BR122013012291B1 - uso de 3-o-acetil-4"-o-isovaleril-tilosina ou um sal de adição de ácido farmacologicamente aceitável ou outro derivado da mesma, ração para suínos, composição revestida estável para adição a uma ração animal e medicamento veterinário - Google Patents
uso de 3-o-acetil-4"-o-isovaleril-tilosina ou um sal de adição de ácido farmacologicamente aceitável ou outro derivado da mesma, ração para suínos, composição revestida estável para adição a uma ração animal e medicamento veterinário Download PDFInfo
- Publication number
- BR122013012291B1 BR122013012291B1 BR122013012291A BR122013012291A BR122013012291B1 BR 122013012291 B1 BR122013012291 B1 BR 122013012291B1 BR 122013012291 A BR122013012291 A BR 122013012291A BR 122013012291 A BR122013012291 A BR 122013012291A BR 122013012291 B1 BR122013012291 B1 BR 122013012291B1
- Authority
- BR
- Brazil
- Prior art keywords
- derivative
- aivlosin
- feed
- acetyl
- acid addition
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 22
- WBPYTXDJUQJLPQ-VMXQISHHSA-N tylosin Chemical compound O([C@@H]1[C@@H](C)O[C@H]([C@@H]([C@H]1N(C)C)O)O[C@@H]1[C@@H](C)[C@H](O)CC(=O)O[C@@H]([C@H](/C=C(\C)/C=C/C(=O)[C@H](C)C[C@@H]1CC=O)CO[C@H]1[C@@H]([C@H](OC)[C@H](O)[C@@H](C)O1)OC)CC)[C@H]1C[C@@](C)(O)[C@@H](O)[C@H](C)O1 WBPYTXDJUQJLPQ-VMXQISHHSA-N 0.000 title claims abstract description 18
- 239000002253 acid Substances 0.000 title claims abstract description 17
- 241001465754 Metazoa Species 0.000 title claims abstract description 16
- 150000003839 salts Chemical class 0.000 title claims abstract description 16
- 239000004182 Tylosin Substances 0.000 title claims abstract description 15
- 229960004059 tylosin Drugs 0.000 title claims abstract description 15
- 229930194936 Tylosin Natural products 0.000 title claims abstract description 14
- 235000019375 tylosin Nutrition 0.000 title claims abstract description 14
- 229940126601 medicinal product Drugs 0.000 title claims abstract description 10
- 241000282898 Sus scrofa Species 0.000 claims abstract description 23
- 238000011282 treatment Methods 0.000 claims abstract description 14
- 241000282887 Suidae Species 0.000 claims abstract description 13
- 208000001848 dysentery Diseases 0.000 claims abstract description 11
- 238000011321 prophylaxis Methods 0.000 claims abstract description 7
- 238000002360 preparation method Methods 0.000 claims abstract description 5
- 239000004098 Tetracycline Substances 0.000 claims description 7
- 235000019364 tetracycline Nutrition 0.000 claims description 7
- 150000003522 tetracyclines Chemical class 0.000 claims description 7
- 239000004480 active ingredient Substances 0.000 claims description 6
- 239000000654 additive Substances 0.000 claims description 6
- 239000003651 drinking water Substances 0.000 claims description 6
- 235000020188 drinking water Nutrition 0.000 claims description 6
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 6
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 6
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 6
- 229960002180 tetracycline Drugs 0.000 claims description 6
- 229930101283 tetracycline Natural products 0.000 claims description 6
- 239000004099 Chlortetracycline Substances 0.000 claims description 4
- 239000004100 Oxytetracycline Substances 0.000 claims description 4
- 230000000996 additive effect Effects 0.000 claims description 4
- CYDMQBQPVICBEU-UHFFFAOYSA-N chlorotetracycline Natural products C1=CC(Cl)=C2C(O)(C)C3CC4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O CYDMQBQPVICBEU-UHFFFAOYSA-N 0.000 claims description 4
