DE69308391T2 - Verfahren zur Trennung von 2-Deoxy-2,2-Difluor-D-Ribofuranosyl-Alkyl-Sulfonat-Anomeren - Google Patents

Verfahren zur Trennung von 2-Deoxy-2,2-Difluor-D-Ribofuranosyl-Alkyl-Sulfonat-Anomeren

Info

Publication number
DE69308391T2
DE69308391T2 DE69308391T DE69308391T DE69308391T2 DE 69308391 T2 DE69308391 T2 DE 69308391T2 DE 69308391 T DE69308391 T DE 69308391T DE 69308391 T DE69308391 T DE 69308391T DE 69308391 T2 DE69308391 T2 DE 69308391T2
Authority
DE
Germany
Prior art keywords
ribofuranosyl
deoxy
difluoro
anomers
separation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69308391T
Other languages
English (en)
Other versions
DE69308391D1 (de
Inventor
Ta-Sen Chou
Timothy James Mccarthy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of DE69308391D1 publication Critical patent/DE69308391D1/de
Application granted granted Critical
Publication of DE69308391T2 publication Critical patent/DE69308391T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69308391T 1992-06-22 1993-06-21 Verfahren zur Trennung von 2-Deoxy-2,2-Difluor-D-Ribofuranosyl-Alkyl-Sulfonat-Anomeren Expired - Lifetime DE69308391T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/902,303 US5256797A (en) 1992-06-22 1992-06-22 Process for separating 2-deoxy-2,2-difluoro-D-ribofuranosyl alkylsulfonate anomers

Publications (2)

Publication Number Publication Date
DE69308391D1 DE69308391D1 (de) 1997-04-10
DE69308391T2 true DE69308391T2 (de) 1997-07-17

Family

ID=25415647

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69308391T Expired - Lifetime DE69308391T2 (de) 1992-06-22 1993-06-21 Verfahren zur Trennung von 2-Deoxy-2,2-Difluor-D-Ribofuranosyl-Alkyl-Sulfonat-Anomeren

Country Status (17)

Country Link
US (1) US5256797A (de)
EP (1) EP0576232B1 (de)
JP (1) JPH0656867A (de)
KR (1) KR100302087B1 (de)
AT (1) ATE149505T1 (de)
BR (1) BR9302426A (de)
CA (1) CA2098888C (de)
CY (1) CY2091B1 (de)
DE (1) DE69308391T2 (de)
DK (1) DK0576232T3 (de)
ES (1) ES2100462T3 (de)
GR (1) GR3023060T3 (de)
HK (1) HK1006022A1 (de)
HU (1) HU217976B (de)
IL (1) IL106074A (de)
MX (1) MX9303714A (de)
TW (1) TW233300B (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX9303713A (es) * 1992-06-22 1994-05-31 Lilly Co Eli Proceso estereoselectivo para preparar un derivadoribofuranosilo enriquecido con alfa anomero.
MY164523A (en) 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
CA2410579C (en) 2000-05-26 2010-04-20 Jean-Pierre Sommadossi Methods and compositions for treating flaviviruses and pestiviruses
RS113904A (en) 2002-06-28 2007-02-05 Idenix (Cayman) Limited 2'-c-methyl-3'-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
US7608600B2 (en) * 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
CN1849142A (zh) 2002-11-15 2006-10-18 埃迪尼克斯(开曼)有限公司 2′－支链核苷和黄病毒突变
JP5116972B2 (ja) 2002-12-12 2013-01-09 イデニクス（ケイマン）リミテツド ２’−分枝ヌクレオシドの製造方法
JP2008503562A (ja) * 2004-06-23 2008-02-07 イデニクス（ケイマン）リミテツド フラビウイルス科による感染症を治療するための５−アザ−７−デアザプリン誘導体
US7214791B2 (en) * 2004-07-01 2007-05-08 Shenzhen Hande Technology Co., Ltd. Method for preparation of 2′-deoxy-2′, 2′-difluoro-β-cytidine or pharmaceutically acceptable salts thereof by using 1,6-anhydro-β-d-glucose as raw material
AT502221A1 (de) * 2005-07-20 2007-02-15 Pharmacon Forschung & Beratung Gmbh Homogemcitabine, verfahren zu ihrer herstellung sowie deren verwendung
JP5254033B2 (ja) 2005-12-23 2013-08-07 イデニク プハルマセウティカルス，インコーポレイテッド 分岐型ヌクレオシドを調製するための合成中間体の製造方法
CA2641719A1 (en) * 2006-02-07 2007-08-16 Chemagis Ltd. Process for preparing gemcitabine and associated intermediates
US20070249823A1 (en) * 2006-04-20 2007-10-25 Chemagis Ltd. Process for preparing gemcitabine and associated intermediates
US20080262215A1 (en) * 2007-04-23 2008-10-23 Chemagis Ltd. Gemcitabine production process
GB0812895D0 (en) * 2008-07-15 2008-08-20 Glycom As Crystalline carbohydrate derivative

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4526988A (en) * 1983-03-10 1985-07-02 Eli Lilly And Company Difluoro antivirals and intermediate therefor
US4965374A (en) * 1987-08-28 1990-10-23 Eli Lilly And Company Process for and intermediates of 2',2'-difluoronucleosides
IL87517A (en) * 1987-08-28 1993-05-13 Lilly Co Eli Process for preparing an enantiomeric mixture of erythro and threo lactones

Also Published As

Publication number Publication date
IL106074A (en) 1998-02-22
US5256797A (en) 1993-10-26
HU217976B (hu) 2000-05-28
KR940000473A (ko) 1994-01-03
MX9303714A (es) 1994-01-31
IL106074A0 (en) 1993-10-20
DE69308391D1 (de) 1997-04-10
BR9302426A (pt) 1994-01-11
CA2098888A1 (en) 1993-12-23
CA2098888C (en) 2003-07-29
EP0576232B1 (de) 1997-03-05
EP0576232A1 (de) 1993-12-29
KR100302087B1 (ko) 2001-10-22
CY2091B1 (en) 2002-04-05
HUT64551A (en) 1994-01-28
JPH0656867A (ja) 1994-03-01
HK1006022A1 (en) 1999-02-05
ATE149505T1 (de) 1997-03-15
ES2100462T3 (es) 1997-06-16
TW233300B (de) 1994-11-01
HU9301826D0 (en) 1993-09-28
DK0576232T3 (da) 1997-07-21
GR3023060T3 (en) 1997-07-30

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