DE69631423D1 - Chinolone und deren therapeutische verwendung - Google Patents
Chinolone und deren therapeutische verwendungInfo
- Publication number
- DE69631423D1 DE69631423D1 DE69631423T DE69631423T DE69631423D1 DE 69631423 D1 DE69631423 D1 DE 69631423D1 DE 69631423 T DE69631423 T DE 69631423T DE 69631423 T DE69631423 T DE 69631423T DE 69631423 D1 DE69631423 D1 DE 69631423D1
- Authority
- DE
- Germany
- Prior art keywords
- chinolones
- therapeutic use
- quinolone
- carboxamides
- phosphodiesterase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 230000001225 therapeutic effect Effects 0.000 title abstract 2
- 108060008682 Tumor Necrosis Factor Proteins 0.000 abstract 1
- 108010037584 Type 4 Cyclic Nucleotide Phosphodiesterases Proteins 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 102000003390 tumor necrosis factor Human genes 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9515812.7A GB9515812D0 (en) | 1995-08-02 | 1995-08-02 | Novel compounds |
GB9515812 | 1995-08-02 | ||
GBGB9523679.0A GB9523679D0 (en) | 1995-11-20 | 1995-11-20 | Novel compounds |
GB9523679 | 1995-11-20 | ||
GBGB9605865.6A GB9605865D0 (en) | 1996-03-20 | 1996-03-20 | Novel compounds |
GB9605865 | 1996-03-20 | ||
GBGB9611898.9A GB9611898D0 (en) | 1996-06-07 | 1996-06-07 | Quinolones and their therapeutic use |
GB9611898 | 1996-06-07 | ||
PCT/GB1996/001866 WO1997004775A1 (en) | 1995-08-02 | 1996-07-31 | Quinolones and their therapeutic use |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69631423D1 true DE69631423D1 (de) | 2004-03-04 |
DE69631423T2 DE69631423T2 (de) | 2004-12-02 |
Family
ID=27451320
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69631423T Expired - Fee Related DE69631423T2 (de) | 1995-08-02 | 1996-07-31 | Chinolone und deren therapeutische verwendung |
Country Status (10)
Country | Link |
---|---|
US (1) | US5753666A (de) |
EP (1) | EP0841927B1 (de) |
JP (1) | JPH11510156A (de) |
AT (1) | ATE258437T1 (de) |
AU (1) | AU695132B2 (de) |
CA (1) | CA2225555A1 (de) |
DE (1) | DE69631423T2 (de) |
ES (1) | ES2211965T3 (de) |
MX (1) | MX9800921A (de) |
WO (1) | WO1997004775A1 (de) |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9605437D0 (en) * | 1996-03-15 | 1996-05-15 | Iaf Biochem Int | Cytomegalovirus inhibiting compounds |
AU755350B2 (en) * | 1997-08-06 | 2002-12-12 | Daiichi Asubio Pharma Co., Ltd. | 1-aryl-1,8-naphthylidin-4-one derivative as type IV phosphodiesterase nhibitor |
AU763636C (en) * | 1998-01-29 | 2004-05-27 | Daiichi Asubio Pharma Co., Ltd. | 1-cycloalkyl-1,8-naphthyridin-4-one derivatives with phosphodiesterase IV inhibitory activity |
WO2000001387A1 (en) * | 1998-07-01 | 2000-01-13 | Celgro, A Division Of Celgene Corporation | Fungal growth inhibitors |
US6248739B1 (en) * | 1999-01-08 | 2001-06-19 | Pharmacia & Upjohn Company | Quinolinecarboxamides as antiviral agents |
CA2399741A1 (en) | 2000-03-21 | 2001-11-01 | Scott D. Larsen | 4-hydroxycinnoline-3-carboxyamides as antiviral agents |
EA200201002A1 (ru) | 2000-03-21 | 2003-02-27 | Фармация Энд Апджон Компани | 4-оксо-1,4-дигидро-3-циннолинкарбоксамиды как противовирусные агенты |
BR0108803A (pt) | 2000-03-21 | 2002-11-05 | Upjohn Co | 4-oxo-1,4-diidro[1,8]naftiridina-3-carboxamidas como agentes antivirais |
