BR112023017720A2 - Composição para liberação in vivo de rna e método de preparação da mesma - Google Patents

Composição para liberação in vivo de rna e método de preparação da mesma

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Publication number
BR112023017720A2
BR112023017720A2 BR112023017720A BR112023017720A BR112023017720A2 BR 112023017720 A2 BR112023017720 A2 BR 112023017720A2 BR 112023017720 A BR112023017720 A BR 112023017720A BR 112023017720 A BR112023017720 A BR 112023017720A BR 112023017720 A2 BR112023017720 A2 BR 112023017720A2
Authority
BR
Brazil
Prior art keywords
mrna
rna
preparation
composition
vivo release
Prior art date
Application number
BR112023017720A
Other languages
English (en)
Inventor
Kwangsung Kim
Hyun Kim Seok
Ae Park Shin
Je Cho Yang
Original Assignee
Eyegene Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eyegene Inc filed Critical Eyegene Inc
Publication of BR112023017720A2 publication Critical patent/BR112023017720A2/pt

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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
    • A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
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    • A61K9/127—Liposomes
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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
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    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
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    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
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    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
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    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
    • A61K48/0041—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being polymeric
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/20011—Coronaviridae
    • C12N2770/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
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  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Birds (AREA)
  • Dispersion Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
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  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
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  • Physics & Mathematics (AREA)
  • Medicinal Preparation (AREA)

Abstract

composição para liberação in vivo de rna e método de preparação da mesma. a presente invenção refere-se a uma composição de liberação de mrna contendo lipossomas à base de lipídeos catiônicos. a composição de liberação de mrna de acordo com a presente descrição é excelente em termos de estabilidade de armazenamento e exibe altas taxas de liberação e expressão intracelular in vivo e, desse modo, pode aumentar a estabilidade e eficiência de vacinas de mrna para terapia de câncer ou vacinas de mrna para prevenção de infecções virais.
BR112023017720A 2021-03-08 2022-03-07 Composição para liberação in vivo de rna e método de preparação da mesma BR112023017720A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20210029929 2021-03-08
PCT/KR2022/003220 WO2022191555A1 (ko) 2021-03-08 2022-03-07 Rna의 체내 전달용 조성물 및 이의 제조방법

Publications (1)

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BR112023017720A2 true BR112023017720A2 (pt) 2023-09-26

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ID=83227942

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Application Number Title Priority Date Filing Date
BR112023017720A BR112023017720A2 (pt) 2021-03-08 2022-03-07 Composição para liberação in vivo de rna e método de preparação da mesma

Country Status (10)

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US (1) US20240148897A1 (pt)
EP (1) EP4306132A1 (pt)
JP (1) JP2024509934A (pt)
KR (1) KR20220126235A (pt)
CN (1) CN117440834A (pt)
AU (1) AU2022232410A1 (pt)
BR (1) BR112023017720A2 (pt)
CA (1) CA3211256A1 (pt)
MX (1) MX2023010461A (pt)
WO (1) WO2022191555A1 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024144348A1 (ko) * 2022-12-29 2024-07-04 주식회사 바이오파마 양이온성 분자 수송체 및 mrna의 이온복합체를 포함하는 백신 조성물
CN115737800B (zh) * 2023-01-09 2023-05-23 江苏瑞科生物技术股份有限公司 一种复合脂质体佐剂及其制备方法

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KR20010069179A (ko) * 1999-05-28 2001-07-23 박종상 유전자 전달용 양이온성 리피드 및 그 제조방법
KR102008787B1 (ko) * 2013-05-23 2019-08-08 압타바이오 주식회사 신규한 양이온 리피드를 포함하는 유전자 전달체
KR101509456B1 (ko) 2013-10-04 2015-04-14 아이진 주식회사 리포폴리사카라이드 유사체 및 이를 포함하는 면역보조 조성물
EP3060257B1 (en) * 2013-10-22 2021-02-24 Translate Bio, Inc. Lipid formulations for delivery of messenger rna
KR102086987B1 (ko) * 2017-08-24 2020-03-10 아이진 주식회사 면역반응 조절물질 및 양이온성 리포좀을 포함하는 면역증강용 조성물 및 이의 용도
KR102042993B1 (ko) 2016-10-31 2019-11-11 아이진 주식회사 면역반응 조절물질 및 이를 포함하는 면역보조제 조성물
KR101979497B1 (ko) * 2017-05-02 2019-05-16 연세대학교 원주산학협력단 양자점-핵산-앱타머-리포좀 복합체, 이의 용도 및 이의 제조방법
CN112384205B (zh) 2018-05-30 2024-05-03 川斯勒佰尔公司 信使rna疫苗及其用途
KR20210029929A (ko) 2019-09-09 2021-03-17 조인셋 주식회사 이차전지 음극, 이를 적용한 이차전지

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WO2022191555A1 (ko) 2022-09-15
EP4306132A1 (en) 2024-01-17
KR20220126235A (ko) 2022-09-15
US20240148897A1 (en) 2024-05-09
CN117440834A (zh) 2024-01-23
MX2023010461A (es) 2023-09-14
AU2022232410A1 (en) 2023-10-05
JP2024509934A (ja) 2024-03-05
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