- 229960004475 chlortetracycline Drugs 0.000 claims description 4
- CYDMQBQPVICBEU-XRNKAMNCSA-N chlortetracycline Chemical group C1=CC(Cl)=C2[C@](O)(C)[C@H]3C[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O CYDMQBQPVICBEU-XRNKAMNCSA-N 0.000 claims description 4
- 235000019365 chlortetracycline Nutrition 0.000 claims description 4
- 229960000625 oxytetracycline Drugs 0.000 claims description 4
- IWVCMVBTMGNXQD-PXOLEDIWSA-N oxytetracycline Chemical compound C1=CC=C2[C@](O)(C)[C@H]3[C@H](O)[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-PXOLEDIWSA-N 0.000 claims description 4
- 235000019366 oxytetracycline Nutrition 0.000 claims description 4
- IWVCMVBTMGNXQD-UHFFFAOYSA-N terramycin dehydrate Natural products C1=CC=C2C(O)(C)C3C(O)C4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-UHFFFAOYSA-N 0.000 claims description 4
- OLLSDNUHBJHKJS-XKORHJEPSA-N [(2s,3s,4r,6s)-6-[(2r,3s,4r,5r,6r)-6-[[(4r,5s,6s,7r,9r,11e,13e,15r,16r)-4-acetyloxy-16-ethyl-15-[[(2r,3r,4r,5r,6r)-5-hydroxy-3,4-dimethoxy-6-methyloxan-2-yl]oxymethyl]-5,9,13-trimethyl-2,10-dioxo-7-(2-oxoethyl)-1-oxacyclohexadeca-11,13-dien-6-yl]oxy]-4-(d Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O.O([C@@H]1[C@@H](C)O[C@H]([C@@H]([C@H]1N(C)C)O)O[C@@H]1[C@@H](C)[C@H](OC(C)=O)CC(=O)O[C@@H]([C@H](/C=C(\C)/C=C/C(=O)[C@H](C)C[C@@H]1CC=O)CO[C@H]1[C@@H]([C@H](OC)[C@H](O)[C@@H](C)O1)OC)CC)[C@H]1C[C@@](C)(O)[C@@H](OC(=O)CC(C)C)[C@H](C)O1 OLLSDNUHBJHKJS-XKORHJEPSA-N 0.000 abstract description 49
- 208000015181 infectious disease Diseases 0.000 abstract description 10
- 239000003814 drug Substances 0.000 abstract description 9
- 244000144977 poultry Species 0.000 abstract description 8
- 231100000252 nontoxic Toxicity 0.000 abstract description 2
- 230000003000 nontoxic effect Effects 0.000 abstract description 2
- 208000012153 swine disease Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 description 17
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 17
- 238000009472 formulation Methods 0.000 description 11
- 230000000694 effects Effects 0.000 description 8
- 229940079593 drug Drugs 0.000 description 7
- 239000007787 solid Substances 0.000 description 7
- 235000013312 flour Nutrition 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 5
- 241000204031 Mycoplasma Species 0.000 description 5
- 239000008186 active pharmaceutical agent Substances 0.000 description 5
- 239000004615 ingredient Substances 0.000 description 5
- 239000000843 powder Substances 0.000 description 5
- 241000894006 Bacteria Species 0.000 description 4
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 4
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 235000010469 Glycine max Nutrition 0.000 description 4
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 4
- 241000209140 Triticum Species 0.000 description 4
- 235000021307 Triticum Nutrition 0.000 description 4
- 150000007513 acids Chemical class 0.000 description 4
- 239000003242 anti bacterial agent Substances 0.000 description 4
- 238000000338 in vitro Methods 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 230000036515 potency Effects 0.000 description 4
- 229940095064 tartrate Drugs 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
- 229940088710 antibiotic agent Drugs 0.000 description 3
- 230000003115 biocidal effect Effects 0.000 description 3
- HCWCAKKEBCNQJP-UHFFFAOYSA-N magnesium orthosilicate Chemical compound [Mg+2].[Mg+2].[O-][Si]([O-])([O-])[O-] HCWCAKKEBCNQJP-UHFFFAOYSA-N 0.000 description 3
- 239000000391 magnesium silicate Substances 0.000 description 3
- 229910052919 magnesium silicate Inorganic materials 0.000 description 3
- 235000019792 magnesium silicate Nutrition 0.000 description 3
- 238000012545 processing Methods 0.000 description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 230000002195 synergetic effect Effects 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- UURAUHCOJAIIRQ-QGLSALSOSA-N tiamulin Chemical compound CCN(CC)CCSCC(=O)O[C@@H]1C[C@@](C)(C=C)[C@@H](O)[C@H](C)[C@@]23CC[C@@H](C)[C@]1(C)[C@@H]2C(=O)CC3 UURAUHCOJAIIRQ-QGLSALSOSA-N 0.000 description 3
- 229960004885 tiamulin Drugs 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- 244000068988 Glycine max Species 0.000 description 2
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 2
- 241001469654 Lawsonia <weevil> Species 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 235000011054 acetic acid Nutrition 0.000 description 2
- ZSLZBFCDCINBPY-ZSJPKINUSA-N acetyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 ZSLZBFCDCINBPY-ZSJPKINUSA-N 0.000 description 2
- 125000002252 acyl group Chemical group 0.000 description 2
- 239000003674 animal food additive Substances 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- 229960003276 erythromycin Drugs 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 239000000945 filler Substances 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 2
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- -1 isovaleryl Chemical group 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000012669 liquid formulation Substances 0.000 description 2
- 229940057995 liquid paraffin Drugs 0.000 description 2
- 239000003120 macrolide antibiotic agent Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 239000000377 silicon dioxide Substances 0.000 description 2
- 229940072172 tetracycline antibiotic Drugs 0.000 description 2
- XYHKNCXZYYTLRG-UHFFFAOYSA-N 1h-imidazole-2-carbaldehyde Chemical compound O=CC1=NC=CN1 XYHKNCXZYYTLRG-UHFFFAOYSA-N 0.000 description 1
- KDVFRMMRZOCFLS-UHFFFAOYSA-N 2-oxopentanoic acid Chemical compound CCCC(=O)C(O)=O KDVFRMMRZOCFLS-UHFFFAOYSA-N 0.000 description 1
- GWYFCOCPABKNJV-UHFFFAOYSA-M 3-Methylbutanoic acid Natural products CC(C)CC([O-])=O GWYFCOCPABKNJV-UHFFFAOYSA-M 0.000 description 1
- 208000031873 Animal Disease Models Diseases 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 241000192125 Firmicutes Species 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 239000004113 Sepiolite Substances 0.000 description 1
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 description 1
- 230000010933 acylation Effects 0.000 description 1
- 238000005917 acylation reaction Methods 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 238000011558 animal model by disease Methods 0.000 description 1
- 150000004945 aromatic hydrocarbons Chemical class 0.000 description 1
- 238000013475 authorization Methods 0.000 description 1
- 150000007514 bases Chemical group 0.000 description 1
- GWYFCOCPABKNJV-UHFFFAOYSA-N beta-methyl-butyric acid Natural products CC(C)CC(O)=O GWYFCOCPABKNJV-UHFFFAOYSA-N 0.000 description 1
- 238000004166 bioassay Methods 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 235000015165 citric acid Nutrition 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid group Chemical group C(CC(O)(C(=O)O)CC(=O)O)(=O)O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 1
- 239000008199 coating composition Substances 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000013058 crude material Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 235000013861 fat-free Nutrition 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000012458 free base Substances 0.000 description 1
- 235000011868 grain product Nutrition 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- UYVZIWWBJMYRCD-ZMHDXICWSA-N isovaleryl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CC(C)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 UYVZIWWBJMYRCD-ZMHDXICWSA-N 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 150000004957 nitroimidazoles Chemical class 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- ZRZNJUXESFHSIO-VYTKZBNOSA-N pleuromutilin Chemical group C([C@H]([C@]1(C)[C@@H](C[C@@](C)(C=C)[C@@H](O)[C@@H]2C)OC(=O)CO)C)C[C@]32[C@H]1C(=O)CC3 ZRZNJUXESFHSIO-VYTKZBNOSA-N 0.000 description 1
- 159000000001 potassium salts Chemical class 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- 230000000384 rearing effect Effects 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 235000019355 sepiolite Nutrition 0.000 description 1
- 229910052624 sepiolite Inorganic materials 0.000 description 1
- 150000004760 silicates Chemical class 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 235000011044 succinic acid Nutrition 0.000 description 1
- 150000003444 succinic acids Chemical class 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 229940040944 tetracyclines Drugs 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 239000000273 veterinary drug Substances 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Fodder In General (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
- Feed For Specific Animals (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0025556.2A GB0025556D0 (en) | 2000-10-18 | 2000-10-18 | Treatment and prophylaxis of disease and infections of pigs and poultry |
| BRPI0114703A BRPI0114703B1 (pt) | 2000-10-18 | 2001-10-15 | uso de 3-o-acetil-4"-o- isovaleril-tilosina ou um sal de adição de ácido farmacologicamente aceitável, ração para suínos, composição revestida estável para adição a uma ração animal e medicamento veterinário |
| PCT/GB2001/004575 WO2002032233A2 (en) | 2000-10-18 | 2001-10-15 | Treatment and prophylaxis of diseases and infections of pigs and poultry with aivlosin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR122013012291B1 true BR122013012291B1 (pt) | 2016-06-21 |
Family
ID=9901546
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR122013012291A BR122013012291B1 (pt) | 2000-10-18 | 2001-10-15 | uso de 3-o-acetil-4"-o-isovaleril-tilosina ou um sal de adição de ácido farmacologicamente aceitável ou outro derivado da mesma, ração para suínos, composição revestida estável para adição a uma ração animal e medicamento veterinário |
| BR122013012293A BR122013012293B1 (pt) | 2000-10-18 | 2001-10-15 | uso de 3-o-acetil-4"-o-isovaleril-tilosina ou um sal de adição de ácido farmacologicamente aceitável ou outro derivado da mesma, ração para aves de criação, composição revestida estável para adição a uma ração animal e medicamento veterinário |
| BRPI0114703A BRPI0114703B1 (pt) | 2000-10-18 | 2001-10-15 | uso de 3-o-acetil-4"-o- isovaleril-tilosina ou um sal de adição de ácido farmacologicamente aceitável, ração para suínos, composição revestida estável para adição a uma ração animal e medicamento veterinário |
| BR122013012292A BR122013012292B1 (pt) | 2000-10-18 | 2001-10-15 | uso de 3-o-acetil-4"-o-isovaleril-tilosina ou um sal de adição de ácido farmacologicamente aceitável ou outro derivado da mesma, ração para aves de criação e suínos, composição revestida estável para adição a uma ração animal e medicamento veterinário |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR122013012293A BR122013012293B1 (pt) | 2000-10-18 | 2001-10-15 | uso de 3-o-acetil-4"-o-isovaleril-tilosina ou um sal de adição de ácido farmacologicamente aceitável ou outro derivado da mesma, ração para aves de criação, composição revestida estável para adição a uma ração animal e medicamento veterinário |
| BRPI0114703A BRPI0114703B1 (pt) | 2000-10-18 | 2001-10-15 | uso de 3-o-acetil-4"-o- isovaleril-tilosina ou um sal de adição de ácido farmacologicamente aceitável, ração para suínos, composição revestida estável para adição a uma ração animal e medicamento veterinário |
| BR122013012292A BR122013012292B1 (pt) | 2000-10-18 | 2001-10-15 | uso de 3-o-acetil-4"-o-isovaleril-tilosina ou um sal de adição de ácido farmacologicamente aceitável ou outro derivado da mesma, ração para aves de criação e suínos, composição revestida estável para adição a uma ração animal e medicamento veterinário |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US20040082524A1 (https=) |
| EP (1) | EP1326599B1 (https=) |
| JP (2) | JP4335524B2 (https=) |
| KR (2) | KR100866021B1 (https=) |
| CN (6) | CN100471501C (https=) |
| AR (2) | AR031002A1 (https=) |
| AT (1) | ATE347888T1 (https=) |
| AU (1) | AU2001295722A1 (https=) |
| BR (4) | BR122013012291B1 (https=) |
| CA (1) | CA2425319C (https=) |
| CY (1) | CY1107480T1 (https=) |
| DE (1) | DE60125212T2 (https=) |
| DK (1) | DK1326599T3 (https=) |
| ES (1) | ES2278788T3 (https=) |
| GB (1) | GB0025556D0 (https=) |
| MX (1) | MXPA03003309A (https=) |
| PL (1) | PL221310B1 (https=) |
| PT (1) | PT1326599E (https=) |
| RU (2) | RU2310446C2 (https=) |
| WO (1) | WO2002032233A2 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0315629D0 (en) * | 2003-07-03 | 2003-08-13 | Eco Animal Health Ltd | New uses for antibiotic |
| PT2043661E (pt) * | 2006-07-13 | 2014-12-22 | Eco Animal Health Ltd | Uso de tilvalosina como agente antiviral |
| GB0613952D0 (en) * | 2006-07-13 | 2006-08-23 | Eco Animal Health Ltd | Antiviral agent |
| RU2487709C2 (ru) * | 2011-06-01 | 2013-07-20 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Белгородская государственная сельскохозяйственная академия имени В.Я. Горина" (ФГБОУ БелГСХА им. В.Я. Горина) | Композиционный препарат для лечения пневмонии поросят |
| WO2014175757A1 (ru) * | 2013-04-22 | 2014-10-30 | Общество с ограниченной ответственностью "Нанобиотех" | Антисептический ветеринарный препарат и способы его использования |
| CN104127429A (zh) * | 2014-07-28 | 2014-11-05 | 邳州正康生物技术有限公司 | 一种用于防治畜禽呼吸道疾病的饮水剂及其制备方法 |
| CN104256168B (zh) * | 2014-09-28 | 2016-05-11 | 山东新希望六和集团有限公司 | 一种猪功能性饲料及其制备方法 |
| CN106361707B (zh) * | 2016-09-30 | 2019-02-26 | 广东温氏大华农生物科技有限公司 | 一种酒石酸泰万菌素颗粒制剂及其制备方法 |
| CN107625779A (zh) * | 2017-10-19 | 2018-01-26 | 洛阳瑞华动物保健品有限公司 | 一种用于抑制猪蓝耳病病毒复制的药物制剂、药剂盒 |
| CN118021765B (zh) * | 2024-04-15 | 2024-08-06 | 中国农业科学院农业环境与可持续发展研究所 | 酒石酸泰万菌素纳米制剂及其制备方法 |
| CN118845646B (zh) * | 2024-09-24 | 2024-12-13 | 中国农业大学 | 一种酒石酸泰万菌素纳米混悬液及其制备方法和应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS52139088A (en) * | 1976-05-15 | 1977-11-19 | Sanraku Inc | Antibiotics tyrocin derivatives and their preparation |
| US4201843A (en) * | 1975-08-01 | 1980-05-06 | Sanraku Ocean Co., Ltd. | Process for manufacturing tylosin derivatives |
| US4092473A (en) * | 1975-08-01 | 1978-05-30 | Sanraku Ocean Co., Ltd. | Tylosin derivatives and their manufacturing process |