EP1265896A1 (de) | 2000-03-21 | 2002-12-18 | PHARMACIA & UPJOHN COMPANY | 4-hydroxy-11,8-naphthyridine-3-carboxamide mit antiviraler wirkung |
PE20011349A1 (es) * | 2000-06-16 | 2002-01-19 | Upjohn Co | 1-aril-4-oxo-1,4-dihidro-3-quinolincarboxamidas como agentes antivirales |
US6562822B2 (en) | 2000-07-12 | 2003-05-13 | Pharmacia & Upjohn Company | Heterocyle carboxamides as antiviral agents |
US6559145B2 (en) | 2000-07-12 | 2003-05-06 | Pharmacia & Upjohn Company | Heterocycle carboxamides as antiviral agents |
US6730682B2 (en) * | 2000-07-12 | 2004-05-04 | Pharmacia & Upjohn Company | Heterocycle carboxamides as antiviral agents |
ES2287170T3 (es) * | 2000-10-12 | 2007-12-16 | MERCK & CO., INC. | Aza- y poliaza-naftalenil-carboxamidas utilies como inhibidores de la vih integrasa. |
CA2425625A1 (en) * | 2000-10-12 | 2002-07-18 | Merck & Co., Inc. | Aza-and polyaza-naphthalenyl carboxamides useful as hiv integrase inhibitors |
DE60138635D1 (de) * | 2000-10-12 | 2009-06-18 | Merck & Co Inc | Aza- und polyaza naphthalenyl karboxamide als inhibitoren der hiv-integrase |
EA007538B1 (ru) | 2000-12-11 | 2006-10-27 | Туларик Инк. | Антагонисты cxcr3 |
US20100074949A1 (en) | 2008-08-13 | 2010-03-25 | William Rowe | Pharmaceutical composition and administration thereof |
TWI243164B (en) | 2001-02-13 | 2005-11-11 | Aventis Pharma Gmbh | Acylated indanyl amines and their use as pharmaceuticals |
PE20020856A1 (es) * | 2001-02-13 | 2002-11-11 | Aventis Pharma Gmbh | 1,2,3,4-tetrahidronaftil aminas aciladas |
EP1397359B1 (de) * | 2001-05-24 | 2005-08-31 | Merck Frosst Canada & Co. | 1-biaryl-1,8-naphthyridin-4-one als phosphodieseterase-inhibitoren |
US6794379B2 (en) | 2001-06-06 | 2004-09-21 | Tularik Inc. | CXCR3 antagonists |
JP4494020B2 (ja) * | 2002-03-15 | 2010-06-30 | メルク・シャープ・エンド・ドーム・コーポレイション | Hivインテグラーゼ阻害剤として有用なn−(置換ベンジル)−8−ヒドロキシ−1,6−ナフチリジン−7−カルボキサミド |
IS7839A (is) * | 2002-11-22 | 2004-05-23 | Merck Frosst Canada Ltd. | 4-oxó-1-(3-setið fenýl-1,4-díhýdró-1,8-naftýridín-3-karboxamíð fosfódíesterasa-4 hindrar |
US7488739B2 (en) * | 2003-07-24 | 2009-02-10 | Astellas Pharma Inc. | Quinolone derivative or salt thereof |
CA2810655C (en) | 2004-06-24 | 2013-12-10 | Vertex Pharmaceuticals Incorporated | Modulators of atp-binding cassette transporters |
US8354427B2 (en) | 2004-06-24 | 2013-01-15 | Vertex Pharmaceutical Incorporated | Modulators of ATP-binding cassette transporters |
DE102004035203A1 (de) | 2004-07-21 | 2006-02-16 | Bayer Healthcare Ag | Substituierte Chinolone |
DE102005030524A1 (de) | 2005-06-30 | 2007-01-18 | Aicuris Gmbh & Co. Kg | Substituierte Chinolone II |
TW200800983A (en) * | 2005-09-14 | 2008-01-01 | Janssen Pharmaceutica Nv | 5-oxo-5,8-dihydro-pyrido-pyrimidines as inhibitors of C-FMS kinase |
DK1954274T3 (da) * | 2005-11-10 | 2011-01-31 | Chemocentryx Inc | Substituerede quinoloner og fremgangsmåder til anvendelse |
AU2006331614A1 (en) * | 2005-12-24 | 2007-07-05 | Vertex Pharmaceuticals Incorporated | Quinolin- 4 - one derivatives as modulators of ABC transporters |
EP3708564A1 (de) | 2005-12-28 | 2020-09-16 | Vertex Pharmaceuticals Incorporated | Eine feste form von n-[2,4-bis-(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxochinolin-3-carboxamid |
