MX2023010461A - Composicion para la entrega in vivo de arn y metodo de preparacion para la misma. - Google Patents
Composicion para la entrega in vivo de arn y metodo de preparacion para la misma.Info
- Publication number
- MX2023010461A MX2023010461A MX2023010461A MX2023010461A MX2023010461A MX 2023010461 A MX2023010461 A MX 2023010461A MX 2023010461 A MX2023010461 A MX 2023010461A MX 2023010461 A MX2023010461 A MX 2023010461A MX 2023010461 A MX2023010461 A MX 2023010461A
- Authority
- MX
- Mexico
- Prior art keywords
- rna
- preparation
- composition
- mrna
- method therefor
- Prior art date
Links
- 238000001727 in vivo Methods 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title 1
- 108700021021 mRNA Vaccine Proteins 0.000 abstract 2
- 229940126582 mRNA vaccine Drugs 0.000 abstract 2
- 108020004999 messenger RNA Proteins 0.000 abstract 2
- 208000036142 Viral infection Diseases 0.000 abstract 1
- -1 cationic lipid Chemical class 0.000 abstract 1
- 230000003834 intracellular effect Effects 0.000 abstract 1
- 239000002502 liposome Substances 0.000 abstract 1
- 238000011275 oncology therapy Methods 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000009385 viral infection Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
- A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
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- A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
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- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
- A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
- A61K8/416—Quaternary ammonium compounds
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- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A61K2039/53—DNA (RNA) vaccination
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- A—HUMAN NECESSITIES
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- A61K2039/55511—Organic adjuvants
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- A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
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- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/577—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 tolerising response
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/70—Biological properties of the composition as a whole
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- A61K39/12—Viral antigens
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- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
- A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
- A61K48/0041—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being polymeric
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/20011—Coronaviridae
- C12N2770/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Birds (AREA)
- Dispersion Chemistry (AREA)
- Mycology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Dermatology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Medicinal Preparation (AREA)
Abstract
La presente descripción se refiere a una composición de administración de ARNm que comprende liposomas catiónicos basados en lípidos. La composición de administración de ARNm de acuerdo con la presente descripción es excelente en términos de estabilidad de almacenamiento y exhibe altas tasas de administración y expresión intracelulares in vivo y, por lo tanto, puede mejorar la estabilidad y eficiencia de las vacunas de ARNm para la terapia del cáncer o vacunas de ARNm para la prevención de infecciones virales.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR20210029929 | 2021-03-08 | ||
PCT/KR2022/003220 WO2022191555A1 (ko) | 2021-03-08 | 2022-03-07 | Rna의 체내 전달용 조성물 및 이의 제조방법 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2023010461A true MX2023010461A (es) | 2023-09-14 |
Family
ID=83227942
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2023010461A MX2023010461A (es) | 2021-03-08 | 2022-03-07 | Composicion para la entrega in vivo de arn y metodo de preparacion para la misma. |
Country Status (10)
Country | Link |
---|---|
US (1) | US20240148897A1 (es) |
EP (1) | EP4306132A1 (es) |
JP (1) | JP2024509934A (es) |
KR (1) | KR20220126235A (es) |
CN (1) | CN117440834A (es) |
AU (1) | AU2022232410A1 (es) |
BR (1) | BR112023017720A2 (es) |
CA (1) | CA3211256A1 (es) |
MX (1) | MX2023010461A (es) |
WO (1) | WO2022191555A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2024144348A1 (ko) * | 2022-12-29 | 2024-07-04 | 주식회사 바이오파마 | 양이온성 분자 수송체 및 mrna의 이온복합체를 포함하는 백신 조성물 |
CN115737800B (zh) * | 2023-01-09 | 2023-05-23 | 江苏瑞科生物技术股份有限公司 | 一种复合脂质体佐剂及其制备方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20010069179A (ko) * | 1999-05-28 | 2001-07-23 | 박종상 | 유전자 전달용 양이온성 리피드 및 그 제조방법 |
KR102008787B1 (ko) * | 2013-05-23 | 2019-08-08 | 압타바이오 주식회사 | 신규한 양이온 리피드를 포함하는 유전자 전달체 |
KR101509456B1 (ko) | 2013-10-04 | 2015-04-14 | 아이진 주식회사 | 리포폴리사카라이드 유사체 및 이를 포함하는 면역보조 조성물 |
EP3060257B1 (en) * | 2013-10-22 | 2021-02-24 | Translate Bio, Inc. | Lipid formulations for delivery of messenger rna |
KR102086987B1 (ko) * | 2017-08-24 | 2020-03-10 | 아이진 주식회사 | 면역반응 조절물질 및 양이온성 리포좀을 포함하는 면역증강용 조성물 및 이의 용도 |
KR102042993B1 (ko) | 2016-10-31 | 2019-11-11 | 아이진 주식회사 | 면역반응 조절물질 및 이를 포함하는 면역보조제 조성물 |
KR101979497B1 (ko) * | 2017-05-02 | 2019-05-16 | 연세대학교 원주산학협력단 | 양자점-핵산-앱타머-리포좀 복합체, 이의 용도 및 이의 제조방법 |
SG11202011587PA (en) | 2018-05-30 | 2020-12-30 | Translate Bio Inc | Messenger rna vaccines and uses thereof |
KR20210029929A (ko) | 2019-09-09 | 2021-03-17 | 조인셋 주식회사 | 이차전지 음극, 이를 적용한 이차전지 |
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2022
- 2022-03-07 US US18/279,689 patent/US20240148897A1/en active Pending
- 2022-03-07 AU AU2022232410A patent/AU2022232410A1/en active Pending
- 2022-03-07 CA CA3211256A patent/CA3211256A1/en active Pending
- 2022-03-07 BR BR112023017720A patent/BR112023017720A2/pt unknown
- 2022-03-07 JP JP2023555319A patent/JP2024509934A/ja active Pending
- 2022-03-07 MX MX2023010461A patent/MX2023010461A/es unknown
- 2022-03-07 CN CN202280019463.5A patent/CN117440834A/zh active Pending
- 2022-03-07 WO PCT/KR2022/003220 patent/WO2022191555A1/ko active Application Filing
- 2022-03-07 EP EP22767451.2A patent/EP4306132A1/en active Pending
- 2022-03-07 KR KR1020220029000A patent/KR20220126235A/ko not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
JP2024509934A (ja) | 2024-03-05 |
AU2022232410A1 (en) | 2023-10-05 |
CA3211256A1 (en) | 2022-09-15 |
BR112023017720A2 (pt) | 2023-09-26 |
EP4306132A1 (en) | 2024-01-17 |
WO2022191555A1 (ko) | 2022-09-15 |
CN117440834A (zh) | 2024-01-23 |
US20240148897A1 (en) | 2024-05-09 |
KR20220126235A (ko) | 2022-09-15 |
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