HUP0300326A2 - Vírusellenes hatású 4-oxo-1,4-dihidro-3-cinnolinkarboxamid-származékok, alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények - Google Patents

Vírusellenes hatású 4-oxo-1,4-dihidro-3-cinnolinkarboxamid-származékok, alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények

Info

Publication number
HUP0300326A2
HUP0300326A2 HU0300326A HUP0300326A HUP0300326A2 HU P0300326 A2 HUP0300326 A2 HU P0300326A2 HU 0300326 A HU0300326 A HU 0300326A HU P0300326 A HUP0300326 A HU P0300326A HU P0300326 A2 HUP0300326 A2 HU P0300326A2
Authority
HU
Hungary
Prior art keywords
group
alkyl
general formula
atom
compounds
Prior art date
Application number
HU0300326A
Other languages
English (en)
Inventor
Scott D. Larsen
Sajiv K. Nair
Valerie A. Vaillancourt
Original Assignee
Pharmacia & Upjohn Co.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Co. filed Critical Pharmacia & Upjohn Co.
Publication of HUP0300326A2 publication Critical patent/HUP0300326A2/hu
Publication of HUP0300326A3 publication Critical patent/HUP0300326A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/28—Cinnolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

A találmány az (I) általános képletű vegyületekre vonatkozik, aképletben A jelentése klór-, brómatom, ciano-, nitrocsoport vagyfluoratom; R1 jelentése R5 vagy -SO2R9 általános képletű csoport; R2,R3 és R4 jelentése azonosan vagy különbözően hidrogénatom,halogénatom, arilcsclport, -S(O)mR6, -(C=O)R6, -(C=O)OR9 általánosképletű csoport, cianocsoport, heterociklus, amely heterociklus egyszánatomon keresztül kapcsolódik, -OR10 általános képletű csoport, -OHet, -NR7R8, -SR10, -Shet, -NHCOR12, -NHSO2R12 általános képletűcsoport, alkilcsoport, amely részben telítetlen lehet, és adottesetben egy vagy több szubsztituenssel, mégpedig R11, -OR13, -SR10, -SR13, -NR7R8 általános képletű csoporttal, halogénatommal, -(C=O)-alkil- vagy, -SOmR9 általános képletű csoporttal helyettesített, R5adott esetben helyettesített alkil- vagy cikloalkilcsoport, R9előnyösen aril-, heteroaril-, alkil- vagy cikloalkilcsoport. Atalálmány kiterjed a fenti vegyületeket tartalmazó vírusellenes hatásúgyógyszerkészítményekre és a vegyületek alkalmazási eljárására is. Ó
HU0300326A 2000-03-21 2001-03-15 4-oxo-1,4-dihydro-3-cinnolinecarboxamides of antiviral effect their use and pharmaceutical compositions containing them HUP0300326A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19129100P 2000-03-21 2000-03-21
PCT/US2001/005811 WO2001070706A2 (en) 2000-03-21 2001-03-15 4-oxo-1,4-dihydro-3-cinnolinecarboxamides as antiviral agents

Publications (2)

Publication Number Publication Date
HUP0300326A2 true HUP0300326A2 (hu) 2003-07-28
HUP0300326A3 HUP0300326A3 (en) 2003-09-29

Family

ID=22704885

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0300326A HUP0300326A3 (en) 2000-03-21 2001-03-15 4-oxo-1,4-dihydro-3-cinnolinecarboxamides of antiviral effect their use and pharmaceutical compositions containing them

Country Status (28)