DE102006005861A1 (de) | 2006-02-09 | 2007-08-23 | Aicuris Gmbh & Co. Kg | Substituierte Chinolone III |
FR2917413B1 (fr) | 2007-06-13 | 2009-08-21 | Sanofi Aventis Sa | Derives de 7-alkynyl-1,8-naphthyridones, leur preparation et leur application en therapeutique |
FR2917412B1 (fr) * | 2007-06-13 | 2009-08-21 | Sanofi Aventis Sa | Derives de 7-alkynyl, 1,8-naphthyridones, leur preparation et leur application en therapeutique |
EP2201010B1 (de) | 2007-09-14 | 2013-11-06 | Vertex Pharmaceuticals Incorporated | Modulatoren des cystic fibrosis transmembrane conductance regulator |
EP2196465A1 (de) | 2008-12-15 | 2010-06-16 | Almirall, S.A. | (3-oxo)pyridazin-4-ylurea-Derivate als PDE4 Hemmern |
WO2010097410A1 (en) | 2009-02-24 | 2010-09-02 | Respiratorius Ab | Novel bronchodilating diazaheteroaryls |
EP2226323A1 (de) | 2009-02-27 | 2010-09-08 | Almirall, S.A. | Neuartige Tetrahydropyrazol[3,4-c]isochinolin-5-amin-Derivate |
KR101852173B1 (ko) | 2009-03-20 | 2018-04-27 | 버텍스 파마슈티칼스 인코포레이티드 | 낭성 섬유증 막횡단 전도도 조절자의 조정자의 제조 방법 |
EP2380890A1 (de) | 2010-04-23 | 2011-10-26 | Almirall, S.A. | Neue 7,8-Dihydro-1,6-Naphthyridin-5(6H)-on-Derivate als PDE4 Inhibitoren |
EP2394998A1 (de) | 2010-05-31 | 2011-12-14 | Almirall, S.A. | 3-(5-Amino-6-oxo-1,6-dihydropyridazin-3-yl)-biphenyl Derivate als PDE4 Inhibitoren |
US8802700B2 (en) | 2010-12-10 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-Binding Cassette transporters |
CN102643268B (zh) * | 2011-12-30 | 2014-05-21 | 沈阳药科大学 | 喹啉类及噌啉类化合物及其应用 |
AU2013207510A1 (en) | 2012-01-06 | 2014-07-31 | The Regents Of The University Of California | Compositions, methods of use, and methods of treatment |
CN104470518A (zh) | 2012-02-27 | 2015-03-25 | 沃泰克斯药物股份有限公司 | 药物组合物及其施用 |
JP6746569B2 (ja) | 2014-10-07 | 2020-08-26 | バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated | 嚢胞性線維症膜貫通コンダクタンス制御因子のモジュレーターの共結晶 |
CN107998131B (zh) * | 2017-12-27 | 2019-09-24 | 湖北工业大学 | 芳香酯类化合物用于制备抗adv-7病毒药物 |
CN111646941A (zh) * | 2020-07-17 | 2020-09-11 | 天津科技大学 | 一种磺酰胺类衍生物及其制备方法和应用 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3524858A (en) * | 1967-05-18 | 1970-08-18 | Warner Lambert Pharmaceutical | 1,4 - dihydro-1-substituted alkyl-6,7-methylenedioxy - 4 - oxoquinoline-3-carboxylic acid |
FR2564832B1 (fr) * | 1984-05-23 | 1987-05-15 | Panmedica Sa | Nouveaux n-acyl derives d'amino-acides et leurs esters, leur procede de preparation et medicaments les contenant |
US4786644A (en) * | 1987-11-27 | 1988-11-22 | Hoechst-Roussel Pharmaceuticals Inc. | 1-aryl-3-quinolinecarboxamide |
JPH02124871A (ja) * | 1988-07-27 | 1990-05-14 | Dainippon Pharmaceut Co Ltd | 1位が置換された複素環式カルボン酸アミド誘導体 |
-
1996
- 1996-07-31 CA CA002225555A patent/CA2225555A1/en not_active Abandoned
- 1996-07-31 EP EP96925909A patent/EP0841927B1/de not_active Expired - Lifetime
- 1996-07-31 DE DE69631423T patent/DE69631423T2/de not_active Expired - Fee Related
- 1996-07-31 JP JP9507375A patent/JPH11510156A/ja not_active Ceased
- 1996-07-31 ES ES96925909T patent/ES2211965T3/es not_active Expired - Lifetime
- 1996-07-31 MX MX9800921A patent/MX9800921A/es not_active IP Right Cessation
- 1996-07-31 AU AU66266/96A patent/AU695132B2/en not_active Ceased
