BR9303658A - Processo para aumentar a quantidade de nucleosideo de beta-anomero - Google Patents

Processo para aumentar a quantidade de nucleosideo de beta-anomero

Info

Publication number
BR9303658A
BR9303658A BR9303658A BR9303658A BR9303658A BR 9303658 A BR9303658 A BR 9303658A BR 9303658 A BR9303658 A BR 9303658A BR 9303658 A BR9303658 A BR 9303658A BR 9303658 A BR9303658 A BR 9303658A
Authority
BR
Brazil
Prior art keywords
nucleoside
beta
anomero
increase
anomer
Prior art date
Application number
BR9303658A
Other languages
English (en)
Inventor
Thomas Charles Britton
Michael Edward Le Tourneau
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of BR9303658A publication Critical patent/BR9303658A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/048—Pyridine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
BR9303658A 1992-09-01 1993-08-31 Processo para aumentar a quantidade de nucleosideo de beta-anomero BR9303658A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US93879192A 1992-09-01 1992-09-01

Publications (1)

Publication Number Publication Date
BR9303658A true BR9303658A (pt) 1994-03-22

Family

ID=25471966

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9303658A BR9303658A (pt) 1992-09-01 1993-08-31 Processo para aumentar a quantidade de nucleosideo de beta-anomero

Country Status (15)

