EA200201002A1 - 4-оксо-1,4-дигидро-3-циннолинкарбоксамиды как противовирусные агенты - Google Patents
4-оксо-1,4-дигидро-3-циннолинкарбоксамиды как противовирусные агентыInfo
- Publication number
- EA200201002A1 EA200201002A1 EA200201002A EA200201002A EA200201002A1 EA 200201002 A1 EA200201002 A1 EA 200201002A1 EA 200201002 A EA200201002 A EA 200201002A EA 200201002 A EA200201002 A EA 200201002A EA 200201002 A1 EA200201002 A1 EA 200201002A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- nrr
- optionally substituted
- alkyl
- sor
- het
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/28—Cinnolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Предлагаются соединение формулы Iили его фармацевтически приемлемая соль, где А представляет собой(a) Cl,(b) Br,(c) CN,(d) NOили(e) F;Rпредставляет собой(a) Rили(b) SORR, Rи Rмогут быть одинаковыми или различными, и выбираются из группы, включающей(a) Н,(b) галоген,(c) арил,(d) S(O)R,(e) (C=O)R,(f) (C=O)OR,(g) циано,(h) het, где указанный het соединен через атом углерода,(i) OR,(j) Ohet,(k) NRR,(j) SR,(m) Shet,(n) NHCOR,(o) NHSOR,(p) Салкил, который может быть частично ненасыщенным и необязательно замещен одним или несколькими заместителями из группы, состоящей из R, OR, SR, SR, NRR, галогена, (С=O)Салкила или SOR; и(q) Rвместе с Rили Rобразуют карбоциклический или гетероциклический радикал, который может быть необязательно замещен NRRили Салкилом, который может быть необязательно замещен OR;Rпредставляет собой(a) (CHCHO)R,(b) Салкил, который может быть частично ненасыщенным и необязательно замещен одним или несколькими заместителями, выбранными из группы, состоящей из NRR, R, SORили ОСалкила, который может быть дополнительно замещен het, ORили NRR, или(c) Сциклоалкил, который может быть частично ненасыщенным и необязательно замещен одним или несколькими заместителями, выбранными из группы, состоящей из R, NRR, SORили Салкила, необязательно замещенного R, NRRили SOR;Rпредставляет собой(a) Cалкил,(b) NRR,(c) арил или(а) het, где указанный het соединен через атом углерода;Rи Rнезависимо представляют собой(a) Н,(b) арил,(c) Салкил, который может быть частично ненасыщенным и необязательно замещен одним или несколькими заместителями, выбранными из группы, состоящей из арила, NRR, R, SOR, CONRRили галогена, или(а) Сциклоалкил, который может быть частично ненасыщенным и необязательно замещен одним или несколькими заместителями, выбранными из группы, состоящей из R, NRR, SORили Салкила, необязательно замещенного R, NRRили SOR, или(е) Rи Rвместе с атомом азота, к которому они присоединены, образуют het;Rпредставляет
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US19129100P | 2000-03-21 | 2000-03-21 | |
PCT/US2001/005811 WO2001070706A2 (en) | 2000-03-21 | 2001-03-15 | 4-oxo-1,4-dihydro-3-cinnolinecarboxamides as antiviral agents |
Publications (1)
Publication Number | Publication Date |
---|---|
EA200201002A1 true EA200201002A1 (ru) | 2003-02-27 |
Family
ID=22704885
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200201002A EA200201002A1 (ru) | 2000-03-21 | 2001-03-15 | 4-оксо-1,4-дигидро-3-циннолинкарбоксамиды как противовирусные агенты |
Country Status (28)
Country | Link |
---|---|
US (1) | US6624160B2 (ru) |
EP (1) | EP1265873B1 (ru) |
JP (1) | JP2003528087A (ru) |
KR (1) | KR20020081479A (ru) |
CN (1) | CN1406228A (ru) |
AR (1) | AR027978A1 (ru) |
AT (1) | ATE252086T1 (ru) |
AU (1) | AU2001247224A1 (ru) |
BR (1) | BR0109487A (ru) |
CA (1) | CA2400000A1 (ru) |
CZ (1) | CZ20023141A3 (ru) |
DE (1) | DE60100999T2 (ru) |
DK (1) | DK1265873T3 (ru) |
EA (1) | EA200201002A1 (ru) |
EE (1) | EE200200541A (ru) |
ES (1) | ES2208581T3 (ru) |
HK (1) | HK1052694A1 (ru) |
HU (1) | HUP0300326A3 (ru) |
IL (1) | IL151787A0 (ru) |
MX (1) | MXPA02009251A (ru) |
NO (1) | NO20024502L (ru) |
NZ (1) | NZ521524A (ru) |
PL (1) | PL357443A1 (ru) |
PT (1) | PT1265873E (ru) |
SI (1) | SI1265873T1 (ru) |
SK (1) | SK12102002A3 (ru) |
WO (1) | WO2001070706A2 (ru) |
ZA (1) | ZA200207540B (ru) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PE20011349A1 (es) * | 2000-06-16 | 2002-01-19 | Upjohn Co | 1-aril-4-oxo-1,4-dihidro-3-quinolincarboxamidas como agentes antivirales |
