BR112022026284A2 - Agentes de ligação, anticorpo, composição farmacêutica, polinucleotídeos, vetores, célula isolada, métodos para interromper, inibir ou bloquear a ligação de lair-1, a atividade de uma célula supressora derivada de mieloide (mdsc), ou a atividade de uma célula t regulatória (treg), método para tratar câncer em um indivíduo, método para inibir o crescimento tumoral, método para aumentar ou intensificar uma resposta imunológica a um tumor ou células tumorais, método para ativar ou intensificar uma resposta imunológica persistente ou a longo prazo a um tumor ou células tumorais, método para inibir a recidiva tumoral ou novo crescimento tumoral, método para induzir uma imunidade persistente ou a longo prazo que inibe recidiva tumoral ou novo crescimento tumoral, método para ativar célula mieloides no microambiente tumoral em um indivíduo com um tumor, método para ativar célula t no microambiente tumoral em um indivíduo com um tumor, método para produzir o agente de ligação - Google Patents

Agentes de ligação, anticorpo, composição farmacêutica, polinucleotídeos, vetores, célula isolada, métodos para interromper, inibir ou bloquear a ligação de lair-1, a atividade de uma célula supressora derivada de mieloide (mdsc), ou a atividade de uma célula t regulatória (treg), método para tratar câncer em um indivíduo, método para inibir o crescimento tumoral, método para aumentar ou intensificar uma resposta imunológica a um tumor ou células tumorais, método para ativar ou intensificar uma resposta imunológica persistente ou a longo prazo a um tumor ou células tumorais, método para inibir a recidiva tumoral ou novo crescimento tumoral, método para induzir uma imunidade persistente ou a longo prazo que inibe recidiva tumoral ou novo crescimento tumoral, método para ativar célula mieloides no microambiente tumoral em um indivíduo com um tumor, método para ativar célula t no microambiente tumoral em um indivíduo com um tumor, método para produzir o agente de ligação

Info

Publication number
BR112022026284A2
BR112022026284A2 BR112022026284A BR112022026284A BR112022026284A2 BR 112022026284 A2 BR112022026284 A2 BR 112022026284A2 BR 112022026284 A BR112022026284 A BR 112022026284A BR 112022026284 A BR112022026284 A BR 112022026284A BR 112022026284 A2 BR112022026284 A2 BR 112022026284A2
Authority
BR
Brazil
Prior art keywords
tumor
cells
enhancement
individual
activating
Prior art date
Application number
BR112022026284A
Other languages
English (en)
Portuguese (pt)
Inventor
Christine Crawley Suzanne
Fan Bin
Chan Li Betty
Benjamin Rivera Lee
Robert Sissons James
Sitrin Jonathan
Wang Yan
Zhao Xuan
Original Assignee
Ngm Biopharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
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Application filed by Ngm Biopharmaceuticals Inc filed Critical Ngm Biopharmaceuticals Inc
Publication of BR112022026284A2 publication Critical patent/BR112022026284A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/74—Inducing cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
BR112022026284A 2020-06-22 2021-06-21 Agentes de ligação, anticorpo, composição farmacêutica, polinucleotídeos, vetores, célula isolada, métodos para interromper, inibir ou bloquear a ligação de lair-1, a atividade de uma célula supressora derivada de mieloide (mdsc), ou a atividade de uma célula t regulatória (treg), método para tratar câncer em um indivíduo, método para inibir o crescimento tumoral, método para aumentar ou intensificar uma resposta imunológica a um tumor ou células tumorais, método para ativar ou intensificar uma resposta imunológica persistente ou a longo prazo a um tumor ou células tumorais, método para inibir a recidiva tumoral ou novo crescimento tumoral, método para induzir uma imunidade persistente ou a longo prazo que inibe recidiva tumoral ou novo crescimento tumoral, método para ativar célula mieloides no microambiente tumoral em um indivíduo com um tumor, método para ativar célula t no microambiente tumoral em um indivíduo com um tumor, método para produzir o agente de ligação BR112022026284A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063042299P 2020-06-22 2020-06-22
US202063122877P 2020-12-08 2020-12-08
PCT/US2021/038251 WO2021262597A2 (en) 2020-06-22 2021-06-21 Lair-1-binding agents and methods of use thereof

Publications (1)

Publication Number Publication Date
BR112022026284A2 true BR112022026284A2 (pt) 2023-03-07

Family

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BR112022026284A BR112022026284A2 (pt) 2020-06-22 2021-06-21 Agentes de ligação, anticorpo, composição farmacêutica, polinucleotídeos, vetores, célula isolada, métodos para interromper, inibir ou bloquear a ligação de lair-1, a atividade de uma célula supressora derivada de mieloide (mdsc), ou a atividade de uma célula t regulatória (treg), método para tratar câncer em um indivíduo, método para inibir o crescimento tumoral, método para aumentar ou intensificar uma resposta imunológica a um tumor ou células tumorais, método para ativar ou intensificar uma resposta imunológica persistente ou a longo prazo a um tumor ou células tumorais, método para inibir a recidiva tumoral ou novo crescimento tumoral, método para induzir uma imunidade persistente ou a longo prazo que inibe recidiva tumoral ou novo crescimento tumoral, método para ativar célula mieloides no microambiente tumoral em um indivíduo com um tumor, método para ativar célula t no microambiente tumoral em um indivíduo com um tumor, método para produzir o agente de ligação

Country Status (15)

Country Link
US (2) US12240899B2 (https=)
EP (1) EP4168451A2 (https=)
JP (1) JP2023532857A (https=)
KR (1) KR20230039640A (https=)
CN (2) CN116209676A (https=)
AU (1) AU2021296168A1 (https=)
BR (1) BR112022026284A2 (https=)
CA (1) CA3187944A1 (https=)
CL (1) CL2022003684A1 (https=)
CO (1) CO2022018537A2 (https=)
IL (1) IL299245A (https=)
MX (1) MX2022016544A (https=)
PE (1) PE20230839A1 (https=)
TW (1) TW202216768A (https=)
WO (1) WO2021262597A2 (https=)

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WO2024215782A1 (en) 2023-04-11 2024-10-17 Ngm Biopharmaceuticals, Inc. Methods of treating osteosarcoma using lair1 binding agents
WO2024215787A1 (en) 2023-04-11 2024-10-17 Ngm Biopharmaceuticals, Inc. Methods of treating osteosarcoma using lair1 binding agents and pd-1 antagonists

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