IT202200008861A1 - Processo per la preparazione di derivati dell’acido colico. - Google Patents

Processo per la preparazione di derivati dell’acido colico. Download PDF

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Publication number
IT202200008861A1
IT202200008861A1 IT102022000008861A IT202200008861A IT202200008861A1 IT 202200008861 A1 IT202200008861 A1 IT 202200008861A1 IT 102022000008861 A IT102022000008861 A IT 102022000008861A IT 202200008861 A IT202200008861 A IT 202200008861A IT 202200008861 A1 IT202200008861 A1 IT 202200008861A1
Authority
IT
Italy
Prior art keywords
preparation
acid derivatives
cholic acid
cholic
derivatives
Prior art date
Application number
IT102022000008861A
Other languages
English (en)
Inventor
Michele Castaldi
Paolo Verzoletto
Graziano Castaldi
Original Assignee
Chemelectiva S R L
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemelectiva S R L filed Critical Chemelectiva S R L
Priority to IT102022000008861A priority Critical patent/IT202200008861A1/it
Priority to PCT/EP2023/060098 priority patent/WO2023213540A1/en
Publication of IT202200008861A1 publication Critical patent/IT202200008861A1/it

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0088—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing unsubstituted amino radicals

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
IT102022000008861A 2022-05-03 2022-05-03 Processo per la preparazione di derivati dell’acido colico. IT202200008861A1 (it)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IT102022000008861A IT202200008861A1 (it) 2022-05-03 2022-05-03 Processo per la preparazione di derivati dell’acido colico.
PCT/EP2023/060098 WO2023213540A1 (en) 2022-05-03 2023-04-19 Process for the preparation of cholic acid derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT102022000008861A IT202200008861A1 (it) 2022-05-03 2022-05-03 Processo per la preparazione di derivati dell’acido colico.

Publications (1)

Publication Number Publication Date
IT202200008861A1 true IT202200008861A1 (it) 2023-11-03

Family

ID=82482876

Family Applications (1)

Application Number Title Priority Date Filing Date
IT102022000008861A IT202200008861A1 (it) 2022-05-03 2022-05-03 Processo per la preparazione di derivati dell’acido colico.

Country Status (2)

Country Link
IT (1) IT202200008861A1 (it)
WO (1) WO2023213540A1 (it)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024083775A1 (en) 2022-10-20 2024-04-25 Chemelectiva S.R.L. Process for the preparation of nor-ursodeoxycholic acid

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020231776A1 (en) * 2019-05-10 2020-11-19 President And Fellows Of Harvard College Small molecule modulators of gut bacterial bile acid metabolism
WO2021214685A1 (en) * 2020-04-21 2021-10-28 Bar Pharmaceuticals Societa' A Responsabilita' Limitata Method for the synthesis of a cholane derivative

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020231776A1 (en) * 2019-05-10 2020-11-19 President And Fellows Of Harvard College Small molecule modulators of gut bacterial bile acid metabolism
WO2021214685A1 (en) * 2020-04-21 2021-10-28 Bar Pharmaceuticals Societa' A Responsabilita' Limitata Method for the synthesis of a cholane derivative

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
CZAJKOWSKA ET AL: "Synthesis of cholaphanes by ring closing metathesis", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM , NL, vol. 48, no. 16, 22 March 2007 (2007-03-22), pages 2851 - 2855, XP005934060, ISSN: 0040-4039, DOI: 10.1016/J.TETLET.2007.02.099 *
G. PIANCATELLI ET AL: "The Synthesis of a C23-Spiroketalic Steroidal Sapogenin", GAZZETTA CHIMICA ITALIANA, vol. 104, 1 January 1974 (1974-01-01), pages 343 - 356, XP009541265 *
HERNANDEZ-HUERTA E. ET AL.: "A Straighforward one-Pot two-Step Conversion of Bile acids into dehomologated alcohols", STEROIDS, vol. 176, 2021, pages 108917, XP086863946, DOI: 10.1016/j.steroids.2021.108917
M.F. SARAIVA ET AL., TETRAHEDRON, vol. 65, 2009, pages 3563 - 3572
PELLICCIARI R ET AL., J. MED. CHEM., vol. 47, 2004, pages 4559 - 4569
PELLICCIARI R ET AL: "BILE ACID DERIVATIVES AS LIGANDS OF THE FARNESOID X RECEPTOR. SYNTHESIS, EVALUATION, AND STRUCTURE-ACTIVITY RELATIONSHIP OF A SERIES OF BODY AND SIDE CHAIN MODIFIED ANALOGUES OF CHENODEOXYCHOLIC ACID", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 47, 26 August 2004 (2004-08-26), pages 4559 - 4569, XP002569577, ISSN: 0022-2623, [retrieved on 20040723], DOI: 10.1021/JM049904B *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024083775A1 (en) 2022-10-20 2024-04-25 Chemelectiva S.R.L. Process for the preparation of nor-ursodeoxycholic acid

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Publication number Publication date
WO2023213540A1 (en) 2023-11-09

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