JP6237779B2 (ja) * | 2012-11-03 | 2017-11-29 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | サイトメガロウイルスの阻害薬 |
KR20230170813A (ko) | 2018-09-12 | 2023-12-19 | 노파르티스 아게 | 항바이러스 피리도피라진디온 화합물 |
KR20220070005A (ko) | 2019-09-26 | 2022-05-27 | 노파르티스 아게 | 항바이러스성 피라졸로피리디논 화합물 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8513639D0 (en) | 1985-05-30 | 1985-07-03 | Ici America Inc | Cinnoline compounds |
GB8702288D0 (en) | 1987-02-02 | 1987-03-11 | Erba Farmitalia | Cinnoline-carboxamides |
ES2193252T3 (es) | 1995-08-02 | 2003-11-01 | Darwin Discovery Ltd | Quinolonas y su uso terapeutico. |
DE69631423T2 (de) | 1995-08-02 | 2004-12-02 | Darwin Discovery Ltd., Slough | Chinolone und deren therapeutische verwendung |
KR20010033405A (ko) | 1997-12-22 | 2001-04-25 | 로렌스 티.마이즌 헬더. | 4-히드록시퀴놀린-3-카르복스아미드 및 히드라지드항바이러스제 |
HUP0002353A3 (en) | 1998-01-29 | 2001-11-28 | Daiichi Asubio Pharma Co Ltd | 1-cycloalkyl-1,8-naphthyridin-4-one derivatives with phoshodiesterase iv inhibitory activity and pharmaceutical compositions containing them |
-
2001
- 2001-03-15 DE DE60100999T patent/DE60100999T2/de not_active Expired - Fee Related
- 2001-03-15 NZ NZ521524A patent/NZ521524A/en unknown
- 2001-03-15 US US09/808,836 patent/US6624160B2/en not_active Expired - Fee Related
- 2001-03-15 KR KR1020027012466A patent/KR20020081479A/ko not_active Application Discontinuation
- 2001-03-15 ES ES01920138T patent/ES2208581T3/es not_active Expired - Lifetime
- 2001-03-15 PT PT01920138T patent/PT1265873E/pt unknown
- 2001-03-15 SK SK1210-2002A patent/SK12102002A3/sk unknown
- 2001-03-15 CN CN01805756A patent/CN1406228A/zh active Pending
- 2001-03-15 IL IL15178701A patent/IL151787A0/xx unknown
- 2001-03-15 HU HU0300326A patent/HUP0300326A3/hu unknown
- 2001-03-15 EE EEP200200541A patent/EE200200541A/xx unknown
- 2001-03-15 DK DK01920138T patent/DK1265873T3/da active
- 2001-03-15 MX MXPA02009251A patent/MXPA02009251A/es active IP Right Grant
- 2001-03-15 BR BR0109487-4A patent/BR0109487A/pt not_active IP Right Cessation
- 2001-03-15 AT AT01920138T patent/ATE252086T1/de not_active IP Right Cessation
- 2001-03-15 PL PL01357443A patent/PL357443A1/xx not_active Application Discontinuation
- 2001-03-15 CZ CZ20023141A patent/CZ20023141A3/cs unknown
- 2001-03-15 JP JP2001568916A patent/JP2003528087A/ja active Pending
- 2001-03-15 EA EA200201002A patent/EA200201002A1/ru unknown
- 2001-03-15 CA CA002400000A patent/CA2400000A1/en not_active Abandoned
- 2001-03-15 EP EP01920138A patent/EP1265873B1/en not_active Expired - Lifetime
- 2001-03-15 SI SI200130046T patent/SI1265873T1/xx unknown
- 2001-03-15 AU AU2001247224A patent/AU2001247224A1/en not_active Abandoned
- 2001-03-15 WO PCT/US2001/005811 patent/WO2001070706A2/en active IP Right Grant
- 2001-03-20 AR ARP010101303A patent/AR027978A1/es unknown
-
2002
- 2002-09-19 ZA ZA200207540A patent/ZA200207540B/en unknown
- 2002-09-20 NO NO20024502A patent/NO20024502L/no not_active Application Discontinuation
-
2003
- 2003-07-09 HK HK03104900.8A patent/HK1052694A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
US6624160B2 (en) | 2003-09-23 |
ES2208581T3 (es) | 2004-06-16 |
HK1052694A1 (zh) | 2003-09-26 |
PT1265873E (pt) | 2004-03-31 |
HUP0300326A3 (en) | 2003-09-29 |
ATE252086T1 (de) | 2003-11-15 |
NO20024502L (no) | 2002-11-20 |
AU2001247224A1 (en) | 2001-10-03 |
EP1265873B1 (en) | 2003-10-15 |
KR20020081479A (ko) | 2002-10-26 |
SI1265873T1 (en) | 2004-02-29 |
US20020045619A1 (en) | 2002-04-18 |
AR027978A1 (es) | 2003-04-23 |
NZ521524A (en) | 2004-04-30 |
WO2001070706A2 (en) | 2001-09-27 |
IL151787A0 (en) | 2003-04-10 |
DE60100999T2 (de) | 2004-09-02 |
MXPA02009251A (es) | 2004-04-05 |
PL357443A1 (en) | 2004-07-26 |
HUP0300326A2 (hu) | 2003-07-28 |
DE60100999D1 (en) | 2003-11-20 |
NO20024502D0 (no) | 2002-09-20 |
WO2001070706A3 (en) | 2002-05-10 |
EP1265873A2 (en) | 2002-12-18 |
CZ20023141A3 (cs) | 2003-02-12 |
JP2003528087A (ja) | 2003-09-24 |
ZA200207540B (en) | 2003-12-19 |
BR0109487A (pt) | 2003-06-10 |
CN1406228A (zh) | 2003-03-26 |
EE200200541A (et) | 2004-04-15 |
SK12102002A3 (sk) | 2003-03-04 |
DK1265873T3 (da) | 2004-02-16 |
CA2400000A1 (en) | 2001-09-27 |
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