Country Link
US (1) US6624160B2 (hu)
EP (1) EP1265873B1 (hu)
JP (1) JP2003528087A (hu)
KR (1) KR20020081479A (hu)
CN (1) CN1406228A (hu)
AR (1) AR027978A1 (hu)
AT (1) ATE252086T1 (hu)
AU (1) AU2001247224A1 (hu)
BR (1) BR0109487A (hu)
CA (1) CA2400000A1 (hu)
CZ (1) CZ20023141A3 (hu)
DE (1) DE60100999T2 (hu)
DK (1) DK1265873T3 (hu)
EA (1) EA200201002A1 (hu)
EE (1) EE200200541A (hu)
ES (1) ES2208581T3 (hu)
HK (1) HK1052694A1 (hu)
HU (1) HUP0300326A3 (hu)
IL (1) IL151787A0 (hu)
MX (1) MXPA02009251A (hu)
NO (1) NO20024502L (hu)
NZ (1) NZ521524A (hu)
PL (1) PL357443A1 (hu)
PT (1) PT1265873E (hu)
SI (1) SI1265873T1 (hu)
SK (1) SK12102002A3 (hu)
WO (1) WO2001070706A2 (hu)
ZA (1) ZA200207540B (hu)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20011349A1 (es) * 2000-06-16 2002-01-19 Upjohn Co 1-aril-4-oxo-1,4-dihidro-3-quinolincarboxamidas como agentes antivirales
US9505775B2 (en) 2012-11-03 2016-11-29 Boehringer Ingelheim International Gmbh Inhibitors of cytomegalovirus
JP7273951B2 (ja) 2018-09-12 2023-05-15 ノバルティス アーゲー 抗ウイルス性ピリドピラジンジオン化合物
KR20220070005A (ko) 2019-09-26 2022-05-27 노파르티스 아게 항바이러스성 피라졸로피리디논 화합물

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8513639D0 (en) 1985-05-30 1985-07-03 Ici America Inc Cinnoline compounds
GB8702288D0 (en) 1987-02-02 1987-03-11 Erba Farmitalia Cinnoline-carboxamides
MX9800922A (es) 1995-08-02 1998-05-31 Darwin Discovery Ltd Quinolonas y su uso terapeutico.
EP0841927B1 (en) 1995-08-02 2004-01-28 Darwin Discovery Limited Quinolones and their therapeutic use
CA2309882A1 (en) 1997-12-22 1999-07-01 Pharmacia & Upjohn Company 4-hydroxyquinoline-3-carboxamides and hydrazides as antiviral agents
KR20010005830A (ko) 1998-01-29 2001-01-15 도리이 신이치로 타입 ⅳ 포스포디에스테라제 억제활성을 지닌 1-사이클로알킬-1,8-나프틸리딘-4-온 유도체

Also Published As

Publication number Publication date
BR0109487A (pt) 2003-06-10
CN1406228A (zh) 2003-03-26
EP1265873B1 (en) 2003-10-15
NO20024502D0 (no) 2002-09-20
WO2001070706A2 (en) 2001-09-27
EP1265873A2 (en) 2002-12-18
MXPA02009251A (es) 2004-04-05
AU2001247224A1 (en) 2001-10-03
KR20020081479A (ko) 2002-10-26
WO2001070706A3 (en) 2002-05-10
EA200201002A1 (ru) 2003-02-27
PL357443A1 (en) 2004-07-26
CA2400000A1 (en) 2001-09-27
DK1265873T3 (da) 2004-02-16
DE60100999D1 (en) 2003-11-20
SK12102002A3 (sk) 2003-03-04
ATE252086T1 (de) 2003-11-15
NO20024502L (no) 2002-11-20
IL151787A0 (en) 2003-04-10
US6624160B2 (en) 2003-09-23
EE200200541A (et) 2004-04-15
NZ521524A (en) 2004-04-30
DE60100999T2 (de) 2004-09-02
US20020045619A1 (en) 2002-04-18
HK1052694A1 (zh) 2003-09-26
JP2003528087A (ja) 2003-09-24
ES2208581T3 (es) 2004-06-16
AR027978A1 (es) 2003-04-23
CZ20023141A3 (cs) 2003-02-12
SI1265873T1 (en) 2004-02-29
ZA200207540B (en) 2003-12-19
HUP0300326A3 (en) 2003-09-29
PT1265873E (pt) 2004-03-31

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Legal Events

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FD9A Lapse of provisional protection due to non-payment of fees