- 1996-07-31 WO PCT/GB1996/001866 patent/WO1997004775A1/en active IP Right Grant
- 1996-07-31 AT AT96925909T patent/ATE258437T1/de not_active IP Right Cessation
- 1996-08-02 US US08/691,339 patent/US5753666A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
MX9800921A (es) | 1998-05-31 |
ES2211965T3 (es) | 2004-07-16 |
EP0841927B1 (de) | 2004-01-28 |
AU695132B2 (en) | 1998-08-06 |
JPH11510156A (ja) | 1999-09-07 |
DE69631423T2 (de) | 2004-12-02 |
WO1997004775A1 (en) | 1997-02-13 |
CA2225555A1 (en) | 1997-02-13 |
US5753666A (en) | 1998-05-19 |
AU6626696A (en) | 1997-02-26 |
ATE258437T1 (de) | 2004-02-15 |
EP0841927A1 (de) | 1998-05-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69631423D1 (de) | Chinolone und deren therapeutische verwendung | |
MX9800922A (es) | Quinolonas y su uso terapeutico. | |
DE69722656D1 (de) | Bicyclische arylcarboxamide und ihre therapeutische verwendung | |
NO20014560L (no) | Quinasoliner og terapautisk anvendelse derav | |
ATE302414T1 (de) | Verbindungen zur immundiagnose von prostatakrebs und deren verwendung | |
ES2143611T3 (es) | Compuestos de peptidilo y su uso terapeutico como inhibidores de metaloproteinasas. | |
CY2311B1 (en) | Compounds useful for treating allergic or inflammatory diseases. | |
IL136738A0 (en) | Inhibition of p38 kinase activity using substituted heterocyclic ureas | |
HK1031832A1 (en) | Inhibition of p38 kinase activity using aryl and heteroaryl substituted heterocyclic ureas | |
DE1019040T1 (de) | Hemmung von p38 kinase aktivität durch arylharnstoff | |
DE69723863D1 (de) | Chinoline und deren therapeutische verwendung | |
DE69622074T2 (de) | Cystin-Silikon-Copolymere und deren Verwendung zur Behandlung von keratinischen Materialien | |
DE69738045D1 (de) | Verwendung von cetrorelix zur behandlung von benigne prostatahypertrophie und prostatakrebs | |
UA66793C2 (uk) | Лептин як стримувач швидкого збільшення пухлини клітини | |
AU3000297A (en) | Use of protein kinase c inhibitors to enhance the clinical efficacy of oncolytic agents and radiation therapy | |
DE69534908D1 (de) | Verwendung von statin zur behandlung von hauterkrankungen | |
DE69620639D1 (de) | Mercaptoalkylpeptidylverbindungen mit einem imidazolsubstituenten und ihre verwendung als inhibitoren der matrix metalloproteinasen (mmp) und/oder des tumor necrosis faktors (tnf) | |
ATE229034T1 (de) | 3-mercaptoacetylamino-1,5-substituierte-2-oxo- azepan derivate und deren verwendung als inhibitoren von matrix-metalloproteinasen | |
DE69329062T2 (de) | Verwendung von inhibitoren der 3-hydroxy-3-methylglutaryl-coenzym a-reduktase als mittel zur krebstherapie | |
PT964860E (pt) | Atropisomeros de 3-heteroaril-4(3h)-quinazolinonas para o tratamento de condicoes neurogenerativas e relacionadas com trauma do sistema nervoso central | |
AU8742198A (en) | Use of cholinesterase inhibitor for treating diseases associated with pro teolytic enzyme activity | |
NO981822L (no) | Anvendelse av proteinet GAX for behandling av cancer | |
ATE303158T1 (de) | Verwendung von beta-interferon zur behandlung der restenose | |
UA10928C2 (uk) | Спосіб профілактики гіперхолестериhемії | |
FR2699807B1 (fr) | Installation de cryochirurgie de tissus biologiques. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |