ATE138929T1 - Verfahren zur anomizierung von nukleosiden - Google Patents
Verfahren zur anomizierung von nukleosidenInfo
- Publication number
- ATE138929T1 ATE138929T1 AT93306886T AT93306886T ATE138929T1 AT E138929 T1 ATE138929 T1 AT E138929T1 AT 93306886 T AT93306886 T AT 93306886T AT 93306886 T AT93306886 T AT 93306886T AT E138929 T1 ATE138929 T1 AT E138929T1
- Authority
- AT
- Austria
- Prior art keywords
- nucleosides
- anomizing
- anomer
- anomeric mixture
- nucleoside
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/048—Pyridine radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US93879192A | 1992-09-01 | 1992-09-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE138929T1 true ATE138929T1 (de) | 1996-06-15 |
Family
ID=25471966
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT93306886T ATE138929T1 (de) | 1992-09-01 | 1993-08-31 | Verfahren zur anomizierung von nukleosiden |
Country Status (15)
Country | Link |
---|---|
US (1) | US5420266A (de) |
EP (1) | EP0587364B1 (de) |
JP (1) | JP3462893B2 (de) |
KR (1) | KR100252451B1 (de) |
AT (1) | ATE138929T1 (de) |
BR (1) | BR9303658A (de) |
CA (1) | CA2105112C (de) |
DE (1) | DE69302977T2 (de) |
DK (1) | DK0587364T3 (de) |
ES (1) | ES2090880T3 (de) |
GR (1) | GR3020426T3 (de) |
HU (1) | HU214980B (de) |
IL (1) | IL106840A (de) |
MX (1) | MX9305301A (de) |
TW (1) | TW356472B (de) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5627160A (en) * | 1993-05-25 | 1997-05-06 | Yale University | L-2',3'-dideoxy nucleoside analogs as anti-hepatitis B (HBV) and anti-HIV agents |
TW374087B (en) * | 1993-05-25 | 1999-11-11 | Univ Yale | L-2',3'-dideoxy nucleotide analogs as anti-hepatitis B(HBV) and anti-HIV agents |
US5637688A (en) * | 1994-12-13 | 1997-06-10 | Eli Lilly And Company | Process for preparing 1-(2'-deoxy-2'-difluoro-d-ribofuranosyl)-4-aminopyrimidin-2-one hydrochloride |
US5869461A (en) * | 1995-03-16 | 1999-02-09 | Yale University | Reducing toxicity of L-nucleosides with D-nucleosides |
CA2171518A1 (en) * | 1995-03-24 | 1996-09-25 | Douglas Patton Kjell | Process for the preparation of 2,2'-anhydro- and 2' -keto-1-(3', 5'-di-o-protected-.beta.-d-arabinofuranosyl) nucleosides |
US5633367A (en) * | 1995-03-24 | 1997-05-27 | Eli Lilly And Company | Process for the preparation of a 2-substituted 3,3-difluorofuran |
US6013790A (en) * | 1996-09-25 | 2000-01-11 | Board Of Regents University Of Nebraska-Lincoln | Heavily fluorinated sugar analogs |
US6248878B1 (en) * | 1996-12-24 | 2001-06-19 | Ribozyme Pharmaceuticals, Inc. | Nucleoside analogs |
MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
EA200601591A1 (ru) | 2000-05-26 | 2007-02-27 | Айденикс (Кайман) Лимитед | Применение рибонуклеозидных соединений для лечения флавивирусных и пестивирусных инфекций |
KR100467016B1 (ko) * | 2002-05-30 | 2005-01-24 | 삼성전자주식회사 | 반도체기판의 세정방법 |
US7608600B2 (en) | 2002-06-28 | 2009-10-27 | Idenix Pharmaceuticals, Inc. | Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections |
BR0312278A (pt) | 2002-06-28 | 2007-06-19 | Idenix Cayman Ltd | éster 2'-c-metil-3'-o-l-valina de ribofuranosil citidina para tratamento de infecções por flaviviridae |
DK1576138T3 (en) | 2002-11-15 | 2017-05-01 | Idenix Pharmaceuticals Llc | 2'-METHYL NUCLEOSIDES IN COMBINATION WITH INTERFERON AND FLAVIVIRIDAE MUTATION |
EP2345658A1 (de) * | 2003-05-30 | 2011-07-20 | Pharmasset, Inc. | Modifizierte fluorinierte Nukleosidanaloga |
CN101023094B (zh) * | 2004-07-21 | 2011-05-18 | 法莫赛特股份有限公司 | 烷基取代的2-脱氧-2-氟代-d-呋喃核糖基嘧啶和嘌呤及其衍生物的制备 |
RU2433124C2 (ru) * | 2004-09-14 | 2011-11-10 | Фармассет, Инк. | Способ получения 2'-фтор-2'-алкилзамещенных или других замещенных рибофуранозилпиримидинов и пуринов и их производных |
WO2006092808A1 (en) * | 2005-03-04 | 2006-09-08 | Dabur Pharma Limited | Intermediate and process for preparing of beta- anomer enriched 21deoxy, 21 ,21-difluoro-d-ribofuranosyl nucleosides |
ES2422290T3 (es) | 2005-12-23 | 2013-09-10 | Idenix Pharmaceuticals Inc | Procedimiento para preparar un producto intermedio sintético para la preparación de nucleósidos ramificados |
US7964580B2 (en) | 2007-03-30 | 2011-06-21 | Pharmasset, Inc. | Nucleoside phosphoramidate prodrugs |
US8173621B2 (en) | 2008-06-11 | 2012-05-08 | Gilead Pharmasset Llc | Nucleoside cyclicphosphates |
PA8855801A1 (es) | 2008-12-23 | 2010-07-27 | Sintesis de nucleosidos de purina | |
AR074897A1 (es) | 2008-12-23 | 2011-02-23 | Pharmasset Inc | Fosforamidatos de nucleosidos |
EP2376514A2 (de) * | 2008-12-23 | 2011-10-19 | Pharmasset, Inc. | Nukleosidanaloga |
TWI583692B (zh) | 2009-05-20 | 2017-05-21 | 基利法瑪席特有限責任公司 | 核苷磷醯胺 |
US8618076B2 (en) | 2009-05-20 | 2013-12-31 | Gilead Pharmasset Llc | Nucleoside phosphoramidates |
US8859756B2 (en) | 2010-03-31 | 2014-10-14 | Gilead Pharmasset Llc | Stereoselective synthesis of phosphorus containing actives |
PL3290428T3 (pl) | 2010-03-31 | 2022-02-07 | Gilead Pharmasset Llc | Tabletka zawierająca krystaliczny (S)-2-(((S)-(((2R,3R,4R,5R)-5-(2,4-diokso-3,4-dihydropirymidyn-1(2H)-ylo)-4-fluoro-3-hydroksy-4-metylotetrahydrofuran-2-ylo)metoksy)(fenoksy)fosforylo)amino)propanian izopropylu |
ES2716158T3 (es) | 2010-11-30 | 2019-06-10 | Gilead Pharmasset Llc | 2'-spiro-nucleótidos para el tratamiento de hepatitis C |
US8889159B2 (en) | 2011-11-29 | 2014-11-18 | Gilead Pharmasset Llc | Compositions and methods for treating hepatitis C virus |
CN102603838B (zh) * | 2012-02-14 | 2015-02-18 | 江苏八巨药业有限公司 | 一种制备吉西他滨盐酸盐的方法 |
PL3038601T3 (pl) | 2013-08-27 | 2020-08-24 | Gilead Pharmasset Llc | Formulacja złożona dwóch związków przeciwwirusowych |
AU2019296174B2 (en) | 2018-06-29 | 2021-10-07 | Changchun Changcheng Pharmaceutical Technology Co., LTD | Phosphorus-containing prodrugs of gemcitabine |
-
1993
- 1993-08-30 CA CA002105112A patent/CA2105112C/en not_active Expired - Lifetime
- 1993-08-30 TW TW082107028A patent/TW356472B/zh active
- 1993-08-30 KR KR1019930017031A patent/KR100252451B1/ko not_active IP Right Cessation
- 1993-08-30 HU HU9302452A patent/HU214980B/hu not_active IP Right Cessation
- 1993-08-30 IL IL10684093A patent/IL106840A/en not_active IP Right Cessation
- 1993-08-31 JP JP21565393A patent/JP3462893B2/ja not_active Expired - Fee Related
- 1993-08-31 DK DK93306886.8T patent/DK0587364T3/da active
- 1993-08-31 EP EP93306886A patent/EP0587364B1/de not_active Expired - Lifetime
- 1993-08-31 ES ES93306886T patent/ES2090880T3/es not_active Expired - Lifetime
- 1993-08-31 BR BR9303658A patent/BR9303658A/pt not_active Application Discontinuation
- 1993-08-31 AT AT93306886T patent/ATE138929T1/de not_active IP Right Cessation
- 1993-08-31 DE DE69302977T patent/DE69302977T2/de not_active Expired - Lifetime
- 1993-08-31 MX MX9305301A patent/MX9305301A/es unknown
-
1994
- 1994-01-03 US US08/176,981 patent/US5420266A/en not_active Expired - Lifetime
-
1996
- 1996-07-02 GR GR960401799T patent/GR3020426T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
DK0587364T3 (da) | 1996-07-01 |
CA2105112A1 (en) | 1994-03-02 |
DE69302977T2 (de) | 1996-10-31 |
HU214980B (hu) | 1998-08-28 |
US5420266A (en) | 1995-05-30 |
JP3462893B2 (ja) | 2003-11-05 |
KR100252451B1 (ko) | 2000-04-15 |
GR3020426T3 (en) | 1996-10-31 |
ES2090880T3 (es) | 1996-10-16 |
EP0587364B1 (de) | 1996-06-05 |
JPH06157571A (ja) | 1994-06-03 |
IL106840A0 (en) | 1993-12-08 |
KR940007053A (ko) | 1994-04-26 |
HU9302452D0 (en) | 1993-11-29 |
TW356472B (en) | 1999-04-21 |
BR9303658A (pt) | 1994-03-22 |
CA2105112C (en) | 2005-08-02 |
HUT65137A (en) | 1994-04-28 |
DE69302977D1 (de) | 1996-07-11 |
MX9305301A (es) | 1994-06-30 |
EP0587364A1 (de) | 1994-03-16 |
IL106840A (en) | 1998-09-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
REN | Ceased due to non-payment of the annual fee |