BR112022014762A2 - Composto, método para a preparação de um composto, e, forma cristalina - Google Patents
Composto, método para a preparação de um composto, e, forma cristalinaInfo
- Publication number
- BR112022014762A2 BR112022014762A2 BR112022014762A BR112022014762A BR112022014762A2 BR 112022014762 A2 BR112022014762 A2 BR 112022014762A2 BR 112022014762 A BR112022014762 A BR 112022014762A BR 112022014762 A BR112022014762 A BR 112022014762A BR 112022014762 A2 BR112022014762 A2 BR 112022014762A2
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- chemical formula
- purification
- synthesizing
- quality
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C07H1/02—Phosphorylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
- C07H7/06—Heterocyclic radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
COMPOSTO, MÉTODO PARA A PREPARAÇÃO DE UM COMPOSTO, E, FORMA CRISTALINA. A presente invenção provê um intermediário útil para a síntese de um inibidor de SGLT e um método para a preparação de um inibidor de SGLT usando o mesmo. De acordo com a presente invenção, desenvolvendo um composto de fórmula química 5 correspondendo a um novo intermediário, a dificuldade de purificação com processos existentes pode ser resolvida, a qualidade de substâncias relacionadas pode ser combinada com apenas uma etapa de purificação e o problema de controle de qualidade em cada etapa pode ser resolvido executando várias etapas in situ. O método para sintetizar um composto de fórmula química 1 usando um composto de fórmula química 5, de acordo com a presente invenção, permite a purificação na etapa de sintetizar um composto de fórmula química 5, resolvendo assim os problemas dos processos de síntese existentes, em que a qualidade das substâncias relacionadas era difícil de controlar passo a passo devido a um processo contínuo e minimizando a quantidade de substâncias relacionadas em um produto final. Além disso, à medida que o número de etapas de purificação aumenta, o processo pode ser simplificado porque a purificação não é necessariamente realizada duas ou mais vezes em uma etapa como na técnica anterior, maximizando assim o rendimento de produção de um derivado de difenilmetano de acordo com a fórmula química 1.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20200024525 | 2020-02-27 | ||
| PCT/KR2021/002507 WO2021172955A1 (ko) | 2020-02-27 | 2021-02-26 | Sglt 저해제의 합성에 유용한 중간체 및 이를 이용한 sglt 저해제의 제조 방법 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112022014762A2 true BR112022014762A2 (pt) | 2022-10-11 |
Family
ID=77490302
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112022014762A BR112022014762A2 (pt) | 2020-02-27 | 2021-02-26 | Composto, método para a preparação de um composto, e, forma cristalina |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20230096670A1 (pt) |
| EP (1) | EP4112612A4 (pt) |
| JP (1) | JP7442663B2 (pt) |
| KR (1) | KR102572714B1 (pt) |
| CN (1) | CN115087649A (pt) |
| AU (1) | AU2021225706A1 (pt) |
| BR (1) | BR112022014762A2 (pt) |
| CA (1) | CA3169604A1 (pt) |
| CL (1) | CL2022002326A1 (pt) |
| CO (1) | CO2022011686A2 (pt) |
| EC (1) | ECSP22067279A (pt) |
| MX (1) | MX2022010220A (pt) |
| PE (1) | PE20221498A1 (pt) |
| WO (1) | WO2021172955A1 (pt) |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5530124A (en) * | 1994-06-30 | 1996-06-25 | The Dupont Merck Pharmaceutical Company | Method for preparing cyclic ureas and their use for the synthesis of HIV protease inhibitors |
| NZ591818A (en) * | 2008-08-22 | 2013-01-25 | Theracos Inc | Processes for the preparation of sglt2 inhibitors |
| KR101513234B1 (ko) * | 2010-09-10 | 2015-04-17 | 주식회사 녹십자 | Sglt2 억제제로서의 신규 티오펜 유도체 및 이를 포함하는 약학 조성물 |
| US9034921B2 (en) | 2011-06-01 | 2015-05-19 | Green Cross Corporation | Diphenylmethane derivatives as SGLT2 inhibitors |
| US9340521B2 (en) * | 2013-03-18 | 2016-05-17 | Green Cross Corporation | Method for dual inhibition of SGLT1 and SGLT2 using diphenylmethane derivatives |
| US10174010B2 (en) * | 2014-03-19 | 2019-01-08 | Hangzhou Pushai Pharmaceutical Technology Co., Ltd. | Canagliflozin monohydrate and its crystalline forms, preparation methods and uses thereof |
| WO2016098016A1 (en) * | 2014-12-17 | 2016-06-23 | Dr. Reddy’S Laboratories Limited | Process for the preparation of sglt2 inhibitors |
| BR112018076243A2 (pt) * | 2016-06-17 | 2019-03-26 | Daewoong Pharmaceutical Co., Ltd. | método para produção de derivado de difenil metano |
| CN108530408A (zh) * | 2018-04-13 | 2018-09-14 | 海门慧聚药业有限公司 | 制备达格列净的方法 |
| MX2021001732A (es) * | 2018-08-13 | 2021-06-23 | Daewoong Pharmaceutical Co Ltd | Preparacion de intermedio util para la sintesis de inhibidor de sglt. |
-
2021
- 2021-02-26 WO PCT/KR2021/002507 patent/WO2021172955A1/ko active Application Filing
- 2021-02-26 EP EP21761658.0A patent/EP4112612A4/en active Pending
- 2021-02-26 KR KR1020210026669A patent/KR102572714B1/ko active IP Right Grant
- 2021-02-26 PE PE2022001824A patent/PE20221498A1/es unknown
- 2021-02-26 US US17/799,054 patent/US20230096670A1/en active Pending
- 2021-02-26 BR BR112022014762A patent/BR112022014762A2/pt unknown
- 2021-02-26 MX MX2022010220A patent/MX2022010220A/es unknown
- 2021-02-26 CN CN202180013608.6A patent/CN115087649A/zh active Pending
- 2021-02-26 AU AU2021225706A patent/AU2021225706A1/en active Pending
- 2021-02-26 CA CA3169604A patent/CA3169604A1/en active Pending
- 2021-02-26 JP JP2022550984A patent/JP7442663B2/ja active Active
-
2022
- 2022-08-19 CO CONC2022/0011686A patent/CO2022011686A2/es unknown
- 2022-08-25 CL CL2022002326A patent/CL2022002326A1/es unknown
- 2022-08-26 EC ECSENADI202267279A patent/ECSP22067279A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2021172955A1 (ko) | 2021-09-02 |
| CN115087649A (zh) | 2022-09-20 |
| CA3169604A1 (en) | 2021-09-02 |
| EP4112612A4 (en) | 2024-04-03 |
| EP4112612A1 (en) | 2023-01-04 |
| PE20221498A1 (es) | 2022-09-29 |
| JP2023514754A (ja) | 2023-04-07 |
| MX2022010220A (es) | 2022-10-10 |
| ECSP22067279A (es) | 2022-09-30 |
| KR102572714B1 (ko) | 2023-08-31 |
| CO2022011686A2 (es) | 2022-08-30 |
| JP7442663B2 (ja) | 2024-03-04 |
| KR20210109476A (ko) | 2021-09-06 |
| CL2022002326A1 (es) | 2023-02-10 |
| AU2021225706A1 (en) | 2022-09-01 |
| US20230096670A1 (en) | 2023-03-30 |
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