Country Link
US (1) US5420266A (pt)
EP (1) EP0587364B1 (pt)
JP (1) JP3462893B2 (pt)
KR (1) KR100252451B1 (pt)
AT (1) ATE138929T1 (pt)
BR (1) BR9303658A (pt)
CA (1) CA2105112C (pt)
DE (1) DE69302977T2 (pt)
DK (1) DK0587364T3 (pt)
ES (1) ES2090880T3 (pt)
GR (1) GR3020426T3 (pt)
HU (1) HU214980B (pt)
IL (1) IL106840A (pt)
MX (1) MX9305301A (pt)
TW (1) TW356472B (pt)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW374087B (en) * 1993-05-25 1999-11-11 Univ Yale L-2',3'-dideoxy nucleotide analogs as anti-hepatitis B(HBV) and anti-HIV agents
US5627160A (en) * 1993-05-25 1997-05-06 Yale University L-2',3'-dideoxy nucleoside analogs as anti-hepatitis B (HBV) and anti-HIV agents
US5637688A (en) * 1994-12-13 1997-06-10 Eli Lilly And Company Process for preparing 1-(2'-deoxy-2'-difluoro-d-ribofuranosyl)-4-aminopyrimidin-2-one hydrochloride
US5869461A (en) * 1995-03-16 1999-02-09 Yale University Reducing toxicity of L-nucleosides with D-nucleosides
US5633367A (en) * 1995-03-24 1997-05-27 Eli Lilly And Company Process for the preparation of a 2-substituted 3,3-difluorofuran
CA2171518A1 (en) * 1995-03-24 1996-09-25 Douglas Patton Kjell Process for the preparation of 2,2'-anhydro- and 2' -keto-1-(3', 5'-di-o-protected-.beta.-d-arabinofuranosyl) nucleosides
US6013790A (en) * 1996-09-25 2000-01-11 Board Of Regents University Of Nebraska-Lincoln Heavily fluorinated sugar analogs
US6248878B1 (en) * 1996-12-24 2001-06-19 Ribozyme Pharmaceuticals, Inc. Nucleoside analogs
MY164523A (en) 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
CA2410579C (en) 2000-05-26 2010-04-20 Jean-Pierre Sommadossi Methods and compositions for treating flaviviruses and pestiviruses
KR100467016B1 (ko) * 2002-05-30 2005-01-24 삼성전자주식회사 반도체기판의 세정방법
RS113904A (en) 2002-06-28 2007-02-05 Idenix (Cayman) Limited 2'-c-methyl-3'-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
US7608600B2 (en) 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
CN1849142A (zh) 2002-11-15 2006-10-18 埃迪尼克斯(开曼)有限公司 2′－支链核苷和黄病毒突变
RU2358979C2 (ru) 2003-05-30 2009-06-20 Фармассет, Инк. Модифицированные фторированные аналоги нуклеозида
CN101023094B (zh) * 2004-07-21 2011-05-18 法莫赛特股份有限公司 烷基取代的2-脱氧-2-氟代-d-呋喃核糖基嘧啶和嘌呤及其衍生物的制备
KR101177590B1 (ko) * 2004-09-14 2012-08-27 파마셋 인코포레이티드 2'-플루오로-2'-알킬 치환되거나 또는 다른 선택적으로치환된 리보퓨라노실 피리미딘 및 퓨린 및 그 유도체의제조
EP1853616B1 (en) * 2005-03-04 2010-02-24 Fresenius Kabi Oncology Limited Intermediate and process for preparing of beta-anomer enriched 2'-deoxy,2',2'-difluoro-d-ribofuranosyl nucleosides
JP5254033B2 (ja) 2005-12-23 2013-08-07 イデニク プハルマセウティカルス，インコーポレイテッド 分岐型ヌクレオシドを調製するための合成中間体の製造方法
US7964580B2 (en) 2007-03-30 2011-06-21 Pharmasset, Inc. Nucleoside phosphoramidate prodrugs
US8173621B2 (en) * 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
KR20110104074A (ko) 2008-12-23 2011-09-21 파마셋 인코포레이티드 퓨린 뉴클레오시드의 합성
US8551973B2 (en) * 2008-12-23 2013-10-08 Gilead Pharmasset Llc Nucleoside analogs
PA8855601A1 (es) * 2008-12-23 2010-07-27 Forformidatos de nucleósidos
US8618076B2 (en) 2009-05-20 2013-12-31 Gilead Pharmasset Llc Nucleoside phosphoramidates
TWI583692B (zh) 2009-05-20 2017-05-21 基利法瑪席特有限責任公司 核苷磷醯胺
US8563530B2 (en) 2010-03-31 2013-10-22 Gilead Pharmassel LLC Purine nucleoside phosphoramidate
CA2794671C (en) 2010-03-31 2018-05-01 Gilead Pharmasset Llc Stereoselective synthesis of phosphorus containing actives
WO2012075140A1 (en) 2010-11-30 2012-06-07 Pharmasset, Inc. Compounds
US8889159B2 (en) 2011-11-29 2014-11-18 Gilead Pharmasset Llc Compositions and methods for treating hepatitis C virus
CN102603838B (zh) * 2012-02-14 2015-02-18 江苏八巨药业有限公司 一种制备吉西他滨盐酸盐的方法
EP4005560A1 (en) 2013-08-27 2022-06-01 Gilead Pharmasset LLC Combination formulation of two antiviral compounds
EP3820879A4 (en) 2018-06-29 2022-04-13 Shanghai Changchengyiyaokeji Company Limited GEMCITABINE PHOSPHORUS-CONTAINING PRODRUGS

Also Published As

Publication number Publication date
CA2105112C (en) 2005-08-02
ATE138929T1 (de) 1996-06-15
DE69302977T2 (de) 1996-10-31
IL106840A0 (en) 1993-12-08
DE69302977D1 (de) 1996-07-11
IL106840A (en) 1998-09-24
CA2105112A1 (en) 1994-03-02
MX9305301A (es) 1994-06-30
HU214980B (hu) 1998-08-28
EP0587364B1 (en) 1996-06-05
KR100252451B1 (ko) 2000-04-15
TW356472B (en) 1999-04-21
HU9302452D0 (en) 1993-11-29
JP3462893B2 (ja) 2003-11-05
DK0587364T3 (da) 1996-07-01
KR940007053A (ko) 1994-04-26
JPH06157571A (ja) 1994-06-03
ES2090880T3 (es) 1996-10-16
HUT65137A (en) 1994-04-28
EP0587364A1 (en) 1994-03-16
US5420266A (en) 1995-05-30
GR3020426T3 (en) 1996-10-31

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Legal Events

Date Code Title Description
EE Request for examination
EG Technical examination (opinion): publication of technical examination (opinion)
FC Decision: refusal
CKFC Appeal: appeal against refusal