| US4559301A (en) * | 1983-03-03 | 1985-12-17 | Eli Lilly And Company | Process for preparing macrocin derivatives |
| DK144084A (da) * | 1983-03-03 | 1984-09-04 | Lilly Co Eli | Makrolid, dets fremstilling og anvendelse |
| US4582822A (en) * | 1984-10-09 | 1986-04-15 | Eli Lilly And Company | Antibiotic A80190, pharmaceutical compositions containing same and method of use |
| DE3725946A1 (de) * | 1987-08-05 | 1989-02-16 | Boehringer Ingelheim Vetmed | Stabilisierter futtermittelzusatz und verfahren zu seiner herstellung |
| SE9801742L (sv) * | 1998-05-18 | 1999-11-19 | Akzo Nobel Nv | Användning av naturliga substanser innehållande tymol vid framställning av djurfoder |
| US6326364B1 (en) * | 1999-02-08 | 2001-12-04 | Cedars-Sinai Medical Center | Use of 5-aminosalicylates as antimicrobial agents |
-
2000
- 2000-10-18 GB GBGB0025556.2A patent/GB0025556D0/en not_active Ceased
-
2001
- 2001-10-15 PL PL362085A patent/PL221310B1/pl unknown
- 2001-10-15 ES ES01976452T patent/ES2278788T3/es not_active Expired - Lifetime
- 2001-10-15 RU RU2003114412/15A patent/RU2310446C2/ru active
- 2001-10-15 DK DK01976452T patent/DK1326599T3/da active
- 2001-10-15 CN CNB2005100910968A patent/CN100471501C/zh not_active Expired - Lifetime
- 2001-10-15 WO PCT/GB2001/004575 patent/WO2002032233A2/en not_active Ceased
- 2001-10-15 DE DE60125212T patent/DE60125212T2/de not_active Expired - Lifetime
- 2001-10-15 RU RU2007105450/15A patent/RU2454230C2/ru active
- 2001-10-15 EP EP01976452A patent/EP1326599B1/en not_active Expired - Lifetime
- 2001-10-15 BR BR122013012291A patent/BR122013012291B1/pt active IP Right Grant
- 2001-10-15 CN CN2005100910864A patent/CN1853644B/zh not_active Expired - Lifetime
- 2001-10-15 PT PT01976452T patent/PT1326599E/pt unknown
- 2001-10-15 CN CNA018173683A patent/CN1469742A/zh active Pending
- 2001-10-15 CN CNA2005100910953A patent/CN1803141A/zh active Pending
- 2001-10-15 JP JP2002535483A patent/JP4335524B2/ja not_active Expired - Lifetime
- 2001-10-15 AT AT01976452T patent/ATE347888T1/de active
- 2001-10-15 BR BR122013012293A patent/BR122013012293B1/pt active IP Right Grant
- 2001-10-15 KR KR1020037004964A patent/KR100866021B1/ko not_active Expired - Lifetime
- 2001-10-15 CA CA002425319A patent/CA2425319C/en not_active Expired - Lifetime
- 2001-10-15 CN CNA2005100893680A patent/CN1771980A/zh active Pending
- 2001-10-15 AU AU2001295722A patent/AU2001295722A1/en not_active Abandoned
- 2001-10-15 US US10/398,086 patent/US20040082524A1/en not_active Abandoned
- 2001-10-15 BR BRPI0114703A patent/BRPI0114703B1/pt active IP Right Grant
- 2001-10-15 MX MXPA03003309A patent/MXPA03003309A/es active IP Right Grant
- 2001-10-15 BR BR122013012292A patent/BR122013012292B1/pt active IP Right Grant
- 2001-10-15 CN CNA2005100910949A patent/CN1803140A/zh active Pending
- 2001-10-17 AR ARP010104881A patent/AR031002A1/es not_active Application Discontinuation
-
2006
- 2006-06-30 US US11/479,721 patent/US20060247184A1/en not_active Abandoned
-
2007
- 2007-03-12 CY CY20071100335T patent/CY1107480T1/el unknown
-
2008
- 2008-07-18 KR KR1020087017633A patent/KR100919725B1/ko not_active Expired - Fee Related
- 2008-07-28 JP JP2008194051A patent/JP5001234B2/ja not_active Expired - Lifetime
-
2014
- 2014-11-03 AR ARP140104085A patent/AR098251A2/es not_active Application Discontinuation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 21/06/2016, OBSERVADAS AS CONDICOES LEGAIS. |
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| B15K | Others concerning applications: alteration of classification |
Ipc: A61K 31/35 (2006.01), A61K 31/65 (2006.01) |