hu) | 2001-05-11 | 2004-04-28 | Pharmacia Corp. | Aromás szulfon-hidroxamátok és proteázgátlókként való alkalmazásuk |
MXPA04010555A (es) | 2002-04-25 | 2005-02-17 | Pharmacia Corp | Acidos piperidinil- y piperazinil-sulfonilmetil hidroxamicos y su uso como inhibidores de proteasa. |
CA2495354A1 (en) * | 2002-08-20 | 2004-03-04 | Yamanouchi Pharmaceutical Co., Ltd. | An agent for inhibiting articular cartilage extracellular matrix degradation |
ATE457716T1 (de) | 2002-12-30 | 2010-03-15 | Angiotech Int Ag | Wirkstofffreisetzung von schnell gelierender polymerzusammensetzung |
US7570250B2 (en) * | 2006-05-04 | 2009-08-04 | Yi-Ming Tseng | Control device including a ball that stores data |
DE202010018378U1 (de) | 2009-04-10 | 2016-04-07 | Tufts Medical Center, Inc. | PAR-1-Aktivierung durch Metalloproteinase-1 (MMP-1) |
JP2019525947A (ja) | 2016-06-01 | 2019-09-12 | エムスリー・バイオテクノロジー・インコーポレイテッドM3 Biotechnology, Inc. | 化合物 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK681287A (da) * | 1986-12-24 | 1988-06-25 | Beecham Group Plc | Hidtil ukendte forbindelser |
ATE106087T1 (de) * | 1987-03-17 | 1994-06-15 | Res Corp Technologies Inc | Synthetische inhibitoren von säugetier- collagenase. |
US5144043A (en) * | 1988-06-15 | 1992-09-01 | Centocor | Cleavable bifunctional coupling agents |
WO1994007481A1 (en) * | 1992-10-02 | 1994-04-14 | Merck & Co., Inc. | N-(mercaptoacyl)peptidyl derivatives as antidegenerative agents |
-
1993
- 1993-11-10 GB GB939323165A patent/GB9323165D0/en active Pending
-
1994
- 1994-11-10 CA CA002173470A patent/CA2173470A1/en not_active Abandoned
- 1994-11-10 AU AU81133/94A patent/AU679286B2/en not_active Ceased
- 1994-11-10 BR BR9408025A patent/BR9408025A/pt not_active Application Discontinuation
- 1994-11-10 ES ES95900237T patent/ES2143611T3/es not_active Expired - Lifetime
- 1994-11-10 JP JP7513690A patent/JPH09505041A/ja not_active Ceased
- 1994-11-10 HU HU9601244A patent/HU217344B1/hu not_active IP Right Cessation
- 1994-11-10 DK DK95900237T patent/DK0728144T3/da active
- 1994-11-10 WO PCT/GB1994/002471 patent/WO1995013289A1/en active IP Right Grant
- 1994-11-10 DE DE69422726T patent/DE69422726T2/de not_active Expired - Fee Related
- 1994-11-10 PL PL94314300A patent/PL180403B1/pl unknown
- 1994-11-10 KR KR1019960702437A patent/KR960705843A/ko active IP Right Grant
- 1994-11-10 CZ CZ19961349A patent/CZ287780B6/cs not_active IP Right Cessation
- 1994-11-10 EP EP95900237A patent/EP0728144B1/en not_active Expired - Lifetime
- 1994-11-10 AT AT95900237T patent/ATE188969T1/de not_active IP Right Cessation
- 1994-11-10 CN CN94194051A patent/CN1134705A/zh active Pending
- 1994-11-10 PT PT95900237T patent/PT728144E/pt unknown
-
1996
- 1996-05-09 FI FI961976A patent/FI961976A0/fi unknown
- 1996-05-09 NO NO961888A patent/NO961888D0/no not_active Application Discontinuation
- 1996-05-10 US US08/644,383 patent/US5853623A/en not_active Expired - Fee Related
-
1998
- 1998-12-28 HK HK98115826A patent/HK1015139A1/xx not_active IP Right Cessation
-
2000
- 2000-03-29 GR GR20000400792T patent/GR3033103T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DE69422726T2 (de) | 2000-06-08 |
AU679286B2 (en) | 1997-06-26 |
JPH09505041A (ja) | 1997-05-20 |
KR960705843A (ko) | 1996-11-08 |
HU217344B1 (hu) | 2002-02-28 |
CZ287780B6 (en) | 2001-02-14 |
HU9601244D0 (en) | 1996-07-29 |
ES2143611T3 (es) | 2000-05-16 |
CA2173470A1 (en) | 1995-05-18 |
PT728144E (pt) | 2000-07-31 |
GB9323165D0 (en) | 1994-01-05 |
FI961976A (fi) | 1996-05-09 |
PL180403B1 (pl) | 2001-01-31 |
US5853623A (en) | 1998-12-29 |
EP0728144A1 (en) | 1996-08-28 |
CN1134705A (zh) | 1996-10-30 |
FI961976A0 (fi) | 1996-05-09 |
NO961888L (no) | 1996-05-09 |
AU8113394A (en) | 1995-05-29 |
GR3033103T3 (en) | 2000-08-31 |
ATE188969T1 (de) | 2000-02-15 |
WO1995013289A1 (en) | 1995-05-18 |
CZ134996A3 (en) | 1996-10-16 |
DE69422726D1 (de) | 2000-02-24 |
HUT73799A (en) | 1996-09-30 |
EP0728144B1 (en) | 2000-01-19 |
DK0728144T3 (da) | 2000-07-03 |
HK1015139A1 (en) | 1999-10-08 |
PL314300A1 (en) | 1996-09-02 |
NO961888D0 (no) | 1996-05-09 |
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